Michel Cohen-Tannoudji

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi [Nobel Prize 2007 for Medicine to Mario Capecchi, Martin Evans and Oliver Smithies: the mutant mice to order]
    Michel Cohen-Tannoudji
    Unité de Génétique Fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Med Sci (Paris) 23:1159-61. 2007
  2. pmc Omcg1 is critically required for mitosis in rapidly dividing mouse intestinal progenitors and embryonic stem cells
    Teddy Léguillier
    Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Departement de Biologie du Developpement, 25 rue du Docteur Roux, F 75015 Paris, France CNRS URA 2578, F 75015 Paris, France
    Biol Open 1:648-57. 2012
  3. doi [A new era in rat genetics]
    Michel Cohen-Tannoudji
    Unité de Génétique Fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Med Sci (Paris) 27:387-90. 2011
  4. ncbi lacZ sequences prevent regulated expression of housekeeping genes
    M Cohen-Tannoudji
    Unite de Biologie du Developpement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris, France
    Mech Dev 90:29-39. 2000
  5. ncbi A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11
    M Cohen-Tannoudji
    Unite de Biologie du Developpement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, 75724, France
    Genomics 68:273-82. 2000
  6. ncbi Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome
    Stephanie Le Bras
    Unité Biologie du Développement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Gene 296:75-86. 2002
  7. pmc Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein
    Jérôme Artus
    Unite de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Cell Biol 25:6289-302. 2005
  8. pmc Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells
    Marie Le Bouteiller
    Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Département de Biologie du Développement et Cellules Souches, F 75015 Paris, France
    J Exp Med 210:2351-69. 2013
  9. pmc PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, USA Institut Pasteur, CNRS URA 2578, Mouse Functional Genetics, Paris, France
    Stem Cells 31:1932-41. 2013
  10. ncbi DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency
    Martin Houlard
    Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Departement de Biologie du Developpement, CNRS URA 2578, Paris, France
    Cell Cycle 10:108-17. 2011

