Pierre Bruhns

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint Properties of mouse and human IgG receptors and their contribution to disease models
    Pierre Bruhns
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    Blood 119:5640-9. 2012
  2. doi request reprint Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
    Pierre Bruhns
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 113:3716-25. 2009
  3. pmc Human FcγRIIA induces anaphylactic and allergic reactions
    Friederike Jönsson
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 119:2533-44. 2012
  4. doi request reprint The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy
    David A Mancardi
    Institut Pasteur, Departement d Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, Paris, France
    Blood 121:1563-73. 2013
  5. doi request reprint Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma
    Marcello Albanesi
    Institut Pasteur, corrected Département d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, corrected 75015 Paris, France
    J Immunol 189:5513-7. 2012
  6. doi request reprint Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis
    David A Mancardi
    Departement d Immunologie, Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, F 75015 Paris, France
    J Immunol 186:1899-903. 2011
  7. doi request reprint A strain of Lactobacillus casei inhibits the effector phase of immune inflammation
    Cecile Schiffer
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, 75015 Paris, France
    J Immunol 187:2646-55. 2011
  8. pmc Mouse and human neutrophils induce anaphylaxis
    Friederike Jönsson
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    J Clin Invest 121:1484-96. 2011
  9. pmc Neutrophils mediate antibody-induced antitumor effects in mice
    Marcello Albanesi
    Departement d Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, Institut Pasteur, Paris, France
    Blood 122:3160-4. 2013
  10. pmc Quorum sensing contributes to activated IgM-secreting B cell homeostasis
    Caroline Montaudouin
    Unité de Biologie des Populations Lymphocytaires, Department d Immunologie, Institut Pasteur, Paris 75015, France
    J Immunol 190:106-14. 2013

Collaborators

Detail Information

Publications13

  1. doi request reprint Properties of mouse and human IgG receptors and their contribution to disease models
    Pierre Bruhns
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    Blood 119:5640-9. 2012
    ....
  2. doi request reprint Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
    Pierre Bruhns
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 113:3716-25. 2009
    ..They therefore highlight the role of specific hFcgammaRs in the therapeutic and pathogenic effects of antibodies in disease...
  3. pmc Human FcγRIIA induces anaphylactic and allergic reactions
    Friederike Jönsson
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 119:2533-44. 2012
    ..Supporting these findings, human mast cells, monocytes and neutrophils produced anaphylactogenic mediators after FcγRIIA engagement. IgG and FcγRIIA may therefore contribute to allergic and anaphylactic reactions in humans...
  4. doi request reprint The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy
    David A Mancardi
    Institut Pasteur, Departement d Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, Paris, France
    Blood 121:1563-73. 2013
    ..Finally, hFcγRI was capable of mediating antibody-induced immunotherapy of metastatic melanoma. Our results unravel novel capabilities of human FcγRI that confirm the role of high-affinity IgG receptors in vivo...
  5. doi request reprint Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma
    Marcello Albanesi
    Institut Pasteur, corrected Département d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, corrected 75015 Paris, France
    J Immunol 189:5513-7. 2012
    ..Our finding that mouse FcγRIII contributes to Ab-induced tumor reduction correlates with clinical data on its human functional equivalent human FcγRIIIA (CD16A)...
  6. doi request reprint Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis
    David A Mancardi
    Departement d Immunologie, Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, F 75015 Paris, France
    J Immunol 186:1899-903. 2011
    ....
  7. doi request reprint A strain of Lactobacillus casei inhibits the effector phase of immune inflammation
    Cecile Schiffer
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, 75015 Paris, France
    J Immunol 187:2646-55. 2011
    ..They might, therefore, prevent inflammation in patients who have already synthesized specific IgE or autoantibodies...
  8. pmc Mouse and human neutrophils induce anaphylaxis
    Friederike Jönsson
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    J Clin Invest 121:1484-96. 2011
    ..These molecules and cells could be potential new targets for the development of anaphylaxis therapeutics if the same mechanism is responsible for anaphylaxis in humans...
  9. pmc Neutrophils mediate antibody-induced antitumor effects in mice
    Marcello Albanesi
    Departement d Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, Institut Pasteur, Paris, France
    Blood 122:3160-4. 2013
    ....
  10. pmc Quorum sensing contributes to activated IgM-secreting B cell homeostasis
    Caroline Montaudouin
    Unité de Biologie des Populations Lymphocytaires, Department d Immunologie, Institut Pasteur, Paris 75015, France
    J Immunol 190:106-14. 2013
    ..We hypothesize that malfunction of this quorum-sensing mechanism may lead to uncontrolled B cell activation and autoimmunity...
  11. pmc FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation
    David A Mancardi
    Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    J Clin Invest 118:3738-50. 2008
    ..We therefore suggest that a similar cooperation may occur between mast cells and hFceRI-expressing lung cells in human allergic asthma...
  12. pmc Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells
    Matthias Lochner
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 208:125-34. 2011
    ..However, this comes at a high cost for the host and can lead to a deregulated B cell response and aggravated inflammatory pathology...
  13. ncbi request reprint The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation
    Isabelle Isnardi
    Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Institut Pasteur, 75015 Paris, France
    Immunol Lett 104:156-65. 2006
    ..This segment, however, did not recruit the adapters Grb2/Grap which were demonstrated to stabilize the recruitment of SHIP1 to the ITIM in murine FcgammaRIIB...