Florent de Vathaire

Summary

Affiliation: Institut Gustave Roussy
Country: France

Publications

  1. doi request reprint Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: a retrospective cohort study
    Florent de Vathaire
    Radiation Epidemiology Group, Inserm U1018, Villejuif, France Institut Gustave Roussy, Villejuif, France Université Paris Sud, Villejuif, France
    Lancet Oncol 13:1002-10. 2012
  2. pmc Thyroid cancer following nuclear tests in French Polynesia
    F de Vathaire
    Radiation Epidemiology Group, U1018 Inserm, Institut Gustave Roussy, 39 rue Camille Desmoulins, INSERM, Villejuif F 94800, France
    Br J Cancer 103:1115-21. 2010
  3. doi request reprint Age at menopause and its influencing factors in a cohort of survivors of childhood cancer: earlier but rarely premature
    Cécile Thomas-Teinturier
    Radiation Epidemiology Group, Center for Research in Epidemiology and Population Health CESP INSERM U1018, Villejuif F 94800, France
    Hum Reprod 28:488-95. 2013
  4. doi request reprint Risk of a second malignant neoplasm after cancer in childhood treated with radiotherapy: correlation with the integral dose restricted to the irradiated fields
    France Nguyen
    INSERM U 605, Villejuif, France Institut Gustave Roussy, Villejuif Cedex, France
    Int J Radiat Oncol Biol Phys 70:908-15. 2008
  5. doi request reprint Breast cancer following radiotherapy for a hemangioma during childhood
    Nadia Haddy
    Radiation Epidemiology Group, CESP Centre for research in Epidemiology and Population Health, INSERM U 1018, 94807 Villejuif, France
    Cancer Causes Control 21:1807-16. 2010
  6. ncbi request reprint Concomitant chemo-radiotherapy and local dose of radiation as risk factors for second malignant neoplasms after solid cancer in childhood: a case-control study
    Sylvie Guerin
    National Institute of Public Health and Medical Research INSERM, Unit 605, Villejuif, France
    Int J Cancer 120:96-102. 2007
  7. doi request reprint Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer
    Markhaba Tukenova
    L Institut National de la Santé et de la Recherche Médicale, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Clin Oncol 28:1308-15. 2010
  8. doi request reprint Role of radiation dose in the risk of secondary leukemia after a solid tumor in childhood treated between 1980 and 1999
    Aurore Allard
    INSERM Unit 605, Villejuif, France
    Int J Radiat Oncol Biol Phys 78:1474-82. 2010
  9. doi request reprint Long-term cardiovascular mortality after radiotherapy for breast cancer
    Kim Bouillon
    Radiation Epidemiology Group CESP Unit 1018 INSERM, Villejuif, France
    J Am Coll Cardiol 57:445-52. 2011
  10. ncbi request reprint Radiation dose and risk of soft tissue and bone sarcoma after breast cancer treatment
    Carole Rubino
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research U605 INSERM, Villejuif, France
    Breast Cancer Res Treat 89:277-88. 2005

Collaborators

Detail Information

Publications49

  1. doi request reprint Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: a retrospective cohort study
    Florent de Vathaire
    Radiation Epidemiology Group, Inserm U1018, Villejuif, France Institut Gustave Roussy, Villejuif, France Université Paris Sud, Villejuif, France
    Lancet Oncol 13:1002-10. 2012
    ..However, little is known of the effect of pancreas irradiation on the risk of diabetes. We assessed the relation between radiation exposure and occurrence of diabetes in a large cohort of long-term childhood cancer survivors...
  2. pmc Thyroid cancer following nuclear tests in French Polynesia
    F de Vathaire
    Radiation Epidemiology Group, U1018 Inserm, Institut Gustave Roussy, 39 rue Camille Desmoulins, INSERM, Villejuif F 94800, France
    Br J Cancer 103:1115-21. 2010
    ..Between 1966 and 1974, France conducted 41 atmospheric nuclear tests in Polynesia, but their potential health effects have not previously been investigated...
