Gerard Eberl

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?
    Gerard Eberl
    Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Nat Rev Immunol 5:413-20. 2005
  2. ncbi request reprint From induced to programmed lymphoid tissues: the long road to preempt pathogens
    Gerard Eberl
    Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Trends Immunol 28:423-8. 2007
  3. doi request reprint Opening the crypt: current facts and hypotheses on the function of cryptopatches
    Gerard Eberl
    Institut Pasteur, Laboratory of Lymphoid Tissue Development CNRS URA1961, Paris 75724, France
    Trends Immunol 31:50-5. 2010
  4. pmc IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 207:273-80. 2010
  5. doi request reprint Lineage relationship analysis of RORgammat+ innate lymphoid cells
    Shinichiro Sawa
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    Science 330:665-9. 2010
  6. doi request reprint RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    Shinichiro Sawa
    Institut Pasteur, Lymphoid Tissue Development Unit, Paris, France
    Nat Immunol 12:320-6. 2011
  7. doi request reprint Lymphotoxin-β receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells
    Naoko Satoh-Takayama
    Innate Immunity Unit, Institut Pasteur, Paris, France
    Eur J Immunol 41:780-6. 2011
  8. doi request reprint CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation
    Andreas J Müller
    Dynamics of Immune Responses, Institut Pasteur, Paris, France
    Immunity 37:147-57. 2012
  9. doi request reprint Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
  10. doi request reprint Inflammation recapitulates the ontogeny of lymphoid stromal cells
    Lucie Peduto
    Laboratory of Lymphoid Tissue Development, Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Paris, France
    J Immunol 182:5789-99. 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?
    Gerard Eberl
    Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Nat Rev Immunol 5:413-20. 2005
    ..I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development...
  2. ncbi request reprint From induced to programmed lymphoid tissues: the long road to preempt pathogens
    Gerard Eberl
    Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
    Trends Immunol 28:423-8. 2007
    ....
  3. doi request reprint Opening the crypt: current facts and hypotheses on the function of cryptopatches
    Gerard Eberl
    Institut Pasteur, Laboratory of Lymphoid Tissue Development CNRS URA1961, Paris 75724, France
    Trends Immunol 31:50-5. 2010
    ..Some of these issues, however, remain hotly debated. Therefore, cryptopatches are coming to the forefront of gut immunology and warrant a comprehensive discussion of their role in the development of the immune system...
  4. pmc IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 207:273-80. 2010
    ..1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets...
  5. doi request reprint Lineage relationship analysis of RORgammat+ innate lymphoid cells
    Shinichiro Sawa
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    Science 330:665-9. 2010
    ..Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts...
  6. doi request reprint RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    Shinichiro Sawa
    Institut Pasteur, Lymphoid Tissue Development Unit, Paris, France
    Nat Immunol 12:320-6. 2011
    ..Our data identify a finely tuned equilibrium among intestinal symbionts, adaptive immunity and RORγt+ ILCs...
  7. doi request reprint Lymphotoxin-β receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells
    Naoko Satoh-Takayama
    Innate Immunity Unit, Institut Pasteur, Paris, France
    Eur J Immunol 41:780-6. 2011
    ..These results indicate that organized lymphoid tissue structures are not critical for the generation of an intact and fully functional intestinal NCR22 cell compartment...
  8. doi request reprint CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation
    Andreas J Müller
    Dynamics of Immune Responses, Institut Pasteur, Paris, France
    Immunity 37:147-57. 2012
    ..Our results thus demonstrate that CD4(+) T cells can exert their protective activity by engaging a minority of infected cells...
  9. doi request reprint Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  10. doi request reprint Inflammation recapitulates the ontogeny of lymphoid stromal cells
    Lucie Peduto
    Laboratory of Lymphoid Tissue Development, Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Paris, France
    J Immunol 182:5789-99. 2009
    ..Our results show that LS cells are both programmed during ontogeny and reinduced during inflammation...
