P Cossart

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: bacterial factors, cellular ligands and signaling
    P Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    EMBO J 17:3797-806. 1998
  2. doi request reprint Listeria monocytogenes, a unique model in infection biology: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Microbes Infect 10:1041-50. 2008
  3. ncbi request reprint The use of host cell machinery in the pathogenesis of Listeria monocytogenes
    P Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Curr Opin Immunol 13:96-103. 2001
  4. pmc The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics
    Pascale Cossart
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    J Biol 8:107. 2009
  5. ncbi request reprint Met, the HGF-SF receptor: another receptor for Listeria monocytogenes
    P Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Trends Microbiol 9:105-7. 2001
  6. ncbi request reprint Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach
    V David
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Sci 111:2877-84. 1998
  7. doi request reprint Non-classical use of clathrin during bacterial infections
    P Cossart
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    J Microsc 231:524-8. 2008
  8. ncbi request reprint Molecular and cellular basis of the infection by Listeria monocytogenes: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Int J Med Microbiol 291:401-9. 2002
  9. ncbi request reprint Invasion of mammalian cells by Listeria monocytogenes: functional mimicry to subvert cellular functions
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Trends Cell Biol 13:23-31. 2003
  10. ncbi request reprint Listeriology (1926-2007): the rise of a model pathogen
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC 2020, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1143-6. 2007

Detail Information

Publications115 found, 100 shown here

  1. pmc Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: bacterial factors, cellular ligands and signaling
    P Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    EMBO J 17:3797-806. 1998
    ..Their study may lead to a better understanding of important questions in cell biology such as ligand receptor signalling and dynamics of actin polymerization in mammalian cells...
  2. doi request reprint Listeria monocytogenes, a unique model in infection biology: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Microbes Infect 10:1041-50. 2008
    ..Together, Listeria, after being recognized as a powerful tool in immunology, now appears as one of the most insightful models in infection biology...
  3. ncbi request reprint The use of host cell machinery in the pathogenesis of Listeria monocytogenes
    P Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Curr Opin Immunol 13:96-103. 2001
    ..Increasing evidence shows that many cellular genes are up- or down-regulated during infection and probably play a role in the establishment of infection, inflammation and induction of the host immune response...
  4. pmc The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics
    Pascale Cossart
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    J Biol 8:107. 2009
    ....
  5. ncbi request reprint Met, the HGF-SF receptor: another receptor for Listeria monocytogenes
    P Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Trends Microbiol 9:105-7. 2001
    ..The first identified ligand for InlB was gC1qR, which has no cytoplasmic domain. The newly discovered InlB receptor, Met, fits with the known InlB-induced signals...
  6. ncbi request reprint Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach
    V David
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Sci 111:2877-84. 1998
    ..Our findings suggest that these latter proteins, which are known to play critical roles in cellular actin rearrangements, may also be involved in the dynamics of Listeria-induced actin assembly...
  7. doi request reprint Non-classical use of clathrin during bacterial infections
    P Cossart
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    J Microsc 231:524-8. 2008
    ..They also shed light on a new function for clathrin in mammalian cells, i.e. internalization of objects much larger than previously accepted...
  8. ncbi request reprint Molecular and cellular basis of the infection by Listeria monocytogenes: an overview
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Int J Med Microbiol 291:401-9. 2002
    ..The virulence gene cluster and its regulation by PrfA will be presented and discussed in the framework of the recently determined genome sequence...
  9. ncbi request reprint Invasion of mammalian cells by Listeria monocytogenes: functional mimicry to subvert cellular functions
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Trends Cell Biol 13:23-31. 2003
    ..Manipulating the bacterial invasion proteins offers us an unprecedented tool with which to understand the complex phenomenon of phagocytosis...
  10. ncbi request reprint Listeriology (1926-2007): the rise of a model pathogen
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC 2020, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1143-6. 2007
    ..Orally acquired listeriosis can now be studied in relevant animal models. Finally, Listeria is among the few bacteria which have so rapidly benefited from comparative genomics. It now ranks among the most documented pathogens...
  11. ncbi request reprint Bacterial invasion: the paradigms of enteroinvasive pathogens
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, INSERM Unité 604, Département de Biologie Cellulaire et Infection, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Science 304:242-8. 2004
    ..The mechanisms underlying bacterial entry, phagosome maturation, and dissemination reveal common strategies as well as unique tactics evolved by individual species to establish infection...
