Margaret E Buckingham

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis
    Takahiko Sato
    Department of Developmental Biology, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Institut Pasteur, Paris, France
    PLoS Genet 6:e1000897. 2010
  2. doi request reprint Gene regulatory networks and transcriptional mechanisms that control myogenesis
    Margaret Buckingham
    CNRS URA 2578, Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France Electronic address
    Dev Cell 28:225-38. 2014
  3. doi request reprint Lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing
    Fabienne Lescroart
    Unité de Génétique Moléculaire du Développement, CNRS URA 2578, Institut Pasteur, 75015, Paris, France
    Circ Res 111:1313-22. 2012
  4. pmc Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo
    Mounia Lagha
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 rue du Dr Roux, Paris, France
    BMC Genomics 11:696. 2010
  5. doi request reprint Tracing cells for tracking cell lineage and clonal behavior
    Margaret E Buckingham
    Molecular Genetics of Development Unit, CNRS URA 2578, Department of Developmental Biology, Institut Pasteur, Paris, France
    Dev Cell 21:394-409. 2011
  6. doi request reprint Distinct and dynamic myogenic populations in the vertebrate embryo
    Margaret Buckingham
    Institut Pasteur, CNRS URA 2578, 28 rue du Dr Roux, 75015 Paris, France
    Curr Opin Genet Dev 19:444-53. 2009
  7. ncbi request reprint The clonal origin of myocardial cells in different regions of the embryonic mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Cell 6:685-98. 2004
  8. doi request reprint Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed
    Daniela Galli
    Department of Developmental Biology, URA 2578 CNRS, Pasteur Institute, 25 rue du Docteur Roux, 75724 Paris, France
    Development 135:1157-67. 2008
  9. ncbi request reprint Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome
    Milan Esner
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 28 rue du Dr Roux, 75 724 Paris Cedex 15, France
    Development 133:737-49. 2006
  10. pmc Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo
    Mounia Lagha
    Departement de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, Paris, France
    PLoS ONE 8:e63143. 2013

