Margaret Buckingham

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint Skeletal muscle progenitor cells and the role of Pax genes
    Margaret Buckingham
    Departement de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    C R Biol 330:530-3. 2007
  2. pmc The formation of skeletal muscle: from somite to limb
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA 1947, Pasteur Institute, Paris, France
    J Anat 202:59-68. 2003
  3. ncbi request reprint How the community effect orchestrates muscle differentiation
    Margaret Buckingham
    CNRS URA1947, Department of Development Biology, Pasteur Institute, 25 rue du Dr Roux, 75015 Paris, France
    Bioessays 25:13-6. 2003
  4. ncbi request reprint Skeletal muscle formation in vertebrates
    M Buckingham
    Unité de Génétique Moléculaire du Développement, CNRS URA1947, Departement de Biologie Moleculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
    Curr Opin Genet Dev 11:440-8. 2001
  5. ncbi request reprint Myogenic progenitor cells and skeletal myogenesis in vertebrates
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA2578, Pasteur Institute, 25 rue du Docteur Roux, 75015 Paris Cedex, France
    Curr Opin Genet Dev 16:525-32. 2006
  6. ncbi request reprint Myogenic progenitor cells in the mouse embryo are marked by the expression of Pax3/7 genes that regulate their survival and myogenic potential
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA2578, Pasteur Institute, 25 rue du Dr Roux, 75015, Paris, France
    Anat Embryol (Berl) 211:51-6. 2006
  7. ncbi request reprint The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 75015 Paris, France
    Annu Rev Cell Dev Biol 23:645-73. 2007
  8. doi request reprint Skeletal muscle stem cells
    Margaret Buckingham
    Pasteur Institute, CNRS URA 2578, 28 rue du Dr Roux, 75015 Paris, France
    Curr Opin Genet Dev 18:330-6. 2008
  9. ncbi request reprint Building the mammalian heart from two sources of myocardial cells
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr Roux, 75015 Paris, France
    Nat Rev Genet 6:826-35. 2005
  10. ncbi request reprint A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
    Frederic Relaix
    C N R S URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Nature 435:948-53. 2005

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Skeletal muscle progenitor cells and the role of Pax genes
    Margaret Buckingham
    Departement de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    C R Biol 330:530-3. 2007
    ..Pax3/7 lies genetically upstream of both MyoD and Myf5, which determine the skeletal muscle fate of these cells. To cite this article: M. Buckingham, C. R. Biologies 330 (2007)...
  2. pmc The formation of skeletal muscle: from somite to limb
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA 1947, Pasteur Institute, Paris, France
    J Anat 202:59-68. 2003
    ....
  3. ncbi request reprint How the community effect orchestrates muscle differentiation
    Margaret Buckingham
    CNRS URA1947, Department of Development Biology, Pasteur Institute, 25 rue du Dr Roux, 75015 Paris, France
    Bioessays 25:13-6. 2003
    ..This raises the question of the co-ordination between these events and the community effect which orchestrates myogenesis...
  4. ncbi request reprint Skeletal muscle formation in vertebrates
    M Buckingham
    Unité de Génétique Moléculaire du Développement, CNRS URA1947, Departement de Biologie Moleculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
    Curr Opin Genet Dev 11:440-8. 2001
    ..The myogenic identity of precursor cells in the adult depends on Pax7, the orthologue of Pax3 which is required for early myogenesis; this finding is of major importance for muscle regeneration and the active field of stem cell research...
  5. ncbi request reprint Myogenic progenitor cells and skeletal myogenesis in vertebrates
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA2578, Pasteur Institute, 25 rue du Docteur Roux, 75015 Paris Cedex, France
    Curr Opin Genet Dev 16:525-32. 2006
    ..New approaches that permit the grafting of purified satellite cells demonstrate their capacity for efficient muscle repair and for self-renewal. Regeneration in amphibians is now also shown to involve Pax-positive progenitor cells...
  6. ncbi request reprint Myogenic progenitor cells in the mouse embryo are marked by the expression of Pax3/7 genes that regulate their survival and myogenic potential
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA2578, Pasteur Institute, 25 rue du Dr Roux, 75015, Paris, France
    Anat Embryol (Berl) 211:51-6. 2006
    ..The latter include the smooth muscle cells of the dorsal aorta that share a common clonal origin with the skeletal muscle of the myotome, thus illustrating the initial multipotency of Pax3 expressing cells...