  3. doi request reprint Age at menopause and its influencing factors in a cohort of survivors of childhood cancer: earlier but rarely premature
    Cécile Thomas-Teinturier
    Radiation Epidemiology Group, Center for Research in Epidemiology and Population Health CESP INSERM U1018, Villejuif F 94800, France
    Hum Reprod 28:488-95. 2013
    ..Is the age at menopause in a cohort of childhood cancer survivors earlier and what are the risk factors associated with earlier age at menopause?..
  4. doi request reprint Risk of a second malignant neoplasm after cancer in childhood treated with radiotherapy: correlation with the integral dose restricted to the irradiated fields
    France Nguyen
    INSERM U 605, Villejuif, France Institut Gustave Roussy, Villejuif Cedex, France
    Int J Radiat Oncol Biol Phys 70:908-15. 2008
    ..To take into account the heterogeneity of the dose distribution so as to evaluate the overall risk of an SMN after a childhood cancer, we therefore focused on the integral dose restricted to the irradiated fields...
  5. doi request reprint Breast cancer following radiotherapy for a hemangioma during childhood
    Nadia Haddy
    Radiation Epidemiology Group, CESP Centre for research in Epidemiology and Population Health, INSERM U 1018, 94807 Villejuif, France
    Cancer Causes Control 21:1807-16. 2010
    ..This paper presents the incidence of breast cancer (BC) in this cohort and its association with radiotherapy...
  6. ncbi request reprint Concomitant chemo-radiotherapy and local dose of radiation as risk factors for second malignant neoplasms after solid cancer in childhood: a case-control study
    Sylvie Guerin
    National Institute of Public Health and Medical Research INSERM, Unit 605, Villejuif, France
    Int J Cancer 120:96-102. 2007
    ..3 (95%CI, 1.1-4.8). Radiation was found to be the foremost treatment-related risk factor for the occurrence of a SMN. Compared to sequential treatment, concomitant chemo-radiotherapy may lead to a higher risk of a SMN...
  7. doi request reprint Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer
    Markhaba Tukenova
    L Institut National de la Santé et de la Recherche Médicale, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Clin Oncol 28:1308-15. 2010
    ..The purpose of this study was to assess the role of treatment in long-term overall and cardiovascular mortality after childhood cancer...
  8. doi request reprint Role of radiation dose in the risk of secondary leukemia after a solid tumor in childhood treated between 1980 and 1999
    Aurore Allard
    INSERM Unit 605, Villejuif, France
    Int J Radiat Oncol Biol Phys 78:1474-82. 2010
    ..The purpose of this study was to estimate the risk of secondary leukemia as a function of radiation dose, taking into account heterogeneous radiation dose distribution...
  9. doi request reprint Long-term cardiovascular mortality after radiotherapy for breast cancer
    Kim Bouillon
    Radiation Epidemiology Group CESP Unit 1018 INSERM, Villejuif, France
    J Am Coll Cardiol 57:445-52. 2011
    ..This study sought to investigate long-term cardiovascular mortality and its relationship to the use of radiotherapy for breast cancer...
  10. ncbi request reprint Radiation dose and risk of soft tissue and bone sarcoma after breast cancer treatment
    Carole Rubino
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research U605 INSERM, Villejuif, France
    Breast Cancer Res Treat 89:277-88. 2005
    ..To quantify the risk of soft tissue and bone sarcomas after breast cancer according to the doses and technical modalities of irradiation...
  11. doi request reprint Radiation therapy and late mortality from second sarcoma, carcinoma, and hematological malignancies after a solid cancer in childhood
    Markhaba Tukenova
    Radiation Epidemiology Group, Centre for research in Epidemiology and Population Health, U1018 Inserm, Villejuif, France
    Int J Radiat Oncol Biol Phys 80:339-46. 2011
    ..To compare patterns of long-term deaths due to secondary carcinomas, sarcomas, and hematological malignancies occurring after childhood cancer in a cohort of patients followed over a median of 28 years...