Collaborators

Detail Information

Publications29

  1. ncbi [Nobel Prize 2007 for Medicine to Mario Capecchi, Martin Evans and Oliver Smithies: the mutant mice to order]
    Michel Cohen-Tannoudji
    Unité de Génétique Fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Med Sci (Paris) 23:1159-61. 2007
  2. pmc Omcg1 is critically required for mitosis in rapidly dividing mouse intestinal progenitors and embryonic stem cells
    Teddy Léguillier
    Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Departement de Biologie du Developpement, 25 rue du Docteur Roux, F 75015 Paris, France CNRS URA 2578, F 75015 Paris, France
    Biol Open 1:648-57. 2012
    ..These findings unravel a crucial role for pre-mRNA processing in the homeostasis of the small intestine and point to a major role of OMCG1 in the maintenance of genome integrity...
  3. doi [A new era in rat genetics]
    Michel Cohen-Tannoudji
    Unité de Génétique Fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Med Sci (Paris) 27:387-90. 2011
    ..This will lead to new opportunities and to increase our capacity to model human pathologies...
  4. ncbi lacZ sequences prevent regulated expression of housekeeping genes
    M Cohen-Tannoudji
    Unite de Biologie du Developpement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris, France
    Mech Dev 90:29-39. 2000
    ....
  5. ncbi A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11
    M Cohen-Tannoudji
    Unite de Biologie du Developpement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, 75724, France
    Genomics 68:273-82. 2000
    ..Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome...
  6. ncbi Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome
    Stephanie Le Bras
    Unité Biologie du Développement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Gene 296:75-86. 2002
    ..This data is an important step towards identifying the genes responsible for the DDK syndrome...
  7. pmc Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein
    Jérôme Artus
    Unite de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Cell Biol 25:6289-302. 2005
    ..Taken together, these results suggest that Omcg1 is an important regulator of the cell cycle in the preimplantation embryo...
  8. pmc Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells
    Marie Le Bouteiller
    Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Département de Biologie du Développement et Cellules Souches, F 75015 Paris, France
    J Exp Med 210:2351-69. 2013
    ....
  9. pmc PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, USA Institut Pasteur, CNRS URA 2578, Mouse Functional Genetics, Paris, France
    Stem Cells 31:1932-41. 2013
    ..Taken together, these data uncover an early role of PDGF signaling in PrE cell survival at the time when PrE and EPI cells are segregated...
  10. ncbi DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency
    Martin Houlard
    Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Departement de Biologie du Developpement, CNRS URA 2578, Paris, France
    Cell Cycle 10:108-17. 2011
    ....
  11. doi Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite
    Aurélie Jory
    Stem Cells and Development, Department of Developmental Biology Pasteur Institute, Centre National de la Recherche Scientifique CNRS URA 2578, 75724 Paris Cedex 15, France
    Stem Cells 27:2769-80. 2009
    ..Thus, we propose that Numb can regulate the self-renewal of dermal and muscle progenitors during a lineage progression...
  12. pmc The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells
    Sarah Cormier
    Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, Paris, France
    Mol Cell Biol 26:3541-9. 2006
    ....
  13. ncbi A high-resolution map around the locus Om on mouse Chromosome 11
    P A Baldacci
    Unite de Biologie du Developpement, U R A C N R S 1960, Institut Pasteur, Paris, France
    Mamm Genome 7:114-6. 1996
    ..The distance between these two markers is about 2 cM. These data should facilitate the positional cloning and molecular characterization of Om...
  14. ncbi The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
    Karim Nacerddine
    Unité d Organisation Nucléaire et Oncogénèse, INSERM U 579, Institut Pasteur, 75724 Paris Cedex 15, France
    Dev Cell 9:769-79. 2005
    ..Together, these findings reveal a major role for Ubc9, and, by implication, for the SUMO pathway, in nuclear architecture and function, chromosome segregation, and embryonic viability in mammals...
  15. ncbi The cell cycle of early mammalian embryos: lessons from genetic mouse models
    Jérôme Artus
    Unite de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, Paris, France
    Cell Cycle 5:499-502. 2006
    ....
  16. pmc Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment
    Franck Coumailleau
    Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Biol Cell 15:4444-56. 2004
    ..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane...
  17. pmc RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development
    Céline Souilhol
    Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, Paris, France
    Mol Cell Biol 26:4769-74. 2006
    ..These results are discussed in the light of recent observations which have challenged this conclusion...
  18. ncbi [Notch signalling pathway and early mammalian embryogenesis]
    Sarah Cormier
    Unité de Génétique Fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Med Sci (Paris) 23:26-8. 2007
  19. pmc Notchless is required for axial skeleton formation in mice
    Sarah Beck-Cormier
    Mouse Functional Genetics, Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France Centre National de la Recherche Scientifique, URA 2578, Institut Pasteur, Paris, France
    PLoS ONE 9:e98507. 2014
    ..We also provide evidence that axial defects are due to an increase in apoptotic cell death in the somite at E9.5. These data demonstrate an essential role for Nle1 during organogenesis and in particular during axial development...
  20. pmc I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells
    Myriam Fenina
    Mouse Functional Genetics, Institut Pasteur, Paris, France
    PLoS ONE 7:e39895. 2012
    ..These data suggest that homologous recombination by meganuclease-induced DSB may be locus dependent in mammalian cells...
  21. pmc Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain
    Marie Monet-Leprêtre
    INSERM U740, Faculté de Médecine Paris 7, Site Villemin, 10 Avenue de Verdun, Paris, France
    Brain 132:1601-12. 2009
    ....
  22. pmc Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation
    Constance Ciaudo
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    PLoS Genet 2:e94. 2006
    ..Our data suggests a role for mRNA nuclear degradation pathways in the critical regulation of spliced Xist mRNA levels and the onset of the X-inactivation process...
  23. ncbi Developmental expression of the Notch signaling pathway genes during mouse preimplantation development
    Sarah Cormier
    Unite de Biologie du Developpement, Institut Pasteur, CNRS URA 2578, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Gene Expr Patterns 4:713-7. 2004
    ..Finally, we show that all the above genes are expressed both in Embryonic and Trophoblast Stem cells (ES and TS cells, respectively). Our results suggest that the Notch pathway may be active during mouse preimplantation development...
  24. ncbi [Inhibition of endocytic recycling by Rififylin]
    Franck Coumailleau
    Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Med Sci (Paris) 21:235-7. 2005
  25. pmc Nas transgenic mouse line allows visualization of Notch pathway activity in vivo
    Céline Souilhol
    CNRS, URA 2578, Paris, F 75015, France
    Genesis 44:277-86. 2006
    ..Thus, the NAS transgenic line constitutes a valuable and versatile tool to gain further insights into the complex and various functions of the Notch signaling pathway...
  26. doi [Reconsidering the roles of female germ cells in ovarian development and folliculogenesis]
    Celine J Guigon
    Universite Paris Diderot, Sorbonne Paris Cité, Équipe Physiologie de l Axe Gonadotrope, Unité Biologie Fonctionnelle et Adaptative, Paris, France
    Biol Aujourdhui 205:223-33. 2011
    ..Overall, these data demonstrate that the female germ cell act on companion somatic cells to regulate ovarian development and folliculogenesis, thereby actively supporting its own maturation...
  27. doi Cell cycle regulation during early mouse embryogenesis
    Jérôme Artus
    Unité de Génétique Fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Cell Endocrinol 282:78-86. 2008
    ..In particular, we analyse the contribution of mutant mice to the study of in vivo cell cycle regulation during early development and discuss possible contributions of cell cycle regulators to developmental programs...
  28. ncbi Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease
    M Cohen-Tannoudji
    Unite de Biologie du Developpement, Institut Pasteur, Paris, France
    Mamm Genome 6:844-9. 1995
    ..They should also provide a valuable animal model in which to test new forms of therapy, and in particular gene delivery into the central nervous system...
  29. ncbi Development of a targeted transgenesis strategy in highly differentiated cells: a powerful tool for functional genomic analysis
    Stefania Puttini
    INSERM U478, Federative Institute of Research 02, Medicine Faculty X Bichat, 16 rue H Huchard, 75018 Paris, France
    J Biotechnol 116:145-51. 2005
    ..The efficient screening strategy we have designed makes possible automation of the transfection and selection steps. Furthermore, this strategy could be applied to a variety of highly differentiated cells...