Jacques Deguine

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression
    Jacques Deguine
    Institut Pasteur, Dynamics of Immune Responses Unit, 75015 Paris, France
    Immunity 33:632-44. 2010
  2. doi request reprint Visualizing the functional diversification of CD8+ T cell responses in lymph nodes
    Hélène Beuneu
    Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Departement d Immunologie, Paris, France
    Immunity 33:412-23. 2010
  3. doi request reprint Dynamic behavior of NK cells during activation in lymph nodes
    Hélène Beuneu
    Institut Pasteur, G5 Dynamiques des Reponses Immunes, Paris, France
    Blood 114:3227-34. 2009
  4. doi request reprint Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation
    Hélène Beuneu
    Institut Pasteur, Dynamics of Immune Responses Unit, F 75015 Paris, France
    J Immunol 187:2084-8. 2011
  5. doi request reprint Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions
    Jacques Deguine
    Dynamics of Immune Responses Unit, Institut Pasteur, 75015 Paris, France
    J Immunol 189:5493-7. 2012
  6. doi request reprint Dynamics of NK cell interactions in vivo
    Jacques Deguine
    Institut Pasteur, Dynamics of Immune Responses Unit, Paris, France
    Immunol Rev 251:154-9. 2013

Collaborators

Detail Information

Publications6

  1. doi request reprint Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression
    Jacques Deguine
    Institut Pasteur, Dynamics of Immune Responses Unit, 75015 Paris, France
    Immunity 33:632-44. 2010
    ..Altogether, our results offer mechanistic insight into how NK cells and CTLs can exert cytotoxic activity with remarkably different contact dynamics...
  2. doi request reprint Visualizing the functional diversification of CD8+ T cell responses in lymph nodes
    Hélène Beuneu
    Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Departement d Immunologie, Paris, France
    Immunity 33:412-23. 2010
    ..Thus, the early set of T cell-DC interactions in lymph nodes largely contribute to the heterogeneity of T cell responses through the generation of functionally divergent clonal progenies...
  3. doi request reprint Dynamic behavior of NK cells during activation in lymph nodes
    Hélène Beuneu
    Institut Pasteur, G5 Dynamiques des Reponses Immunes, Paris, France
    Blood 114:3227-34. 2009
    ..That NK cells become activated while remaining motile may constitute an efficient strategy for sampling local concentrations of cytokines around DCs in secondary lymphoid tissues...
  4. doi request reprint Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation
    Hélène Beuneu
    Institut Pasteur, Dynamics of Immune Responses Unit, F 75015 Paris, France
    J Immunol 187:2084-8. 2011
    ..Our results suggest that type I IFNs produced following viral infection simultaneously target accessory cells for IL-15 transpresentation and NK cells themselves and that these two pathways cooperate for NK cell priming...
  5. doi request reprint Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions
    Jacques Deguine
    Dynamics of Immune Responses Unit, Institut Pasteur, 75015 Paris, France
    J Immunol 189:5493-7. 2012
    ..Thus, complementary signals mediated by recognition of stress ligands and tumor-specific Abs may contribute to the efficacy of NK cells during mAb therapy...
  6. doi request reprint Dynamics of NK cell interactions in vivo
    Jacques Deguine
    Institut Pasteur, Dynamics of Immune Responses Unit, Paris, France
    Immunol Rev 251:154-9. 2013
    ..We review here our recent understanding of NK cell interactions in vivo at steady state, during inflammation, and during tumor elimination, emphasizing the similarities and differences with T cells...