  12. ncbi request reprint Role of radiotherapy and chemotherapy in the risk of secondary leukaemia after a solid tumour in childhood
    Nadia Haddy
    National Institute of Public Health and Medical Research INSERM Unit 605, Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif, France
    Eur J Cancer 42:2757-64. 2006
    ..Our results suggest that the long-term risk of secondary leukaemia could be higher than previously reported...
  13. doi request reprint Thyroid adenomas after solid cancer in childhood
    Nadia Haddy
    Radiation Epidemiology Group, INSERM, Villejuif, France
    Int J Radiat Oncol Biol Phys 84:e209-15. 2012
    ..Very few childhood cancer survivor studies have been devoted to thyroid adenomas. We assessed the role of chemotherapy and the radiation dose to the thyroid in the risk of thyroid adenoma after childhood cancer...
  14. doi request reprint Family history of thyroid cancer and the risk of differentiated thyroid cancer in French polynesia
    Pauline Brindel
    Radiation Epidemiology Group U1018, INSERM, Villejuif Cedex, France
    Thyroid 20:393-400. 2010
    ..0; 95% CI, 2.4-48.8) than in individuals of mixed origin (OR, 2.1; 95% CI, 0.8-5.9). Conclusion: Our study shows that the familial inheritance of differentiated thyroid cancer is particularly high in Maohi populations...
  15. doi request reprint Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy
    Nadia Haddy
    INSERM, U605, Villejuif, France
    Radiother Oncol 93:377-82. 2009
    ..This paper presents the incidence of differentiated thyroid adenomas and carcinomas after radiotherapy in this cohort...
  16. ncbi request reprint Treatment-adjusted predisposition to second malignant neoplasms after a solid cancer in childhood: a case-control study
    Sylvie Guerin
    L Institut National de la Santé et de la Recherche Médicale, Villejuif, France
    J Clin Oncol 25:2833-9. 2007
    ..The aim of this study was to investigate the independent role of the FMN in the onset of any SMN...
  17. doi request reprint Anthropometric factors in differentiated thyroid cancer in French Polynesia: a case-control study
    Pauline Brindel
    INSERM Unit 605, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Cancer Causes Control 20:581-90. 2009
    ....
  18. doi request reprint Health outcomes of children fathered by patients treated with radioiodine for thyroid cancer
    Jerome Philippe Garsi
    Inserm U605 Institut Gustave Roussy Université Paris XI, Villejuif, France
    Clin Endocrinol (Oxf) 71:880-3. 2009
    ..Radiation is known to be mutagenic. The present study analyses birth outcomes and the health of offspring from men previously exposed to (131) I treatment for thyroid carcinoma...
  19. doi request reprint Long-term mortality from second malignant neoplasms in 5-year survivors of solid childhood tumors: temporal pattern of risk according to type of treatment
    Markhaba Tukenova
    Radiation Epidemiology Group, CESP Centre for research in Epidemiology and Population Health, U1018, INSERM, Villejuif, France
    Cancer Epidemiol Biomarkers Prev 19:707-15. 2010
    ..The temporal pattern in mortality from late second malignant neoplasms in solid childhood cancer survivors, according to the type of treatment, has not been investigated in detail...
  20. ncbi request reprint Malignant breast tumors after radiotherapy for a first cancer during childhood
    Catherine Guibout
    National Institute of Health and Medical Research, Cancer Epidemiology Research Unit U605 INSERM, Physics Department, Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif, France
    J Clin Oncol 23:197-204. 2005
    ..To assess the specific role of treatment and type of first cancer (FC) in the risk of long-term subsequent breast cancer (BC) among childhood cancer survivors...
  21. doi request reprint Frequency distribution of second solid cancer locations in relation to the irradiated volume among 115 patients treated for childhood cancer
    Ibrahima Diallo
    U605 Institut National de la Santé et de la Recherche Médicale, Villejuif, France
    Int J Radiat Oncol Biol Phys 74:876-83. 2009
    ....