  7. ncbi request reprint The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 75015 Paris, France
    Annu Rev Cell Dev Biol 23:645-73. 2007
    ..Finally, we consider the molecular mechanisms that underlie the function of Pax transcription factors, including the cofactors and regulatory networks with which they interact...
  8. doi request reprint Skeletal muscle stem cells
    Margaret Buckingham
    Pasteur Institute, CNRS URA 2578, 28 rue du Dr Roux, 75015 Paris, France
    Curr Opin Genet Dev 18:330-6. 2008
    ....
  9. ncbi request reprint Building the mammalian heart from two sources of myocardial cells
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr Roux, 75015 Paris, France
    Nat Rev Genet 6:826-35. 2005
    ..It also has an important influence on the interpretation of mutant phenotypes in the mouse, with consequences for the classification and prognosis of human congenital heart defects...
  10. ncbi request reprint A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
    Frederic Relaix
    C N R S URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Nature 435:948-53. 2005
    ....
  11. ncbi request reprint Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
    Lina Kassar-Duchossoy
    Stem Cells and Development, Department of Developmental Biology, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 431:466-71. 2004
    ..We revise the epistatic relationship of the MRFs, in which both Myf5 and Mrf4 act upstream of Myod to direct embryonic multipotent cells into the myogenic lineage...
  12. pmc Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells
    Frederic Relaix
    Unité de Génétique Moléculaire du Développement, Centre National de la Recherche Scientifique URA 2578, Departement de Biologie du Developpement
    J Cell Biol 172:91-102. 2006
    ..These findings underline the importance of cell survival in controlling the stem cell populations of adult tissues and demonstrate a role for upstream factors in this context...
  13. pmc Divergent functions of murine Pax3 and Pax7 in limb muscle development
    Frederic Relaix
    Centre National de la Recherche Scientifique CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Genes Dev 18:1088-105. 2004
    ....
  14. pmc Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo
    Mounia Lagha
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 rue du Dr Roux, Paris, France
    BMC Genomics 11:696. 2010
    ..Few Pax3 target genes have been identified. Identifying genes that lie genetically downstream of Pax3 is therefore an important endeavour in elucidating the myogenic gene regulatory network...
  15. pmc Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression
    Colin G Crist
    Centre National de Recherche Scientifique Unité de Recherche Associée 2578, Department of Developmental Biology, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 106:13383-7. 2009
    ..We therefore conclude that miR-27b regulates Pax3 protein levels and this down-regulation ensures rapid and robust entry into the myogenic differentiation program...
  16. ncbi request reprint Non conservation of function for the evolutionarily conserved prdm1 protein in the control of the slow twitch myogenic program in the mouse embryo
    Stephane D Vincent
    Department of Developmental Biology, CNRS URA 2575, Institut Pasteur, Paris, France
    Mol Biol Evol 29:3181-91. 2012
    ....
  17. pmc Characterization of Pax3-expressing cells from adult blood vessels
    Olivier Goupille
    Molecular Genetics of Morphogenesis Unit, Department of Developmental Biology, URA CNRS 2578, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    J Cell Sci 124:3980-8. 2011
    ..These observations are discussed with respect to the origin and function of Pax3-expressing cells in blood vessels, and more general questions of cell fate determination and adult cell plasticity and reprogramming...
  18. pmc A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis
    Takahiko Sato
    Department of Developmental Biology, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Institut Pasteur, Paris, France
    PLoS Genet 6:e1000897. 2010
    ..These results reveal a novel genetic network, comprising a Pax3/Dmrt2/Myf5 regulatory cascade that operates in stem cells of the epaxial dermomyotome to initiate skeletal muscle formation...
  19. pmc Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs
    Julien Giordani
    Département de Génétique et Développement, Institut Cochin, Universite Paris Descartes, Paris, France
    Proc Natl Acad Sci U S A 104:11310-5. 2007
    ..Six homeoproteins, which also directly regulate the myogenic differentiation gene Myogenin and lie genetically upstream of Pax3, thus control hypaxial myogenesis at multiple levels...
