Croixmarie V, Umbdenstock T, Cloarec O, Moreau A, Pascussi J, Boursier Neyret C, et al. Integrated comparison of drug-related and drug-induced ultra performance liquid chromatography/mass spectrometry metabonomic profiles using human hepatocyte cultures. Anal Chem. 2009;81:6061-9 pubmed publisher
..This global approach coupled to a statistical pretreatment of the data, enabling the separate capture of both drug related and drug induced biomarkers, represents a powerful technique for future mechanistic studies using cellular tools. ..