B Dujon

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Large-scale exploration of growth inhibition caused by overexpression of genomic fragments in Saccharomyces cerevisiae
    Jeanne Boyer
    Unité de Génétique Moléculaire des Levures, URA2171 CNRS and UFR 927 Université Pierre et Marie Curie, Paris Cedex 15, France
    Genome Biol 5:R72. 2004
  2. pmc A novel design of whole-genome microarray probes for Saccharomyces cerevisiae which minimizes cross-hybridization
    Emmanuel Talla
    Institut Pasteur, Unité de Génétique Moléculaire des Levures URA 2171 CNRS, UFR 927 Université PM Curie, 25 rue du Docteur Roux, F 75724 Paris Cedex 15, France
    BMC Genomics 4:38. 2003
  3. ncbi request reprint European Functional Analysis Network (EUROFAN) and the functional analysis of the Saccharomyces cerevisiae genome
    B Dujon
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, Paris, France
    Electrophoresis 19:617-24. 1998
  4. ncbi request reprint Genome evolution in yeasts
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie
    Nature 430:35-44. 2004
  5. ncbi request reprint Yeasts illustrate the molecular mechanisms of eukaryotic genome evolution
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures URA2171 CNRS and UFR927 University P M Curie, Institut Pasteur, 25 rue du Docteur Roux, F 75724 Paris, Cedex 15, France
    Trends Genet 22:375-87. 2006
  6. ncbi request reprint The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
    B Dujon
    Unité de Génétique Moléculaire des Levures URA 1149 CNRS and UFR 927Univ P M Curie, Institut Pasteur, Paris, France
    Nature 387:98-102. 1997
  7. ncbi request reprint The yeast genome project: what did we learn?
    B Dujon
    Unité de Génétique Moléculaire des Levures URA 1149 CNRS, Paris, France
    Trends Genet 12:263-70. 1996
  8. ncbi request reprint Hemiascomycetous yeasts at the forefront of comparative genomics
    Bernard Dujon
    Unité de Génétique moléculaire des levures associated with CNRS and University Pierre and Marie Curie, Institut Pasteur, 25 rue du Docteur Roux, F 75724 Paris Cedex 15, France
    Curr Opin Genet Dev 15:614-20. 2005
  9. ncbi request reprint Genomic exploration of the hemiascomycetous yeasts: 12. Kluyveromyces marxianus var. marxianus
    B Llorente
    Unité de Génétique Moléculaire des Levures URA 2171 du CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, Paris, France
    FEBS Lett 487:71-5. 2000
  10. ncbi request reprint Genomic exploration of the hemiascomycetous yeasts: 13. Pichia angusta
    G Blandin
    Unité de Génétique Moléculaire des Levures URA 2171 du CNRS, UFR 927 Univ P and M Curie, Département des Biotechnologie, Institut Pasteur, Paris, France
    FEBS Lett 487:76-81. 2000

Detail Information

Publications71

  1. pmc Large-scale exploration of growth inhibition caused by overexpression of genomic fragments in Saccharomyces cerevisiae
    Jeanne Boyer
    Unité de Génétique Moléculaire des Levures, URA2171 CNRS and UFR 927 Université Pierre et Marie Curie, Paris Cedex 15, France
    Genome Biol 5:R72. 2004
    ....
  2. pmc A novel design of whole-genome microarray probes for Saccharomyces cerevisiae which minimizes cross-hybridization
    Emmanuel Talla
    Institut Pasteur, Unité de Génétique Moléculaire des Levures URA 2171 CNRS, UFR 927 Université PM Curie, 25 rue du Docteur Roux, F 75724 Paris Cedex 15, France
    BMC Genomics 4:38. 2003
    ..The design and quality of the microarray probes are of critical importance for hybridization experiments as well as subsequent analysis of the data...
  3. ncbi request reprint European Functional Analysis Network (EUROFAN) and the functional analysis of the Saccharomyces cerevisiae genome
    B Dujon
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, Paris, France
    Electrophoresis 19:617-24. 1998
    ..With a central repository of mutant yeast strains, and a centralized database, EUROFAN lays the foundations for the future of genomics with yeast serving both as a model and a tool...
