Ala Eddine Deghmane

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Late repression of NF-κB activity by invasive but not non-invasive meningococcal isolates is required to display apoptosis of epithelial cells
    Ala Eddine Deghmane
    Institut Pasteur, Invasive Bacterial Infections Unit, Paris, France
    PLoS Pathog 7:e1002403. 2011
  2. pmc Differential modulation of TNF-alpha-induced apoptosis by Neisseria meningitidis
    Ala Eddine Deghmane
    Institut Pasteur, Invasive Bacterial Infections Unit, Paris, France
    PLoS Pathog 5:e1000405. 2009
  3. ncbi request reprint Down-regulation of pili and capsule of Neisseria meningitidis upon contact with epithelial cells is mediated by CrgA regulatory protein
    Ala Eddine Deghmane
    unité des Neisseria, 28 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Mol Microbiol 43:1555-64. 2002
  4. pmc Experimental meningococcal sepsis in congenic transgenic mice expressing human transferrin
    Marek Szatanik
    Unité des Infections Bactérienne Invasives, Institut Pasteur, Paris, France
    PLoS ONE 6:e22210. 2011
  5. ncbi request reprint The duality of virulence and transmissibility in Neisseria meningitidis
    Muhamed Kheir Taha
    Unité des Neisseria and Centre National de Référence des Méningocoque, Institut Pasteur, Paris, France
    Trends Microbiol 10:376-82. 2002
  6. ncbi request reprint The Neisseria meningitidis adhesion regulatory protein CrgA acts through oligomerization and interaction with RNA polymerase
    Ala Eddine Deghmane
    unité des Neisseria, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 47:135-43. 2003
  7. ncbi request reprint Emergence of new virulent Neisseria meningitidis serogroup C sequence type 11 isolates in France
    Ala Eddine Deghmane
    Invasive Bacterial Infections Unit, Neisseria Unit, and National Reference Center for Meningococci, Institut Pasteur, Paris, France
    J Infect Dis 202:247-50. 2010
  8. ncbi request reprint Analysis in vitro and in vivo of the transcriptional regulator CrgA of Neisseria meningitidis upon contact with target cells
    Ala Eddine Deghmane
    unité des Neisseria, Institut Pasteur, 28 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Mol Microbiol 53:917-27. 2004
  9. doi request reprint Invasive serogroup w meningococcal disease in children: a national survey from 2001 to 2008 in France
    Jean Gaschignard
    Hopital Robert Debre, Assistance Publique des Hopitaux de Paris, 49 boulevard Serrurier, Paris, France
    Pediatr Infect Dis J 32:798-800. 2013
  10. pmc Differential expression of genes that harbor a common regulatory element in Neisseria meningitidis upon contact with target cells
    Ala Eddine Deghmane
    unité des Neisseria, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 71:2897-901. 2003

