Jean Marc Cavaillon

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint Pro- versus anti-inflammatory cytokines: myth or reality
    J M Cavaillon
    Department of Physiopathology, Institut Pasteur, Paris, France
    Cell Mol Biol (Noisy-le-grand) 47:695-702. 2001
  2. ncbi request reprint Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock
    Virginie Maxime
    Unit Cytokines and Inflammation, Institut Pasteur, 75015 Paris, France
    J Infect Dis 191:138-44. 2005
  3. ncbi request reprint Determining the degree of immunodysregulation in sepsis
    Jean Marc Cavaillon
    Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Contrib Nephrol 156:101-11. 2007
  4. ncbi request reprint Cytokine cascade in sepsis
    Jean Marc Cavaillon
    UP Cytokine and Inflammation, Institut Pasteur, Paris, France
    Scand J Infect Dis 35:535-44. 2003
  5. ncbi request reprint Endotoxin tolerance: is there a clinical relevance?
    Jean Marc Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 9:101-7. 2003
  6. ncbi request reprint Reprogramming of circulatory cells in sepsis and SIRS
    J M Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 11:311-20. 2005
  7. ncbi request reprint Mechanisms of immunodysregulation in sepsis
    Jean Marc Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    Contrib Nephrol 144:76-93. 2004
  8. ncbi request reprint Compartmentalization of the inflammatory response in sepsis and SIRS
    Jean Marc Cavaillon
    Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 12:151-70. 2006
  9. ncbi request reprint Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review
    J M Cavaillon
    Department of Physiopathology, Institut Pasteur, Paris, France
    J Endotoxin Res 7:85-93. 2001
  10. pmc Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis
    Jean Marc Cavaillon
    Cytokines and Inflammation Unit, Institut Pasteur, rue Dr Roux, 75015 Paris, France
    Crit Care 10:233. 2006

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Pro- versus anti-inflammatory cytokines: myth or reality
    J M Cavaillon
    Department of Physiopathology, Institut Pasteur, Paris, France
    Cell Mol Biol (Noisy-le-grand) 47:695-702. 2001
    ....
  2. ncbi request reprint Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock
    Virginie Maxime
    Unit Cytokines and Inflammation, Institut Pasteur, 75015 Paris, France
    J Infect Dis 191:138-44. 2005
    ..Renewed interest in glucocorticoid treatment for septic shock offers an opportunity to analyze this regulatory loop in humans...
  3. ncbi request reprint Determining the degree of immunodysregulation in sepsis
    Jean Marc Cavaillon
    Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Contrib Nephrol 156:101-11. 2007
    ..Thus, the immune dysregulation observed in sepsis corresponds to a reprogramming of circulating leukocytes...
  4. ncbi request reprint Cytokine cascade in sepsis
    Jean Marc Cavaillon
    UP Cytokine and Inflammation, Institut Pasteur, Paris, France
    Scand J Infect Dis 35:535-44. 2003
    ..Although TNF contributes towards favouring the production of many other cytokines within a complex cascade, there are numerous examples to illustrate that its presence is not a prerequisite for these productions...
  5. ncbi request reprint Endotoxin tolerance: is there a clinical relevance?
    Jean Marc Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 9:101-7. 2003
    ..In conclusion, in vitro and in vivo endotoxin tolerance, either experimental or due to clinical status, are similar but not identical...
  6. ncbi request reprint Reprogramming of circulatory cells in sepsis and SIRS
    J M Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 11:311-20. 2005
    ..e. isolated monocytes versus peripheral blood mononuclear cells versus whole blood assays), and the nature of the analyzed cytokines (e.g. IL-1beta versus IL-1ra; TNF versus IL-10) have a profound influence on the outcome of the response...
  7. ncbi request reprint Mechanisms of immunodysregulation in sepsis
    Jean Marc Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    Contrib Nephrol 144:76-93. 2004
  8. ncbi request reprint Compartmentalization of the inflammatory response in sepsis and SIRS
    Jean Marc Cavaillon
    Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 12:151-70. 2006
    ....
