Jean Michel Coindre

Summary

Affiliation: Institut Bergoni
Country: France

Publications

  1. ncbi request reprint Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group
    J M Coindre
    Department of Pathology, Bergonie Institute, Bordeaux, France
    Cancer 91:1914-26. 2001
  2. ncbi request reprint Immunohistochemistry in the diagnosis of soft tissue tumours
    J M Coindre
    Department of Pathology, Institut Bergonié and University Victor Segalen Bordeaux 2, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Histopathology 43:1-16. 2003
  3. doi request reprint Well-differentiated and dedifferentiated liposarcomas
    Jean Michel Coindre
    Department of Pathology and INSERM U916, Institut Bergonie, Bordeaux, France
    Virchows Arch 456:167-79. 2010
  4. pmc Clinicians' adherence versus non adherence to practice guidelines in the management of patients with sarcoma: a cost-effectiveness assessment in two European regions
    Lionel Perrier
    University of Lyon, F 69007 Lyon, France
    BMC Health Serv Res 12:82. 2012
  5. ncbi request reprint [Sarcoma: tumour banks and evolution of diagnostic procedures]
    J M Coindre
    Institut Bergonie, Laboratoire de Pathologie, Departement de Pathologie, INSERM U916, Universite Victor Segalen Bordeaux, France
    Bull Cancer 97:613-20. 2010
  6. ncbi request reprint Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Mod Pathol 16:256-62. 2003
  7. ncbi request reprint Grading of soft tissue sarcomas: review and update
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Arch Pathol Lab Med 130:1448-53. 2006
  8. ncbi request reprint Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues: clinicopathologic and molecular analysis of 44 patients from the French sarcoma group
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Cancer 107:1055-64. 2006
  9. ncbi request reprint Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    J Pathol 203:822-30. 2004
  10. doi request reprint [Molecular biology of soft-tissue sarcomas]
    J M Coindre
    Departement de Pathologie, Institut Bergonie, Universite Victor Segalen, Bordeaux, France
    Bull Cancer 97:1337-45. 2010

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group
    J M Coindre
    Department of Pathology, Bergonie Institute, Bordeaux, France
    Cancer 91:1914-26. 2001
    ....
  2. ncbi request reprint Immunohistochemistry in the diagnosis of soft tissue tumours
    J M Coindre
    Department of Pathology, Institut Bergonié and University Victor Segalen Bordeaux 2, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Histopathology 43:1-16. 2003
    ..The respective roles of immunohistochemistry and molecular biology are underlined...
  3. doi request reprint Well-differentiated and dedifferentiated liposarcomas
    Jean Michel Coindre
    Department of Pathology and INSERM U916, Institut Bergonie, Bordeaux, France
    Virchows Arch 456:167-79. 2010
    ..These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS...
  4. pmc Clinicians' adherence versus non adherence to practice guidelines in the management of patients with sarcoma: a cost-effectiveness assessment in two European regions
    Lionel Perrier
    University of Lyon, F 69007 Lyon, France
    BMC Health Serv Res 12:82. 2012
    ....
  5. ncbi request reprint [Sarcoma: tumour banks and evolution of diagnostic procedures]
    J M Coindre
    Institut Bergonie, Laboratoire de Pathologie, Departement de Pathologie, INSERM U916, Universite Victor Segalen Bordeaux, France
    Bull Cancer 97:613-20. 2010
    ....
  6. ncbi request reprint Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Mod Pathol 16:256-62. 2003
    ....
  7. ncbi request reprint Grading of soft tissue sarcomas: review and update
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Arch Pathol Lab Med 130:1448-53. 2006
    ..However, grading is useful in more than 90% of adult soft tissue sarcomas and has been adapted to pediatric nonrhabdomyosarcomatous sarcomas. Current grading is not suitable for core needle biopsies...
  8. ncbi request reprint Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues: clinicopathologic and molecular analysis of 44 patients from the French sarcoma group
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Cancer 107:1055-64. 2006
    ..The diagnosis of CCS usually is easy but may be challenging in unusual sites, and the detection of EWS-ATF1 fusion transcripts is helpful to rule out a metastatic melanoma...
  9. ncbi request reprint Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity
    Jean Michel Coindre
    Department of Pathology, Institut Bergonie, Bordeaux, France
    J Pathol 203:822-30. 2004
    ..Quantitative PCR showed amplification of MDM2 in six and of CDK4 in seven of nine inflammatory MFHs. In conclusion, this study strongly suggests that most so-called inflammatory MFHs are dedifferentiated liposarcomas...
  10. doi request reprint [Molecular biology of soft-tissue sarcomas]
    J M Coindre
    Departement de Pathologie, Institut Bergonie, Universite Victor Segalen, Bordeaux, France
    Bull Cancer 97:1337-45. 2010
    ..Leiomyosarcomas, pleomorphic rhabdomyosarcomas, pleomorphic liposarcomas, myxofibrosarcomas, poorly differentiated sarcomas (so-called MFH and fibrosarcomas) belong to this category and show no specific molecular abnormality...