  4. ncbi request reprint Genome evolution in yeasts
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie
    Nature 430:35-44. 2004
    ....
  5. ncbi request reprint Yeasts illustrate the molecular mechanisms of eukaryotic genome evolution
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures URA2171 CNRS and UFR927 University P M Curie, Institut Pasteur, 25 rue du Docteur Roux, F 75724 Paris, Cedex 15, France
    Trends Genet 22:375-87. 2006
    ....
  6. ncbi request reprint The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
    B Dujon
    Unité de Génétique Moléculaire des Levures URA 1149 CNRS and UFR 927Univ P M Curie, Institut Pasteur, Paris, France
    Nature 387:98-102. 1997
    ....
  7. ncbi request reprint The yeast genome project: what did we learn?
    B Dujon
    Unité de Génétique Moléculaire des Levures URA 1149 CNRS, Paris, France
    Trends Genet 12:263-70. 1996
    ..Offering the possibility of large-scale reverse genetics, yeast will be a powerful model for post-sequencing studies. But geneticists are now faced with the difficulty of asking novel questions...
  8. ncbi request reprint Hemiascomycetous yeasts at the forefront of comparative genomics
    Bernard Dujon
    Unité de Génétique moléculaire des levures associated with CNRS and University Pierre and Marie Curie, Institut Pasteur, 25 rue du Docteur Roux, F 75724 Paris Cedex 15, France
    Curr Opin Genet Dev 15:614-20. 2005
    ..As major steps of the evolutionary history of hemiascomycetous genomes emerge, precise questions on the general mechanisms of their evolution can be addressed, using both experimental and in silico methods...
  9. ncbi request reprint Genomic exploration of the hemiascomycetous yeasts: 12. Kluyveromyces marxianus var. marxianus
    B Llorente
    Unité de Génétique Moléculaire des Levures URA 2171 du CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, Paris, France
    FEBS Lett 487:71-5. 2000
    ..cerevisiae. Only 42 K. marxianus identified genes are without detectable homolog in the baker's yeast. However, we identified several genetic rearrangements between these two yeast species...
  10. ncbi request reprint Genomic exploration of the hemiascomycetous yeasts: 13. Pichia angusta
    G Blandin
    Unité de Génétique Moléculaire des Levures URA 2171 du CNRS, UFR 927 Univ P and M Curie, Département des Biotechnologie, Institut Pasteur, Paris, France
    FEBS Lett 487:76-81. 2000
    ..cerevisiae, solo long terminal repeats, the whole ribosomal DNA cluster, and segments of mitochondrial DNA. The P. angusta sequences were deposited in EMBL under the accession numbers AL430961 to AL436044...
  11. ncbi request reprint Genomic exploration of the hemiascomycetous yeasts: 20. Evolution of gene redundancy compared to Saccharomyces cerevisiae
    B Llorente
    Unité de Génétique Moléculaire des Levures URA 2171 du CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, Paris, France
    FEBS Lett 487:122-33. 2000
    ..This is best explained by a dynamic equilibrium resulting from numerous events of gene duplication and deletion rather than by a massive duplication event occurring in some lineages and not in others...
  12. ncbi request reprint Genomic exploration of the hemiascomycetous yeasts: 10. Kluyveromyces thermotolerans
    A Malpertuy
    Unité de Génétique Moléculaire des Levures URA 2171 du CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, Paris, France
    FEBS Lett 487:61-5. 2000
    ..A lower level of conservation is observed with orthologues to genes of S. cerevisiae previously classified as orphans. Gene order was found to be conserved between S. cerevisiae and K. thermotolerans in 56.5% of studied cases...
