Florence Buseyne

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Frequencies of ex vivo-activated human immunodeficiency virus type 1-specific gamma-interferon-producing CD8+ T cells in infected children correlate positively with plasma viral load
    Florence Buseyne
    Laboratoire d Immunopathologie Virale, Département de Médecine Moléculaire, URA CNRS 1930, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    J Virol 76:12414-22. 2002
  2. pmc Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children
    F Buseyne
    Laboratoire d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Hopital Necker Enfants Malades, 75015 Paris, France
    J Virol 75:4941-6. 2001
  3. ncbi request reprint Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children: impact of age
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    Virology 354:271-9. 2006
  4. ncbi request reprint The frequency of HIV-specific interferon- gamma -producing CD8 T cells is associated with both age and level of antigenic stimulation in HIV-1-infected children
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, Institut Pasteur, Paris, France
    J Infect Dis 192:1781-6. 2005
  5. ncbi request reprint In HIV type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 75015 Paris, France
    AIDS Res Hum Retroviruses 21:719-27. 2005
  6. ncbi request reprint A vaccinia-based elispot assay for detection of CD8+ T cells from HIV-1 infected children
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    J Immunol Methods 298:105-18. 2005
  7. ncbi request reprint Inverse correlation between memory Gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children
    Florence Buseyne
    Laboratoire d Immunopathologie Virale, Unité de Recherche Associée Centre National de la Recherche Scientifique 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    J Infect Dis 186:1589-96. 2002
  8. ncbi request reprint Not all tetramer binding CD8+ T cells can produce cytokines and chemokines involved in the effector functions of virus-specific CD8+ T lymphocytes in HIV-1 infected children
    Daniel Scott-Algara
    Unité de Biologie des Rétrovirus, Institut Pasteur, Paris, France
    J Clin Immunol 25:57-67. 2005
  9. doi request reprint In untreated HIV-1-infected children, PBMC-associated HIV DNA levels and cell-free HIV RNA levels are correlated to distinct T-lymphocyte populations
    Daniel Scott-Algara
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 25 rue du Dr Roux, Paris, France
    J Acquir Immune Defic Syndr 53:553-63. 2010
  10. ncbi request reprint Prevalence and risk factors associated with antiretroviral resistance in HIV-1-infected children
    Constance Delaugerre
    Department of Virology, Necker Hospital, Paris, France
    J Med Virol 79:1261-9. 2007

Detail Information

Publications11

  1. pmc Frequencies of ex vivo-activated human immunodeficiency virus type 1-specific gamma-interferon-producing CD8+ T cells in infected children correlate positively with plasma viral load
    Florence Buseyne
    Laboratoire d Immunopathologie Virale, Département de Médecine Moléculaire, URA CNRS 1930, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    J Virol 76:12414-22. 2002
    ..In conclusion, our results show that the ex vivo-activated IFN-gamma-producing HIV-specific CD8+ T-cell subset is dependent upon continuous antigenic stimulation...
  2. pmc Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children
    F Buseyne
    Laboratoire d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Hopital Necker Enfants Malades, 75015 Paris, France
    J Virol 75:4941-6. 2001
    ..These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines...
  3. ncbi request reprint Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children: impact of age
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    Virology 354:271-9. 2006
    ..The poor Nef-specific CD8 T cell response in HIV-infected children contrasts with dominance of Nef-specific responses in infected adults...
  4. ncbi request reprint The frequency of HIV-specific interferon- gamma -producing CD8 T cells is associated with both age and level of antigenic stimulation in HIV-1-infected children
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, Institut Pasteur, Paris, France
    J Infect Dis 192:1781-6. 2005
    ..In conclusion, the frequency of HIV-specific IFN- gamma -producing CD8 T cells in children is primarily determined by both age and plasma viral load...
  5. ncbi request reprint In HIV type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 75015 Paris, France
    AIDS Res Hum Retroviruses 21:719-27. 2005
    ..This result adds further support to the hypothesis that cooperation between the antiviral immune response and antiviral drugs could be helpful for therapeutic management of HIV-infected patients...
  6. ncbi request reprint A vaccinia-based elispot assay for detection of CD8+ T cells from HIV-1 infected children
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    J Immunol Methods 298:105-18. 2005
    ....
  7. ncbi request reprint Inverse correlation between memory Gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children
    Florence Buseyne
    Laboratoire d Immunopathologie Virale, Unité de Recherche Associée Centre National de la Recherche Scientifique 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    J Infect Dis 186:1589-96. 2002
    ..The inverse correlation between virus load and Gag-specific CTLs was independent of CD4(+) T cell counts. In conclusion, this study showed the beneficial role of HIV-specific CTLs in children who survived after age 5 years...
  8. ncbi request reprint Not all tetramer binding CD8+ T cells can produce cytokines and chemokines involved in the effector functions of virus-specific CD8+ T lymphocytes in HIV-1 infected children
    Daniel Scott-Algara
    Unité de Biologie des Rétrovirus, Institut Pasteur, Paris, France
    J Clin Immunol 25:57-67. 2005
    ..This is the first report in the context of pediatric HIV-1 infection showing that only a fraction of HIV-1-specific CD8+ T cells have the capacity to produce cytokines and chemokines implicated in their antiviral functions...
  9. doi request reprint In untreated HIV-1-infected children, PBMC-associated HIV DNA levels and cell-free HIV RNA levels are correlated to distinct T-lymphocyte populations
    Daniel Scott-Algara
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 25 rue du Dr Roux, Paris, France
    J Acquir Immune Defic Syndr 53:553-63. 2010
    ..The associations between the level of infected cells and immune markers have been poorly studied, particularly in perinatally infected children...
  10. ncbi request reprint Prevalence and risk factors associated with antiretroviral resistance in HIV-1-infected children
    Constance Delaugerre
    Department of Virology, Necker Hospital, Paris, France
    J Med Virol 79:1261-9. 2007
    ..In conclusion, antiretroviral resistance is common among treated HIV-1-infected children and prevalence was similar with those observed in adult population in the same year period. However, adolescent boys seem to be at greater risk...
  11. ncbi request reprint DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation
    Arnaud Moris
    Groupe Virus et Immunité, URA CNRS 1930, Institut Pasteur, Paris, France
    Blood 103:2648-54. 2004
    ..Altogether, our results highlight new aspects of DC-SIGN interactions with HIV-1. The lectin does not significantly protect captured virions against degradation and promotes MHC-I exogenous presentation of HIV-1 antigens...