Research Topics
Genomes and Genes
| Michel Cohen-TannoudjiSummaryAffiliation: Institut Pasteur Country: France Publications
| Collaborators
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Detail Information
Publications
[Nobel Prize 2007 for Medicine to Mario Capecchi, Martin Evans and Oliver Smithies: the mutant mice to order]Michel Cohen-Tannoudji
, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
Med Sci (Paris) 23:1159-61. 2007
[A new era in rat genetics]Michel Cohen-Tannoudji
Unité de Génétique Fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
Med Sci (Paris) 27:387-90. 2011..This will lead to new opportunities and to increase our capacity to model human pathologies...- lacZ sequences prevent regulated expression of housekeeping genesM Cohen-Tannoudji
Unite de Biologie du Developpement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris, France
Mech Dev 90:29-39. 2000.... - A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11M Cohen-Tannoudji
Unite de Biologie du Developpement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, 75724, France
Genomics 68:273-82. 2000..Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome... - Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndromeStephanie Le Bras
Unité Biologie du Développement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Gene 296:75-86. 2002..This data is an important step towards identifying the genes responsible for the DDK syndrome... 
Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear proteinJérôme Artus
Unite de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Cell Biol 25:6289-302. 2005..Taken together, these results suggest that Omcg1 is an important regulator of the cell cycle in the preimplantation embryo...- Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somiteAurélie Jory
Stem Cells and Development, Department of Developmental Biology Pasteur Institute, Centre National de la Recherche Scientifique CNRS URA 2578, 75724 Paris Cedex 15, France
Stem Cells 27:2769-80. 2009..Thus, we propose that Numb can regulate the self-renewal of dermal and muscle progenitors during a lineage progression... - The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cellsSarah Cormier
Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, Paris, France
Mol Cell Biol 26:3541-9. 2006.... - A high-resolution map around the locus Om on mouse Chromosome 11P A Baldacci
Unite de Biologie du Developpement, U R A C N R S 1960, Institut Pasteur, Paris, France
Mamm Genome 7:114-6. 1996..The distance between these two markers is about 2 cM. These data should facilitate the positional cloning and molecular characterization of Om... - The SUMO pathway is essential for nuclear integrity and chromosome segregation in miceKarim Nacerddine
Unité d Organisation Nucléaire et Oncogénèse, INSERM U 579, Institut Pasteur, 75724 Paris Cedex 15, France
Dev Cell 9:769-79. 2005..Together, these findings reveal a major role for Ubc9, and, by implication, for the SUMO pathway, in nuclear architecture and function, chromosome segregation, and embryonic viability in mammals... - RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic developmentCéline Souilhol
Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, Paris, France
Mol Cell Biol 26:4769-74. 2006..These results are discussed in the light of recent observations which have challenged this conclusion... - DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiencyMartin Houlard
Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Departement de Biologie du Developpement, CNRS URA 2578, Paris, France
Cell Cycle 10:108-17. 2011.... - Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartmentFranck Coumailleau
Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Mol Biol Cell 15:4444-56. 2004..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane... - [Notch signalling pathway and early mammalian embryogenesis]Sarah Cormier
, CNRS URA 2578, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Med Sci (Paris) 23:26-8. 2007 - I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cellsMyriam Fenina
Mouse Functional Genetics, Institut Pasteur, Paris, France
PLoS ONE 7:e39895. 2012..These data suggest that homologous recombination by meganuclease-induced DSB may be locus dependent in mammalian cells... - Omcg1 is critically required for mitosis in rapidly dividing mouse intestinal progenitors and embryonic stem cellsTeddy Léguillier
Institut Pasteur, Unité de Génétique Fonctionnelle de la Souris, Departement de Biologie du Developpement, 25 rue du Docteur Roux, F 75015 Paris, France CNRS URA 2578, F 75015 Paris, France
Biol Open 1:648-57. 2012..These findings unravel a crucial role for pre-mRNA processing in the homeostasis of the small intestine and point to a major role of OMCG1 in the maintenance of genome integrity... - Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivationConstance Ciaudo
Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
PLoS Genet 2:e94. 2006..Our data suggests a role for mRNA nuclear degradation pathways in the critical regulation of spliced Xist mRNA levels and the onset of the X-inactivation process... - Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domainMarie Monet-Leprêtre
INSERM U740, Faculté de Médecine Paris 7, Site Villemin, 10 Avenue de Verdun, Paris, France
Brain 132:1601-12. 2009.... - Developmental expression of the Notch signaling pathway genes during mouse preimplantation developmentSarah Cormier
Unite de Biologie du Developpement, Institut Pasteur, CNRS URA 2578, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Gene Expr Patterns 4:713-7. 2004..Finally, we show that all the above genes are expressed both in Embryonic and Trophoblast Stem cells (ES and TS cells, respectively). Our results suggest that the Notch pathway may be active during mouse preimplantation development... - Cell cycle regulation during early mouse embryogenesisJérôme Artus
Unité de Génétique Fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Cell Endocrinol 282:78-86. 2008..In particular, we analyse the contribution of mutant mice to the study of in vivo cell cycle regulation during early development and discuss possible contributions of cell cycle regulators to developmental programs... - [Inhibition of endocytic recycling by Rififylin]Franck Coumailleau
, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
Med Sci (Paris) 21:235-7. 2005 - [Reconsidering the roles of female germ cells in ovarian development and folliculogenesis]Celine J Guigon
Universite Paris Diderot, Sorbonne Paris Cité, Équipe Physiologie de l Axe Gonadotrope, Unité Biologie Fonctionnelle et Adaptative, Paris, France
Biol Aujourdhui 205:223-33. 2011..Overall, these data demonstrate that the female germ cell act on companion somatic cells to regulate ovarian development and folliculogenesis, thereby actively supporting its own maturation... - The cell cycle of early mammalian embryos: lessons from genetic mouse modelsJérôme Artus
Unite de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, Paris, France
Cell Cycle 5:499-502. 2006.... - Nas transgenic mouse line allows visualization of Notch pathway activity in vivoCéline Souilhol
CNRS, URA 2578, Paris, F 75015, France
Genesis 44:277-86. 2006..Thus, the NAS transgenic line constitutes a valuable and versatile tool to gain further insights into the complex and various functions of the Notch signaling pathway... - Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs diseaseM Cohen-Tannoudji
Unite de Biologie du Developpement, Institut Pasteur, Paris, France
Mamm Genome 6:844-9. 1995..They should also provide a valuable animal model in which to test new forms of therapy, and in particular gene delivery into the central nervous system... - Development of a targeted transgenesis strategy in highly differentiated cells: a powerful tool for functional genomic analysisStefania Puttini
INSERM U478, Federative Institute of Research 02, Medicine Faculty X. Bichat, 16 rue H. Huchard, 75018 Paris, France
J Biotechnol 116:145-51. 2005..The efficient screening strategy we have designed makes possible automation of the transfection and selection steps. Furthermore, this strategy could be applied to a variety of highly differentiated cells...