  13. pmc Eucaryotic genome evolution through the spontaneous duplication of large chromosomal segments
    Romain Koszul
    Unité de Génétique Moléculaire des Levures, Département de Structure et Dynamique des Génomes, Institut Pasteur, Paris, France
    EMBO J 23:234-43. 2004
    ..Aneuploidization events or suppressor mutations that do not involve large-scale rearrangements accounted for the rest of the reversion events (in 26 and 16% of the strains, respectively)...
  14. pmc Random exploration of the Kluyveromyces lactis genome and comparison with that of Saccharomyces cerevisiae
    O Ozier-Kalogeropoulos
    Unité de Génétique Moléculaire des Levures URA 1300, CNRS and UFR 927, Universite Pierre et Marie Curie, Paris, France
    Nucleic Acids Res 26:5511-24. 1998
    ..cerevisiae counterparts than with any of the other organisms examined. Conserved gene order relationships (synteny) between the two yeast species are also observed for half of the cases studied...
  15. ncbi request reprint Sequence and analysis of a 26.9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae
    J Boyer
    Unité de Génétique Moléculaire des Levures URA 1149 du CNRS and UFR927, Universite Pierre et Marie Curie, Institut Pasteur, Paris, France
    Yeast 12:1575-86. 1996
    ..The present sequence corresponds to coordinates 772,331 to 799,187 of the entire chromosome XV sequence which can be retrieved by anonymous ftp (ftp. mips. embnet. org)...
  16. ncbi request reprint Self-catalyzed cleavage of the yeast nucleoporin Nup145p precursor
    M T Teixeira
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, Departement des Biotechnologies, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 274:32439-44. 1999
    ..Taken altogether, our data are consistent with a proteolytic mechanism involving an N>O acyl rearrangement and a subsequent ester intermediate uncovered in other self-processing proteins...
  17. ncbi request reprint Genomic exploration of the hemiascomycetous yeasts: 3. Methods and strategies used for sequence analysis and annotation
    F Tekaia
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR927 Univ P M Curie, Institut Pasteur, Paris, France
    FEBS Lett 487:17-30. 2000
    ....
  18. ncbi request reprint Genome-wide nuclear morphology screen identifies novel genes involved in nuclear architecture and gene-silencing in Saccharomyces cerevisiae
    Maria Teresa Teixeira
    Département de Structure et Dynamique des Génomes, Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Univ P M Curie, Institut Pasteur, 25 rue du Docteur Roux, 75724 Cedex 15, Paris, France
    J Mol Biol 321:551-61. 2002
    ..Interestingly, these nuclear morphology alterations were associated with chromatin-silencing defects. These genes provide a molecular context to explore the functional link between nuclear architecture and gene silencing...
  19. pmc Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region
    Pierre Therizols
    Unité de Génétique Moléculaire des Levures URA 2171 Centre National de la Recherche Scientifique, UFR 927 Université Pierre et Marie Curie, Département Structure et Dynamique des Génomes, Institut Pasteur, 75724 Paris Cedex, France
    J Cell Biol 172:189-99. 2006
    ..They also indicate that anchoring of telomeres is essential for efficient repair of DSBs occurring therein and is important for preserving genome integrity...
  20. ncbi request reprint Pervasiveness of gene conservation and persistence of duplicates in cellular genomes
    F Tekaia
    Unité de Génétique Moléculaire des Levures CNRS URA1300 and Université Pierre et Marie Curie UFR927, Institut Pasteur, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    J Mol Evol 49:591-600. 1999
    ..The methodology we have developed ensures stability and comparability of our results as the number of completely sequenced genomes increases...
  21. ncbi request reprint Evolution of gene order in the genomes of two related yeast species
    G Fischer
    Unité de Génétique Moléculaire des Levures, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, Institut Pasteur, 75724 Paris Cedex 15, France
    Genome Res 11:2009-19. 2001
    ..Surprisingly, gross chromosomal rearrangements such as translocations have only a minor effect on gene order reshuffling as they account for <10% of the synteny breakpoints...
  22. ncbi request reprint Mitochondrial DNA repairs double-strand breaks in yeast chromosomes
    M Ricchetti
    Unité de Physicochimie des Macromolécules Biologiques URA1773 du CNRS, Institut Pasteur, Paris, France
    Nature 402:96-100. 1999
    ..Thus, colonization of the yeast genome by mitochondrial DNA is an ongoing process...
  23. ncbi request reprint The complete mitochondrial genome sequence of the pathogenic yeast Candida (Torulopsis) glabrata
    Romain Koszul
    Unité de Génétique Moléculaire des Levures URA 2171 du CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, 25 rue du Docteur Roux, 75724 Cedex 15, Paris, France
    FEBS Lett 534:39-48. 2003
    ..Three group I introns each with an intronic open reading frame are present in the COX1 gene. This sequence is available under accession number AJ511533...
  24. ncbi request reprint Analysis of microsatellites in 13 hemiascomycetous yeast species: mechanisms involved in genome dynamics
    Alain Malpertuy
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Mol Evol 56:730-41. 2003
    ....
  25. pmc Segmental duplications arise from Pol32-dependent repair of broken forks through two alternative replication-based mechanisms
    Celia Payen
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie Paris 6, UFR927, Paris, France
    PLoS Genet 4:e1000175. 2008
    ....
  26. pmc Dynamic evolution of megasatellites in yeasts
    Thomas Rolland
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, Department Genomes and Genetics, Paris, France
    Nucleic Acids Res 38:4731-9. 2010
    ..These mechanisms actively cooperate to create new megasatellites, that may play an important role in the adaptation of Candida glabrata to its human host...
  27. ncbi request reprint Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway
    B Llorente
    Unité de Génétique Moléculaire des Levures URA 1300 CNRS, UFR927 Univ P and M Curie, Departement des Biotechnologies, Institut Pasteur, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Mol Microbiol 32:1140-52. 1999
    ..Expression of all three genes is regulated in the same way. Several other examples of gene fusions exist in the same biosynthetic pathway when eukaryotic genes are compared with prokaryotic ones...
  28. pmc Unusual composition of a yeast chromosome arm is associated with its delayed replication
    Celia Payen
    Institut Pasteur, CNRS, URA, Universite Pierre et Marie Curie, Paris, France
    Genome Res 19:1710-21. 2009
    ....
  29. pmc Stability of large segmental duplications in the yeast genome
    Romain Koszul
    Unité de Génétique Moléculaire des Levures CNRS URA2171, UFR927 Université Pierre et Marie Curie, Département de Structure et Dynamique des Génomes, Institut Pasteur, Paris, 75724 Cedex 15, France
    Genetics 172:2211-22. 2006
    ....
  30. doi request reprint Genomic polymorphism in the population of Candida glabrata: gene copy-number variation and chromosomal translocations
    Héloïse Muller
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, UPMC Univ Paris 06, CNRS URA 2171, 25 rue du Dr Roux, Paris, France
    Fungal Genet Biol 46:264-76. 2009
    ..Gene tandems often encode cell wall proteins suggesting a possible role in adaptation to the environment...
  31. ncbi request reprint Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w)
    B Llorente
    Unit e de G en etique Mol eculaire des Levures URA 2171 CNRS, UFR927 Univ P and M Curie, D epartement des Biotechnologies, Institut Pasteur, 25 rue du Dr Roux, F 75724 Cedex 15, Paris, France
    FEBS Lett 475:237-41. 2000
    ..Its apparent K(m) of 1.7 microM is low enough to allow the uptake of the low concentrations of nicotinic acid normally secreted by wild type cells...
  32. ncbi request reprint Group I introns as mobile genetic elements: facts and mechanistic speculations--a review
    B Dujon
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, Paris, France
    Gene 82:91-114. 1989
    ..Furthermore, the observed distribution also predicts that horizontal transfer of intron sequences must occur between unrelated species, using vectors yet to be discovered...
  33. doi request reprint Complete mitochondrial genome sequences of three Nakaseomyces species reveal invasion by palindromic GC clusters and considerable size expansion
    Christiane Bouchier
    Institut Pasteur, Plate Forme Génomique, Paris, France
    FEMS Yeast Res 9:1283-92. 2009
    ..Sequences are available under EMBL accession numbers FM995164, FM995165, and FM995166...