  12. pmc Manipulation of host membrane machinery by bacterial pathogens
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, F 75015 Paris, France
    Curr Opin Cell Biol 22:547-54. 2010
    ..In this review we discuss several of the canonical host pathways targeted by bacterial pathogens and emerging areas of investigation in this exciting field...
  13. pmc Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, Institut Pasteur, F 75015 Paris, France
    Proc Natl Acad Sci U S A 108:19484-91. 2011
    ....
  14. ncbi request reprint FbpA, a novel multifunctional Listeria monocytogenes virulence factor
    S Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
    Mol Microbiol 53:639-49. 2004
    ..Thus, FbpA, in addition to being a fibronectin-binding protein, behaves as a chaperone or an escort protein for two important virulence factors and appears as a novel multifunctional virulence factor of L. monocytogenes...
  15. ncbi request reprint Internalin-mediated invasion of epithelial cells by Listeria monocytogenes is regulated by the bacterial growth state, temperature and the pleiotropic activator prfA
    S Dramsi
    Laboratoire de Génétique Moléculaire des Listeria, Institut Pasteur, Paris, France
    Mol Microbiol 9:931-41. 1993
    ..Internalin is also detected in substantial amounts in culture supernatants. Taken together, these data suggest that surface-bound internalin plays an important role in bacterial entry but do not exclude a role for the released form...
  16. pmc Identification of four new members of the internalin multigene family of Listeria monocytogenes EGD
    S Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Infect Immun 65:1615-25. 1997
    ..The identity of such an aspect remains to be determined...
  17. ncbi request reprint A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier
    M Lecuit
    , Station Centrale de Microscopie Electronique, Institut Pasteur, 75724 Paris Cedex 15, France
    Science 292:1722-5. 2001
    ..These results illustrate how relevant animal models for human infections can be generated...
  18. ncbi request reprint Comparative genomics of Listeria species
    P Glaser
    , , Service d'Informatique Scientifique, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris, France
    Science 294:849-52. 2001
    ..The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events...
  19. pmc A role for cofilin and LIM kinase in Listeria-induced phagocytosis
    H Bierne
    , Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Biol 155:101-12. 2001
    ..We propose a model in which cofilin is involved in the formation and disruption of the phagocytic cup as a result of its local progressive enrichment...
  20. ncbi request reprint The Listeria monocytogenes protein InlB is an agonist of mammalian phosphoinositide 3-kinase
    K Ireton
    Unité des Interactions Bactéries Cellules, 28 rue du Dr Roux, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Biol Chem 274:17025-32. 1999
    ..These results identify InlB as the first reported non-mammalian agonist of PI 3-kinase and demonstrate similarities in the signal transduction events elicited by this bacterial protein and known agonists such as epidermal growth factor...
  21. pmc Expression in Escherichia coli and sequence analysis of the listeriolysin O determinant of Listeria monocytogenes
    J Mengaud
    Unite de genie microbiologique, Institut Pasteur, Paris, France
    Infect Immun 56:766-72. 1988
    ..By DNA-DNA hybridization, the listeriolysin O gene was detected in all L. monocytogenes strains tested, even in the nonhemolytic type strain. The gene was absent in other species of the genus Listeria...
  22. ncbi request reprint Attenuated mutants of the intracellular bacterium Listeria monocytogenes obtained by single amino acid substitutions in listeriolysin O
    E Michel
    Departement des Biotechnologies, Institut Pasteur, Paris, France
    Mol Microbiol 4:2167-78. 1990
    ....
  23. pmc Identification of the structural gene encoding the SH-activated hemolysin of Listeria monocytogenes: listeriolysin O is homologous to streptolysin O and pneumolysin
    J Mengaud
    Unite de genie microbiologique, Institut Pasteur, Paris, France
    Infect Immun 55:3225-7. 1987
    ..The deduced amino acid sequence of this open reading frame revealed that listeriolysin O is homologous to streptolysin O and pneumolysin, although homologies were not detectable at the DNA level...
  24. pmc Identification of a new operon involved in Listeria monocytogenes virulence: its first gene encodes a protein homologous to bacterial metalloproteases
    J Mengaud
    Unite de genie microbiologique, Institut Pasteur, Paris, France
    Infect Immun 59:1043-9. 1991
    ..It was renamed prtA. Northern RNA blot analysis indicated that prtA is the first gene of a 6-kb operon, suggesting that the lecithinase-negative phenotype of the mutant might be due to a polar effect of the transposon insertion...