  20. doi request reprint The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system
    Philippe Daubas
    Institut Pasteur, CNRS URA 2578, Department of Developmental Biology, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 327:71-82. 2009
    ..The Wnt-beta catenin signalling pathway is also implicated. Finally we show that post-transcriptional regulation of Myf5 gene expression involves miRNA repression acting through the Myf5-3'UTR...
  21. ncbi request reprint Direct isolation of satellite cells for skeletal muscle regeneration
    Didier Montarras
    CNRS Unité de Recherche Associée 2578, Department of Developmental Biology, INSERM, Pasteur Institute, 75724 Paris Cedex 15, France
    Science 309:2064-7. 2005
    ..Such cells, grafted into muscles of mdx nu/nu mice, contributed both to fiber repair and to the muscle satellite cell compartment. Expansion of these cells in culture before engraftment reduced their regenerative capacity...
  22. ncbi request reprint Analysis of a key regulatory region upstream of the Myf5 gene reveals multiple phases of myogenesis, orchestrated at each site by a combination of elements dispersed throughout the locus
    Juliette Hadchouel
    Departement de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Development 130:3415-26. 2003
    ....
  23. doi request reprint Muscle satellite cells are primed for myogenesis but maintain quiescence with sequestration of Myf5 mRNA targeted by microRNA-31 in mRNP granules
    Colin G Crist
    CNRS URA 2578, Department of Developmental Biology, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cell Stem Cell 11:118-26. 2012
    ..We therefore propose a model in which posttranscriptional mechanisms hold quiescent stem cells poised to enter a tissue-specific differentiation program...
  24. doi request reprint An adult tissue-specific stem cell in its niche: a gene profiling analysis of in vivo quiescent and activated muscle satellite cells
    Giorgia Pallafacchina
    Molecular Genetics of Development Unit, Department of Developmental Biology, URA CNRS 2578, Institut Pasteur, Paris, France
    Stem Cell Res 4:77-91. 2010
    ..In keeping with this, we demonstrate that metalloproteinase function is required for efficient regeneration in vivo...
  25. ncbi request reprint An enhancer directs differential expression of the linked Mrf4 and Myf5 myogenic regulatory genes in the mouse
    Ted Hung Tse Chang
    Departement de Biologie du Developpement, CNRS URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    Dev Biol 269:595-608. 2004
    ..These observations identify A17 as a sequence that targets sites of myogenesis in vivo and raise questions about the mutually exclusive modes of expression and possible promoter/enhancer interactions at the Mrf4-Myf5 locus...
  26. ncbi request reprint [The mouse as a model for heart morphogenesis in mammals: the origin of myocytes and studies with cardiac explants]
    Stephane Zaffran
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25, rue du Dr Roux, Paris, 75015 France
    J Soc Biol 197:187-94. 2003
    ..The Mlc3f-nlacZ-2 line, which marks the right atrium, allowed us to determine the time window during which left-right signaling confers left-right atrial identity...
  27. ncbi request reprint Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD
    S Tajbakhsh
    Department of Molecular Biology, Centre National de la Recherche Scientifique, Unité de Recherche Associe 1947, Pasteur Institute, Paris, France
    Cell 89:127-38. 1997
    ..Therefore, Pax-3 and Myf-5 define two distinct myogenic pathways, and MyoD acts genetically downstream of these genes for myogenesis in the body. This genetic hierarchy does not appear to operate for head muscle formation...
  28. pmc A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb
    Lola Bajard
    Centre National de la Recherche Scientifique URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 20:2450-64. 2006
    ..Mutation of the Pax3 site abolishes all expression controlled by the 145-bp sequence in transgenic mouse embryos. We conclude that Pax3 directly regulates Myf5 in the hypaxial somite and its derivatives...
  29. pmc Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium
    Yusuke Watanabe
    Department of Developmental Biology, Centre National de la Recherche Scientifique CNRS Unité de Recherche Associée 2578, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 109:18273-80. 2012
    ..Our findings provide a paradigm for transcriptional mechanisms that underlie the changes in regulatory networks during the transition from progenitor state to that of the differentiated tissue...
  30. doi request reprint Lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing
    Fabienne Lescroart
    Unité de Génétique Moléculaire du Développement, CNRS URA 2578, Institut Pasteur, 75015, Paris, France
    Circ Res 111:1313-22. 2012
    ..Whereas the heart forms from 2 sources of progenitor cells, the first and second heart fields, genetic tracing has suggested a distinct origin for caval vein myocardium, from a proposed third heart field...