Collaborators

Detail Information

Publications19

  1. pmc Late repression of NF-κB activity by invasive but not non-invasive meningococcal isolates is required to display apoptosis of epithelial cells
    Ala Eddine Deghmane
    Institut Pasteur, Invasive Bacterial Infections Unit, Paris, France
    PLoS Pathog 7:e1002403. 2011
    ..Our data provide insights to understand the meningococcal duality between invasiveness and asymptomatic carriage...
  2. pmc Differential modulation of TNF-alpha-induced apoptosis by Neisseria meningitidis
    Ala Eddine Deghmane
    Institut Pasteur, Invasive Bacterial Infections Unit, Paris, France
    PLoS Pathog 5:e1000405. 2009
    ..meningitidis. However, our data strongly suggest that carriage isolates of meningococci reduce inflammatory response and apoptosis induction, resulting in the protection of their ecological niche at the human nasopharynx...
  3. ncbi request reprint Down-regulation of pili and capsule of Neisseria meningitidis upon contact with epithelial cells is mediated by CrgA regulatory protein
    Ala Eddine Deghmane
    unité des Neisseria, 28 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Mol Microbiol 43:1555-64. 2002
    ..CrgA may play a central regulatory role in meningococcal adhesion, particularly in switching from initial to intimate adhesion by downregulating the bacterial surface structures that hinder this adhesion...
  4. pmc Experimental meningococcal sepsis in congenic transgenic mice expressing human transferrin
    Marek Szatanik
    Unité des Infections Bactérienne Invasives, Institut Pasteur, Paris, France
    PLoS ONE 6:e22210. 2011
    ..This new approach should enable detailed analysis of the pathophysiology of meningococcal sepsis and its relationships with flu infection...
  5. ncbi request reprint The duality of virulence and transmissibility in Neisseria meningitidis
    Muhamed Kheir Taha
    Unité des Neisseria and Centre National de Référence des Méningocoque, Institut Pasteur, Paris, France
    Trends Microbiol 10:376-82. 2002
    ..These events probably occur frequently, thus explaining not only the heterogeneous nature of meningococcal populations in carriers but probably also the evolutionary success of this human-restricted bacterium...
  6. ncbi request reprint The Neisseria meningitidis adhesion regulatory protein CrgA acts through oligomerization and interaction with RNA polymerase
    Ala Eddine Deghmane
    unité des Neisseria, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 47:135-43. 2003
    ..Therefore, the binding of CrgA and its interaction with RNA polymerase may inhibit the clearance of meningococcal promoters that are repressed by CrgA during the intimate adhesion of N. meningitidis to target cells...
  7. ncbi request reprint Emergence of new virulent Neisseria meningitidis serogroup C sequence type 11 isolates in France
    Ala Eddine Deghmane
    Invasive Bacterial Infections Unit, Neisseria Unit, and National Reference Center for Meningococci, Institut Pasteur, Paris, France
    J Infect Dis 202:247-50. 2010
    ..These isolates may be responsible for a peak in the incidence of serogroup C meningococcal infection in France, for which there is no routine vaccination to date...
  8. ncbi request reprint Analysis in vitro and in vivo of the transcriptional regulator CrgA of Neisseria meningitidis upon contact with target cells
    Ala Eddine Deghmane
    unité des Neisseria, Institut Pasteur, 28 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Mol Microbiol 53:917-27. 2004
    ..Upon contact with target cells, CrgA was released from the DNA, allowing transcription of the target gene to proceed to elongation and facilitating tight control of the expression of genes regulated by CrgA...
  9. doi request reprint Invasive serogroup w meningococcal disease in children: a national survey from 2001 to 2008 in France
    Jean Gaschignard
    Hopital Robert Debre, Assistance Publique des Hopitaux de Paris, 49 boulevard Serrurier, Paris, France
    Pediatr Infect Dis J 32:798-800. 2013
    ..Isolates of the clonal complex sequence type-22 were associated with nonmeningeal presentation. Further investigations of clinical tropism of meningococcal W isolates are warranted. ..
  10. pmc Differential expression of genes that harbor a common regulatory element in Neisseria meningitidis upon contact with target cells
    Ala Eddine Deghmane
    unité des Neisseria, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 71:2897-901. 2003
    ....
  11. doi request reprint Corticosteroid therapy in genotype ST-11 meningococcal infections
    Fouad Madhi
    Service de Pediatrie, Centre Hospitalier Intercommunal, Paris, France
    Pediatr Infect Dis J 32:291-3. 2013
    ..Genotypes of meningococcal isolates should be considered with corticosteroids therapy for meningococcal disease...
  12. doi request reprint Could the multicomponent meningococcal serogroup B vaccine (4CMenB) control Neisseria meningitidis capsular group X outbreaks in Africa?
    Eva Hong
    Institut Pasteur, Invasive Bacterial Infections Unit, Paris, France
    Vaccine 31:1113-6. 2013
    ..4CMenB vaccine can be considered for further investigation to control MenX outbreaks in Africa...
  13. doi request reprint Functional impacts of the diversity of the meningococcal factor H binding protein
    Eva Hong
    Institut Pasteur, Invasive Bacterial Infections Unit and National Reference Centre for Meningococci, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Vaccine 31:183-9. 2012
    ..They also provide data on the diversity of fhbp before the introduction of vaccines targeting fHbp and stress the need to include characterization of fHbp in typing schemes of meningococcal isolates...
  14. doi request reprint Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis
    Maria Leticia Zarantonelli
    Institut Pasteur, unité des Neisseria, 25 28 Rue du Dr Roux, Paris 75724, France
    Cell Host Microbe 13:735-45. 2013
    ..Our results suggest that antibiotic resistance imposes a cost to the success of the pathogen and may potentially explain the lack of clonal expansion of Pen(I) strains...
  15. pmc Target gene sequencing to define the susceptibility of Neisseria meningitidis to ciprofloxacin
    Eva Hong
    Institut Pasteur, Invasive Bacterial Infections Unit and National Reference Centre for Meningococci, Paris, France
    Antimicrob Agents Chemother 57:1961-4. 2013
    ..These data suggest a MIC of ≥ 0.064 μg/ml as the ciprofloxacin breakpoint for meningococci and argue for the molecular detection of ciprofloxacin resistance...
  16. doi request reprint Emerging drugs for acute bacterial meningitis
    Ala Eddine Deghmane
    Institut Pasteur, National Reference Centre for Meningococci, Invasive Bacterial Infections Provisional Unit, 28 rue du Dr Roux, Paris 75015, France
    Expert Opin Emerg Drugs 14:381-93. 2009
    ..Other drugs that neutralize bacterial factors or host mechanisms involved in induction of inflammatory response are under development...
  17. pmc Lipocalin 2 in cerebrospinal fluid as a marker of acute bacterial meningitis
    Tamazoust Guiddir
    Institut Pasteur, Invasive Bacterial Infections Unit and National Reference Centre for Meningococci, 28 rue du Dr Roux, 75724 Paris, Cedex 15, France
    BMC Infect Dis 14:276. 2014
    ..We aimed to investigate whether the detection of lipocalin 2, a protein of the acute innate immunity response, may be used as a marker for acute bacterial meningitis...
  18. ncbi request reprint A model of meningococcal bacteremia after respiratory superinfection in influenza A virus-infected mice
    Jean Michel Alonso
    unité des Neisseria, French National Reference Center for the Meningococci, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    FEMS Microbiol Lett 222:99-106. 2003
    ..Therefore, this model of meningococcal disease in adult mice reproduces the pathogenesis of human meningococcemia with fatal sepsis, and is useful for analyzing known or new genes identified in genomic studies...
  19. ncbi request reprint Immediate outcomes of bacterial meningitis in childhood may benefit from slow initial β-lactam infusion and oral paracetamol
    Muhamed Kheir Taha
    Institut Pasteur, Invasive Bacterial Infections Unit and National Reference Centre for Meningococci, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Future Microbiol 6:1125-9. 2011
    ....