  9. ncbi request reprint Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review
    J M Cavaillon
    Department of Physiopathology, Institut Pasteur, Paris, France
    J Endotoxin Res 7:85-93. 2001
    ....
  10. pmc Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis
    Jean Marc Cavaillon
    Cytokines and Inflammation Unit, Institut Pasteur, rue Dr Roux, 75015 Paris, France
    Crit Care 10:233. 2006
    ..The term 'cellular reprogramming', which has been proposed to qualify the process of endotoxin tolerance, defines well the immune status of circulating leukocytes in septic and SIRS patients...
  11. ncbi request reprint Adherence influences monocyte responsiveness to interleukin-10
    Anne France Petit-Bertron
    UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    J Leukoc Biol 73:145-54. 2003
    ..Altogether, these data illustrate that adherence modulates the properties and the anti-inflammatory effects of IL-10...
  12. ncbi request reprint Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome
    Christophe Adrie
    Medical ICU, Cochin Hospital, Paris, France
    Circulation 106:562-8. 2002
    ..We investigated the immunoinflammatory profile of patients successfully resuscitated after cardiac arrest, representing a model of whole-body ischemia/reperfusion syndrome...
  13. ncbi request reprint Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression
    Minou Adib-Conquy
    Cytokines and Inflammation Unit, Institut Pasteur, 75724 Paris, France
    J Biol Chem 277:27927-34. 2002
    ....
  14. ncbi request reprint Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients
    Minou Adib-Conquy
    Cytokines and Inflammation Unit, Institut Pasteur, Paris, France
    Crit Care Med 34:2377-85. 2006
    ..In this study, we addressed the specificity of this hyporeactivity and investigated some of the possible associated mechanistic events...
  15. ncbi request reprint Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists
    Jörg H Fritz
    Groupe d Immunité Innée et Signalisation, Institut Pasteur, Paris, France
    Eur J Immunol 35:2459-70. 2005
    ....
  16. pmc Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation
    Oh Yoen Kim
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr, Roux, Paris, France
    Crit Care 14:R61. 2010
    ..So far, the analyses were mainly performed without taking into account monocytes subpopulations...
  17. pmc Neutrophils in cystic fibrosis display a distinct gene expression pattern
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Mol Med 14:36-44. 2008
    ..Altogether, this study clearly demonstrates that blood PMNs from CF patients display a profound modification of gene expression profile associated with the disease, suggesting a state of activation of these cells...
  18. ncbi request reprint Compartmentalization of tolerance to endotoxin
    Catherine Fitting
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Infect Dis 189:1295-303. 2004
    ..Therefore, our objective was to set up an ex vivo model of tolerance to endotoxin...
  19. ncbi request reprint Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation
    Minou Adib-Conquy
    UP Cytokines and Inflammation, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Am J Respir Crit Care Med 168:158-64. 2003
    ..In conclusion, the immunodysregulation described for patients with trauma is not a generalized phenomenon but depends on the stimulus and the signaling pathway...
  20. ncbi request reprint Adherence modifies the regulation of gene expression induced by interleukin-10
    Anne France Petit-Bertron
    UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Cytokine 29:1-12. 2005
    ..Furthermore, the inhibition of the expression of SOCS1 by IL-10 in the absence of adherence, may explain its priming effects on a subsequent LPS stimulation that we previously described...
  21. doi request reprint Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
    Ronan Kapetanovic
    Institut Pasteur, Unité Cytokines and Inflammation, Département Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
    Microbes Infect 12:759-67. 2010
    ..aureus-induced pneumonia, but that it contributes to the inflammatory response in the lungs. Interestingly, the absence of NOD2 led to a lesser inflammation and was finally beneficial for the animal recovery...
  22. pmc The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response
    Aurelia Delaune
    Institut Pasteur, Biology of Gram Positive Pathogens, Department of Microbiology, Paris, France
    Infect Immun 80:3438-53. 2012
    ..Taken together, our results indicate that WalKR play an important role in virulence and eliciting the host inflammatory response by controlling autolytic activity...