  11. doi request reprint Adult-type rhabdomyosarcoma: analysis of 57 cases with clinicopathologic description, identification of 3 morphologic patterns and prognosis
    Nathalie Stock
    Bergonié Institute and INSERM U 916, Bordeaux, France
    Am J Surg Pathol 33:1850-9. 2009
    ..In conclusion, adult-type RMS is a rare sarcoma occurring mainly in the extremities and trunk wall with 2 main histologic patterns, spindle cell, and pleomorphic patterns, which represent the end of the spectrum of a single entity...
  12. ncbi request reprint Surgical resection and radiotherapy for primary retroperitoneal soft tissue sarcoma
    Laurent Gilbeau
    Radiation Oncology Department, Institut Bergonie, Regional Cancer Center, 229, cours de l Argonne, 33076 Bordeaux, France
    Radiother Oncol 65:137-43. 2002
    ..Forty-five patients were consecutively treated for primary retroperitoneal soft tissue sarcoma with surgery in combination with radiation therapy in the same institution. The median follow-up time was 53 months (7-108)...
  13. ncbi request reprint [Gastrointestinal stromal tumors: definition, histological, immunohistochemical, and molecular features, and diagnostic strategy]
    Jean Michel Coindre
    Departement de Pathologie, Institut Bergonie, 33076 Bordeaux Cedex
    Ann Pathol 25:358-85; quiz 357. 2005
    ..Proper understanding and utilisation of the diagnostic criteria and classification of GIST by pathologists are essential for good patient management...
  14. doi request reprint Genetic profiling identifies two classes of soft-tissue leiomyosarcomas with distinct clinical characteristics
    Antoine Italiano
    Department of Medical Oncology, INSERM U916, Institut Bergonie, Bordeaux, France
    Clin Cancer Res 19:1190-6. 2013
    ..Data about the prognostic factors of soft-tissue leiomyosarcomas and their correlation with molecular profile are limited...
  15. ncbi request reprint Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive cases
    Manuela Pelmus
    Bergonie Institute, Bordeaux, France
    Am J Surg Pathol 26:1434-40. 2002
    ....
  16. ncbi request reprint Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimens
    Isabelle Hostein
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Cancer 101:2817-24. 2004
    ..Two specific translocations have been found in ARMS, and fusion transcripts can be detected by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of paraffin-embedded tissue (PET)...
  17. ncbi request reprint Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data--a study from the French Federation of Cancer Centers Sarcoma Group
    Marie Josee Terrier-Lacombe
    Department of Pathology, Gustave Roussy Institute, Villejuif, France
    Am J Surg Pathol 27:27-39. 2003
    ....
  18. doi request reprint Trends in survival for patients with metastatic soft-tissue sarcoma
    Antoine Italiano
    Department of Medical Oncology, Bergonie Institute, Bordeaux, France
    Cancer 117:1049-54. 2011
    ..The objective of this study was to determine whether the overall survival of patients with metastatic soft tissue sarcoma (STS) has improved over the last 20 years...
  19. ncbi request reprint Comparative genomic hybridization study of paraffin-embedded dedifferentiated liposarcoma fixed with Holland Bouin's fluid
    Isabelle Hostein
    Department of Pathology, Institut Bergonie, Bordeaux Cedex, France
    Diagn Mol Pathol 12:166-73. 2003
    ....
  20. ncbi request reprint Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas
    Matthieu Bui Nguyen Binh
    Department of Pathology, Institut Bergonié and Université Victor Segalen, Bordeaux, France
    Am J Surg Pathol 31:1557-66. 2007
    ..Moreover, DLPS with a myogenic component have a low metastatic potential, similar to conventional DLPS and significantly lower to the metastatic potential of leiomyosarcomas...
  21. doi request reprint Prognostic factors influencing progression-free survival determined from a series of sporadic desmoid tumors: a wait-and-see policy according to tumor presentation
    Sébastien Salas
    Departement de Pathologie, Institut Bergonié 229, cours de l Argonne, Bordeaux, France CEDEX 33076
    J Clin Oncol 29:3553-8. 2011
    ..We present the results of the largest series of sporadic desmoid tumors ever published to determine the prognostic factors of these rare tumors...
  22. doi request reprint Patterns of care, prognosis, and survival in patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib
    Antoine Italiano
    Institut Bergonie, Bordeaux, France
    Ann Surg Oncol 19:1551-9. 2012
    ..Data regarding the management and outcome of patients with metastatic gastrointestinal stromal tumors (GIST) refractory to 1st-line imatinib and 2nd-line sunitinib are limited...
  23. ncbi request reprint Impact of molecular analysis on the final sarcoma diagnosis: a study on 763 cases collected during a European epidemiological study
    Agnes Neuville
    Department of Pathology, Bergonie Cancer Institute, University of Bordeaux, 229 Cours de l Argonne, Bordeaux Cedex, France
    Am J Surg Pathol 37:1259-68. 2013
    ....
  24. ncbi request reprint Breast ductal carcinoma in situ with microinvasion: a definition supported by a long-term study of 1248 serially sectioned ductal carcinomas
    Isabelle de Mascarel
    Department of Pathology, Institut Bergonie, Regional Cancer Center, Bordeaux, France
    Cancer 94:2134-42. 2002
    ..With this definition, the authors attempted to evaluate the clinical significance of microinvasion...
  25. ncbi request reprint Superficial soft tissue sarcomas (S-STS): a study of 367 patients from the French Sarcoma Group (FSG) database
    Sébastien Salas
    Department of Pathology, Bergonie Institute, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Eur J Cancer 45:2091-102. 2009
    ..We describe the clinical characteristics of a large series of S-STS (N=367) from the French Sarcoma Group (GSF-GETO) database and analyse the prognostic factors affecting outcome...
  26. doi request reprint Nucleic acid quality preservation by an alcohol-based fixative: comparison with frozen tumors in a routine pathology setting
    Isabelle Hostein
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Diagn Mol Pathol 20:52-62. 2011
    ..Tissue fixation with the MF is an important improvement for molecular pathologic diagnosis, enabling a combination of routine pathologic diagnoses and current molecular diagnoses if they are carried out near the processing time...
  27. ncbi request reprint YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas: genetic and pathological correlations
    Sabrina Croce
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Mod Pathol 26:1390-400. 2013
    ..Overall, for endometrial sarcoma cases with high-grade morphology we recommend to test for YWHAE rearrangements by FISH break-apart, a cost- and time-efficient method, and to complete the investigation by RT-PCR in borderline cases. ..
  28. ncbi request reprint Smooth muscle differentiation identifies two classes of poorly differentiated pleomorphic sarcomas with distinct outcome
    Gaëlle Pérot
    1 Institut Bergonié, Department of Pathology, Bordeaux, France 2 INSERM U916, Bordeaux, France
    Mod Pathol 27:840-50. 2014
    ..Collectively, our results show that the smooth muscle differentiation classification method may be a useful diagnostic tool as well as a relevant prognostic tool for undifferentiated pleomorphic sarcomas. ..
  29. ncbi request reprint Reproducibility of MDM2 and CDK4 staining in soft tissue tumors
    Matthieu Bui Nguyen Binh
    Department of Pathology, Bergonié Institute and University Victor Segalen, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Am J Clin Pathol 125:693-7. 2006
    ..80) and CDK4 (kappa, 0.93). Immunostaining for MDM2 and CDK4 is a reproducible technique that may be exported to different laboratories for routine use. Tissue microarray is indicated for studying large series...
  30. doi request reprint Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group
    Laila Chbani
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Am J Clin Pathol 131:222-7. 2009
    ..Loss of expression of INI1 is frequent in the conventional and large cell subtypes of ES and can be used as a diagnostic marker, but it has no prognostic impact...
  31. pmc MED12 alterations in both human benign and malignant uterine soft tissue tumors
    Gaëlle Pérot
    INSERM U916, Institut Bergonié Cancer Institute, Bordeaux, France
    PLoS ONE 7:e40015. 2012
    ..We propose here that MED12 alterations could be implicated in the development of smooth muscle tumor and that its expression could be inhibited in malignant tumors...
  32. doi request reprint ERCC5/XPG, ERCC1, and BRCA1 gene status and clinical benefit of trabectedin in patients with soft tissue sarcoma
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Cancer 117:3445-56. 2011
    ....
  33. ncbi request reprint Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 cases
    Jean Michel Coindre
    Department of Pathology, Bergonie Institute, Bordeaux, France
    Cancer 98:2700-7. 2003
    ....
  34. doi request reprint Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
    Frederic Chibon
    Departement de Pathologie, Institut Bergonie, Bordeaux, France
    Nat Med 16:781-7. 2010
    ..Application of the signature will permit more selective use of adjuvant therapies for people with sarcomas, leading to decreased iatrogenic morbidity and improved outcomes for such individuals...
  35. ncbi request reprint Intimal sarcoma is the most frequent primary cardiac sarcoma: clinicopathologic and molecular retrospective analysis of 100 primary cardiac sarcomas
    Agnes Neuville
    University of Bordeaux INSERM U916 Department of Biopathology, Institut Bergonie, Bordeaux Department of Pathology, Centre Georges Francois Leclerc, Dijon Department of Pathology, Hopital Europeen Georges Pompidou, Paris Department of Pathology, Hopital du Haut leveque, Pessac Department of Pathology, Hopital Universitaire, Lyon Department of Pathology, Hopital Rangueil, Toulouse Department of Pathology, Institut Gustave Roussy, Villejuif Department of Pathology, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson Department of Pathology, Hopital Universitaire, Rennes, France
    Am J Surg Pathol 38:461-9. 2014
    ..As resections are limited to the left atrium, this histologic subtype could benefit from therapies targeting PDGFRA or MDM2. ..