  22. doi request reprint Long-term evaluation of Ifosfamide-related nephrotoxicity in children
    Odile Oberlin
    Pediatrics and Biostatistics Departments, and l Institut National de la Santé et de la Recherche Médicale, Institut Gustave Roussy, Villejuif, France
    J Clin Oncol 27:5350-5. 2009
    ..Ifosfamide is widely used in pediatric oncology but its nephrotoxicity may become a significant issue in survivors. This study is aimed at evaluating the incidence of late renal toxicity of ifosfamide and its risk factors...
  23. doi request reprint Dietary iodine and thyroid cancer risk in French Polynesia: a case-control study
    Enora Clero
    Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, U1018 Inserm, Villejuif, France
    Thyroid 22:422-9. 2012
    ..Iodine is suspected to play a role in this high incidence. The objective of this study was to assess whether low dietary iodine is related to a higher risk of thyroid cancer in the French Polynesian population...
  24. doi request reprint Therapeutic administration of 131I for differentiated thyroid cancer: radiation dose to ovaries and outcome of pregnancies
    Jerome Philippe Garsi
    INSERM U605, Villejuif, France
    J Nucl Med 49:845-52. 2008
    ....
  25. doi request reprint Dietary patterns, goitrogenic food, and thyroid cancer: a case-control study in French Polynesia
    Enora Clero
    Radiation Epidemiology Group, CESP Centre for research in Epidemiology and Population Health, U1018 Inserm, Villejuif, France
    Nutr Cancer 64:929-36. 2012
    ..The protective effect of cassava on this cancer does not seem to be substantially different from that of cabbage, which was the main goitrogenic food studied to date...
  26. doi request reprint Long-term mortality in a cohort study of 6,800 French breast cancer patients treated between 1954 and 1983
    Houda Boukheris
    National Institute of Health and Medical Research, Villejuif, France
    Acta Oncol 47:1122-32. 2008
    ..To investigate the impact of initial tumour characteristics and loco-regional radiotherapy on long-term survival following breast cancer diagnosis...
  27. doi request reprint Total heart volume as a function of clinical and anthropometric parameters in a population of external beam radiation therapy patients
    Audrey Nadège Ilembe Badouna
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Radiation Epidemiology Team, Villejuif, France
    Phys Med Biol 57:473-84. 2012
    ..84 for females). These results demonstrate that, among anthropometric parameters, weight plays an important role in predicting THV. These findings should be taken into account when assigning a computational phantom to a patient...
  28. doi request reprint Second malignant neoplasms in digestive organs after childhood cancer: a cohort-nested case-control study
    Markhaba Tukenova
    Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France
    Int J Radiat Oncol Biol Phys 82:e383-90. 2012
    ..The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer...
  29. ncbi request reprint Radiation dose, chemotherapy and risk of soft tissue sarcoma after solid tumours during childhood
    Axelle Menu-Branthomme
    National Institute of Public Health and Medical Research, Unit XUR521, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Int J Cancer 110:87-93. 2004
    ..A closer surveillance of children treated with this treatment combination is strongly recommended...
  30. ncbi request reprint Long-term risk of second malignant neoplasms after neuroblastoma in childhood: role of treatment
    Carole Rubino
    Research Unit of Cancer Epidemiology XU521 INSERM, Institut Gustave Roussy, Villejuif, France
    Int J Cancer 107:791-6. 2003
    ..For these patients, many more years of follow-up are required to appreciate their overall risks of treatment-related SMNs...
  31. doi request reprint Cancer mortality among French nuclear contract workers
    Sylvie Guerin
    Unit 605, INSERM, Villejuif, France
    Am J Ind Med 52:916-25. 2009
    ..Nuclear workers from French contracting companies have received higher doses than workers from Electricité de France (EDF) or Commissariat à l'Energie Atomique (CEA)...