Collaborators

Detail Information

Publications27

  1. pmc A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis
    Takahiko Sato
    Department of Developmental Biology, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Institut Pasteur, Paris, France
    PLoS Genet 6:e1000897. 2010
    ..These results reveal a novel genetic network, comprising a Pax3/Dmrt2/Myf5 regulatory cascade that operates in stem cells of the epaxial dermomyotome to initiate skeletal muscle formation...
  2. doi request reprint Gene regulatory networks and transcriptional mechanisms that control myogenesis
    Margaret Buckingham
    CNRS URA 2578, Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France Electronic address
    Dev Cell 28:225-38. 2014
    ..Myogenic determination and subsequent differentiation depend on members of the MyoD family. We discuss new insights into mechanisms underlying the transcriptional activity of these factors. ..
  3. doi request reprint Lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing
    Fabienne Lescroart
    Unité de Génétique Moléculaire du Développement, CNRS URA 2578, Institut Pasteur, 75015, Paris, France
    Circ Res 111:1313-22. 2012
    ..Whereas the heart forms from 2 sources of progenitor cells, the first and second heart fields, genetic tracing has suggested a distinct origin for caval vein myocardium, from a proposed third heart field...
  4. pmc Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo
    Mounia Lagha
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 rue du Dr Roux, Paris, France
    BMC Genomics 11:696. 2010
    ..Few Pax3 target genes have been identified. Identifying genes that lie genetically downstream of Pax3 is therefore an important endeavour in elucidating the myogenic gene regulatory network...
  5. doi request reprint Tracing cells for tracking cell lineage and clonal behavior
    Margaret E Buckingham
    Molecular Genetics of Development Unit, CNRS URA 2578, Department of Developmental Biology, Institut Pasteur, Paris, France
    Dev Cell 21:394-409. 2011
    ..Technological advances in genetically engineered permanent cell labeling, together with a multiplicity of fluorescent markers and sophisticated imaging, open new possibilities for prospective and retrospective clonal analysis...
  6. doi request reprint Distinct and dynamic myogenic populations in the vertebrate embryo
    Margaret Buckingham
    Institut Pasteur, CNRS URA 2578, 28 rue du Dr Roux, 75015 Paris, France
    Curr Opin Genet Dev 19:444-53. 2009
    ..Further insights into myogenic populations that contribute to trunk and limb development at different stages are summarized and the distinct regulatory networks that underlie the formation of head muscles are discussed...
  7. ncbi request reprint The clonal origin of myocardial cells in different regions of the embryonic mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Cell 6:685-98. 2004
    ..These results are not consistent with the prespecification of the cardiac tube as a segmented structure. They are discussed in the context of different heart fields and of the evolution of the heart...
  8. doi request reprint Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed
    Daniela Galli
    Department of Developmental Biology, URA 2578 CNRS, Pasteur Institute, 25 rue du Docteur Roux, 75724 Paris, France
    Development 135:1157-67. 2008
    ..This report provides new insights into the contribution of the SHF to atrial myocardium and the effect of Pitx2c on the formation of the left atrium...
  9. ncbi request reprint Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome
    Milan Esner
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 28 rue du Dr Roux, 75 724 Paris Cedex 15, France
    Development 133:737-49. 2006
    ..These results are discussed in terms of the paraxial mesoderm contribution to the aorta and of the mesoangioblast stem cells that derive from it...
  10. pmc Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo
    Mounia Lagha
    Departement de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, Paris, France
    PLoS ONE 8:e63143. 2013
    ..Itm2a mutant mice are viable and fertile with no overt phenotype during skeletal muscle formation or regeneration. Potential compensatory mechanisms are discussed...
  11. doi request reprint Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors
    Mounia Lagha
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 75015 Paris, France
    Dev Cell 17:892-9. 2009
    ..This provides insight into how cell fate choices are orchestrated by these lineage genes in the dermomyotome...
  12. ncbi request reprint Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart
    Marguerite Lemonnier
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 279:55651-8. 2004
    ..This site binds myocyte enhancer factor (MEF)2 factors, principally MEF2D and MEF2A in cardiocyte nuclear extracts. These results are discussed in the context of MEF2 activity and of the regulation of the alpha-cardiac actin locus...
  13. pmc A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb
    Lola Bajard
    Centre National de la Recherche Scientifique URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 20:2450-64. 2006
    ..Mutation of the Pax3 site abolishes all expression controlled by the 145-bp sequence in transgenic mouse embryos. We conclude that Pax3 directly regulates Myf5 in the hypaxial somite and its derivatives...
  14. pmc Oriented clonal cell growth in the developing mouse myocardium underlies cardiac morphogenesis
    Sigolène M Meilhac
    Departement de Biologie du Developpement, Institut Pasteur, 28 rue de Dr Roux, 75724 Paris Cedex 15, France
    J Cell Biol 164:97-109. 2004
    ..Our results show that the myocardium, from the time of its formation, is a polarized and regionalized tissue and point to the role of oriented clonal cell growth in cardiac chamber morphogenesis...
  15. ncbi request reprint Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field
    Fanny Bajolle
    Department of Developmental Biology, URA 2578 CNRS, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris, France
    Dev Biol 313:25-34. 2008
    ....
  16. ncbi request reprint Integration of embryonic and fetal skeletal myogenic programs at the myosin light chain 1f/3f locus
    Peter S Zammit
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 313:420-33. 2008
    ..Together our observations provide insights into the regulation of fetal myogenesis and the mechanisms by which temporally distinct genetic programs are integrated at a single locus...
  17. doi request reprint How to make a heart: the origin and regulation of cardiac progenitor cells
    Stephane D Vincent
    Institut Pasteur, Departement de Biologie du Developpement, CNRS URA 2578, Paris, France
    Curr Top Dev Biol 90:1-41. 2010
    ..Analysis of signaling pathways that impact the SHF, as well as regulatory factors, is beginning to reveal mechanisms that control cardiac progenitor cell behavior...
  18. ncbi request reprint Right ventricular myocardium derives from the anterior heart field
    Stephane Zaffran
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr Roux, Paris, 75015, France
    Circ Res 95:261-8. 2004
    ..This study demonstrates the differences in the embryological origin of right and left ventricular myocardium, which has important implications for congenital heart disease...
  19. pmc Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program
    Mounia Lagha
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 22:1828-37. 2008
    ..These results provide new insight into the Pax-initiated regulatory network that modulates stem cell maintenance versus tissue differentiation...
  20. ncbi request reprint The A17 enhancer directs expression of Myf5 to muscle satellite cells but Mrf4 to myonuclei
    Ted Hung Tse Chang
    Departement de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, Paris, France
    Dev Dyn 236:3419-26. 2007
    ..Importantly, therefore, this promoter-specific activity directed by A17 reflects aspects of the expression profiles of the endogenous Myf5 and Mrf4 genes...
  21. ncbi request reprint Cell history determines the maintenance of transcriptional differences between left and right ventricular cardiomyocytes in the developing mouse heart
    Robert G Kelly
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 25 rue du Dr Roux, Paris 75015, France
    J Cell Sci 116:5005-13. 2003
    ..Epigenetic mechanisms may therefore be involved in maintaining patterning of the mammalian myocardium...
  22. pmc Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries
    Yusuke Watanabe
    Department of Developmental Biology, URA CNRS 2578, Institut Pasteur, 25 rue du Dr Roux 75015 Paris, France
    Circ Res 106:495-503. 2010
    ..Previous studies of hypomorphic and conditional Fgf8 mutants show disrupted outflow tract (OFT) and right ventricle (RV) development, whereas Fgf10 mutants do not have detectable OFT defects...
  23. ncbi request reprint Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries
    Fanny Bajolle
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, Paris, France
    Circ Res 98:421-8. 2006
    ..We propose that failure of normal rotation of OFT myocardium may underlie major forms of congenital heart disease...
  24. doi request reprint Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer
    Philippe Daubas
    Centre National de la Recherche Scientifique URA 2578, Department of Developmental and Stem Cell Biology, Pasteur Institute, 25 rue du Dr Roux, 75015 Paris, France
    Dev Biol 376:236-44. 2013
    ..However, in the case of the -111 kb-Myf5 enhancer, Six has less effect and we conclude that Pax regulation plays a major role in controlling this aspect of the Myf5 gene expression at the onset of myogenesis in the embryo...
  25. doi request reprint Quantitative analysis of polarity in 3D reveals local cell coordination in the embryonic mouse heart
    Jean François Le Garrec
    Institut Pasteur, Unit of Molecular Genetics of Development, Department of Developmental Biology, F 75015 Paris, France
    Development 140:395-404. 2013
    ..We show further alignment of these axes locally in the plane of the heart surface. Our method is generally applicable to other sets of vectors or axes in 3D tissues to map the regions where they show significant alignment...
  26. ncbi request reprint A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Development 130:3877-89. 2003
    ..We discuss how the characteristics of myocardial cell growth, which we describe, underlie the formation of the heart tube and its subsequent regionalised expansion...
  27. ncbi request reprint The anterior heart-forming field: voyage to the arterial pole of the heart
    Robert G Kelly
    CNRS URA 1947, Dept of Developmental Biology, Pasteur Institute, 28 rue du Dr Roux, Paris, France
    Trends Genet 18:210-6. 2002
    ..Discovery of the anterior heart-forming field has important implications for the interpretation of cardiac defects in mouse mutants and for the study of human congenital heart disease...