  25. ncbi request reprint L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein
    C Kocks
    Laboratoire de Génétique Moléculaire des Listeria, Institut Pasteur, Paris, France
    Cell 68:521-31. 1992
    ..Our results indicate that it is a 610 amino acid protein with an apparent molecular weight of 90 kd...
  26. ncbi request reprint Pleiotropic control of Listeria monocytogenes virulence factors by a gene that is autoregulated
    J Mengaud
    Unite de genie microbiologique, Institut Pasteur, Paris, France
    Mol Microbiol 5:2273-83. 1991
    ..In late-exponential growth and at the beginning of the stationary phase, prfA transcripts of 1 kb are predominantly detected. Our results demonstrate that since prfA controls plcA transcription, it also regulates its own synthesis...
  27. pmc Transcriptional mapping and nucleotide sequence of the Listeria monocytogenes hlyA region reveal structural features that may be involved in regulation
    J Mengaud
    Unite de genie microbiologique, Institut Pasteur, Paris, France
    Infect Immun 57:3695-701. 1989
    ..These two promoter regions are separated by a palindromic sequence T-T-A-A-C-A-A/T-T-G-T-T-A-A. This palindrome was also found upstream from the ORF D promoter, suggesting that all three genes are similarly regulated...
  28. ncbi request reprint Entry of Listeria monocytogenes into hepatocytes requires expression of inIB, a surface protein of the internalin multigene family
    S Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Mol Microbiol 16:251-61. 1995
    ..These results provide the first insight into the cell tropism displayed by L. monocytogenes...
  29. ncbi request reprint Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocci
    J L Gaillard
    Laboratoire de Microbiologie, Faculte de Medecine Necker Enfants Malades, Paris, France
    Cell 65:1127-41. 1991
    ..As evidenced by Southern blot analysis, inlA is part of a gene family. One of them is the gene situated directly downstream of inlA, called inlB, which also encodes a leucine-rich repeat protein...
  30. doi request reprint Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
    Olivier Disson
    Institut Pasteur, Groupe Microorganismes et Barrières de l Hôte, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 455:1114-8. 2008
    ....
  31. ncbi request reprint Synergy between the N- and C-terminal domains of InlB for efficient invasion of non-phagocytic cells by Listeria monocytogenes
    R Jonquieres
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Microbiol 42:955-65. 2001
    ..Our results thus provide the first evidence for a synergy between two host factor-binding domains of a bacterial invasion protein, and reinforce similarities between InlB and mammalian growth factors...
  32. ncbi request reprint Characterization of a large motility gene cluster containing the cheR, motAB genes of Listeria monocytogenes and evidence that PrfA downregulates motility genes
    E Michel
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    FEMS Microbiol Lett 169:341-7. 1998
    ..In a delta prfA strain, motA expression was derepressed at 37 degrees C, suggesting that PrfA, the transcriptional activator of virulence genes, downregulates motility genes in Listeria at 37 degrees C...
  33. pmc A role for alpha-and beta-catenins in bacterial uptake
    M Lecuit
    Unité des Interactions Bactéries Cellules, Station Centrale de Microscopie Electronique, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 97:10008-13. 2000
    ..Taken together, these results reveal that E-cadherin, via beta- and alpha-catenins, can trigger dynamic events of actin polymerization and membrane extensions culminating in bacterial uptake...
  34. pmc The virulence gene cluster of Listeria monocytogenes is also present in Listeria ivanovii, an animal pathogen, and Listeria seeligeri, a nonpathogenic species
    E Gouin
    Unité des Interactions Bactéries Cellules, Centre National de la Recherche Scientifique URA 1300, Institut Pasteur, Paris, France
    Infect Immun 62:3550-3. 1994
    ..This virulence gene cluster was detected exclusively in hemolytic Listeria species, Listeria ivanovii, an animal pathogen, and Listeria seeligeri, a nonpathogenic species...
  35. pmc Expression of ActA, Ami, InlB, and listeriolysin O in Listeria monocytogenes of human and food origin
    C Jacquet
    Laboratoire des Listeria, Centre National de Référence des Listeria World Health Organization Collaborating Center for Foodborne Listeriosis, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Appl Environ Microbiol 68:616-22. 2002
    ..89; P = 1 x 10(-2)) and central nervous system infections were associated with group ActA2 strains (OR = 3.04; P = 1 x 10(-3)) and group ActA3 strains (OR = 3.91; P = 1 x 10(-3))...
  36. ncbi request reprint Listeria monocytogenes: a multifaceted model
    Mélanie Hamon
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris 75015, France
    Nat Rev Microbiol 4:423-34. 2006
    ..Moreover, the vast amount of knowledge that has been gathered through in-depth comparative genomic analyses and in vivo studies makes L. monocytogenes one of the most well-studied bacterial pathogens...
  37. ncbi request reprint Species specificity of the Listeria monocytogenes InlB protein
    Nadia Khelef
    Institut Pasteur, Unité des Interactions Bactéries Cellules, 25 28 Rue du Docteur Roux, Paris, F 75015 France
    Cell Microbiol 8:457-70. 2006
    ..These results unravel a second L. monocytogenes species specificity critical for understanding human listeriosis and emphasize the need for developing new animal models for studying InlA and InlB functions in the same animal model...
  38. ncbi request reprint Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells
    Esteban Veiga
    Unité des Interactions Bactéries Cellules, Institut Pasteur INSERM U604, INRA USC2020, 28 rue du Dr Roux, 75015 Paris, France
    Nat Cell Biol 7:894-900. 2005
    ....
  39. ncbi request reprint Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells
    Sandra Sousa
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    J Cell Sci 117:2121-30. 2004
    ..These results provide the first evidence for the role of an unconventional myosin in bacterial internalization and a novel example of the exploitation of mammalian proteins, by a pathogen, to establish a successful infection...
  40. ncbi request reprint InlB: an invasion protein of Listeria monocytogenes with a novel type of surface association
    L Braun
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Mol Microbiol 25:285-94. 1997
    ..This motif may have important consequences for the release of surface proteins involved in interactions with eukaryotic cells...
  41. pmc Role of lipid rafts in E-cadherin-- and HGF-R/Met--mediated entry of Listeria monocytogenes into host cells
    Stephanie Seveau
    Unité des Interactions Bactéries Cellules, INSERM U604, Institut Pasteur, 75015 Paris Cedex 15, France
    J Cell Biol 166:743-53. 2004
    ..Our work, in addition to documenting for the first time the role of lipid rafts in Listeria entry, provides the first evidence that E-cadherin and HGF-R require lipid domain integrity for their full activity...
  42. doi request reprint Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game
    Serge Mostowy
    Institut Pasteur, Département de Biologie Cellulaire et Infection, Unité des Interactions Bactéries Cellules, Paris, F 75015 France
    Cell Motil Cytoskeleton 66:816-23. 2009
    ..The challenge is now to decipher how all of these components orchestrate themselves to permit entry into normally non-phagocytic cells...
  43. ncbi request reprint Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii
    Juan J Martinez
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Cell 123:1013-23. 2005
    ..An affinity chromatography approach identified the rickettsial protein rOmpB as a ligand for Ku70. This is the first report of a receptor-ligand interaction involved in the internalization of any rickettsial species...
  44. ncbi request reprint InlB, a surface protein of Listeria monocytogenes that behaves as an invasin and a growth factor
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Cell Sci 115:3357-67. 2002
    ..Therefore, studies of InlB may help us to analyze the previously noticed similarities between growth factor receptor activation and phagocytosis...
  45. ncbi request reprint WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Cell Sci 118:1537-47. 2005
    ....
  46. ncbi request reprint Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis
    Olivier Dussurget
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Mol Microbiol 45:1095-106. 2002
    ..Taken together, these results demonstrate that BSH is a novel PrfA-regulated L. monocytogenes virulence factor involved in the intestinal and hepatic phases of listeriosis...
  47. doi request reprint Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes
    Matteo Bonazzi
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Cell Microbiol 10:2208-22. 2008
    ....
  48. doi request reprint Candida albicans internalization by host cells is mediated by a clathrin-dependent mechanism
    Emilia Moreno-Ruiz
    Institut Pasteur, Unité Biologie et Pathogénicité Fongiques, F 75015 Paris, France
    Cell Microbiol 11:1179-89. 2009
    ..Finally, beads coated with Als3 were internalized in a clathrin-dependent manner. These data indicate that C. albicans, like L. monocytogenes, hijacks the clathrin-dependent endocytic machinery to invade host cells...
  49. pmc The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosis
    Nicolas Personnic
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Infect Immun 78:1979-89. 2010
    ..These results strongly suggest that InlH is a stress-induced surface protein that facilitates pathogen survival in tissues by tempering the inflammatory response...
  50. ncbi request reprint Auto, a surface associated autolysin of Listeria monocytogenes required for entry into eukaryotic cells and virulence
    Didier Cabanes
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 51:1601-14. 2004
    ..During infection, the autolytic activity of Auto may also be critical. Auto appears thus as a novel type of L. monocytogenes virulence factor...
  51. pmc Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex
    P Kussel-Andermann
    Unité de Génétique des Déficits Sensoriels, CNRS URA 1968 and Unité des Interactions Bactéries Cellules, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 19:6020-9. 2000
    ..In myosin VIIA-defective mutants, inactivity of the vezatin-myosin VIIA complex at both sites could account for splaying out of the hair cell stereocilia...
  52. pmc gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes
    L Braun
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    EMBO J 19:1458-66. 2000
    ..After E-cadherin, the receptor for internalin, gC1q-R is the second identified mammalian receptor promoting entry of L. monocytogenes into mammalian cells...
  53. ncbi request reprint A single substitution in the putative helix-turn-helix motif of the pleiotropic activator PrfA attenuates Listeria monocytogenes virulence
    B Sheehan
    Unité des Interactions Bactéries Cellules, CNRS URA 1300, Institut Pasteur, Paris, France
    Mol Microbiol 20:785-97. 1996
    ..Our results strongly support the hypothesis that PrfA is a structural and functional homologue of CAP. In addition, they establish a clear correlation between DNA binding by PrfA, virulence-gene activation, and virulence...
  54. ncbi request reprint Listeria monocytogenes ferritin protects against multiple stresses and is required for virulence
    Olivier Dussurget
    Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC2020, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    FEMS Microbiol Lett 250:253-61. 2005
    ..A comparative proteomic analysis revealed an effect of the fri deletion on the levels of listeriolysin O and several stress proteins. Together, our study demonstrates that fri has multiple roles that contribute to Listeria virulence...
  55. pmc Sortase B, a new class of sortase in Listeria monocytogenes
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    J Bacteriol 186:1972-82. 2004
    ..SrtB-mediated anchoring could therefore be required to anchor surface proteins involved in the adaptation of this microorganism to different environmental conditions...
  56. pmc Septin 11 restricts InlB-mediated invasion by Listeria
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris F 75015, France
    J Biol Chem 284:11613-21. 2009
    ..Because SEPT2 is essential for the InlB-mediated entry of Listeria, but SEPT11 is not, our findings distinguish the roles of different mammalian septins...
  57. ncbi request reprint The role of clathrin-dependent endocytosis in bacterial internalization
    Esteban Veiga
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015 France
    Trends Cell Biol 16:499-504. 2006
    ..This contrasts with the generally accepted dogma but agrees with previous studies of bacterial and viral infections and also of phagocytosis...
  58. ncbi request reprint Exploitation of host cell cytoskeleton and signalling during Listeria monocytogenes entry into mammalian cells
    Javier Pizarro-Cerda
    Unité des Interactions Bactéries Cellules, Département Biologie Cellulaire et Infection, Institut Pasteur, 28, rue du Docteur Roux, 75724 Paris, France
    C R Biol 327:115-23. 2004
    ..Listeria appears as an instrumental model for addressing critical questions concerning both the complex process of bacterial pathogenesis and also fundamental molecular processes, such as phagocytosis...
  59. ncbi request reprint Distinct protein patterns associated with Listeria monocytogenes InlA- or InlB-phagosomes
    Javier Pizarro-Cerda
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris, France
    Cell Microbiol 4:101-15. 2002
    ..These results suggest that MSF is a putative effector of the InlB-mediated internalization of L. monocytogenes into host cells...
  60. ncbi request reprint Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002
    ..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
  61. pmc Listeria monocytogenes internalin and E-cadherin: from bench to bedside
    Matteo Bonazzi
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015, France
    Cold Spring Harb Perspect Biol 1:a003087. 2009
    ....
  62. pmc Listeria monocytogenes impairs SUMOylation for efficient infection
    David Ribet
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, F 75015 Paris, France
    Nature 464:1192-5. 2010
    ..Together, our results reveal that Listeria, and probably other pathogens, dampen the host response by decreasing the SUMOylation level of proteins critical for infection...
  63. pmc Listeriolysin O: a genuine cytolysin optimized for an intracellular parasite
    Shaynoor Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Biol 156:943-6. 2002
    ..This finding highlights how subtle changes in proteins can be exploited by bacterial pathogens to establish and maintain the integrity of their specific niches...
  64. ncbi request reprint Bacterial entry into cells: a role for the endocytic machinery
    Matteo Bonazzi
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    FEBS Lett 580:2962-7. 2006
    ..Here we review the pathways followed by Listeria monocytogenes to enter into non-phagocytic cells, as a model for the subversion of cellular functions to induce pathogens internalization...
  65. pmc Complete genome sequence of the animal pathogen Listeria ivanovii, which provides insights into host specificities and evolution of the genus Listeria
    C Buchrieser
    Institut Pasteur, Biologie des Bactéries Intracellulaires and CNRS URA 2171, 75724 Paris, France
    J Bacteriol 193:6787-8. 2011
    ..The sequence and its analysis are available at an interactive genome browser at the Institut Pasteur (http://genolist.pasteur.fr/LivaList/)...
  66. ncbi request reprint Identification of phosphatidylinositol-specific phospholipase C activity in Listeria monocytogenes: a novel type of virulence factor?
    J Mengaud
    Unite de genie microbiologique, Institut Pasteur, Paris, France
    Mol Microbiol 5:367-72. 1991
    ..monocytogenes and L. ivanovii. PI-PLC activity was lost and virulence decreased when the plcA gene was disrupted in the chromosome. This suggests that the PI-PLC of L. monocytogenes might be involved in virulence...
  67. pmc Listeria monocytogenes surface proteins: from genome predictions to function
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Microbiol Mol Biol Rev 71:377-97. 2007
    ..This diversity offers new clues about the molecular bases of Listeria pathogenesis...
  68. doi request reprint Entrapment of intracytosolic bacteria by septin cage-like structures
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris F 75015, France
    Cell Host Microbe 8:433-44. 2010
    ..Finally, we show that septin cages entrap bacteria targeted to autophagy. Together, these results reveal an unsuspected mechanism of host defense that restricts dissemination of invasive pathogens...
  69. ncbi request reprint Type II phosphatidylinositol 4-kinases promote Listeria monocytogenes entry into target cells
    Javier Pizarro-Cerda
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Cell Microbiol 9:2381-90. 2007
    ..Strikingly, knockdown of the PI(4)P ligand and clathrin adaptor AP-1 strongly inhibits bacterial entry. Together, our results reveal a yet non-described role for type II PI4Ks in phagocytosis...
  70. doi request reprint Post-translational modifications in host cells during bacterial infection
    David Ribet
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, Paris, France
    FEBS Lett 584:2748-58. 2010
    ..This review focuses on how bacterial pathogens can interfere with host post-translational modifications to promote their own survival and replication...
  71. doi request reprint Clathrin-mediated endocytosis: what works for small, also works for big
    Javier Pizarro-Cerda
    Département de Biologie Cellulaire et Infection, Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Bioessays 32:496-504. 2010
    ..The role of actin downstream of clathrin seems to be critical for this still poorly characterized process. The historical frontier between endocytosis and phagocytosis is vanishing in the light of this new role for clathrin...
  72. ncbi request reprint Listeria InlB takes a different route to met
    Esteban Veiga
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015 France
    Cell 130:218-9. 2007
    ..In this issue, Niemann et al. (2007) provide the first structural evidence that InlB does not compete for the same interaction site on Met as the natural ligand HGF...
  73. pmc Histone modifications induced by a family of bacterial toxins
    Mélanie Anne Hamon
    Unité des Interactions Bactéries Cellules, Unité de Régulation pigénétique, and Génopole, Plate forme 2, Institut Pasteur, F 75015 Paris, France
    Proc Natl Acad Sci U S A 104:13467-72. 2007
    ....
  74. pmc Real-time observation of listeria monocytogenes-phagocyte interactions in living zebrafish larvae
    Jean Pierre Levraud
    Macrophages et Développement de l Immunité, Institut Pasteur, Paris, France
    Infect Immun 77:3651-60. 2009
    ..monocytogenes pathogenesis and particularly for the dissection of its interactions with phagocytes in vivo, a key factor of L. monocytogenes virulence...
  75. doi request reprint The Listeria transcriptional landscape from saprophytism to virulence
    Alejandro Toledo-Arana
    Institut Pasteur, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 459:950-6. 2009
    ..Together, our data unravel successive and coordinated global transcriptional changes during infection and point to previously unknown regulatory mechanisms in bacteria...
