Jerome Couturier

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. doi [Diagnosis of HER2 gene amplification in breast carcinoma]
    J Couturier
    Service de génétique oncologique, Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Pathol Biol (Paris) 56:375-9. 2008
  2. ncbi Strong correlation between results of fluorescent in situ hybridization and immunohistochemistry for the assessment of the ERBB2 (HER-2/neu) gene status in breast carcinoma
    J Couturier
    Department of Genetics, Institut Curie, Section Médicale, Paris, France
    Mod Pathol 13:1238-43. 2000
  3. doi [Genomic classification of renal cell tumors in adults]
    Jerome Couturier
    Service de génétique oncologique, Institut Curie Hôpital, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Ann Pathol 28:402-8. 2008
  4. doi Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors
    Fariba Nemati
    Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, Paris, France
    Clin Cancer Res 16:2352-62. 2010
  5. ncbi Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
    Christophe Rosty
    Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Oncogene 24:7094-104. 2005
  6. ncbi Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases
    Marine Lefevre
    Department of Pathology, Tenon, Institut Curie, Paris, France
    Am J Surg Pathol 29:1576-81. 2005
  7. ncbi Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma
    Gudrun Schleiermacher
    INSERM Unité 509, Laboratoire de Pathologie Moléculaire des Cancers, Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, Paris, France
    Cancer Genet Cytogenet 141:32-42. 2003
  8. pmc Fine mapping of whole RB1 gene deletions in retinoblastoma patients confirms PCDH8 as a candidate gene for psychomotor delay
    Laurent Castera
    Departement de Biologie des Tumeurs, Institut Curie, Paris, France
    Eur J Hum Genet 21:460-4. 2013
  9. doi Accumulation of segmental alterations determines progression in neuroblastoma
    Gudrun Schleiermacher
    L Institut National de la Santé et de la Recherche Médicale U830, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Clin Oncol 28:3122-30. 2010
  10. doi Patient-derived xenografts recapitulate molecular features of human uveal melanomas
    Cecile Laurent
    Institut Curie, Paris, France
    Mol Oncol 7:625-36. 2013

Detail Information

Publications55

  1. doi [Diagnosis of HER2 gene amplification in breast carcinoma]
    J Couturier
    Service de génétique oncologique, Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Pathol Biol (Paris) 56:375-9. 2008
    ..Clusters of signals are characteristic of amplifications. The process designed for the assessment of HER2 is a model of strategies that will be used for the evaluation of markers involved in future targeted therapies...
  2. ncbi Strong correlation between results of fluorescent in situ hybridization and immunohistochemistry for the assessment of the ERBB2 (HER-2/neu) gene status in breast carcinoma
    J Couturier
    Department of Genetics, Institut Curie, Section Médicale, Paris, France
    Mod Pathol 13:1238-43. 2000
    ..Thus, under standardized conditions, IHC is a reliable and economical test to assess the ERBB2 status in tumors. The use of FISH could be limited to the verification of the status of tumors displaying a weak membrane immunostaining...
  3. doi [Genomic classification of renal cell tumors in adults]
    Jerome Couturier
    Service de génétique oncologique, Institut Curie Hôpital, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Ann Pathol 28:402-8. 2008
    ..2, and TFEB, in 6p21. So, molecular diagnosis, either by identification of specific translocations, or by genomic profiling, can be of valuable help for typing renal tumors when histological classification is difficult...
  4. doi Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors
    Fariba Nemati
    Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, Paris, France
    Clin Cancer Res 16:2352-62. 2010
    ..The aim of this study was to develop and characterize a panel of human uveal melanoma xenografts transplanted into immunodeficient mice...
  5. ncbi Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
    Christophe Rosty
    Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Oncogene 24:7094-104. 2005
    ..HPV expression level may thus provide a biological marker useful for prognosis assessment and specific therapy of the disease...
  6. ncbi Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases
    Marine Lefevre
    Department of Pathology, Tenon, Institut Curie, Paris, France
    Am J Surg Pathol 29:1576-81. 2005
    ..These results suggest that adult papillary renal tumors with oncocytic cells might be a distinct variant in the papillary renal cell carcinoma group...
  7. ncbi Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma
    Gudrun Schleiermacher
    INSERM Unité 509, Laboratoire de Pathologie Moléculaire des Cancers, Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, Paris, France
    Cancer Genet Cytogenet 141:32-42. 2003
    ..Altogether these data suggest that neuroblastoma is characterized by rearrangements that predominantly involve chromosome fragments replicating early in the S-phase...