  32. ncbi request reprint Radiation exposure and familial aggregation of cancers as risk factors for colorectal cancer after radioiodine treatment for thyroid carcinoma
    Carole Rubino
    National Institute of Public Health and Medical Research, INSERM, Unit 605, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Int J Radiat Oncol Biol Phys 62:1084-9. 2005
    ..The aim of this study in thyroid cancer patients was to evaluate the role of familial factors in the risk of colorectal cancer and their potential interaction with radioiodine exposure...
  33. ncbi request reprint Radiation dose, chemotherapy and risk of lung cancer after breast cancer treatment
    Carole Rubino
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research U521 INSERM, Institut Gustave Roussy, Villejuif, France
    Breast Cancer Res Treat 75:15-24. 2002
    ..10) per gray delivered to the site of lung cancer was evidenced. Our results agree with previous studies in favor of an increased risk of lung cancer after radiation therapy for breast cancer...
  34. doi request reprint Relationship between the brain radiation dose for the treatment of childhood cancer and the risk of long-term cerebrovascular mortality
    Nadia Haddy
    Radiation Epidemiology Group, INSERM U1018 CESP, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Brain 134:1362-72. 2011
    ..In conclusion, among 5-year survivors of childhood cancer, the radiation dose to the brain during radiotherapy was significantly associated with long-term cerebrovascular mortality...
  35. doi request reprint Expression of cell cycle biomarkers and telomere length in papillary thyroid carcinoma: a comparative study between radiation-associated and spontaneous cancers
    Mihaela Achille
    Laboratoire de Radiobiologie et Oncologie, DSV DRR Commissariat à l Energie Atomique, Villejuif, France
    Am J Clin Oncol 32:1-8. 2009
    ..To better define the biologic profile of radiation-induced and sporadic PTC, we compared in these two groups of PTC the expression of cell cycle regulatory proteins and telomere length...
  36. ncbi request reprint Anthracyclines, mitoxantrone, radiotherapy, and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer
    Marie Cecile Le Deley
    Biostatistics and Epidemiology Unit, Department of Medicine, Institut Gustave Roussy, Villejuif, France
    J Clin Oncol 25:292-300. 2007
    ..To determine the risk factors for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after breast cancer...
  37. ncbi request reprint Radiation dose and long term risk of cardiac pathology following radiotherapy and anthracyclin for a childhood cancer
    Laurence Guldner
    National Institute of Health and Medical Research INSERM, Institut Gustave Roussy, Villejuif, France
    Radiother Oncol 81:47-56. 2006
    ..To determine the cardiac status in children 15 years (yrs) or more after a solid tumour treatment...
  38. doi request reprint A multi-plane source model for out-of-field head scatter dose calculations in external beam photon therapy
    Mohamed Amine Benadjaoud
    CESP Centre for research in Epidemiology and Population Health, Radiation Epidemiology Team, Villejuif, France
    Phys Med Biol 57:7725-39. 2012
    ..These results should be taken into account when evaluating doses to the remaining volume at risk in external beam radiotherapy planning...
  39. ncbi request reprint The risk of multiple primary breast and thyroid carcinomas
    Elisabeth Adjadj
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research, Gustave Roussy Institute, Villejuif, France
    Cancer 98:1309-17. 2003
    ....
  40. ncbi request reprint Poorly differentiated follicular thyroid carcinoma: prognostic factors and relevance of histological classification
    Melania Pulcrano
    Nuclear Medicine and Endocrine Oncology, Commissariat à l Energie Atomique LRC29V, Institut Gustave Roussy and University Paris Sud, Villejuif, France
    Thyroid 17:639-46. 2007
    ....
