Pascale Bourhy

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint Evaluation of an in-house ELISA using the intermediate species Leptospira fainei for diagnosis of leptospirosis
    Pascale Bourhy
    1Institut Pasteur, Biology of Spirochetes Unit, National Reference Center and WHO Collaborating Center for Leptospirosis, Paris, France
    J Med Microbiol 62:822-7. 2013
  2. pmc Isolation and characterization of new Leptospira genotypes from patients in Mayotte (Indian Ocean)
    Pascale Bourhy
    Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 4:e724. 2010
  3. pmc The scc spirochetal coiled-coil protein forms helix-like filaments and binds to nucleic acids generating nucleoprotein structures
    Khalil Mazouni
    Laboratoire des Spirochètes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Bacteriol 188:469-76. 2006
  4. pmc A genomic island of the pathogen Leptospira interrogans serovar Lai can excise from its chromosome
    Pascale Bourhy
    Laboratoire des Spirochètes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Infect Immun 75:677-83. 2007
  5. pmc The OmpA-like protein Loa22 is essential for leptospiral virulence
    Paula Ristow
    Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France
    PLoS Pathog 3:e97. 2007
  6. doi request reprint Biofilm formation by saprophytic and pathogenic leptospires
    Paula Ristow
    Unité de Biologie des Spirochètes, Institut Pasteur, 75724 Paris Cedex 15, France
    Microbiology 154:1309-17. 2008
  7. pmc Comparison of real-time PCR assays for detection of pathogenic Leptospira spp. in blood and identification of variations in target sequences
    Pascale Bourhy
    Institut Pasteur, Unité de Biologie des Spirochètes, France
    J Clin Microbiol 49:2154-60. 2011
  8. pmc Complete nucleotide sequence of the LE1 prophage from the spirochete Leptospira biflexa and characterization of its replication and partition functions
    Pascale Bourhy
    Laboratoire des Spirochètes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Bacteriol 187:3931-40. 2005
  9. pmc Serovar diversity of pathogenic Leptospira circulating in the French West Indies
    Pascale Bourhy
    Institut Pasteur, Unité de Biologie des Spirochètes, National Reference Center and WHO Collaborating Center for Leptospirosis, Paris, France
    PLoS Negl Trop Dis 7:e2114. 2013
  10. pmc Random insertional mutagenesis of Leptospira interrogans, the agent of leptospirosis, using a mariner transposon
    Pascale Bourhy
    Laboratoire des Spirochètes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Bacteriol 187:3255-8. 2005

Collaborators

Detail Information

Publications10

  1. doi request reprint Evaluation of an in-house ELISA using the intermediate species Leptospira fainei for diagnosis of leptospirosis
    Pascale Bourhy
    1Institut Pasteur, Biology of Spirochetes Unit, National Reference Center and WHO Collaborating Center for Leptospirosis, Paris, France
    J Med Microbiol 62:822-7. 2013
    ..The overall performance of this in-house ELISA suggests applicability as a rapid screening test for the diagnosis of leptospirosis in resource-limited settings and in hospitals and laboratories where a MAT is not available...
  2. pmc Isolation and characterization of new Leptospira genotypes from patients in Mayotte (Indian Ocean)
    Pascale Bourhy
    Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 4:e724. 2010
    ..To date, Leptospira isolates have never been isolated in this endemic region...
  3. pmc The scc spirochetal coiled-coil protein forms helix-like filaments and binds to nucleic acids generating nucleoprotein structures
    Khalil Mazouni
    Laboratoire des Spirochètes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Bacteriol 188:469-76. 2006
    ..These results provide the first insight into a unique DNA binding filament-forming coiled-coil protein that could play an important role in the subcellular architecture of the spirochetal microorganism...
  4. pmc A genomic island of the pathogen Leptospira interrogans serovar Lai can excise from its chromosome
    Pascale Bourhy
    Laboratoire des Spirochètes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Infect Immun 75:677-83. 2007
    ..interrogans virulent strains. This genomic island, containing a high proportion of novel genes, may have an important role in spreading genes, including virulence factors, among bacterial populations...
  5. pmc The OmpA-like protein Loa22 is essential for leptospiral virulence
    Paula Ristow
    Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France
    PLoS Pathog 3:e97. 2007
    ..Loa22 is therefore necessary for virulence of L. interrogans in the animal model and represents, to our knowledge, the first genetically defined virulence factor in Leptospira species...
  6. doi request reprint Biofilm formation by saprophytic and pathogenic leptospires
    Paula Ristow
    Unité de Biologie des Spirochètes, Institut Pasteur, 75724 Paris Cedex 15, France
    Microbiology 154:1309-17. 2008
    ..The formation of such a biofilm is consistent with the life of saprophytic strains in water and may help pathogenic strains to survive in environmental habitats and to colonize the host...
  7. pmc Comparison of real-time PCR assays for detection of pathogenic Leptospira spp. in blood and identification of variations in target sequences
    Pascale Bourhy
    Institut Pasteur, Unité de Biologie des Spirochètes, France
    J Clin Microbiol 49:2154-60. 2011
    ..However, it is important to continually evaluate and, if necessary, modify the primers and/or probes used to ensure effective detection of the circulating Leptospira isolates...
  8. pmc Complete nucleotide sequence of the LE1 prophage from the spirochete Leptospira biflexa and characterization of its replication and partition functions
    Pascale Bourhy
    Laboratoire des Spirochètes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Bacteriol 187:3931-40. 2005
    ..These results enable the construction of new shuttle vectors for studying the genetics of Leptospira spp. This study will also contribute to a better knowledge of phages unrelated to lambdoid phages...
  9. pmc Serovar diversity of pathogenic Leptospira circulating in the French West Indies
    Pascale Bourhy
    Institut Pasteur, Unité de Biologie des Spirochètes, National Reference Center and WHO Collaborating Center for Leptospirosis, Paris, France
    PLoS Negl Trop Dis 7:e2114. 2013
    ..In this study, we describe the serological and molecular features of leptospires isolated from 104 leptospirosis patients in Guadeloupe (n = 85) and Martinique (n = 19) and six rats captured in Guadeloupe, between 2004 and 2012...
  10. pmc Random insertional mutagenesis of Leptospira interrogans, the agent of leptospirosis, using a mariner transposon
    Pascale Bourhy
    Laboratoire des Spirochètes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Bacteriol 187:3255-8. 2005
    ..interrogans mutants. This approach of transposon mutagenesis will be useful for understanding the spirochetal physiology and the pathogenic mechanisms of Leptospira, which remain largely unknown...