Research Topics
Genomes and Genes
| Gerard EberlSummaryAffiliation: Institut Pasteur Country: France Publications
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Detail Information
Publications
Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?Gerard Eberl
Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
Nat Rev Immunol 5:413-20. 2005..I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development...- From induced to programmed lymphoid tissues: the long road to preempt pathogensGerard Eberl
Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
Trends Immunol 28:423-8. 2007.... 
Opening the crypt: current facts and hypotheses on the function of cryptopatchesGerard Eberl
Institut Pasteur, Laboratory of Lymphoid Tissue Development CNRS URA1961, Paris 75724, France
Trends Immunol 31:50-5. 2010..Some of these issues, however, remain hotly debated. Therefore, cryptopatches are coming to the forefront of gut immunology and warrant a comprehensive discussion of their role in the development of the immune system...
IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursorsNaoko Satoh-Takayama
Cytokines and Lymphoid Development Unit, Institut Pasteur, 75724 Paris, France
J Exp Med 207:273-80. 2010..1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets...- Lineage relationship analysis of RORgammat+ innate lymphoid cellsShinichiro Sawa
Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
Science 330:665-9. 2010..Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts... - RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiotaShinichiro Sawa
Institut Pasteur, Lymphoid Tissue Development Unit, Paris, France
Nat Immunol 12:320-6. 2011..Our data identify a finely tuned equilibrium among intestinal symbionts, adaptive immunity and RORγt+ ILCs... - Lymphotoxin-β receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cellsNaoko Satoh-Takayama
Innate Immunity Unit, Institut Pasteur, Paris, France
Eur J Immunol 41:780-6. 2011..These results indicate that organized lymphoid tissue structures are not critical for the generation of an intact and fully functional intestinal NCR22 cell compartment... - CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentationAndreas J Müller
Dynamics of Immune Responses, Institut Pasteur, Paris, France
Immunity 37:147-57. 2012..Our results thus demonstrate that CD4(+) T cells can exert their protective activity by engaging a minority of infected cells... - Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defenseNaoko Satoh-Takayama
Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
Immunity 29:958-70. 2008..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces... - Inflammation recapitulates the ontogeny of lymphoid stromal cellsLucie Peduto
Laboratory of Lymphoid Tissue Development, Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Paris, France
J Immunol 182:5789-99. 2009..Our results show that LS cells are both programmed during ontogeny and reinduced during inflammation... - Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cellsMarie Cherrier
Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
J Exp Med 209:729-40. 2012..Notch is therefore a necessary switch to engage the LTi developmental pathway, but needs to be turned off later to avoid diversion to the T cell fate... - Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunityGernot Sellge
Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, Paris, France
J Immunol 184:2076-85. 2010..These findings bring new insights into the adaptive immune response to Shigella infection and highlight the importance of pathogen-specific Th17 cell immunity for secondary immune protection... - Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cellsMatthias Lochner
Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
J Exp Med 208:125-34. 2011..However, this comes at a high cost for the host and can lead to a deregulated B cell response and aggravated inflammatory pathology... - Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunityCaspar Ohnmacht
Institut Pasteur, Lymphoid Tissue Development Unit, 75724 Paris, France
Cell Microbiol 13:653-9. 2011..Here we discuss the view that the immune system in general, and type 17 immunity in particular, develop to maintain the equilibrium of the host with its symbionts... - Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cellsMatthias Lochner
Lymphoid Tissue Development Unit, Department of Immunology, Institut Pasteur, 75724 Paris, France
J Immunol 186:1531-7. 2011..These results demonstrate that a complex microbiota and cognate Ag are required to generate a properly regulated set of RORγt(+) T cells and Th17 cells... - Development and evolution of RORγt+ cells in a microbe's worldGerard Eberl
Lymphoid Tissue Development Unit, Institut Pasteur, Paris, France CNRS, URA1961, Paris, France
Immunol Rev 245:177-88. 2012..The development and evolution of RORγt(+) cells is intimately associated with the construction of a stable host-microbe interface... - Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasisDjahida Bouskra
Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961
Nature 456:507-10. 2008..Our results demonstrate that intestinal bacterial commensals and the immune system communicate through an innate detection system to generate adaptive lymphoid tissues and maintain intestinal homeostasis... - Bacteria and MAMP-induced morphogenesis of the immune systemGerard Eberl
Institut Pasteur, Development of Lymphoid Tissues Unit, Paris 75724, France
Curr Opin Immunol 22:448-54. 2010.... - The development of LTi cellsMarie Cherrier
Institut Pasteur, Lymphoid Tissue Development Unit, Paris 75724, France
Curr Opin Immunol 24:178-83. 2012..We suggest that the re-programming of RORγt in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury... - In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cellsMatthias Lochner
Laboratory of Lymphoid Tissue Development, Centre National de la Recherche Scientifique URA1961, Institut Pasteur, Paris 75724, France
J Exp Med 205:1381-93. 2008.... - Characterization of the thymic IL-7 niche in vivoNuno L Alves
Cytokines and Lymphoid Development Unit, Lymphocyte Development Unit, Plate Forme Technologique Centre d Ingénierie Génétique Murine, and Laboratory of Lymphoid Tissue Development, Institut Pasteur, Paris, France
Proc Natl Acad Sci U S A 106:1512-7. 2009..This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo...