Research Topics
Genomes and Genes | Jean Marc CavaillonSummaryAffiliation: Institut Pasteur Country: France Publications
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Publications
Sir Marc Armand Ruffer and Giulio Bizzozero: the first reports on efferocytosisJean Marc Cavaillon
Institut Pasteur, 28 rue Dr Roux, Paris, France
J Leukoc Biol 93:39-43. 2013..They both reported among the very first descriptions of efferocytosis...- Good and bad feverJean Marc Cavaillon
Unit of Cytokines and Inflammation, Department of Infection and Epidemiology, Institut Pasteur, 28 rue Dr Roux, F 75015 Paris, France
Crit Care 16:119. 2012..A new investigation reports an association of the use of antipyretic drugs with poorer outcome among patients with sepsis. In contrast, high temperature in non-infectious intensive care patients is associated with higher mortality... 
In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosisOumaima Ibrahim-Granet
Unité de Recherche Cytokines and Inflammation, Institut Pasteur Paris France
BMC Microbiol 10:105. 2010..Studies on the pathogenesis of IA have been limited by the difficulty to monitor disease progression in real-time. For real-time monitoring of the infection, we recently engineered a bioluminescent A. fumigatus strain...- Immune status in sepsis: the bug, the site of infection and the severity can make the differenceJean Marc Cavaillon
Département Infection et Epidémiologie, Unité Cytokines and Inflammation, Institut Pasteur, 28 rue Dr, Roux F 75015 Paris, France
Crit Care 14:167. 2010..Their study illustrates the heterogeneity of patients with sepsis and points out that numerous key parameters of severe infection influence immune status... - The historical milestones in the understanding of leukocyte biology initiated by Elie MetchnikoffJean Marc Cavaillon
Department Infection and Epidemiology, Institut Pasteur, Paris, France
J Leukoc Biol 90:413-24. 2011..This is illustrated by studies about the nature of the antibody-producing cells, which were first thought to belong to the RES, before being identified as plasmocytes and lymphocytes... - Monocyte TREM-1 membrane expression in non-infectious inflammationJean Marc Cavaillon
Unit Cytokines and Inflammation, Institut Pasteur, 75015 Paris, France
Crit Care 13:152. 2009..The increased expression on monocytes and neutrophils of triggering receptor expressed on myeloid cells 1 is a hallmark of both infectious and non-infectious inflammation... - Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytesCristina D Ciornei
Unité Cytokines and Inflammation, Institut Pasteur, Paris, France
Innate Immun 16:288-301. 2010..Our results, therefore, show that P. aeruginosa biofilm LPS undergoes structural modifications that only partially contribute to an increased inflammatory response from human monocytes... 
Adherence influences monocyte responsiveness to interleukin-10Anne France Petit-Bertron
UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
J Leukoc Biol 73:145-54. 2003..Altogether, these data illustrate that adherence modulates the properties and the anti-inflammatory effects of IL-10...- Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndromeChristophe Adrie
Medical ICU, Cochin Hospital, Paris, France
Circulation 106:562-8. 2002..We investigated the immunoinflammatory profile of patients successfully resuscitated after cardiac arrest, representing a model of whole-body ischemia/reperfusion syndrome... - Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expressionMinou Adib-Conquy
Cytokines and Inflammation Unit, Institut Pasteur, 75724 Paris, France
J Biol Chem 277:27927-34. 2002.... - Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patientsMinou Adib-Conquy
Cytokines and Inflammation Unit, Institut Pasteur, Paris, France
Crit Care Med 34:2377-85. 2006..In this study, we addressed the specificity of this hyporeactivity and investigated some of the possible associated mechanistic events... - Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonistsJörg H Fritz
Groupe d Immunité Innée et Signalisation, Institut Pasteur, Paris, France
Eur J Immunol 35:2459-70. 2005.... - Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammationOh Yoen Kim
Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr, Roux, Paris, France
Crit Care 14:R61. 2010..So far, the analyses were mainly performed without taking into account monocytes subpopulations... - Adherence modifies the regulation of gene expression induced by interleukin-10Anne France Petit-Bertron
UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
Cytokine 29:1-12. 2005..Furthermore, the inhibition of the expression of SOCS1 by IL-10 in the absence of adherence, may explain its priming effects on a subsequent LPS stimulation that we previously described... - Neutrophils in cystic fibrosis display a distinct gene expression patternMinou Adib-Conquy
Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