  36. doi request reprint Paratesticular rhabdomyoma: a morphologically distinct sclerosing variant
    Vickie Y Jo
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Department of Pathology, University of Florida College of Medicine, Gainesville, FL Department of Pathology, Institut Bergonie, Bordeaux, France
    Am J Surg Pathol 37:1737-42. 2013
    ..However, this rare paratesticular subset of rhabdomyomas appears to be morphologically distinct from rhabdomyomas at other locations and appears to represent a separate variant...
  37. doi request reprint Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas
    Andrea T Deyrup
    Department of Pathology, University of South Carolina School of Medicine Greenville, Greenville, SC Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA Department of Pathology and INSERM U916 Institut Bergonié Laboratory of Pathology, Universite Victor Segalen Bordeaux 2, Bordeaux, France Department of Pathology, University Hospital, Lausanne, Switzerland
    Am J Surg Pathol 37:1373-8. 2013
    ....
  38. doi request reprint Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas
    Pauline Lagarde
    Institut Nationalde la Santé et de la Recherche Médicale INSERM U916 Institut Bergonie, France
    J Clin Oncol 31:608-15. 2013
    ..Here we investigate whether these signatures can also predict outcomes in SS...
  39. doi request reprint "Metronomic" chemotherapy in advanced soft tissue sarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Chemother Pharmacol 66:197-202. 2010
    ..Endothelial cells are the primary target of metronomic chemotherapy. We report the safety and the efficacy of metronomic chemotherapy in metastatic STS patients...
  40. doi request reprint BRAF mutation status in gastrointestinal stromal tumors
    Isabelle Hostein
    1Department of Pathology, Institut Bergonie, Bordeaux, France
    Am J Clin Pathol 133:141-8. 2010
    ....
  41. doi request reprint Temsirolimus in advanced leiomyosarcomas: patterns of response and correlation with the activation of the mammalian target of rapamycin pathway
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, Cedex, France
    Anticancer Drugs 22:463-7. 2011
    ..Further investigations of the phosphoinositide 3-kinases/PTEN/Akt/mTOR pathway are needed to explore the role of mTOR inhibitors, either alone or in combination, in patients with advanced sarcoma...
  42. doi request reprint A quality control program for mutation detection in KIT and PDGFRA in gastrointestinal stromal tumours
    Isabelle Hostein
    Department of Pathology, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    J Gastroenterol 46:586-94. 2011
    ..Genotyping and accurate detection of KIT/PDGFRA mutations in GIST are becoming increasingly useful for clinicians in the management of the disease...
  43. pmc Prognostic value of PLAGL1-specific CpG site methylation in soft-tissue sarcomas
    Anne Lise Peille
    Institut Bergonie, Comprehensive Cancer Centre, Bordeaux, France Univ Bordeaux, Bordeaux, France INSERM U916 VINCO, Bordeaux, France
    PLoS ONE 8:e80741. 2013
    ..Such a biomarker may be relevant for identifying patients likely to derive greater benefit from treatment. ..
  44. ncbi request reprint Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients
    Valérie Le Morvan
    Laboratory of Pharmacology of Anticancer Agents EA 515, Institut Bergonié and Université Victor Segalen Bordeaux 2, Bordeaux, France
    Int J Cancer 119:1732-5. 2006
    ..For XPD, both alleles were lost with a similar frequency. Our results raise the potential implication of the XPG Asp1104His polymorphism in the occurrence of chromosomal translocations associated with specific subtypes of sarcomas...
  45. ncbi request reprint [Surgery of recurrent soft tissue sarcoma of the extremities and the trunk wall: a comparison to primary sarcoma]
    Eberhard Stoeckle
    Service de chirurgi, Institut Bergonie, Centre Regional de Lutte Contre le Cancer, 229, cours de l Argonne, 33076 Bordeaux Cedex
    Bull Cancer 91:853-60. 2004
    ..To evaluate the place of conservative surgery in locally recurrent soft tissue sarcoma of the extremities and the trunk wall...
  46. ncbi request reprint [Update on soft tissue sarcomas]
    Binh Nguyen Bui
    Institut Bergonie, Centre Regional de Lutte Contre le Cancer, 229, cours de l Argonne, 33076 Bordeaux Cedex
    Bull Cancer 89:100-7. 2002
    ..It can hopefully regarded as an example for targeted therapies, which may come with a better understanding of the molecular mechanisms triggered by the fundamental, specific genetic alterations shown in sarcoma...
  47. ncbi request reprint [Digitalized imaging pathology: application to quality control in cancer diagnosis]
    Celine Merino
    Departement de Pathologie, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux
    Ann Pathol 25:18-24. 2005
    ..To test a double histology reading system based on digitalized imaging for cancer diagnosis...