  34. ncbi request reprint 'Mass-murder' of ORFs from three regions of chromosome XI from Saccharomyces cerevisiae
    C Fairhead
    Unité de Génétique Moléculaire des Levures UFR927 Univ P et M Curie and URA 1300, CNRS, Institut Pasteur, 25 rue du Dr Roux, F 75724, Paris Cedex 15
    Gene 223:33-46. 1998
    ..We have found no synthetic phenotypes resulting from a combination of deleted genes and have always been able to attribute a mutant phenotype to a single gene...
  35. pmc Megasatellites: a peculiar class of giant minisatellites in genes involved in cell adhesion and pathogenicity in Candida glabrata
    Agnès Thierry
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, F 75015 Paris, France
    Nucleic Acids Res 36:5970-82. 2008
    ..Most of the time, these minisatellites are not conserved between C. glabrata and S. cerevisiae, although their host genes are well conserved, raising the question of an active mechanism creating minisatellites de novo in hemiascomycetes...
  36. doi request reprint Yeast evolutionary genomics
    Bernard Dujon
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, Centre National de la Recherche Scientifique University Pierre and Marie Curie Paris, 25 rue du Docteur Roux, F75724 Paris Cedex 15, France
    Nat Rev Genet 11:512-24. 2010
    ..I also discuss how results from yeasts can be extended to other eukaryotes...
  37. pmc Origin and fate of pseudogenes in Hemiascomycetes: a comparative analysis
    Ingrid Lafontaine
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, Paris, France
    BMC Genomics 11:260. 2010
    ..Among yeasts, only the genome of the S. cerevisiae reference strain has been analyzed so far for pseudogenes...
  38. pmc Chromosome arm length and nuclear constraints determine the dynamic relationship of yeast subtelomeres
    Pierre Therizols
    Unité de Génétique Moléculaire des Levures, Centre National de la Recherche Scientifique, Institut Pasteur, Université Pierre et Marie Curie 75724 Paris, France
    Proc Natl Acad Sci U S A 107:2025-30. 2010
    ..Our results suggest that interactions between subtelomeres are nonspecific and instead governed by physical constraints, including chromosome structure, attachment to the SPB, and nuclear crowding...
  39. pmc Highly variable rates of genome rearrangements between hemiascomycetous yeast lineages
    Gilles Fischer
    Unité de Génétique Moléculaire des Levures CNRS URA 2171, UFR927 Université Pierre et Marie Curie, Département de Structure et Dynamique des Génomes, Institut Pasteur, Paris, France
    PLoS Genet 2:e32. 2006
    ..This work reveals that the high plasticity of eukaryotic genomes results from rearrangement rates that vary between lineages but also at different evolutionary times of a given lineage...
  40. ncbi request reprint Structure of Kluyveromyces lactis subtelomeres: duplications and gene content
    Cécile Fairhead
    Unité de Génétique Moléculaire des Levures, Département Structure et Dynamique des Génomes, Institut Pasteur, Paris, France
    FEMS Yeast Res 6:428-41. 2006
    ....
  41. doi request reprint Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata
    Agnès Thierry
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, CNRS URA2171, Université Pierre et Marie Curie UFR 927, 25 rue du Dr Roux, 75015, Paris, France
    Cell Mol Life Sci 67:671-6. 2010
    ..Their putative role in promoting genome rearrangements by interfering with DNA replication will also be discussed...
  42. pmc Insertion of horizontally transferred genes within conserved syntenic regions of yeast genomes
    Thomas Rolland
    Unité de Génétique Moléculaire des Levures CNRS URA 2171, UFR927 Université Pierre et Marie Curie, Département Génomes et Génétique, Institut Pasteur, Paris, France
    PLoS ONE 4:e6515. 2009
    ....