  31. doi request reprint Lack of in vivo functional compensation between Pax family groups II and III in rodents
    Shinichiro Hayashi
    Universite Pierre et Marie Curie, Univ Paris 06, UMR S 787, Paris, France
    Mol Biol Evol 28:2787-98. 2011
    ..Our result suggests that Pax3/7 and Pax2/5/8 functions evolved independently after duplication of the ancestral progenitor Pax genes...
  32. ncbi request reprint Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5
    S Tajbakhsh
    Département de Biologie Moléculaire CNRS URA 1947, Institut Pasteur, 75724 Paris Cedex 15, France
    Development 125:4155-62. 1998
    ....
  33. doi request reprint Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors
    Mounia Lagha
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 75015 Paris, France
    Dev Cell 17:892-9. 2009
    ..This provides insight into how cell fate choices are orchestrated by these lineage genes in the dermomyotome...
  34. pmc The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo
    Frederic Relaix
    CNRS URA 2375, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Genes Dev 17:2950-65. 2003
    ..This gain-of-function allele provides a new approach to the molecular and cellular analysis of the role of Pax3 and of its target genes in vivo...
  35. ncbi request reprint Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
    S Tajbakhsh
    Unité de Génétique Moléculaire du Développement, CNRS URA1947, Paris, France
    Nature 384:266-70. 1996
    ..In its absence, muscle progenitors, having activated myf-5, remain multipotent and differentiate into other somitic derivatives according to their local environment...
  36. pmc Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesis
    Frederic Relaix
    UPMC Paris 06, UMR S 787, Paris, France
    PLoS Genet 9:e1003425. 2013
    ..We show that Myod regulatory regions are directly controlled by Six proteins and that, in the absence of Six1 and Six4, Six2 can compensate...
  37. doi request reprint Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo
    Fabienne Lescroart
    Institut Pasteur, Unité de Génétique Moléculaire du Développement, CNRS URA 2578, 28 rue du Dr Roux, Paris, France
    Development 137:3269-79. 2010
    ....
  38. ncbi request reprint Gene targeting the myf-5 locus with nlacZ reveals expression of this myogenic factor in mature skeletal muscle fibres as well as early embryonic muscle
    S Tajbakhsh
    Department of Molecular Biology, CNRS URA1947, Pasteur Institute, Paris, France
    Dev Dyn 206:291-300. 1996
    ..These results suggest that the myf-5 gene is not activated in only a subset of muscle cells and are consistent with the results on the MyoD knockout mice...
  39. ncbi request reprint Modular long-range regulation of Myf5 reveals unexpected heterogeneity between skeletal muscles in the mouse embryo
    J Hadchouel
    Departement de Biologie Moleculaire, CNRS URA 1947, Institut Pasteur, 75724 Paris Cedex 15, France
    Development 127:4455-67. 2000
    ..Such regulatory heterogeneity may underlie the observed restriction of myopathies to particular muscle subgroups...
  40. doi request reprint Lying low but ready for action: the quiescent muscle satellite cell
    Didier Montarras
    Department of Developmental and Stem Cell Biology, CNRS URA 2578, Institut Pasteur, Paris, France
    FEBS J 280:4036-50. 2013
    ..Post-transcriptional regulation, through microRNA repression of a potential cell cycle activator, further illustrates how these cells are ready for action. ..
  41. doi request reprint Conotruncal defects associated with anomalous pulmonary venous connections
    Fanny Bajolle
    Service de Cardiologie Pediatrique, centre de référence malformations cardiaques congénitales complexes M3C, Hopital Necker Enfants Malades, AP HP, 149, rue de Sevres, 75015 Paris, France
    Arch Cardiovasc Dis 102:105-10. 2009
    ..However, recent studies have revealed a role for the myocardium in the formation of both the arterial and venous poles of the heart...
  42. doi request reprint Distinct and dynamic myogenic populations in the vertebrate embryo
    Margaret Buckingham
    Institut Pasteur, CNRS URA 2578, 28 rue du Dr Roux, 75015 Paris, France
    Curr Opin Genet Dev 19:444-53. 2009
    ..Further insights into myogenic populations that contribute to trunk and limb development at different stages are summarized and the distinct regulatory networks that underlie the formation of head muscles are discussed...