  48. doi request reprint Molecular characterization by array comparative genomic hybridization and DNA sequencing of 194 desmoid tumors
    Sébastien Salas
    Department of Pathology, INSERM U916, Bergonie Institute, 229 Cours de l Argonne, Bordeaux Cedex, France
    Genes Chromosomes Cancer 49:560-8. 2010
    ..A better understanding of the pathogenetic pathways in the initiation and progression of desmoid tumors requires studies of 8q and 20q gains, as well as of 6q and 5q losses, and study of the Wnt/beta-catenin pathway...
  49. doi request reprint MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone
    Fanny Dujardin
    Department of Pathology, Trousseau University Hospital and University François Rabelais, Tours Cedex 9, France
    Mod Pathol 24:624-37. 2011
    ....
  50. ncbi request reprint First case report of a fetal synovial sarcoma confirmed by molecular detection of SYT-SSX fusion gene transcripts
    Sébastien Duband
    Department of Pathology, Saint Etienne University Hospital Center, Bellevue Hospital, St Etienne, France
    Am J Perinatol 25:517-20. 2008
    ..The positive detection of the SYT-SSX1 fusion transcripts with reverse-transcription polymerase chain reaction in formalin-fixed and paraffin-embedded tissue confirmed the synovial sarcoma diagnosis...
  51. pmc Consistent SMARCB1 homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material
    François Le Loarer
    Pathology Department, Memorial Sloan Kettering Cancer Center, New York, NY Pathology Department, Institut Bergonié Cancer Center, Bordeaux, France
    Genes Chromosomes Cancer 53:475-86. 2014
    ..Alternative mechanisms of SMARCB1 inactivation in SMARCB1-disomic ES remain to be identified, but appear unrelated to large genomic abnormalities in other SWI/SNF subunits...
  52. ncbi request reprint Human herpesvirus 8 immunostaining: a sensitive and specific method for diagnosing Kaposi sarcoma in paraffin-embedded sections
    Yves Marie Robin
    Department of Pathology, Oscar Lambret Cancer Center, Lille, France
    Am J Clin Pathol 121:330-4. 2004
    ..The LNA-1 anti-HHV-8 antibody is a reliable marker of all variants of KS. Because KS mimickers are consistently negative for this marker, its use for diagnostic purposes is recommended...
  53. doi request reprint Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases
    Nadège Dreux
    Department of Pathology, Institut Bergonie, 229 Cours de l Argonne, Bordeaux Cedex, France
    Mod Pathol 23:1657-66. 2010
    ..Finally, and may be more importantly, HMGA2 is useful for the diagnosis of benign fibrous histiocytoma, nodular fasciitis and vulvovaginal benign mesenchymal tumors...
  54. ncbi request reprint [Impact of pathological review by an expert on the diagnosis and management of patients with cancer in Aquitania]
    Nadège Lapeyrere
    Réseau de cancérologie d Aquitaine, 229, cours de l Argonne, 33076 Bordeaux Cedex, France
    Ann Pathol 28:478-85. 2008
    ..The goal of this work was to evaluate the impact of expert pathological second opinion on the diagnosis and management of patients with cancer, in a French region (Aquitaine) and with an economic point of view...
  55. ncbi request reprint [Diagnostic approach to breast papillary lesions]
    Gaetan MacGrogan
    Departement de Pathologie, Institut Bergonie, Bordeaux
    Ann Pathol 23:601-10. 2003
    ....
  56. ncbi request reprint Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics and Department of Pathology, Nice University Hospital, Nice, France
    Clin Cancer Res 15:5696-703. 2009
    ..Our goal was to determine whether the absence of CDK4 amplification was (a) correlated to a specific clinico-histopathologic profile; and (b) compensated by another genomic anomaly involving the CCND1/CDK4/P16INK4a/RB1/E2F pathway...
  57. doi request reprint [Sarcomas, example of a pathologist network organization]
    Agnes Neuville
    Universite Victor Segalen, Institut Bergonie, Departement de Pathologie, laboratoire d anatomie pathologie et Inserm U916, 229, cours de l Argonne, 33076 Bordeaux Cedex, France
    Bull Cancer 100:1275-81. 2013
    ..Moreover, data and material collect allows a better knowledge of these tumors and an improvement of the rules for their diagnostic management. ..
  58. ncbi request reprint Detection of a new mutation in KIT exon 9 in a gastrointestinal stromal tumor
    Isabelle Hostein
    Department of Pathology, Institut Bergonie, Bordeaux Cedex, France
    Int J Cancer 118:2089-91. 2006
    ..More surprisingly, the sequence inserted corresponds to the complementary sequence of the wild allele but in the opposite sense. To our knowledge, this mutation has never been previously described...
  59. pmc Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer 118:5878-87. 2012
    ..The scale of genetic abnormalities in these pathways remains unknown in angiosarcoma (AS)...