  23. doi request reprint CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis
    Marianna Parlato
    Unit of Cytokines and Inflammation, Department of Infection and Epidemiology, Institut Pasteur, 75015 Paris, France
    J Immunol 192:2449-59. 2014
    ..Our results suggest a novel aspect of CD24-mediated immunoregulation and represent, to our knowledge, the first report showing the role of CD24 in the delayed/defective cell death in sepsis. ..
  24. doi request reprint NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis
    Fernando Souza-Fonseca-Guimarães
    Institut Pasteur, Unité Cytokines et Inflammation, Département Infection et Epidémiologie, F 75015 Paris, France
    J Immunol 188:5850-8. 2012
    ..We show that this tolerance is associated with a reduction of the CD27(+)CD11b(-) subset in the spleen related to the presence of regulatory T cells and mainly mediated by TGF-β...
  25. doi request reprint Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytes
    Cristina D Ciornei
    Unité Cytokines and Inflammation, Institut Pasteur, Paris, France
    Innate Immun 16:288-301. 2010
    ..Our results, therefore, show that P. aeruginosa biofilm LPS undergoes structural modifications that only partially contribute to an increased inflammatory response from human monocytes...
  26. doi request reprint Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes
    Ronan Kapetanovic
    Institut Pasteur, Cytokines and Inflammation Unit, Paris, France
    Am J Physiol Cell Physiol 300:C850-9. 2011
    ..The influence of the compartments on cell properties and behavior should be taken into account, to better understand cell physiology and host-pathogen interaction, and to define efficient strategies to fight infection...
  27. ncbi request reprint The Bw cells, a novel B cell population conserved in the whole genus Mus
    Aude Thiriot
    Unité d Immunophysiopathologie Infectieuse, Institut Pasteur, Department Immunologie, Paris, France
    J Immunol 179:6568-78. 2007
    ....
  28. doi request reprint Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*
    Francois Philippart
    Department of Infection and Epidemiology, Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Crit Care Med 40:2987-96. 2012
    ..We investigated why this phenomenon cannot be observed with murine alveolar macrophages...
  29. doi request reprint Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice
    Christian E Demeure
    Yersinia Research Unit, Institut Pasteur, Paris, France
    J Infect Dis 205:134-43. 2012
    ....
  30. ncbi request reprint Compensatory anti-inflammatory response syndrome
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Thromb Haemost 101:36-47. 2009
    ..Thus, CARS may be considered as an adapted compartmentalized response with the aim to silence some acute proinflammatory genes, and to maintain the possible expression of certain genes involved in the anti-infectious process...
  31. ncbi request reprint Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors
    Isabelle Cloëz-Tayarani
    UP Cytokines and Inflammation, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
    Int Immunol 15:233-40. 2003
    ..Accordingly, we detected the presence of 5-HT(2A) receptors in PBMC by Western blot analysis. Our data support a role of 5-HT in inflammation through its effect on cytokine production in PBMC...
  32. pmc DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patients
    Catherine Fitting
    Unit Cytokines and Inflammation, Department of Infection and Epidemiology, Institut Pasteur, Paris, France
    PLoS ONE 7:e38916. 2012
    ..The concordance in bacterial identification between microbiology and the VYOO® test was 46.2%. This study demonstrates that these new technologies offer great hopes, but improvements are still needed...
  33. pmc Resilience to bacterial infection: difference between species could be due to proteins in serum
    H Shaw Warren
    Infectious Disease Unit, Institut Pasteur, Paris, France
    J Infect Dis 201:223-32. 2010
    ..The involvement of circulating proteins as key molecules raises hope that the process might be manipulated to create better animal models and potentially new drug targets...
  34. pmc Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages
    Ronan Kapetanovic
    Cytokines and Inflammation Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Infect Immun 75:830-7. 2007
    ..Taken together, these results show the contribution of phagocytosis and Nod molecules to the response to HKSA in macrophages and also identify possible cross talk between Nod1 and Nod2...
  35. ncbi request reprint Monocytes/macrophages and sepsis
    Jean Marc Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    Crit Care Med 33:S506-9. 2005
  36. ncbi request reprint Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection
    Minou Adib-Conquy
    Cytokines and Inflammation Unit, Institute Pasteur, Paris, France
    Shock 28:406-10. 2007
    ..In conclusion, sTREM-1 and PCT are not specific for infection and can increase markedly in acute inflammation without infection...