  43. pmc Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program
    Mounia Lagha
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 22:1828-37. 2008
    ..These results provide new insight into the Pax-initiated regulatory network that modulates stem cell maintenance versus tissue differentiation...
  44. doi request reprint The formation of the embryonic mouse heart: heart fields and myocardial cell lineages
    Yusuke Watanabe
    Department of Developmental Biology, Pasteur Institute, Paris, France
    Ann N Y Acad Sci 1188:15-24. 2010
    ..Knowledge about the origin and genetic regulation of cells that contribute to the heart and associated vasculature is important for the diagnosis and treatment of congenital heart malformations...
  45. ncbi request reprint Expression of myogenic factors in the mouse: myf-5, the first member of the MyoD gene family to be transcribed during skeletal myogenesis
    M Buckingham
    CNRS ERS 67, Departement de Biologie Moleculaire, Institut Pasteur, Paris
    C R Acad Sci III 316:1032-46. 1993
    ..We discuss the unexpected finding which was made with the myf-5/nlsLacZ mice, that myf-5 is also expressed in the central nervous system...
  46. ncbi request reprint Muscle differentiation. Which myogenic factors make muscle?
    M Buckingham
    Department of Molecular Biology, Pasteur Institute, CNRS ERS 67, Paris, France
    Curr Biol 4:61-3. 1994
    ..Mice lacking myogenin have little skeletal muscle as fibres fail to differentiate. Lack of both MyoD and myf-5 results in no skeletal muscle and apparently no myoblasts, suggesting that these factors act earlier in muscle development...
  47. ncbi request reprint Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons
    P Daubas
    CNRS URA 1947, Department de Biologie Moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    Development 127:319-31. 2000
    ..This phenomenon may be widespread and it remains to be seen how many other potentially potent regulatory genes, in addition to Myf5, when activated do not accumulate protein at inappropriate sites in the embryo...
  48. doi request reprint Gene regulatory networks and transcriptional mechanisms that control myogenesis
    Margaret Buckingham
    CNRS URA 2578, Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France Electronic address
    Dev Cell 28:225-38. 2014
    ..Myogenic determination and subsequent differentiation depend on members of the MyoD family. We discuss new insights into mechanisms underlying the transcriptional activity of these factors. ..
  49. pmc A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene
    F Catala
    Centre National de la Recherche Scientifique, URA 1947, Department of Molecular Biology, Pasteur Institute, Paris, France
    Mol Cell Biol 15:4585-96. 1995
    ..Mutations within the CArG box distinguish between the binding of this complex and binding of SRF; only SRF binding is directly involved in the specific regulation of the MLC1A gene in skeletal muscle cell lines...
  50. ncbi request reprint [Induction phenomena during vertebrate limb development and homeo box gene expression]
    B Robert
    Institut Pasteur, Paris, France
    Ann Genet 36:39-46. 1993
    ..These genes might be implicated in patterning events at these sites through the activation of other genes directly involved in the definition of positional information, such as Hox genes...
  51. ncbi request reprint Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome
    Milan Esner
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 28 rue du Dr Roux, 75 724 Paris Cedex 15, France
    Development 133:737-49. 2006
    ..These results are discussed in terms of the paraxial mesoderm contribution to the aorta and of the mesoangioblast stem cells that derive from it...
  52. ncbi request reprint [The mouse as a model of heart morphogenesis in mammals: origin and lineage of myocytes]
    Sigolène Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25, rue du Dr Roux, 75015 Paris
    J Soc Biol 197:179-86. 2003
    ..Right and left ventricular lineages appear to segregate early, in agreement with the existence of two populations of cardiac precursors, the so-called primary (or posterior) and secondary (or anterior) heart fields...
  53. pmc Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice
    R Kelly
    Centre National de la Recherche Scientifique Unité de Recherche Associée 1947, Department of Molecular Biology, Pasteur Institute, Paris, France
    J Cell Biol 129:383-96. 1995
    ..We show here that transgene-directed expression of the MLC3F promoter reflects low level expression of endogenous MLC3F transcripts in the mouse heart...
