Eric Deutsch

..This transition also signals a substantial worsening of prognosis. Here, we review the most important findings in prostate carcinogenesis and the molecular anomalies associated with the androgen-refractory stage...

..Therefore, these data suggest that Tyrphostin AG1024 could represent the basis of a novel therapy for STI571 refractory CML...

..Altogether, these data support the contention that AZD1152 mediates radiosensitization in vivo by enhancing mitotic catastrophe, which can be used as a biomarker of treatment efficacy...

..Promising preliminary data render these proteins potential targets for therapeutic development against cancer...

..The present study evaluated the efficacy of combining BCL-2 ODN and radiation in small-cell lung cancers (SCLC) cell lines...

..The combination of RAF and mTOR inhibitors is effective for enhancing antitumoral effects in cells with deregulation of both RAS-RAF and PI3K, possibly through the cross-inhibition of 4E binding protein 1 and S6 protein...

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..This model could provide in vivo evidence of the antitumor efficacy of combining a MMP inhibitor with ionizing radiation to target radiation-induced invasion and angiogenesis...

..Here we report all the different published clinical trials focusing on efficacy and toxicity in order to clarify and to summarise the present state-of-the-art of this particularly promising combination in solid tumour management...

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..We sought to compare and refine bioluminescent orthotopic mouse models of human localized NSCLC...

..Altogether these results suggest that Chir-124-mediated radiosensitization is profoundly influenced by the p53 and cell cycle checkpoint system...

..We review the incidence and clinical patterns of the gastrointestinal and hepatic toxic effects induced by the main molecular-targeted therapies and propose some hypotheses for the causes of each adverse event...

..Therefore, KRAS mutations should not be used as molecular predictors of response to conventional chemotherapy...

..Further investigations are warranted with regard to the molecular mechanisms underlying its actions and its dependency regarding p53 status...

..We examined the potential therapeutic effect of NS398, a selective cyclooxygenase-2 (COX-2) inhibitor, combined with irradiation on human prostate adenocarcinoma DU145 cells...

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..The data suggest that conditioning regimens including TBI should not be used when a bone marrow transplantation procedure is planned in these patients...

..New therapies targeting some of these abnormalities are under clinical evaluation and predictive factors of response are needed to personalize these therapies...

..These data suggest a novel and highly translatable therapeutic approach to cervix cancer, by inhibition of adhesion and invasion of circulating HPV-positive tumor cells, using Cidofovir and/or ROCK inhibition...

..Preclinical data on putative CSC targets are emerging by now. These preliminary studies are critical for the next generation of lung cancer therapies...

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..A caveat is directed at radiation oncologists, at the expense of scientific reliability and validity which surely, should not be compromised...

..This provides a good rationale to further assess EHT 6706 in combination protocols and confirm these effects in vivo...

..Development of a risk model with intermediate endpoints is essential for future chemoprevention studies...

..The objective of this article is to review the concept of targeted antiangiogenic agents and the early clinical results of their use in combination with radiation therapy...

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..These findings reveal a novel link between the oncoprotein BCR-ABL and the tumor-suppressor protein BRCA1...

..e. the mucosa, the mesenchyme, and blood vessels. Functional studies will be necessary to validate the present results...

..For advanced disease, chemotherapy alone has given very disappointing results. A multidisciplinary approach combining biological assessment of targets with clinical trials to evaluate new targeted drugs should be considered...

..It will be necessary to rethink phase I strategies, toxicity endpoints, and trial designs and concepts in order to fully optimize these regimens...

..These results indicate that pharmacologic inhibitors with enhanced specificity for class I PI3K may be of benefit when combined with radiotherapy...

..These results provide the basis for a novel anticancer strategy to enhance the therapeutic ratio of IR in EBV-related cancers...

..In conclusion, we found a novel effect on DNA repair of the CDK inhibitor roscovitine, which acts as a radiosensitizer in vitro and in vivo in breast cancer cells lacking a functional p53...

..This study provides the basis for a new anticancer strategy to enhance the antitumor effect of ionizing radiation in HPV-related cancers, without increase deleterious effects...

..Only when data can be easily exchanged will the entire biological community be able to derive the full benefit from such microarray studies...

..This Review highlights the most relevant studies in this exciting area of research, focusing in particular on the role of IGF1R in resistance to other receptor-targeted therapies for cancer...

..Together, these data demonstrate that PAI-1 plays a critical role in radiation-induced intestinal damage, suggesting that PAI-1 is an attractive target for preventing or reducing the side effects of radiation therapy...

..These data suggested that Ritonavir could clinically improve the tumor response to radiation therapy, especially in head and neck carcinoma...

..These approaches attempt to widen the therapeutic ratio of radiation, i.e. to increase specifically tumor radiation response with little impact on normal tissue response...

..Thus, radiosensitization of human cancer cells that express mutated K-RAS occurred under conditions where AZD3409 inihibits the activation of farneyslated H-RAS, but did not inhibit K-RAS activation...

..Moreover, we demonstrate in vitro that ECs influence these fundamental mechanisms involved in radiation-induced vascular damages...