J M Chatel
Affiliation: Institut National de la Recherche Agronomique
Michon C, Christophe M, Kuczkowska K, Langella P, Eijsink V, Mathiesen G, et al
. Surface display of an anti-DEC-205 single chain Fv fragment in Lactobacillus plantarum increases internalization and plasmid transfer to dendritic cells in vitro and in vivo. Microb Cell Fact. 2015;14:95 pubmed publisher
..It is likely that the more embedded localization of aDec in the latter case is favorable when cells are exposed to the harsh conditions of the gastro-intestinal tract. ..
de Azevedo M, Meijerink M, Taverne N, Pereira V, LeBlanc J, Azevedo V, et al
. Recombinant invasive Lactococcus lactis can transfer DNA vaccines either directly to dendritic cells or across an epithelial cell monolayer. Vaccine. 2015;33:4807-12 pubmed publisher
..These results suggest that DCs could sample bacteria containing the DNA vaccine across the epithelial barrier and express the antigen. ..
Aubry C, Michon C, Chain F, Chvatchenko Y, Goffin L, Zimmerli S, et al
. Protective effect of TSLP delivered at the gut mucosa level by recombinant lactic acid bacteria in DSS-induced colitis mouse model. Microb Cell Fact. 2015;14:176 pubmed publisher
..TSLP showed an anti-inflammatory protective role in DSS-induced colitis. We have demonstrated that a short and early administration of LL-TSLP is more efficient than a long lasting treatment. ..
Almeida J, Breyner N, Mahi M, Ahmed B, Benbouziane B, Boas P, et al
. Expression of fibronectin binding protein A (FnBPA) from Staphylococcus aureus at the cell surface of Lactococcus lactis improves its immunomodulatory properties when used as protein delivery vector. Vaccine. 2016;34:1312-8 pubmed publisher
..Altogether, the results suggest that FnBPA displays adjuvant properties when used in the context of mucosal delivery using L. lactis as a live vector. ..
Michon C, Langella P, Eijsink V, Mathiesen G, Chatel J. Display of recombinant proteins at the surface of lactic acid bacteria: strategies and applications. Microb Cell Fact. 2016;15:70 pubmed publisher
..Surface-display technologies have other potential applications, such as degradation of biomass, which is of importance for some potential industrial applications of LAB. ..
Chatel J, Pothelune L, Ah Leung S, Corthier G, Wal J, Langella P. In vivo transfer of plasmid from food-grade transiting lactococci to murine epithelial cells. Gene Ther. 2008;15:1184-90 pubmed publisher
..We demonstrated for the first time the transfer of a functional plasmid to the epithelial membrane of the small intestine in mice by noninvasive food-grade lactococci. ..