  76. pmc The Listeria monocytogenes virulence factor InlJ is specifically expressed in vivo and behaves as an adhesin
    Christophe Sabet
    UIBC, Institut Pasteur, INSERM, U604, INRA, USC2020, 25 rue du Dr Roux, Paris F 75015, France
    Infect Immun 76:1368-78. 2008
    ..innocua promotes bacterial adherence to human cells in vitro. Taken together, these results strongly suggest that InlJ acts as a novel L. monocytogenes sortase-anchored adhesin specifically expressed during infection in vivo...
  77. pmc Septins regulate bacterial entry into host cells
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS ONE 4:e4196. 2009
    ..We previously identified SEPT9 associated with phagosomes containing latex beads coated with the Listeria surface protein InlB...
  78. pmc Listeriolysin O-mediated calcium influx potentiates entry of Listeria monocytogenes into the human Hep-2 epithelial cell line
    Shaynoor Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 71:3614-8. 2003
    ..These results indicate that L. monocytogenes-induced mobilization of extracellular Ca(2+) by LLO and activation of downstream Ca(2+)-dependent signaling are required for efficient cell invasion...
  79. ncbi request reprint VirR, a response regulator critical for Listeria monocytogenes virulence
    Pierre Mandin
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, France
    Mol Microbiol 57:1367-80. 2005
    ..This study identifies a second key virulence regulon in L. monocytogenes, after the prfA regulon...
  80. ncbi request reprint Molecular determinants of Listeria monocytogenes virulence
    Olivier Dussurget
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, 75015 Paris, France
    Annu Rev Microbiol 58:587-610. 2004
    ..This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis...
  81. ncbi request reprint ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion
    Sandra Sousa
    Unité des Interactions Bactéries Cellules Institut Pasteur, INSERM U604, INRA USC2020, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Cell Biol 7:954-60. 2005
    ..monocytogenes entry. Altogether, our results show that ARHGAP10 is a new component of cell-cell junctions that controls alpha-catenin recruitment and has a key role during L. monocytogenes uptake...
  82. ncbi request reprint Transcriptome analysis of Listeria monocytogenes identifies three groups of genes differently regulated by PrfA
    Eliane Milohanic
    Unité des Interactions Bactéries Cellules and Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 28, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 47:1613-25. 2003
    ..This study reveals that PrfA can act as an activator or a repressor and suggests that PrfA may directly or indirectly activate different sets of genes in association with different sigma factors...
  83. pmc LPXTG protein InlJ, a newly identified internalin involved in Listeria monocytogenes virulence
    Christophe Sabet
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, Paris, France
    Infect Immun 73:6912-22. 2005
    ..In conclusion, this postgenomic approach identified InlJ as a new virulence factor among the proteins belonging to the internalin family in L. monocytogenes...
  84. ncbi request reprint Subversion of cellular functions by Listeria monocytogenes
    Javier Pizarro-Cerda
    Unité des Interactions Bactéries Cellules INSERM U604 INRA USC2020, Institut Pasteur, Paris, France
    J Pathol 208:215-23. 2006
    ....
  85. ncbi request reprint Comparison of the genome sequences of Listeria monocytogenes and Listeria innocua: clues for evolution and pathogenicity
    Carmen Buchrieser
    Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    FEMS Immunol Med Microbiol 35:207-13. 2003
    ....
  86. pmc Invasive and adherent bacterial pathogens co-Opt host clathrin for infection
    Esteban Veiga
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Cell Host Microbe 2:340-51. 2007
    ..We also revealed a nonendocytic role for clathrin required for extracellular EPEC infections...
  87. pmc Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin
    Marc Lecuit
    Unité des Interactions Bactéries Cellules and Unité d Histotechnologie et Pathologie, Institut Pasteur, Paris 75015, France
    Proc Natl Acad Sci U S A 101:6152-7. 2004
    ..monocytogenes to target and cross the placental barrier. Such a ligand-receptor interaction allowing a pathogen to specifically cross the placental villous trophoblast barrier has not been reported previously...
  88. ncbi request reprint Bacterial adhesion and entry into host cells
    Javier Pizarro-Cerda
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015 France
    Cell 124:715-27. 2006
    ....
  89. ncbi request reprint Control of Listeria superoxide dismutase by phosphorylation
    Cristel Archambaud
    Institut Pasteur, Unité des Interactions Bactéries Cellules, INSERM, U604, INRA, USC2020, F 75015 Paris, France
    J Biol Chem 281:31812-22. 2006
    ..monocytogenes virulence. This is the first example of a bacterial SOD post-translationally controlled by phosphorylation, suggesting a possible new host innate mechanism to counteract a virulence factor...