  60. ncbi request reprint Primary malignant fibrous histiocytoma of the pancreas: benefit of the multidisciplinary approach
    Julien Jarry
    Bergonie Cancer Institute, 229 Cours de l Argonne, Bordeaux 33000, France
    Eur J Gastroenterol Hepatol 22:765-8. 2010
    ....
  61. doi request reprint Grading of soft tissue sarcomas: from histological to molecular assessment
    Agnes Neuville
    1Department of Biopathology, Institut Bergonié and INSERM U916 2Laboratory of Pathology, University Victor Ségalen Bordeaux 3Translational Research, Institut Bergonie, Bordeaux, France
    Pathology 46:113-20. 2014
    ....
  62. ncbi request reprint [Pseudoangiomatous spindle cell lipoma: about six cases]
    Fouad Zouaidia
    Departement de Pathologie, Institut Bergonie, 229, cours de l Argonne, 33076 Bordeaux, France
    Ann Pathol 31:242-5. 2011
    ..Nine cases have been previously described in the literature. In this retrospective study, we report six cases reviewed in the department of pathology at the Bergonié Institute between 01/01/1987 and 31/12/2009...
  63. ncbi request reprint Evaluating surgery quality in soft tissue sarcoma
    Eberhard Stoeckle
    Department of Surgery, Institut Bergonie, Regional Cancer Centre, 229 Cours de I Argonne, 33076 Bordeaux Cedex, France
    Recent Results Cancer Res 179:229-42. 2009
    ..Soft tissue sarcoma should also be treated in specialised centres. Surgery quality depends on obtained margins that are determined best by close collaboration between the surgeon and the pathologist...
  64. ncbi request reprint Histology and imaging of soft tissue sarcomas
    Michèle Kind
    Département d Imagerie Médicale, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Eur J Radiol 72:6-15. 2009
    ..The appearance observed on imaging should always be taken into consideration for the interpretation of the microbiopsy by the pathologist...
  65. ncbi request reprint [A finger nodule in a child]
    Amel Douggaz
    Departement de Pathologie, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux
    Ann Pathol 27:47-8. 2007
  66. ncbi request reprint Inflammatory myofibroblastic tumor: a spinal case with aggressive clinical course and ALK overexpression. Case report
    Laetitia Lacoste-Collin
    Department of Pathology, CHU Rangueil, Toulouse, France
    J Neurosurg 98:218-21. 2003
    ..The occurrence of IMT in the spinal cord has rarely been reported. In this case, ALK overexpression was associated with early multifocal recurrence. This has been recently reported in this tumor typein other locations...
  67. pmc Epithelial atypia in biopsies performed for microcalcifications. practical considerations about 2,833 serially sectioned surgical biopsies with a long follow-up
    Isabelle de Mascarel
    Department of Pathology, Institut Bergonie, Regional Cancer Center, Bordeaux, France
    Virchows Arch 451:1-10. 2007
    ..Epithelial atypia could be more a risk marker of concomitant than subsequent cancer...
  68. ncbi request reprint [Arterial myopericytoma: a case report]
    Anne Rullier
    Service d Anatomie Pathologique, Hopital Pellegrin, CHU de Bordeaux, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Ann Pathol 30:325-7. 2010
    ..Usually, the lesion is small and shows a myopericytic differentiation. The cells are short, fusiform and arranged concentrically around small vascular lumen. We reported here the second case of arterial mural myopericytoma...
  69. pmc High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Genes Chromosomes Cancer 51:207-18. 2012
    ..These results suggest the possibility of a newly defined subgroup of primitive round cell sarcomas characterized by CIC rearrangements, distinct from Ewing sarcoma family of tumors...
  70. ncbi request reprint Molecular detection of the synovial sarcoma translocation t(X;18) by real-time polymerase chain reaction in paraffin-embedded material
    Isabelle Hostein
    Department of Molecular Oncology, Institut Curie, Paris, France
    Diagn Mol Pathol 11:16-21. 2002
    ..In addition, the t(X;18) can be detected not only on frozen but also on paraffin-embedded tumor samples...
  71. ncbi request reprint Rearrangement involving chromosomes 1 and 8 in a retroperitoneal lipoma
    Cyril Foa
    UF Recherche Clinique 0952, Laboratoire de Genetique, CHU de Nice, Nice, France
    Cancer Genet Cytogenet 133:156-9. 2002
    ..Of great importance is the determination of such genetic markers as additional tools for the differential diagnosis between benign and malignant forms of adipose tumors, and to avoid erroneous diagnoses...
  72. ncbi request reprint Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomas
    Pu Yan
    University Institute of Pathology, Lausanne, Switzerland
    Int J Cancer 98:851-6. 2002
    ..Few STSs that showed a TRF pattern suggestive of alternative lengthening of telomeres (ALT) may contain ALT subpopulations...
  73. ncbi request reprint Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group
    Sandra Gebhard
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 26:601-16. 2002
    ..It shows a wide range of morphologic appearances, but tumor grade and histology have no effect on patient outcome...