  11. pmc Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells
    Marie Cherrier
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 209:729-40. 2012
    ..Notch is therefore a necessary switch to engage the LTi developmental pathway, but needs to be turned off later to avoid diversion to the T cell fate...
  12. doi request reprint Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity
    Gernot Sellge
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, Paris, France
    J Immunol 184:2076-85. 2010
    ..These findings bring new insights into the adaptive immune response to Shigella infection and highlight the importance of pathogen-specific Th17 cell immunity for secondary immune protection...
  13. doi request reprint Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity
    Caspar Ohnmacht
    Institut Pasteur, Lymphoid Tissue Development Unit, 75724 Paris, France
    Cell Microbiol 13:653-9. 2011
    ..Here we discuss the view that the immune system in general, and type 17 immunity in particular, develop to maintain the equilibrium of the host with its symbionts...
  14. pmc Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells
    Matthias Lochner
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 208:125-34. 2011
    ..However, this comes at a high cost for the host and can lead to a deregulated B cell response and aggravated inflammatory pathology...
  15. doi request reprint Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells
    Matthias Lochner
    Lymphoid Tissue Development Unit, Department of Immunology, Institut Pasteur, 75724 Paris, France
    J Immunol 186:1531-7. 2011
    ..These results demonstrate that a complex microbiota and cognate Ag are required to generate a properly regulated set of RORγt(+) T cells and Th17 cells...
  16. doi request reprint Development and evolution of RORγt+ cells in a microbe's world
    Gerard Eberl
    Lymphoid Tissue Development Unit, Institut Pasteur, Paris, France CNRS, URA1961, Paris, France
    Immunol Rev 245:177-88. 2012
    ..The development and evolution of RORγt(+) cells is intimately associated with the construction of a stable host-microbe interface...
  17. doi request reprint Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    Djahida Bouskra
    Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961
    Nature 456:507-10. 2008
    ..Our results demonstrate that intestinal bacterial commensals and the immune system communicate through an innate detection system to generate adaptive lymphoid tissues and maintain intestinal homeostasis...
  18. doi request reprint Bacteria and MAMP-induced morphogenesis of the immune system
    Gerard Eberl
    Institut Pasteur, Development of Lymphoid Tissues Unit, Paris 75724, France
    Curr Opin Immunol 22:448-54. 2010
    ....
  19. pmc Origin, trafficking, and intraepithelial fate of gut-tropic T cells
    Delphine Guy-Grand
    Unité de Lymphopoièse, 2 Unité de Developpement des Tissus Lymphoïdes, 3 Unité de Dynamiques des Réponses Immunes, 4 Unité d Immunité Innée, 5 Unité de Biologie des Populations Lymphocytaires, Institut Pasteur, 75015 Paris, France
    J Exp Med 210:1839-54. 2013
    ..These events occur continuously as part of the normal IEL dynamics. ..
  20. doi request reprint The development of LTi cells
    Marie Cherrier
    Institut Pasteur, Lymphoid Tissue Development Unit, Paris 75724, France
    Curr Opin Immunol 24:178-83. 2012
    ..We suggest that the re-programming of RORγt in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury...
  21. pmc In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells
    Matthias Lochner
    Laboratory of Lymphoid Tissue Development, Centre National de la Recherche Scientifique URA1961, Institut Pasteur, Paris 75724, France
    J Exp Med 205:1381-93. 2008
    ....
  22. pmc Characterization of the thymic IL-7 niche in vivo
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Lymphocyte Development Unit, Plate Forme Technologique Centre d Ingénierie Génétique Murine, and Laboratory of Lymphoid Tissue Development, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 106:1512-7. 2009
    ..This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo...
  23. doi request reprint Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis
    Maria Leticia Zarantonelli
    Institut Pasteur, unité des Neisseria, 25 28 Rue du Dr Roux, Paris 75724, France
    Cell Host Microbe 13:735-45. 2013
    ..Our results suggest that antibiotic resistance imposes a cost to the success of the pathogen and may potentially explain the lack of clonal expansion of Pen(I) strains...