  37. pmc Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING)
    Fernando Souza-Fonseca-Guimarães
    Institut Pasteur, Unit of Cytokines and Inflammation, Department Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
    J Biol Chem 288:10715-21. 2013
    ..Our study thereby allows us to gain insight into the mechanisms of synergy between accessory cytokines and CpG-ODN in NK cells. It also identifies a new and alternative signaling pathway for CpG-ODN in murine NK cells...
  38. pmc Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection
    Charlène Blanchet
    Institut Pasteur, Cytokines and Inflammation, Département Infection et Epidémiologie, Paris, France
    PLoS ONE 9:e87927. 2014
    ..Their presence is protective for local pulmonary infection, whereas it becomes detrimental in the peritoneal infection. ..
  39. ncbi request reprint Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10
    Anne France Petit-Bertron
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Cytokine 41:54-60. 2008
    ....
  40. ncbi request reprint Stress molecules in sepsis and systemic inflammatory response syndrome
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    FEBS Lett 581:3723-33. 2007
    ..g. High mobility group box-1); that share some properties with PAMPs. Thus, numerous similarities occur during infectious and non-infectious systemic inflammation...
  41. ncbi request reprint Early events in innate immunity in the recognition of microbial pathogens
    Ronan Kapetanovic
    Department Infection and Epidemiology, Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Expert Opin Biol Ther 7:907-18. 2007
    ..Cytokines enhance phagocytosis and leukocyte microbicidal activity, allow cellular recruitment into the infectious focus, boost hematopoiesis, induce fever and lead to the production of acute phase proteins...
  42. pmc Translocation of bacterial NOD2 agonist and its link with inflammation
    Oh Yoen Kim
    Cytokines and Inflammation Unit, Institut Pasteur, 28 rue Dr, Roux, 75015 Paris, France
    Crit Care 13:R124. 2009
    ..The process could be more frequently identified if peptidoglycan, derived from both Gram-negative and Gram-positive bacteria, was measured...
  43. pmc Immune status in sepsis: the bug, the site of infection and the severity can make the difference
    Jean Marc Cavaillon
    Département Infection et Epidémiologie, Unité Cytokines and Inflammation, Institut Pasteur, 28 rue Dr, Roux F 75015 Paris, France
    Crit Care 14:167. 2010
    ..Their study illustrates the heterogeneity of patients with sepsis and points out that numerous key parameters of severe infection influence immune status...
  44. doi request reprint Wild-derived mouse strains, a valuable model to study B cell responses
    Aude Thiriot
    Unité de Biologie des Populations Lymphocytaires, Institut Pasteur, Dept Immunologie, CNRS URA 1961, Paris 75724 Cedex 15, France
    Mol Immunol 46:601-12. 2009
    ..Our findings therefore highlight the relevance of wild-derived mouse strains and TLR-L to study B cell physiology...
  45. pmc In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis
    Oumaima Ibrahim-Granet
    Unité de Recherche Cytokines and Inflammation, Institut Pasteur Paris France
    BMC Microbiol 10:105. 2010
    ..Studies on the pathogenesis of IA have been limited by the difficulty to monitor disease progression in real-time. For real-time monitoring of the infection, we recently engineered a bioluminescent A. fumigatus strain...
  46. pmc Natural killer (NK) cells in antibacterial innate immunity: angels or devils?
    Fernando Souza-Fonseca-Guimarães
    Institut Pasteur, Cytokines and Inflammation Unit, Department of Infection and Epidemiology, Paris, France
    Mol Med 18:270-85. 2012
    ..Accordingly, as the main source of IFN-γ in the early phase of infection, NK cells display both beneficial and deleterious effects, depending on the circumstances...
  47. pmc Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability
    Blandine Geny
    Unités des Bactéries Anaérobies et Toxines, Paris, France
    Am J Pathol 170:1003-17. 2007
    ..We conclude that the cells most susceptible to lethal toxin are lung vascular endothelial cells, the adherens junctions of which were altered after intoxication...