  8. pmc Fine mapping of whole RB1 gene deletions in retinoblastoma patients confirms PCDH8 as a candidate gene for psychomotor delay
    Laurent Castera
    Departement de Biologie des Tumeurs, Institut Curie, Paris, France
    Eur J Hum Genet 21:460-4. 2013
    ....
  9. doi Accumulation of segmental alterations determines progression in neuroblastoma
    Gudrun Schleiermacher
    L Institut National de la Santé et de la Recherche Médicale U830, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Clin Oncol 28:3122-30. 2010
    ..We explored the role of segmental alterations in tumor progression and the possibility of evolution from indolent to aggressive genomic types...
  10. doi Patient-derived xenografts recapitulate molecular features of human uveal melanomas
    Cecile Laurent
    Institut Curie, Paris, France
    Mol Oncol 7:625-36. 2013
    ..These models therefore constitute valuable preclinical tool for drug screening in UM...
  11. ncbi Overexpression/amplification of HER-2/neu is uncommon in invasive carcinoma of the uterine cervix
    Christophe Rosty
    Departement de Pathologie, Institut Curie, Section Médicale, Paris, France
    Int J Gynecol Pathol 23:13-7. 2004
    ..Overexpression/amplification of HER-2/neu is uncommon in invasive cervical carcinoma, suggesting that there is little indication for using anti-p185c-erbB2 therapy in the treatment of these patients...
  12. ncbi A deep intronic mutation in the RB1 gene leads to intronic sequence exonisation
    Catherine Dehainault
    Service de génétique oncologique, Institut Curie, Paris, France
    Eur J Hum Genet 15:473-7. 2007
    ..This is the first report of a deep intronic mutation in RB1 and is a proof of concept that some undetected RB1 mutations should be investigated at the cDNA level, particularly in hereditary forms of retinoblastoma...
  13. pmc A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer
    Jean Philippe Meyniel
    Department of Translational Research, Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    BMC Cancer 10:222. 2010
    ..The purpose of the present work was to develop genomic and transcriptomic tools to further refine the pathological diagnosis of ovarian tumors after a previous history of breast cancer...
  14. doi MDM2 as a modifier gene in retinoblastoma
    Laurent Castera
    Pharm D, Department of Oncogenetics, Institut Curie, Paris, France
    J Natl Cancer Inst 102:1805-8. 2010
    ....
  15. doi Frequent genomic structural alterations at HPV insertion sites in cervical carcinoma
    Martine Peter
    Department of Tumour Biology, Institut Curie, F 75248 Paris, France
    J Pathol 221:320-30. 2010
    ..Structural alterations of the host genome are frequently observed at the integration site of HPV DNA in cervical cancer and may act in oncogenesis...
  16. doi Renal translocation carcinomas: clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature
    Philippe Camparo
    HIA Val de Grace, Van Andel Research Institute, Paris, France
    Am J Surg Pathol 32:656-70. 2008
    ..Our results suggest that these differentially expressed genes may serve as novel diagnostic or prognostic markers...
  17. doi Fine-needle aspiration as a diagnostic technique in 50 cases of primary Ewing sarcoma/peripheral neuroectodermal tumor. Institut Curie's experience
    Jerzy Klijanienko
    Department of Tumor Biology, Institut Curie, Paris, France
    Diagn Cytopathol 40:19-25. 2012
    ..In conclusion, FNA assisted by genomic techniques is powerful methods to accurate diagnose ES/PNET...
  18. doi Diagnostic and prognostic information obtained on fine-needle aspirates of primary neuroblastic tumors: Proposal for a cytology prognostic score
    Jerzy Klijanienko
    Department of Pathology, Institut Curie, Paris, France
    Cancer Cytopathol 119:411-23. 2011
    ..The use of cytological material for diagnosis and prognosis in patients with neuroblastic tumors is poorly described in the literature...
  19. doi Overall genomic pattern is a predictor of outcome in neuroblastoma
    Isabelle Janoueix-Lerosey
    INSERM U830, Laboratoire de Génétique et Biologie des Cancers, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Clin Oncol 27:1026-33. 2009
    ..For a comprehensive overview of the genetic alterations of neuroblastoma, their association and clinical significance, we conducted a whole-genome DNA copy number analysis...
  20. ncbi Visualizing chromosomes as transcriptome correlation maps: evidence of chromosomal domains containing co-expressed genes--a study of 130 invasive ductal breast carcinomas
    Fabien Reyal
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Paris, France
    Cancer Res 65:1376-83. 2005
    ..Transcription correlation maps are a new way of visualizing transcriptome data. They will help to identify new genes involved in tumor progression and new mechanisms of gene regulation in tumors...