  43. pmc The asexual yeast Candida glabrata maintains distinct a and alpha haploid mating types
    Héloïse Muller
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS URA 2171, Université Pierre et Marie Curie Paris 6 UFR927, F75015 Paris, France
    Eukaryot Cell 7:848-58. 2008
    ..Nonetheless, cells maintain specificity through regulation of the alpha1 and alpha2 genes and, more surprisingly, through differential splicing of the a1 transcript...
  44. doi request reprint SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination
    Alix Kerrest
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR 927, 25 rue du Dr Roux, F 75015 Paris, France
    Nat Struct Mol Biol 16:159-67. 2009
    ..In the absence of Srs2 or Sgs1, DNA damage accumulates and is processed by homologous recombination, triggering repeat rearrangements...
  45. doi request reprint Promiscuous DNA in the nuclear genomes of hemiascomycetous yeasts
    Christine Sacerdot
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA 2171, Universite Pierre et Marie Curie Paris 06, Paris, France
    FEMS Yeast Res 8:846-57. 2008
    ..The dynamics of NUMT acquisition and loss are illustrated here by their species-specific distribution...
  46. pmc Comparative genomics and molecular dynamics of DNA repeats in eukaryotes
    Guy Franck Richard
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR927, 25 rue du Dr Roux, F 75015, Paris, France
    Microbiol Mol Biol Rev 72:686-727. 2008
    ....
  47. ncbi request reprint Molecular evolution of minisatellites in hemiascomycetous yeasts
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures, Universite Pierre et Marie Curie, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Biol Evol 23:189-202. 2006
    ....
  48. ncbi request reprint Cooperative evolution in protein complexes of yeast from comparative analyses of its interaction network
    Massimo Vergassola
    Unité Génomique des Microorganismes Pathogènes, Structure and Dynamics of Genomes Department, Institute Pasteur, CNRS URA 2171, 28 rue du Dr Roux, F 757724 Paris Cedex 15, France
    Proteomics 5:3116-9. 2005
    ..The coevolution is found to be largely independent of the tendency of the subunits to have similar abundances...
  49. pmc Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeast
    Emmanuelle Fabre
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 30:3540-7. 2002
    ..CAG- or CUG-containing transcripts show a non-homogeneous cellular localization. We propose that long mRNAs result from transcription slippage, and discuss the possible implications for human diseases...
  50. ncbi request reprint Comparative genomics of hemiascomycete yeasts: genes involved in DNA replication, repair, and recombination
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, Paris Cedex, France
    Mol Biol Evol 22:1011-23. 2005
    ..lactis. Phylogenetic analyses show that the duplicated SGS1 gene evolved faster than the original gene, probably leading to a specialization of function of the duplicated copy...
  51. ncbi request reprint Amino acid composition of genomes, lifestyles of organisms, and evolutionary trends: a global picture with correspondence analysis
    Fredj Tekaia
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR927, Univ P M Curie, Paris, Institut Pasteur, 25, rue du Dr Roux, F 75724, Paris Cedex 15, France
    Gene 297:51-60. 2002
    ..Various results are discussed both on methodological and biological grounds. The evolutionary perspectives opened by our analyses are noted...
  52. ncbi request reprint Contractions and expansions of CAG/CTG trinucleotide repeats occur during ectopic gene conversion in yeast, by a MUS81-independent mechanism
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR 927 Univ Pierre et Marie Curie, Department Structure and Dynamics of Genomes, Institut Pasteur, 75724 Paris Cedex 15, France
    J Mol Biol 326:769-82. 2003
    ..We concluded that trinucleotide repeat rearrangements occur frequently during ectopic but not during allelic recombination, by a mechanism that does not require crossover formation...
  53. ncbi request reprint Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast
    Miria Ricchetti
    Unité de Génétique Moléculaire des Levures, UFR 927 Univ P et M Curie and URA 2171 CNRS, Structure and Dynamics of Genomes Departement, Institut Pasteur, Paris, France
    J Mol Biol 328:847-62. 2003
    ..Furthermore, subtelomeric rearrangements depend on the recombination process, which, unexpectedly, also promotes the joining of heterologous sequences. Finally, we report that the Rad52 protein increases the efficiency of NHEJ...