  54. pmc A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300
    S Molinari
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Mol Cell Biol 24:2944-57. 2004
    ..These results demonstrate the importance of this novel complex in the transcriptional regulation of the cardiac actin gene and suggest a potential role in chromatin remodeling associated with muscle gene activation...
  55. ncbi request reprint Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo
    M O Ott
    Department of Molecular Biology, CNRS UA 1148, Pasteur Institute, Paris, France
    Development 111:1097-107. 1991
    ..The time and place of myf-5 expression are consistent with a role in the early events of myogenic differentiation, possibly during determination of the myogenic lineage...
  56. ncbi request reprint Megarole for microRNA in muscle disease
    Colin G Crist
    CNRS URA, Department of Developmental Biology, Institut Pasteur, Paris, France
    Cell Metab 12:425-6. 2010
    ..2010) shows that the presence of functional dystrophin is required for NO-dependent nitrosylation of the HDAC2 repressor and subsequent activation of a group of microRNAs required for muscle function...
  57. ncbi request reprint Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis
    D Sassoon
    Department of Molecular Biology, Pasteur Institute, Paris, France
    Nature 341:303-7. 1989
    ....
  58. ncbi request reprint Msx1 is close but not allelic to either Hm or Hx on mouse chromosome 5
    B Robert
    Unité de Génétique Moléculaire du Développement et ERS CNRS 67, Institut Pasteur, Paris, France
    Mamm Genome 5:446-9. 1994
    ..Il6 did not recombine with either Hm or Hx and, therefore, provides a point of access for the analysis of these mutations at the molecular level...
  59. ncbi request reprint The in vivo form of the murine class VI POU protein Emb is larger than that encoded by previously described transcripts
    F Relaix
    C N R S URA 2578, Department of Developmental Biology, Pasteur Institute, 75724 Paris Cedex 15, France
    Gene 333:35-46. 2004
    ....
  60. doi request reprint Genetic regulation of skeletal muscle development
    Keren Bismuth
    INSERM UMR S 787 Myology Group, Avenir Team Mouse Molecular Genetics, UPMC Faculté de Médecine Pitié Salpêtrière, Institut de Myologie, 105 Boulevard de l Hôpital, Paris, France
    Exp Cell Res 316:3081-6. 2010
    ..In this review we will summarize the current knowledge on the regulatory circuits that lead to the establishment of skeletal muscle in these different anatomical regions...
  61. pmc Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis
    B Robert
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    EMBO J 8:91-100. 1989
    ..The pronounced accumulation and regional localization of Hox-7 transcripts in mandibular and limb processes point to a specific morphogenetic role for this mouse homeobox gene...
  62. pmc Developmental regulation of myosin gene expression in mouse cardiac muscle
    G E Lyons
    Department of Molecular Biology, Unité de Recherche Associée Centre national de la Recherche Scientifique 1148 Pasteur Institute, Paris, France
    J Cell Biol 111:2427-36. 1990
    ..This dynamic pattern of changes in the myosin phenotype in the prenatal mouse heart suggests that there are different regulatory mechanisms for cell-specific expression of myosin isoforms during cardiac development...
  63. pmc The expression of myosin genes in developing skeletal muscle in the mouse embryo
    G E Lyons
    Department of Molecular Biology, U R A CNRS 1148, Pasteur Institute, Paris, France
    J Cell Biol 111:1465-76. 1990
    ..The data presented are the first detailed study of myosin gene expression at these early stages of skeletal muscle development...
  64. ncbi request reprint The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds
    B Robert
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    Genes Dev 5:2363-74. 1991
    ..When a quail ridge is grafted over nonexpressing mesoderm, a new site of expression is induced. Therefore, Hox-7 and Hox-8 depend on a functional ridge for their continued expression in the limb bud and can be induced by it...
  65. ncbi request reprint Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter
    O Cohen-Haguenauer
    INSERM U12, Hopital des Enfants Malades, Paris, France
    Hum Genet 78:65-70. 1988
    ..7-kb TaqI fragment corresponds indeed to a functional gene...
  66. doi request reprint Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7
    M Lagha
    Department of Developmental Biology, CNRS URA2578, Pasteur Institute, 75015 Paris, France
    Cold Spring Harb Symp Quant Biol 73:307-15. 2008
    ..This and other aspects of Pax3/7 function in regulating the behavior of skeletal muscle stem cells are discussed...