  48. doi request reprint TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals
    Minou Adib-Conquy
    Institut Pasteur, Unité Cytokines and Inflammation, Département Infection et Epidémiologie, Paris, France
    Immunol Cell Biol 92:256-62. 2014
    ....
  49. pmc Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cells
    Laurence Bassinet
    Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Infect Immun 72:5530-3. 2004
    ..This finding confirms the important role of adenylate cyclase-hemolysin in the pathogenicity of the bacterium...
  50. doi request reprint Sir Marc Armand Ruffer and Giulio Bizzozero: the first reports on efferocytosis
    Jean Marc Cavaillon
    Institut Pasteur, 28 rue Dr Roux, Paris, France
    J Leukoc Biol 93:39-43. 2013
    ..They both reported among the very first descriptions of efferocytosis...
  51. doi request reprint The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff
    Jean Marc Cavaillon
    Department Infection and Epidemiology, Institut Pasteur, Paris, France
    J Leukoc Biol 90:413-24. 2011
    ..This is illustrated by studies about the nature of the antibody-producing cells, which were first thought to belong to the RES, before being identified as plasmocytes and lymphocytes...
  52. pmc Monocyte TREM-1 membrane expression in non-infectious inflammation
    Jean Marc Cavaillon
    Unit Cytokines and Inflammation, Institut Pasteur, 75015 Paris, France
    Crit Care 13:152. 2009
    ..The increased expression on monocytes and neutrophils of triggering receptor expressed on myeloid cells 1 is a hallmark of both infectious and non-infectious inflammation...
  53. ncbi request reprint Low titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection
    Amelie Guihot
    1 Laboratory of Immunity and Infection, UPMC Univ Paris 06, UMR S945, Paris, France
    Am J Respir Crit Care Med 189:1240-9. 2014
    ..The biology of fatal pandemic influenza infection remains undefined...
  54. ncbi request reprint 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors
    Isabelle Cloëz-Tayarani
    UP Cytokines and Inflammation, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Life Sci 76:429-43. 2004
    ..A 5-HT2A antagonist, ketanserin, and a 5-HT transport inhibitor, fluoxetine, both failed to block the activation of ERK by 5-HT. Our results indicate that 5-HT activates ERK, but not p38, MAP kinase of human PBMC via a 5-HT1A receptor...
  55. ncbi request reprint Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial
    Didier Payen
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, University Paris, Paris, France
    Crit Care Med 37:803-10. 2009
    ..We sought to assess the effect of early application of hemofiltration on the degree of organ dysfunction and plasma cytokine levels in patients with severe sepsis or septic shock...
  56. ncbi request reprint Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?
    Mihai G Netea
    Dept of Medicine, Division of General Internal Medicine, University Medical Center St Radboud, Geert Grooteplein 8, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Trends Immunol 23:135-9. 2002
    ..Strictly cylindrical LPS molecules (e.g. the lipid A precursor Ia or from Rhodobacter sphaeroides) have antagonistic properties at the level of TLRs...
  57. ncbi request reprint LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation
    Andy Wullaert
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    J Biol Chem 282:81-90. 2007
    ..Taken together, these results implicate ABIN-3 as a novel negative feedback regulator of LPS-induced NF-kappaB activation...
  58. ncbi request reprint beta2-Adrenoceptor blockade partially restores ex vivo TNF production following hemorrhagic shock
    Karim Asehnoune
    AP HP, Univ Paris Sud, Hopital Bicetre, Departement d Anesthesie Reanimation, EA3540, F 94275 Le Kremlin Bicetre, France
    Cytokine 34:212-8. 2006
    ..Finally, this study demonstrates that beta(2)-adrenoceptor ligands play an important role in blood leukocyte deactivation to LPS after hemorrhagic shock...
  59. ncbi request reprint Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB
    Lynn Verstrepen
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, Ghent, Belgium
    J Cell Mol Med 12:316-29. 2008
    ..Altogether, these data indicate an important role for NF-kappaB-dependent gene expression of ABIN-3 in the negative feedback regulation of TNF receptor and toll-like receptor 4 induced NF-kappaB activation...