  74. ncbi request reprint Docetaxel and gemcitabine combination in 133 advanced soft-tissue sarcomas: a retrospective analysis
    Jacques Olivier Bay
    Centre Jean Perrin, Clermont Ferrand, France
    Int J Cancer 119:706-11. 2006
    ..For the other histological subtypes, the response was not encouraging, but the survival for patients in response or stable suggests further investigation...
  75. ncbi request reprint Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two cases
    Jean François Egger
    University Institute of Pathology, Lausanne, Switzerland
    Mod Pathol 15:998-1004. 2002
    ..We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas...
  76. ncbi request reprint Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Gro
    Louis Guillou
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 31:1387-402. 2007
    ..The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related...
  77. ncbi request reprint JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas
    Odette Mariani
    Institut Curie, Genetics and Biology of Cancers, 26 Rue d Ulm, 75248 Paris Cedex 05, France INSERM U830, F 75005 Paris, France
    Cancer Cell 11:361-74. 2007
    ..We confirm by cellular and xenograft mouse models recapitulating these sarcoma genetics that the failure to differentiate is dependent upon JUN amplification/overexpression...
  78. ncbi request reprint ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications
    Frederic Chibon
    INSERM U509, Molecular Pathology of Cancers, Institut Curie, Paris, France
    Genes Chromosomes Cancer 40:32-7. 2004
    ..These observations indicate that ASK1 is a target for new therapeutic management of these aggressive tumors...
  79. ncbi request reprint Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR
    Nicolas Sirvent
    Laboratoire de Génétique Somatique des Tumeurs Solides, Faculte de Medecine, CNRS UMR 6543, Nice University Hospital, Avenue de Valombrose, 06100 Nice, France
    Am J Surg Pathol 31:1476-89. 2007
    ..In conclusion, we recommend that the evaluation of MDM2-CDK4 amplification using FISH or Q-PCR be used to supplement IHC analysis when diagnosis of adipose tissue tumors is not possible based on clinical and histologic information alone...
  80. doi request reprint HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
    ..We also found a frequent amplification and overexpression of YEATS4, an oncogene that inactivates P53, suggesting that YEATS4 might play an important role together with MDM2 in WDLPS/DDLPS oncogenesis...
  81. ncbi request reprint Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis
    Louis Guillou
    Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
    J Clin Oncol 22:4040-50. 2004
    ..To assess the prognostic value of SYT-SSX fusion type, in comparison with other factors, in a population of 165 patients with synovial sarcoma (SS)...
  82. doi request reprint Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Faculty of Medicine, Nice University Hospital, 28 Avenue de Valombrose, 06107 Nice, France
    Cancer Genet Cytogenet 184:99-104. 2008
    ..On the basis of cytogenetic and molecular findings, some SCL may constitute an independent entity rather than being regarded as variants of WDLPS...
  83. ncbi request reprint Retroperitoneal liposarcomas: follow-up analysis of dedifferentiation after clinicopathologic reexamination of 86 liposarcomas and malignant fibrous histiocytomas
    Elizabeth Fabre-Guillevin
    Department of Medical Oncology, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France
    Cancer 106:2725-33. 2006
    ..The objectives of the current retrospective study were: 1( to analyze the relation between DDLs and tumors previously diagnosed as MFHs; 2) to trace the evolution of liposarcomas, and 3) to assess the consequences of dedifferentiation...
  84. ncbi request reprint Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Lab Invest 85:408-15. 2005
    ..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion...
  85. ncbi request reprint [Recent entities in soft tissue tumor pathology. Part 2]
    Muriel Genevay
    Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne, Suisse
    Ann Pathol 23:135-48. 2003
    ..The role of immunohistochemistry and molecular pathology in the identification and delineation of these new entities is emphasized...
  86. ncbi request reprint alpha-fetoprotein expression in a dedifferentiated liposarcoma
    Martino Bosco
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Virchows Arch 448:517-20. 2006
    ..Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma...
  87. ncbi request reprint Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances
    Ahmed Idbaih
    INSERM U509, Laboratoire de Pathologie Moléculaire des Cancers, Institut Curie, Paris, France
    Lab Invest 85:176-81. 2005
    ..The characterization of common gene alterations in both tumor groups would suggest a closer relationship between these two types of soft tissue sarcomas...
  88. ncbi request reprint Primary clear cell sarcoma of the ileum: an uncommon and misleading site
    Lorenzo Taminelli
    Department of Pathology, University Hospital, Lausanne, Switzerland
    Virchows Arch 447:772-7. 2005
    ..This case demonstrates that the gastrointestinal tract is a potential site for primary clear cell sarcoma of soft tissues, and, furthermore, that cytogenetics and/or molecular techniques play a central role in the diagnosis...