  21. ncbi Genomic organization of amplified MYC genes suggests distinct mechanisms of amplification in tumorigenesis
    John Herrick
    Unité Stabilité des Génomes, Département de Structure et Dynamique des Génomes, Institut Pasteur, Paris, France
    Cancer Res 65:1174-9. 2005
    ..Interestingly, different amplification patterns seem to be correlated with the disease outcome, thus providing new insights into HPV-related cancer development and tumor progression...
  22. doi Hybrid oncocytic/chromophobe renal cell tumours do not display genomic features of chromophobe renal cell carcinomas
    Nicolas Poté
    Department of Pathology, Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris Descartes University, Paris, France
    Virchows Arch 462:633-8. 2013
    ..From a diagnostic perspective, an array-CGH analysis could be performed in ambiguous ChRCC/RO cases to formally exclude the diagnosis of ChRCC...
  23. doi Clear-cell papillary renal cell carcinoma: 24 cases of a distinct low-grade renal tumour and a comparative genomic hybridization array study of seven cases
    Julien Adam
    Department of Pathology, Hopital Necker Enfants Malades, AP HP, Paris Université Paris Descartes, Paris, France
    Histopathology 58:1064-71. 2011
    ..To report clinicopathological and genomic characteristics of (ccpRCC), a rare, recently characterized renal tumour entity...
  24. doi In vivo efficacy of photodynamic therapy in three new xenograft models of human retinoblastoma
    Isabelle Aerts
    INSERM U 612, Centre de Recherche, Institut Curie, 26 Rue d Ulm, 75 248 Paris cedex 05, France
    Photodiagnosis Photodyn Ther 7:275-83. 2010
    ..Photodynamic therapy represents a nonmutagenic therapeutic approach, and may reduce the incidence of secondary tumors. To study the in vivo efficacy of photodynamic therapy, human retinoblastoma xenografts were established in nude mice...
  25. doi Choroidal melanoma: does endoresection prevent neovascular glaucoma in patient treated with proton beam irradiation?
    Nathalie Cassoux
    Department of Ocular Oncology, Institut Curie, Paris, France
    Retina 33:1441-7. 2013
    ..To evaluate the efficacy of endoresection after proton beam radiotherapy to prevent neovascular glaucoma (NVG) in patients treated for choroidal melanoma...
  26. doi Genomic profiling and identification of high-risk uveal melanoma by array CGH analysis of primary tumors and liver metastases
    Julien Trolet
    Department of Bioinformatics, Institut Curie, Paris, France
    Invest Ophthalmol Vis Sci 50:2572-80. 2009
    ..The purpose of this study was to analyze genomic profiles in a large series of ocular tumors and liver metastases and design a genome-based classifier for metastatic risk assessment...
  27. doi High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patients
    Cecile Laurent
    Institut Curie, Paris, France
    Cancer Res 71:666-74. 2011
    ..Our findings suggest that PTP4A3 or its cellular substrates could constitute attractive therapeutic targets to treat metastatic uveal melanomas...
  28. ncbi Cyto-histological correlations in primary, recurrent and metastatic rhabdomyosarcoma: the institut Curie's experience
    Jerzy Klijanienko
    Department of Tumor Biology, Institut Curie, Paris, France
    Diagn Cytopathol 35:482-7. 2007
    ..9% vs. 6.7%), mitotic figures (57.1% vs. 18.9%), and cyto-nuclear atypia (77.1% vs. 43.2%). Inversely, spindle-shaped cells were more frequently seen in nonalveolar versus alveolar RMSs (37.8% vs. 20.9%)...
  29. pmc Human papillomavirus mutational insertion: specific marker of circulating tumor DNA in cervical cancer patients
    Maura Campitelli
    Department of Radiation Oncology, Institut Curie, Hospital, Paris, France
    PLoS ONE 7:e43393. 2012
    ..To determine whether the sequence of the cell-viral junction could be used in clinical practice as a specific marker of ctDNA, we analyzed a series of cervical cancer patient serums...
  30. ncbi High efficacy of combined rituximab and gemcitabine on Epstein-Barr virus-associated human B-cell lymphoma obtained after Hodgkin's xenograft in immunodeficient mice
    Didier Decaudin
    Department of Clinical Hematology, Section de Recherche, Institut Curie, Paris, France
    Anticancer Drugs 17:685-95. 2006
    ..This result therefore indicates that combined rituximab and gemcitabine could be an alternative approach in patients with posttransplant lymphoproliferative disease...