  41. ncbi request reprint Cancer mortality after radiotherapy for a skin hemangioma during childhood
    Marie Gabrielle Dondon
    INSERM U605, Institut Gustave Roussy, rue Camille Desmoulins, Villejuif 94805, France
    Radiother Oncol 72:87-93. 2004
    ..A cohort study was performed as part of a European Radiation Protection Program to investigate the carcinogenic effect of treatment with ionizing radiation in early childhood. This paper presents mortality after radiotherapy in this cohort...
  42. doi request reprint The carcinogenic effects of radioiodine therapy for thyroid carcinoma
    Florent de Vathaire
    Unit of Cancer Epidemiology Unit 605 of the National Institute for Health and Medical Research INSERM, Villejuif, France
    Nat Clin Pract Endocrinol Metab 4:180-1. 2008
  43. doi request reprint Pooled analysis of two case-control studies in New Caledonia and French Polynesia of body mass index and differentiated thyroid cancer: the importance of body surface area
    Enora Clero
    Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, U1018 Inserm, Villejuif, France
    Thyroid 20:1285-93. 2010
    ..In this study we evaluated further the relationship between body mass index (BMI) and other anthropometric parameters on the incidence of thyroid cancer in the New Caledonia and French Polynesia populations...
  44. ncbi request reprint Genetic epidemiology of neuroblastoma: a study of 426 cases at the Institut Gustave-Roussy in France
    Taraneh Shojaei-Brosseau
    Unité de Recherches en Epidémiologie des Cancers INSERM U521, Institut Gustave Roussy, Villejuif Cedex, France
    Pediatr Blood Cancer 42:99-105. 2004
    ..The aim of this study was to estimate the fraction of inherited cases and penetrance associated with a carrier status, and to investigate the hypothesis that susceptibility cancer genes might be non-specific...
  45. ncbi request reprint Risk of secondary leukemia after a solid tumor in childhood according to the dose of epipodophyllotoxins and anthracyclines: a case-control study by the Société Française d'Oncologie Pédiatrique
    Marie Cecile Le Deley
    Biostatistics and Epidemiology Unit, the Radiophysics Unit, the Department of Pediatric Oncology, the Cytogenetics Laboratory, Institut Gustave Roussy, Villejuif, France
    J Clin Oncol 21:1074-81. 2003
    ..To estimate the risk of secondary leukemia as a function of the dose of epipodophyllotoxins and anthracyclines...
  46. doi request reprint Testicular function of survivors of childhood cancer: a comparative study between ifosfamide- and cyclophosphamide-based regimens
    Vita Ridola
    Department of Pediatric and Adolescent Oncology, Institut Gustave Roussy, Villejuif, France
    Eur J Cancer 45:814-8. 2009
    ..This study aimed at comparing gonadal toxicity of ifosfamide versus cyclophosphamide received during childhood...
  47. ncbi request reprint [Cardiac toxicity of cancer treatment regimes in children and adolescents: physiopathology, clinical data and the paediatric oncologist's point of view]
    Francois Pein
    Département d Oncologie de l Enfant et l Adolescent, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif
    Bull Cancer 91:185-91. 2004
    ..Other cytotoxic drugs such as high-dose cyclophosphamide, amsacrin, 5-FU and tubulin acting agents are also mentioned as a result of their cardiac toxicity, but this is not usually dose-cumulative...
  48. ncbi request reprint Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in native women in French Polynesia: a population-based case-control study
    Pauline Brindel
    Unit 605, INSERM, Villejuif, France
    Am J Epidemiol 167:219-29. 2008
    ..This study confirms the role of menstrual and reproductive factors in the risk of differentiated thyroid cancer in Pacific island populations...
  49. ncbi request reprint Characteristics of follicular cell-derived thyroid carcinomas occurring after external radiation exposure: results of a case control study nested in a cohort
    Carole Rubino
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research U521 INSERM, Villejuif, France
    Thyroid 12:299-304. 2002
    ..1-6.5), and conversely the frequency of follicular histology was similar in male cases and in male controls (OR = 0.3, 95% CI: 0.1-1.4). The risks of recurrence and of thyroid cancer related death were similar in cases and in controls...