  54. pmc Uneven distribution of mating types among genotypes of Candida glabrata isolates from clinical samples
    Sylvain Brisse
    Institut Pasteur, Genotyping of Pathogens and Public Health, F 75015 Paris, France
    Eukaryot Cell 8:287-95. 2009
    ..Our data are consistent with rare independent mating type switching events occurring preferentially from type a to alpha, although the alternative possibility of selection favoring type a isolates cannot be excluded...
  55. ncbi request reprint Gene relics in the genome of the yeast Saccharomyces cerevisiae
    Ingrid Lafontaine
    Unité de Génétique Moléculaire des Levures, CNRS URA 2171, Institut Pasteur, Université Pierre et Marie Curie UFR 927, 25, rue du Docteur Roux 75724, Paris, Cedex 15, France
    Gene 335:1-17. 2004
    ..We present a compilation of all the data available, leading to a total of 278 pseudogenes in the genome of S. cerevisiae...
  56. pmc Continued colonization of the human genome by mitochondrial DNA
    Miria Ricchetti
    Unité de Génétique Moléculaire des Levures UFR 927 Univ P et M Curie and URA 2171 CNRS, Department of Structure and Dynamics of Genomes, Institut Pasteur, Paris, France
    PLoS Biol 2:E273. 2004
    ....
  57. ncbi request reprint Comparative genomics in hemiascomycete yeasts: evolution of sex, silencing, and subtelomeres
    Emmanuelle Fabre
    Unité de Génétique Moléculaire des Levures, URA2171 CNRS, UFR Université Pierre et Marie Curie, Département Structure et Dynamique des Génomes, Institut Pasteur, 75724 Cedex Paris, France
    Mol Biol Evol 22:856-73. 2005
    ..We have also found that in all species studied, subtelomeric gene families exist and are specific to each species...
  58. ncbi request reprint The complete mitochondrial genome of the yeast Kluyveromyces thermotolerans
    Emmanuel Talla
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS, UFR 927 Université PM Curie, Institut Pasteur, 25 rue du Docteur Roux, F 75724 Paris Cedex 15, France
    FEBS Lett 579:30-40. 2005
    ..Interestingly, the predicted secondary structure of the abnormal tRNAThr1 contains 10 nucleotides in its anticodon loop. This sequence is available under EMBL Accession No. AJ634268...
  59. pmc Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins
    M T Teixeira
    Unité de Génétique Moléculaire des levures URA 1300 CNRS and UPR 927 Univ P M Curie, Institut Pasteur, Departement des Biotechnologies, Paris, France
    EMBO J 16:5086-97. 1997
    ..These data suggest that N- and C-domains of Nup145p perform independent functions, and that the in vivo cleavage observed is of functional importance...
  60. pmc The genomic tree as revealed from whole proteome comparisons
    F Tekaia
    Unité de Génétique Moléculaire des Levures URA1300 Centre National de la Recherche Scientifique CNRS and UFR927 University Pierre and Marie Curie, Institut Pasteur, 75724 Paris Cedex 15, France
    Genome Res 9:550-7. 1999
    ..Genomic trees represent an additional approach for the understanding of evolution at the genomic level and may contribute to the proper assessment of the evolutionary relationships between extant species...
  61. ncbi request reprint The complete sequence of the 8.2 kb segment left of MAT on chromosome III reveals five ORFs, including a gene for a yeast ribokinase
    A Thierry
    Unité de Génétique Moléculaire des Levures URA 1149 du CNRS, Institut Pasteur, Paris, France
    Yeast 6:521-34. 1990
    ..YCR524 (923 codons) codes for a putative membrane protein. YCR521, 522 and 524, have each been disrupted by insertion of a URA3 cassette and are non-essential genes. An active ARS element is located within YCR523 or its vicinity...
