Affiliation: Institut Gustave Roussy
Ma Y, Moors A, Camougrand N, Dokudovskaya S. The SEACIT complex is involved in the maintenance of vacuole-mitochondria contact sites and controls mitophagy. Cell Mol Life Sci. 2019;: pubmed publisher
..In addition, the SEACIT subcomplex is involved in the maintenance of the vacuole-mitochondria contact sites. Thus, the SEA complex appears to be an important link between the TORC1 pathway and regulation of mitochondria quality control. ..
Algret R, Fernandez Martinez J, Shi Y, Kim S, Pellarin R, Cimermancic P, et al
. Molecular architecture and function of the SEA complex, a modulator of the TORC1 pathway. Mol Cell Proteomics. 2014;13:2855-70 pubmed publisher
..The SEA complex emerges as a platform that can coordinate both structural and enzymatic activities necessary for the effective functioning of the TORC1 pathway. ..
Dokudovskaya S, Rout M. SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway. J Cell Sci. 2015;128:2219-28 pubmed publisher
..We will also provide an overview of the consequences of GATOR deregulation in cancer and other diseases. ..
Ma Y, Vassetzky Y, Dokudovskaya S. mTORC1 pathway in DNA damage response. Biochim Biophys Acta Mol Cell Res. 2018;1865:1293-1311 pubmed publisher
..We also describe how anticancer therapies benefit from simultaneous targeting of the DDR and mTOR pathways. ..
Dokudovskaya S, Waharte F, Schlessinger A, Pieper U, Devos D, Cristea I, et al
. A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics. 2011;10:M110.006478 pubmed publisher
..These data demonstrate that the SEA complex is an additional member of a family of membrane coating and vesicle tethering assemblies, extending the repertoire of protocoatomer-related complexes. ..
Ma Y, Silveri L, LaCava J, Dokudovskaya S. Tumor suppressor NPRL2 induces ROS production and DNA damage response. Sci Rep. 2017;7:15311 pubmed publisher
..Combined, these results demonstrate a new role for the NPRL2, distinct from its function in mTORC1 regulation. ..