F de Vathaire

..The purpose of this study was to assess the role of treatment in long-term overall and cardiovascular mortality after childhood cancer...

..Between 1966 and 1974, France performed 41 atmospheric nuclear weapon tests in the Mururoa and Fangataufa atolls in French Polynesia...

..The thyroid gland is among the most radiosensitive organs. However, little is known about the long-term risk of developing a thyroid tumor after fractionated external radiotherapy for cancer during childhood...

..This result suggests that there is a common mechanism for the occurrence of neuroblastoma and of differentiated thyroid tumour...

..This study suggests that the oncogenic effect of radiations might be increased by chemotherapy, and that the combination of the two treatment modalities might be one of the major factors responsible for overall risk of SMN...

..When compared with radiotherapy alone, the addition of chemotherapy increases the risk of solid SMN after a first cancer in childhood, but does not significantly modify the variation of this risk during the time after the first cancer...

..The risk of sarcoma was 30.6 higher for doses of more than 44 Gray than for doses of less than 15 Gray. CONCLUSIONS: High doses of radiation strongly increase the risk of bone and soft tissue sarcoma...

..The risk associated with chemotherapy should justify the implementation of skin surveillance for early detection of melanoma in these patients...

..The purpose of this study was to estimate the risk of secondary leukemia as a function of radiation dose, taking into account heterogeneous radiation dose distribution...

..When digestive tract cancers were excluded, the overall excess relative risk of second cancer per estimated effective sievert received to the whole body was -0.2 (P = 0.6)...

..10) per gray delivered to the site of lung cancer was evidenced. Our results agree with previous studies in favor of an increased risk of lung cancer after radiation therapy for breast cancer...

..In conclusion, radiotherapy may contribute to an increased risk of melanoma as a SMN, but only at very high doses of low linear energy transfer radiation. Common genetic origins between gonadal tumours and malignant melanomas are likely...

..A study of cancer incidence is planned...

....

..Between 1966 and 1974, France conducted 41 atmospheric nuclear tests in Polynesia, but their potential health effects have not previously been investigated...

..For these patients, many more years of follow-up are required to appreciate their overall risks of treatment-related SMNs...

..These data indicate that there is no scientific reason to avoid the use of 131I even in young patients when therapeutic benefits can be obtained...

..1-6.5), and conversely the frequency of follicular histology was similar in male cases and in male controls (OR = 0.3, 95% CI: 0.1-1.4). The risks of recurrence and of thyroid cancer related death were similar in cases and in controls...

..This study strongly emphasizes the need to limit the heart irradiation during radiotherapy, particularly, for patients who also received or were susceptible to later received adriamycin...

..0; 95% CI, 1.4 to 30.9). CONCLUSION: The reported high risk of BC after childhood Hodgkin's disease treatment seems to be due not only to a higher radiation dose to the breasts, but also to a specific susceptibility...

..This study aimed at comparing gonadal toxicity of ifosfamide versus cyclophosphamide received during childhood...

..This relationship was limited to endometrial cancers and did not modify the relationship with radiation dose. Our results suggest that high radiation doses slightly increase the risk of second malignancies after breast cancer...

..In case of contamination with radioiodines, administration of potassium iodide can prevent thyroid irradiation...

..The temporal pattern in mortality from late second malignant neoplasms in solid childhood cancer survivors, according to the type of treatment, has not been investigated in detail...

..3 (95%CI, 1.1-4.8). Radiation was found to be the foremost treatment-related risk factor for the occurrence of a SMN. Compared to sequential treatment, concomitant chemo-radiotherapy may lead to a higher risk of a SMN...

..Nuclear workers from French contracting companies have received higher doses than workers from Electricité de France (EDF) or Commissariat à l'Energie Atomique (CEA)...

....

..The aim of this study was to investigate the independent role of the FMN in the onset of any SMN...

..To take into account the heterogeneity of the dose distribution so as to evaluate the overall risk of an SMN after a childhood cancer, we therefore focused on the integral dose restricted to the irradiated fields...

..To investigate the impact of initial tumour characteristics and loco-regional radiotherapy on long-term survival following breast cancer diagnosis...

..This paper presents the incidence of differentiated thyroid adenomas and carcinomas after radiotherapy in this cohort...

..To determine the risk factors for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after breast cancer...

..To estimate the risk of secondary leukemia as a function of the dose of epipodophyllotoxins and anthracyclines...

..Ifosfamide is widely used in pediatric oncology but its nephrotoxicity may become a significant issue in survivors. This study is aimed at evaluating the incidence of late renal toxicity of ifosfamide and its risk factors...

..Other cytotoxic drugs such as high-dose cyclophosphamide, amsacrin, 5-FU and tubulin acting agents are also mentioned as a result of their cardiac toxicity, but this is not usually dose-cumulative...

....

....

..The risk increases with the dose of adriamycin and radiation received to the heart, without evidence for threshold...

..They should be treated until the disappearance of any uptake or until a cumulative activity of 22 GBq has been administered. In the other patients, other treatment modalities should be used when tumor progression has been documented...

..The risk of cancer increased with age in the reference population and increased faster in the cohort, because the standardised incidence ratio is constant over a long period...

..0 expected from national mortality statistics. There was no difference in the risk of leukaemia mortality according to sex, age, size of the population increase or region (Ile de France versus others)...

..This study confirms the role of menstrual and reproductive factors in the risk of differentiated thyroid cancer in Pacific island populations...

....

..To better define the biologic profile of radiation-induced and sporadic PTC, we compared in these two groups of PTC the expression of cell cycle regulatory proteins and telomere length...

..Results indicate that cisplatinum exhibits a high and specific tumoricidal property and appears to be valid in bone marrow purging...

..Although present results are preliminary and our research is ongoing, they appear encouraging, since such patient-adjusted phantoms are crucial in the optimization of radiation protection of patients and for follow-up studies...

....

....

..We found some arguments for the existence of non-specific genetic susceptibility, which would slightly in crease the probability of developing any cancer...

..However, in combination with radiotherapy, chemotherapy showed a significant potentiating effect. Relapse was found to be an independent risk factor for development of an SMST, with a higher relative risk for females than for males...

..Our results suggest that the long-term risk of secondary leukaemia could be higher than previously reported...

..However, the study population was small and no interaction was found between these two factors...

..A closer surveillance of children treated with this treatment combination is strongly recommended...

..A thorough compilation of the results of all radiation monitoring that was performed in French Polynesia in 1966-1974 would be likely to greatly improve the reliability and the precision of the dose estimates...

..The incidence of acute non-lymphocytic leukaemia (ANLL) decreased from 3.3 x 10(-5) between 1985 and 1989, an unexpectedly high incidence, to 0.8 x 10(-5) between 1990 and 1995...

..These patients need to be followed up in the future...

..However, no clinical trials of hyaluronan as a treatment option for pressure ulcers have been reported as yet...