  90. ncbi request reprint A FRET analysis to unravel the role of cholesterol in Rac1 and PI 3-kinase activation in the InlB/Met signalling pathway
    Stephanie Seveau
    Institute Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Cell Microbiol 9:790-803. 2007
    ....
  91. pmc A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 104:997-1002. 2007
    ..The presence of deacetylase genes in other pathogenic bacteria indicates that PG N-deacetylation could be a general mechanism used by bacteria to evade the host innate immune system...
  92. ncbi request reprint Subversion of phosphoinositide metabolism by intracellular bacterial pathogens
    Javier Pizarro-Cerda
    Unité des Interactions Bactéries Cellules Unité INSERM 604, Institut Pasteur, 75724 Paris Cedex 15, France
    Nat Cell Biol 6:1026-33. 2004
    ....
  93. ncbi request reprint Internalins: a complex family of leucine-rich repeat-containing proteins in Listeria monocytogenes
    H Bierne
    Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC2020, Institut Pasteur, F 75015 Paris, France
    Microbes Infect 9:1156-66. 2007
    ....
  94. ncbi request reprint Early signaling events involved in the entry of Rickettsia conorii into mammalian cells
    Juan J Martinez
    Institut Pasteur, Unité des Interactions Bactéries Cellules, INSERM U604, Département de Biologie Cellulaire et Infection, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Cell Sci 117:5097-106. 2004
    ..This is the first report that documents the mechanism of entry of a rickettsial species into mammalian cells...
  95. pmc Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein
    Didier Cabanes
    Unité des Interactions Bactéries Cellules Institut Pasteur, INSERM U604, INRA USC 2020, Paris, France
    EMBO J 24:2827-38. 2005
    ..Vip thus appears as a new virulence factor exploiting Gp96 as a receptor for cell invasion and/or signalling events that may interfere with the host immune response in the course of the infection...
  96. ncbi request reprint Small noncoding RNAs controlling pathogenesis
    Alejandro Toledo-Arana
    Institut Pasteur, Unité des Interactions Bactéries Cellules, INSERM, U604, and INRA, USC2020, Paris, F 75015, France
    Curr Opin Microbiol 10:182-8. 2007
    ..An updated view on bacterial models responsible for important infections illustrates the key role of sRNAs in the control of pathogenesis...
  97. pmc Nucleotide sequence of the lecithinase operon of Listeria monocytogenes and possible role of lecithinase in cell-to-cell spread
    J A Vazquez-Boland
    Unite de genie microbiologique, Institut Pasteur, Paris, France
    Infect Immun 60:219-30. 1992
    ..ivanovii and L. seeligeri, and sequences hybridizing to ORFX, -Y, and -Z were found in L. innocua. In contrast to this, sequences hybridizing to ldh or ORFB were detected in all Listeria species (including the nonpathogenic ones)...
  98. pmc LipA, a tyrosine and lipid phosphatase involved in the virulence of Listeria monocytogenes
    Renate Kastner
    Max F Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Dr Bohr Gasse 9 4, 1030 Vienna, Austria
    Infect Immun 79:2489-98. 2011
    ..Bacteria lacking LipA are severely attenuated in virulence in vivo, thus revealing a so-far-undescribed enzymatic activity involved in Listeria infection...
  99. ncbi request reprint Listeria monocytogenes evades killing by autophagy during colonization of host cells
    Cheryl L Birmingham
    Cell Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Autophagy 3:442-51. 2007
    ..Together, our results demonstrate that L. monocytogenes utilizes multiple mechanisms to avoid destruction by the autophagy system during colonization of macrophages...
  100. ncbi request reprint Bacterial invasion: a new strategy to dominate cytoskeleton plasticity
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, INSERM U604, Paris 75015, France
    Dev Cell 6:314-5. 2004
    ..identify mechanisms by which the Salmonella protein SipA interferes with ADF/cofilin and gelsolin function. Thus Salmonella not only triggers actin polymerization but also counteracts the major F-actin destabilizing proteins...
  101. ncbi request reprint The RickA protein of Rickettsia conorii activates the Arp2/3 complex
    Edith Gouin
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Nature 427:457-61. 2004
    ..Thus RickA-induced actin polymerization, by generating long actin filaments reminiscent of those present in filopodia, has potential as a tool for studying filopodia formation...