  89. ncbi request reprint Primary intrathoracic synovial sarcoma: a clinicopathologic study of 40 t(X;18)-positive cases from the French Sarcoma Group and the Mesopath Group
    Hugues Begueret
    From the Department of Pathology, Hopital Haut Leveque, Pessac, France
    Am J Surg Pathol 29:339-46. 2005
    ..In conclusion, intrathoracic SS are rare but aggressive tumors with poor prognosis. In this unusual location, the detection of SYT-SSX fusion transcripts is a valuable diagnostic adjunct...
  90. ncbi request reprint Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the "missing link" between lipomas and liposarcomas?
    Antoine Italiano
    Faculty of Medicine, Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Nice, France
    Int J Cancer 121:308-15. 2007
    ..Some of these intermediary forms may correspond to a genomic premalignant condition while some may have no malignant potential...
  91. ncbi request reprint [Recommendations for the management of GIST patients]
    Jean Yves Blay
    Unité Inserm 590, Centre Leon Berard, 69008 Lyon
    Bull Cancer 92:907-18. 2005
    ..A national consensus meeting was therefore organized in order to identify the optimal management procedures for patients with GIST in localized and advanced stages...
  92. ncbi request reprint Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group
    Carole Gengler
    Department of Pathology, University Institute of Pathology, Lausanne, Switzerland
    Cancer 109:1584-98. 2007
    ....
  93. ncbi request reprint The use of clustering software for the classification of comparative genomic hybridization data. an analysis of 109 malignant fibrous histiocytomas
    Frederic Chibon
    INSERM U509, Molecular Pathology of Cancers, Institut Curie, Paris, France
    Cancer Genet Cytogenet 141:75-8. 2003
    ..We confirm our preliminary CGH results and demonstrate that two main clusters of tumors are present in the series analyzed...
  94. ncbi request reprint Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion
    Laurence Bianchini
    Laboratoire de génétique des tumeurs solides, Faculte de Medecine, Centre Hospitalier Universitaire de Nice, Universite de Nice Sophia Antipolis, Nice, France
    Virchows Arch 452:689-96. 2008
    ..2 were disrupted by this rearrangement. Although rare, the existence of cases of DFSP negative for the COL1A1-PDGFB fusion has to be taken in consideration when performing molecular diagnosis for a tumor suspected to be a DFSP...
  95. ncbi request reprint COL1A1-PDGFB gene fusion demonstrates a common histogenetic origin for dermatofibrosarcoma protuberans and its granular cell variant
    Georges Maire
    UF Recherche clinique 0952 and Laboratoire de Cytogénétique, Université de Bordeaux II and Institut Bergonié, France
    Am J Surg Pathol 26:932-7. 2002
    ..This case analysis demonstrated the utility of molecular genetics as a powerful tool for the diagnosis of atypical forms of dermatofibrosarcoma protuberans...
  96. doi request reprint Elevated FDG uptake in Kaposi sarcoma mimicking Hodgkin's lymphoma relapse
    Gerald Bonardel
    Nuclear Medicine HIA Val de Grâce, Paris, France
    Clin Nucl Med 33:624-6. 2008
  97. ncbi request reprint Dermatofibrosarcoma protuberans occurring in two brothers: Role of environmental or genetic factors?
    Thomas Jouary
    J Am Acad Dermatol 57:S58-60. 2007
  98. ncbi request reprint [Soft tissue myoepithelioma, a rare tumor. A case report]
    Magali Colombat
    Service d Anatomie et Cytologie Pathologiques, Centre Hospitalier General, 1 avenue Michel de l Hospital, 02321 Saint Quentin
    Ann Pathol 23:55-8. 2003
    ..It has to be differentiated from extraskeletal myxoid chondrosarcoma, parachordoma and synovial sarcoma. Most of myoepitheliomas are benign. However, metastasis may occur in a minority of cases...
  99. ncbi request reprint [Inflammatory myofibroblastic tumors]
    Nicolas Sirvent
    Service de Pediatrie, Hopital de l Archet, CHU de Nice, 06202 Nice Cedex 3
    Ann Pathol 22:453-60. 2002
    ..The search for rearrangement of ALK by fluorescence in situ hybridization (FISH) is a useful complementary tool for IMT diagnosis...
  100. ncbi request reprint The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylation
    Isabelle Guilleret
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Carcinogenesis 23:2025-30. 2002
    ..In conclusion, this study shows that hTERC expression is indeed regulated during carcinogenesis, but this regulation is unlikely to depend on hTERC methylation, cell proliferation rate, telomere length or hTERT expression...
  101. ncbi request reprint Malignant peripheral nerve sheath tumors are t(X;18)-negative sarcomas. Molecular analysis of 25 cases occurring in neurofibromatosis type 1 patients, using two different RT-PCR-based methods of detection
    Jean Michel Coindre
    Bergonié Institute and the University of Bordeaux 2, France
    Mod Pathol 15:589-92. 2002
    ..Laboratories that use PCR-based techniques for diagnostic purposes would benefit from quality assurance programs...