  60. pmc Simple method for repurification of endotoxins for biological use
    Alina Tirsoaga
    Equipe Endotoxines, UMR 8619 du CNRS, IBBMC, Universite de Paris Sud, 91405 Orsay, France
    Appl Environ Microbiol 73:1803-8. 2007
    ..Applied to different lipopolysaccharides, the method also improved their mass spectra, thus facilitating their structural analysis...
  61. ncbi request reprint Corticosteroids in sepsis: from bench to bedside?
    Djillali Annane
    Raymond Poincare Hospital, School of Medicine Paris Ile de France Ouest, University of Versailles Saint Quentin en Yvelinnes, 92380 Garches, France
    Shock 20:197-207. 2003
    ..Through these anti-inflammatory and cardiovascular effects, low doses of glucorticoids may improve septic shock survival...
  62. ncbi request reprint "Septic Plasma": an immunosuppressive milieu
    Jean Marc Cavaillon
    Am J Respir Crit Care Med 166:1417-8. 2002
  63. ncbi request reprint Endotoxin and anti-endotoxin. The contribution of the schools of Koch and Pasteur: life, milestone-experiments and concepts of Richard Pfeiffer (Berlin) and Alexandre Besredka (Paris)
    Ernst Th Rietschel
    Department of Immunochemistry and Biochemical Microbiology, Research Centre Borstel, Centre for Medicine and Biosciences, Borstel, Germany
    J Endotoxin Res 8:71-82. 2002
  64. ncbi request reprint Endotoxin and anti-endotoxin. The contribution of the schools of Koch and Pasteur: life, milestone-experiments and concepts of Richard Pfeiffer (Berlin) and Alexandre Besredka (Paris)
    Ernst Th Rietschel
    Department of Immunochemistry and Biochemical Microbiology, Centre for Medicine and Biosciences, Research Centre Borstel, Parkallee 22, D 23845 Borstel, Germany
    J Endotoxin Res 8:3-16. 2002
  65. ncbi request reprint Septic shock
    Djillali Annane
    Service de Reanimation, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Lancet 365:63-78. 2005
    ..Other therapeutic strategies are under investigation, including those that target late proinflammatory mediators, endothelium, or the neuroendocrine system...
  66. ncbi request reprint Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosis
    Harriet Corvol
    Departement de Pneumologie Pediatrique Institut National de la Santé et de la Recherche Médicale E213, Hopital Armand Trousseau, 75012 Paris, France
    Am J Physiol Lung Cell Mol Physiol 284:L997-1003. 2003
    ..They provide support to the hypothesis that not only the CF genotype but also the local environment may modify the functional properties of the neutrophils...
  67. ncbi request reprint A tribute to Ernst Th. Rietschel: the gentleman scientist
    Jean Marc Cavaillon
    J Endotoxin Res 13:3-5. 2007
  68. ncbi request reprint Richard Pfeiffer and Alexandre Besredka: creators of the concept of endotoxin and anti-endotoxin
    Ernst Th Rietschel
    Department of Immunochemistry and Biochemical Microbiology, Leibniz Centre for Medicine and Biosciences, Research Centre Borstel, Parkallee 22, 23845 Borstel, Germany
    Microbes Infect 5:1407-14. 2003
    ..Endotoxin and anti-endotoxin antibodies have since then fascinated researchers of many disciplines and continue to do so, particularly in the fields of diagnosis, prevention, and therapy of severe Gram-negative infections...
  69. ncbi request reprint Influence of resuscitation volume on blood cells TNF production in a murine model of haemorrhage
    Karim Asehnoune
    Service d Anesthésie Réanimation and Unité Propre de Recherche de l Enseignement Supérieur, Equipe d Accueil, UPRES EA 3540, Hopital de Bicetre, AP HP, 94275 Le Kremlin Bicetre, France
    Resuscitation 68:127-33. 2006
    ..In the present murine model of haemorrhage, modifying resuscitation volume influences in vitro TNF production in whole blood cultures challenged by LPS...