  31. doi Genetic determinants of uveal melanoma
    Jerome Couturier
    Department of Genetics, Institut Curie Hôpital, Paris, France
    Dev Ophthalmol 49:150-65. 2012
    ..3, coding for a protein promoting cell migration, is highly overexpressed in class 2 tumors. The overall expression signature of class 2 tumors suggests they may originate from neuroectodermal stem cells...
  32. ncbi Phyllodes tumors of the breast segregate in two groups according to genetic criteria
    Marick Lae
    Departement de Biologie des Tumeurs, Service de Pathologie, Institut Curie Hôpital, Paris, France
    Mod Pathol 20:435-44. 2007
    ..Helpful additional pathological criteria for differentiating the two genetic groups of phyllodes tumors are the nuclear size and the mitotic rate...
  33. doi The Bloom syndrome protein limits the lethality associated with RAD51 deficiency
    Kenza Lahkim Bennani-Belhaj
    Institut Curie, Centre de Recherche, Centre Universitaire, Orsay, France
    Mol Cancer Res 8:385-94. 2010
    ..These findings provide insight into the molecular basis of some cancers possibly associated with variants of the RAD51 gene family...
  34. ncbi Gastric inflammatory myofibroblastic tumors in children: an unpredictable course
    Thierry Lazure
    Department of Pathology, Hopital Bicetre, Le Kremlin Bicetre, Paris, France
    J Pediatr Gastroenterol Nutr 34:319-22. 2002
  35. doi Genomic amplification is not a frequent event in uveal melanomas
    Manuel Jorge Rodrigues
    Institut Curie, Paris, France
    Am J Pathol 183:638-40. 2013
    ..This Correspondence relates to the article by Lake et al that reported copy number and genotyping analysis on formalin-fixed, paraffin-embedded samples using genome-wide SNP arrays version 6.0. ..
  36. doi MYC and MYCN amplification can be reliably assessed by aCGH in medulloblastoma
    Franck Bourdeaut
    INSERM U830, Laboratory of Genetics and Biology of Cancers, Curie Institute, Paris, France
    Cancer Genet 206:124-9. 2013
    ....
  37. ncbi Fine-needle aspiration cytology combined with flow cytometry immunophenotyping is a rapid and accurate approach for the evaluation of suspicious superficial lymphoid lesions
    Claire Mathiot
    Hematology Laboratory, Department of Tumor Biology, Institut Curie, Paris, France
    Diagn Cytopathol 34:472-8. 2006
    ....
  38. doi Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis
    Xavier Sastre-Garau
    Department of Pathology, Institut Curie, Paris, France
    J Pathol 218:48-56. 2009
    ..This information will help the development of novel approaches for the assessment and therapy of MCC and biologically related tumours...
  39. doi Three new BLM gene mutations associated with Bloom syndrome
    Mounira Amor-Gueret
    Institut Curie, Centre de Recherche, Orsay, France
    Genet Test 12:257-61. 2008
    ..All these mutations introduce a stop codon, and may therefore be considered to have deleterious biological effect. This approach should make it possible to identify new mutations and to correlate them with clinical information...
  40. ncbi Genotype-phenotype correlations in hereditary familial retinoblastoma
    Melissa Taylor
    Service d Oncologie Pediatrique, Institut Curie, Paris, France
    Hum Mutat 28:284-93. 2007
    ..Our analysis suggests in some cases the influence of modifier factors probably involved in mRNA level regulation and/or pRB pathway regulation...
  41. ncbi Mucinous tubular and spindle cell carcinoma: a report of 15 cases and a review of the literature
    Sophie Ferlicot
    Service d Anatomie Pathologique, Hopital de Bicetre, Paris, France
    Virchows Arch 447:978-83. 2005
    ..Further investigations are required to determine the frequency and true prognosis of these tumors, which are easily identifiable morphologically...
  42. ncbi Role of chemotherapy resistance genes in outcome of neuroblastoma
    Patricia De Cremoux
    Department of Tumor Biology, Institut Curie, 26 Rue d Ulm, Paris Cedex, France
    Pediatr Blood Cancer 48:311-7. 2007
    ..Most patients with localized disease usually have a favorable prognosis, but patients with advanced disease have a poor prognosis despite combination chemotherapy. Treatment failure may be attributable to resistance to cytotoxic drugs...
  43. ncbi Five new cases of juvenile renal cell carcinoma with translocations involving Xp11.2: a cytogenetic and morphologic study
    Christine Perot
    Laboratoire de Cytogenetique, Hopital Saint Antoine, Paris, France
    Cancer Genet Cytogenet 143:93-9. 2003
    ..Renal cell carcinomas with translocations involving Xp11.2 form a specific entity characterized by subtle pathologic features and younger age of occurrence, especially for those with the t(X;17)...