Mol Med 14:36-44. 2008..Altogether, this study clearly demonstrates that blood PMNs from CF patients display a profound modification of gene expression profile associated with the disease, suggesting a state of activation of these cells... - The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory responseAurelia Delaune
Institut Pasteur, Biology of Gram Positive Pathogens, Department of Microbiology, Paris, France
Infect Immun 80:3438-53. 2012..Taken together, our results indicate that WalKR play an important role in virulence and eliciting the host inflammatory response by controlling autolytic activity... - Cytokine cascade in sepsisJean Marc Cavaillon
UP Cytokine and Inflammation, Institut Pasteur, Paris, France
Scand J Infect Dis 35:535-44. 2003..Although TNF contributes towards favouring the production of many other cytokines within a complex cascade, there are numerous examples to illustrate that its presence is not a prerequisite for these productions... - Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptorsIsabelle Cloëz-Tayarani
UP Cytokines and Inflammation, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
Int Immunol 15:233-40. 2003..Accordingly, we detected the presence of 5-HT(2A) receptors in PBMC by Western blot analysis. Our data support a role of 5-HT in inflammation through its effect on cytokine production in PBMC... - Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophagesRonan Kapetanovic
Cytokines and Inflammation Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Infect Immun 75:830-7. 2007..Taken together, these results show the contribution of phagocytosis and Nod molecules to the response to HKSA in macrophages and also identify possible cross talk between Nod1 and Nod2... - NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsisFernando Souza-Fonseca-Guimarães
Institut Pasteur, Unité Cytokines et Inflammation, Département Infection et Epidémiologie, F 75015 Paris, France
J Immunol 188:5850-8. 2012..We show that this tolerance is associated with a reduction of the CD27(+)CD11b(-) subset in the spleen related to the presence of regulatory T cells and mainly mediated by TGF-β... - Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytesRonan Kapetanovic
Institut Pasteur, Cytokines and Inflammation Unit, Paris, France
Am J Physiol Cell Physiol 300:C850-9. 2011..The influence of the compartments on cell properties and behavior should be taken into account, to better understand cell physiology and host-pathogen interaction, and to define efficient strategies to fight infection... - Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumoniaRonan Kapetanovic
Institut Pasteur, Unité Cytokines and Inflammation, Département Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
Microbes Infect 12:759-67. 2010..aureus-induced pneumonia, but that it contributes to the inflammatory response in the lungs. Interestingly, the absence of NOD2 led to a lesser inflammation and was finally beneficial for the animal recovery... - The Bw cells, a novel B cell population conserved in the whole genus MusAude Thiriot
Unité d Immunophysiopathologie Infectieuse, Institut Pasteur, Department Immunologie, Paris, France
J Immunol 179:6568-78. 2007.... - Determining the degree of immunodysregulation in sepsisJean Marc Cavaillon
Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
Contrib Nephrol 156:101-11. 2007..Thus, the immune dysregulation observed in sepsis corresponds to a reprogramming of circulating leukocytes... - Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*Francois Philippart
From the Department of Infection and Epidemiology, Unit Cytokines and Inflammation, Institut Pasteur, Paris, France FP, CF, J MC and Service de réanimation polyvalente, Groupe Hospitalier Paris Saint Joseph, Paris, France FP
Crit Care Med 40:2987-96. 2012..We investigated why this phenomenon cannot be observed with murine alveolar macrophages... - Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG miceChristian E Demeure
Yersinia Research Unit, Institut Pasteur, Paris, France
J Infect Dis 205:134-43. 2012.... - Resilience to bacterial infection: difference between species could be due to proteins in serumH Shaw Warren
Infectious Disease Unit, Institut Pasteur, Paris, France
J Infect Dis 201:223-32. 2010..The involvement of circulating proteins as key molecules raises hope that the process might be manipulated to create better animal models and potentially new drug targets... - DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patientsCatherine Fitting
Unit Cytokines and Inflammation, Department of Infection and Epidemiology, Institut Pasteur, Paris, France
PLoS ONE 7:e38916. 2012..The concordance in bacterial identification between microbiology and the VYOO® test was 46.2%. This study demonstrates that these new technologies offer great hopes, but improvements are still needed... - Endotoxin tolerance: is there a clinical relevance?Jean Marc Cavaillon
UP Cytokines and Inflammation, Institut Pasteur, Paris, France
J Endotoxin Res 9:101-7. 2003..In conclusion, in vitro and in vivo endotoxin tolerance, either experimental or due to clinical status, are similar but not identical... - Stress molecules in sepsis and systemic inflammatory response syndromeMinou Adib Conquy
Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
FEBS Lett 581:3723-33. 2007..g. High mobility group box-1); that share some properties with PAMPs. Thus, numerous similarities occur during infectious and non-infectious systemic inflammation... - Compensatory anti-inflammatory response syndromeMinou Adib-Conquy
Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
Thromb Haemost 101:36-47. 2009..Thus, CARS may be considered as an adapted compartmentalized response with the aim to silence some acute proinflammatory genes, and to maintain the possible expression of certain genes involved in the anti-infectious process... - Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infectionMinou Adib-Conquy
Cytokines and Inflammation Unit, Institute Pasteur, Paris, France
Shock 28:406-10. 2007..In conclusion, sTREM-1 and PCT are not specific for infection and can increase markedly in acute inflammation without infection... - Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsisJean Marc Cavaillon
Cytokines and Inflammation Unit, Institut Pasteur, rue Dr Roux, 75015 Paris, France
Crit Care 10:233. 2006..The term 'cellular reprogramming', which has been proposed to qualify the process of endotoxin tolerance, defines well the immune status of circulating leukocytes in septic and SIRS patients... - Early events in innate immunity in the recognition of microbial pathogensRonan Kapetanovic
Department Infection and Epidemiology, Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
Expert Opin Biol Ther 7:907-18. 2007..Cytokines enhance phagocytosis and leukocyte microbicidal activity, allow cellular recruitment into the infectious focus, boost hematopoiesis, induce fever and lead to the production of acute phase proteins... - Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10Anne France Petit-Bertron
Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
Cytokine 41:54-60. 2008.... - Compartmentalization of the inflammatory response in sepsis and SIRSJean Marc Cavaillon
Cytokines and Inflammation, Institut Pasteur, Paris, France
J Endotoxin Res 12:151-70. 2006.... - Translocation of bacterial NOD2 agonist and its link with inflammationOh Yoen Kim
Cytokines and Inflammation Unit, Institut Pasteur, 28 rue Dr, Roux, 75015 Paris, France
Crit Care 13:R124. 2009..The process could be more frequently identified if peptidoglycan, derived from both Gram-negative and Gram-positive bacteria, was measured... - Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeabilityBlandine Geny
Unités des Bactéries Anaérobies et Toxines, Paris, France
Am J Pathol 170:1003-17. 2007..We conclude that the cells most susceptible to lethal toxin are lung vascular endothelial cells, the adherens junctions of which were altered after intoxication... - Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammationMinou Adib-Conquy
UP Cytokines and Inflammation, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Am J Respir Crit Care Med 168:158-64. 2003..In conclusion, the immunodysregulation described for patients with trauma is not a generalized phenomenon but depends on the stimulus and the signaling pathway... - Natural killer (NK) cells in antibacterial innate immunity: angels or devils?Fernando Souza-Fonseca-Guimarães
Institut Pasteur, Cytokines and Inflammation Unit, Department of Infection and Epidemiology, Paris, France
Mol Med 18:270-85. 2012..Accordingly, as the main source of IFN-γ in the early phase of infection, NK cells display both beneficial and deleterious effects, depending on the circumstances... - Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cellsLaurence Bassinet
Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
Infect Immun 72:5530-3. 2004..This finding confirms the important role of adenylate cyclase-hemolysin in the pathogenicity of the bacterium... - Wild-derived mouse strains, a valuable model to study B cell responsesAude Thiriot
Unité de Biologie des Populations Lymphocytaires, Institut Pasteur, Dept Immunologie, CNRS URA 1961, Paris 75724 Cedex 15, France
Mol Immunol 46:601-12. 2009..Our findings therefore highlight the relevance of wild-derived mouse strains and TLR-L to study B cell physiology... - 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptorsIsabelle Cloëz-Tayarani
UP Cytokines and Inflammation, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
Life Sci 76:429-43. 2004..A 5-HT2A antagonist, ketanserin, and a 5-HT transport inhibitor, fluoxetine, both failed to block the activation of ERK by 5-HT. Our results indicate that 5-HT activates ERK, but not p38, MAP kinase of human PBMC via a 5-HT1A receptor... - Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trialDidier Payen
Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, University Paris, Paris, France
Crit Care Med 37:803-10. 2009..We sought to assess the effect of early application of hemofiltration on the degree of organ dysfunction and plasma cytokine levels in patients with severe sepsis or septic shock...