  62. ncbi request reprint The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
    C Jacq
    Laboratoire de Genetique Moleculaire, URA 1302 du CNRS, Ecole Normale Superieure, Paris, France
    Nature 387:75-8. 1997
    ..Chromosome IV shares with chromosomes II, V, XII, XIII and XV some long clustered duplications which partly explain its origin...
  63. ncbi request reprint Generation and characterization of an ordered lambda clone array for the 460-kb region surrounding the murine Xist sequence
    C Rougeulle
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Mamm Genome 5:416-23. 1994
    ..The orientation of the Xist sequence in relation to the telomere and centromere of the X Chromosome (Chr) has been established with this contig and shown to be inverted compared to that in human...
  64. ncbi request reprint Novel transporters from hemiascomycete yeasts
    Benoît De Hertogh
    Unité de Génétique GENA, Universite Catholique de Louvain, Louvain la Neuve, Belgique
    J Mol Microbiol Biotechnol 6:19-28. 2003
    ..Integr. Genomics 2002;2:154-170; http://cbi.labri.u-bordeaux.fr/Genolevures]. These novel hemiascomycete transporters comprise 3 channels, 23 secondary transporters, 5 primary transporters and 5 membrane proteins of unknown function...
  65. ncbi request reprint Characterization of the I-Spom I endonuclease from fission yeast: insights into the evolution of a group I intron-encoded homing endonuclease
    Stefan Pellenz
    Institut für Biologie IV Mikrobiologie, Rheinisch Westfälische Technische Hochschule Aachen, D 52056 Aachen, Germany
    J Mol Evol 55:302-13. 2002
    ..Based on the results, we speculate on the evolution of site-specific homing endonucleases encoded by group I introns in eukaryotes...
  66. ncbi request reprint Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast
    Sophie Loeillet
    Institut Curie, Section de Recherche, UMR144 Centre National de la Recherche Scientifique, Génétique Moléculaire de la Recombinaison, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    DNA Repair (Amst) 4:459-68. 2005
    ..Altogether, these data suggest that the pathological interactions between the rad27Delta and specific nupDelta mutations result from the accumulation of unrepaired DNA damages...
  67. ncbi request reprint Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata
    Irene Castano
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Mol Microbiol 55:1246-58. 2005
    ..The analysis here is the first evidence that multiple EPA genes encode adhesins and demonstrates that transcription of at least two of these adhesins is regulated by subtelomeric silencing...
  68. ncbi request reprint Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6
    Susana Rodriguez-Navarro
    Departamento de Bioquimica y Biologia Molecular, Universitat de Valencia, C Dr Moliner 50, E 46100, Burjassot, Spain
    Yeast 19:1261-76. 2002
    ..Whereas copy 1 is required for conditions in which B(6) is essential for growth, copies 2 and 3 seem more related with B(1) biosynthesis during the exponential phase...
  69. pmc Molecular evolution of eukaryotic genomes: hemiascomycetous yeast spliceosomal introns
    Elisabeth Bon
    Laboratoire de Génétique Moléculaire et Cellulaire CNRS INRA, Institut National Agronomique Paris Grignon, F 78850 Thiverval Grignon, France
    Nucleic Acids Res 31:1121-35. 2003
    ....
  70. pmc The RNA polymerase III-dependent family of genes in hemiascomycetes: comparative RNomics, decoding strategies, transcription and evolutionary implications
    Christian Marck
    Service de Biochimie et de Génétique Moléculaire, Bât 144 CEA Saclay, 91191 Gif sur Yvette, France
    Nucleic Acids Res 34:1816-35. 2006
    ..We finally determined the bipartite A- and B-box sequences recognized by TFIIIC. These minimal sequences are nearly conserved throughout hemiascomycetes and were satisfactorily retrieved at appropriate locations in other Pol III genes...
  71. ncbi request reprint Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae
    Benoît De Hertogh
    Unité de Génétique, Faculté d Agronomie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Funct Integr Genomics 2:154-70. 2002
    ..Compared with a previous TC of the yeast genome, we classified an additional set of 538 membrane proteins (transporters and non-transporters) and identified 111 novel phylogenetic subfamilies...