  44. pmc Integration of viral sequences into the c-myc gene in two mammary adenocarcinomas induced by polyomavirus in athymic nude mice
    M Berebbi
    CNRS ER 105, Villejuif, France
    J Virol 69:5935-45. 1995
    ..This deleted region in the episomal virus genome was systematically found integrated in chromosomal DNA, thus arguing for the importance of Py integration in the induction of mammary tumor...
  45. pmc Agreement between chromogenic in situ hybridisation (CISH) and FISH in the determination of HER2 status in breast cancer
    L Arnould
    Department of Pathology, Centre GF Leclerc, 1 rue Pr Marion, 21034 Dijon Cedex, France
    Br J Cancer 88:1587-91. 2003
    ..Our results allow us to think that, in many laboratories, CISH may also be an excellent method to calibrate the IHC procedures or, as a quality control test, to check regularly that the IHC signal is in agreement with the gene status...
  46. ncbi Calibration of immunohistochemistry for assessment of HER2 in breast cancer: results of the French multicentre GEFPICS study
    A Vincent-Salomon
    Institut Curie, Paris, France
    Histopathology 42:337-47. 2003
    ..This prompted us to perform a multicentric IHC calibration test to achieve a maximum accuracy of HER2-IHC compared with HER2-FISH taken as the reference method...
  47. ncbi Quality assessment of genetic markers used for therapy stratification
    I M Ambros
    Children s Cancer Research Institute, Kinderspitalgasse 6, A 1090 Vienna, Austria
    J Clin Oncol 21:2077-84. 2003
    ..Materials and..
  48. ncbi Comprehensive screening for constitutional RB1 mutations by DHPLC and QMPSF
    C Houdayer
    Service de génétique oncologique, Institut Curie, Paris, France
    Hum Mutat 23:193-202. 2004
    ..Finally, considering the benefits to retinoblastoma patients, RB1 testing should be widely implemented in routine healthcare because our study clearly illustrates its feasibility...
  49. ncbi Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breast
    X Sastre-Garau
    Department of Pathology, CNRS UMR144, Institut Curie, Paris, France
    Histopathology 45:142-7. 2004
    ..Akt has been found to be involved in the HER-2/neu signal transduction pathway and Akt activation has been associated with increased cell size in various models...
  50. pmc Multiplex PCR/liquid chromatography assay for detection of gene rearrangements: application to RB1 gene
    C Dehainault
    Service de génétique oncologique, Pathologie moléculaire des cancers, Institut Curie, Paris, France
    Nucleic Acids Res 32:e139. 2004
    ..MP/LC appears to be an easy, versatile, and cost-effective method, which is particularly relevant to denaturing HPLC (DHPLC) users since it broadens the spectrum of available applications on a DHPLC system...
  51. pmc HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: a possible tool for anti-HER2 therapy management?
    A Vincent-Salomon
    Department of Tumor Biology, Institut Curie, Paris, France
    Br J Cancer 96:654-9. 2007
    ..Therefore, the efficiency of anti-HER2 adjuvant therapy could be evaluated, in a clinical trial, by sequential detection of HER2-positive micrometastatic cells within the bone marrow, before and after treatment...
  52. pmc Chromosomal CGH identifies patients with a higher risk of relapse in neuroblastoma without MYCN amplification
    G Schleiermacher
    INSERM U830, Institut Curie, Paris, France
    Br J Cancer 97:238-46. 2007
    ..Further studies using higher-resolution CGH are needed to better characterise atypical genomic alterations...
  53. ncbi hSNF5/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities
    F Bourdeaut
    INSERM U509, Laboratoire de Pathologie Moléculaire des Cancers, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Pathol 211:323-30. 2007
    ..The molecular investigation should be performed in infants when a rhabdoid predisposition syndrome is suspected...
  54. ncbi A new member of the ETS family fused to EWS in Ewing tumors
    M Peter
    Laboratoire de Transfert, Institut Curie, Paris, France
    Oncogene 14:1159-64. 1997
    ..Following a scheme similar to previously described translocations in Ewing tumors, a t(2;22) chromosome translocation fuses the N-terminal domain of EWS to the ETS DNA binding domain of FEV...
  55. ncbi In neuroblastic tumours, Schwann cells do not harbour the genetic alterations of neuroblasts but may nevertheless share the same clonal origin
    F Bourdeaut
    INSERM, U830, Section de Recherche, Unité de Génétique et Biologie des Cancers, Institut Curie, Paris, France
    Oncogene 27:3066-71. 2008
    ..However, in tumours with both stroma-rich and -poor components, our results suggest that cells from both areas share a common progenitor...