Michel Bornens

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. ncbi request reprint Centrosome composition and microtubule anchoring mechanisms
    Michel Bornens
    Institut Curie, Section Recherche, UMR144 du Centre National de la Recherche Scientifique, 26 Rue d Ulm, 75248, Cedex 05, Paris, France
    Curr Opin Cell Biol 14:25-34. 2002
  2. pmc A role for centrin 3 in centrosome reproduction
    S Middendorp
    Institut Curie, Section Recherche, UMR 144 du CNRS, 75248 Paris Cedex 05, France
    J Cell Biol 148:405-16. 2000
  3. ncbi request reprint Origin and evolution of the centrosome
    Michel Bornens
    UMR 144 CNRS Institut Curie, 75248 Paris 05, France
    Adv Exp Med Biol 607:119-29. 2007
  4. doi request reprint The centrosome in cells and organisms
    Michel Bornens
    UMR144 du Centre Nationale de la Recherche Scientifique, Institut Curie, 26 Rue d Ulm, Paris Cedex 05, France
    Science 335:422-6. 2012
  5. pmc Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity
    Manuel Thery
    Biologie du cycle cellulaire et de la motilité, and Service d Imagerie, Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 5, France
    Proc Natl Acad Sci U S A 103:19771-6. 2006
  6. doi request reprint External forces control mitotic spindle positioning
    Jenny Fink
    Institut Curie, CNRS UMR 144, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Cell Biol 13:771-8. 2011
  7. pmc Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity
    Guy Keryer
    Institut Curie, Section Recherche, Unité Mixte Recherche 144 Centre National de la Recherche Scientifique, 75248 Paris, France
    Mol Biol Cell 14:4260-71. 2003
  8. pmc hPOC5 is a centrin-binding protein required for assembly of full-length centrioles
    Juliette Azimzadeh
    Institut Curie, Centre National de la Recherche Scientifique Unité Mixte de Recherche 144, Paris, France
    J Cell Biol 185:101-14. 2009
  9. pmc A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint
    Stéphanie Miserey-Lenkei
    UMR 144 CNRS IC, Institut Curie, Paris, France
    EMBO J 25:278-89. 2006
  10. ncbi request reprint Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex
    Aurélie Hoppeler-Lebel
    Institut Curie, Section Recherche, UMR144 CNRS, 75248 Paris Cedex, France
    J Cell Sci 120:3299-308. 2007

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Centrosome composition and microtubule anchoring mechanisms
    Michel Bornens
    Institut Curie, Section Recherche, UMR144 du Centre National de la Recherche Scientifique, 26 Rue d Ulm, 75248, Cedex 05, Paris, France
    Curr Opin Cell Biol 14:25-34. 2002
    ..The potential use of the generational asymmetry of centrosomes or spindle pole bodies for controlling cell polarity is also a growing theme...
  2. pmc A role for centrin 3 in centrosome reproduction
    S Middendorp
    Institut Curie, Section Recherche, UMR 144 du CNRS, 75248 Paris Cedex 05, France
    J Cell Biol 148:405-16. 2000
    ..Our results demonstrate that, in spite of the large differences in centrosome structure among widely divergent species, the centrosome pathway of reproduction is conserved...
  3. ncbi request reprint Origin and evolution of the centrosome
    Michel Bornens
    UMR 144 CNRS Institut Curie, 75248 Paris 05, France
    Adv Exp Med Biol 607:119-29. 2007
    ....
  4. doi request reprint The centrosome in cells and organisms
    Michel Bornens
    UMR144 du Centre Nationale de la Recherche Scientifique, Institut Curie, 26 Rue d Ulm, Paris Cedex 05, France
    Science 335:422-6. 2012
    ..Here I will discuss the role of the centrosome in cell polarity, resulting from its ability to position the nucleus at the cell center, and discuss how centrosome innovation might have been critical during metazoan evolution...
  5. pmc Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity
    Manuel Thery
    Biologie du cycle cellulaire et de la motilité, and Service d Imagerie, Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 5, France
    Proc Natl Acad Sci U S A 103:19771-6. 2006
    ..We conclude that, in addition to molecular composition and mechanical properties, ECM geometry plays a key role in developmental processes...
  6. doi request reprint External forces control mitotic spindle positioning
    Jenny Fink
    Institut Curie, CNRS UMR 144, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Cell Biol 13:771-8. 2011
    ..We propose that cells divide according to cues provided by their mechanical micro-environment, aligning daughter cells with the external force field...
  7. pmc Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity
    Guy Keryer
    Institut Curie, Section Recherche, Unité Mixte Recherche 144 Centre National de la Recherche Scientifique, 75248 Paris, France
    Mol Biol Cell 14:4260-71. 2003
    ..Together, these results suggest a challenging possibility, namely, that centrosome activity could depend upon nucleocytoplasmic exchange of centrosomal proteins and local Ran-dependent concentration at the centrosome...
  8. pmc hPOC5 is a centrin-binding protein required for assembly of full-length centrioles
    Juliette Azimzadeh
    Institut Curie, Centre National de la Recherche Scientifique Unité Mixte de Recherche 144, Paris, France
    J Cell Biol 185:101-14. 2009
    ....
  9. pmc A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint
    Stéphanie Miserey-Lenkei
    UMR 144 CNRS IC, Institut Curie, Paris, France
    EMBO J 25:278-89. 2006
    ..Rab6A', through its interaction with p150(Glued) and GAPCenA, may thus participate in a pathway involved in the metaphase/anaphase transition...
  10. ncbi request reprint Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex
    Aurélie Hoppeler-Lebel
    Institut Curie, Section Recherche, UMR144 CNRS, 75248 Paris Cedex, France
    J Cell Sci 120:3299-308. 2007
    ..We propose that CAP350 specifically stabilises Golgi-associated microtubules and in this way participates in the maintenance of a continuous pericentrosomal Golgi ribbon...
  11. ncbi request reprint Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function
    Nathalie Delgehyr
    Institut Curie, Research Section UMR144 du Centre National de la Recherche Scientifique, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Sci 118:1565-75. 2005
    ..We therefore propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome...
  12. doi request reprint Simple and rapid process for single cell micro-patterning
    Ammar Azioune
    Systems Biology for Cell Division and Cell Polarity, Institut Curie, CNRS, UMR144, 26 Rue d Ulm, 75005, Paris, France
    Lab Chip 9:1640-2. 2009
    ..Finally, large glass plates were patterned with high homogeneity enabling the assembly of micro-patterned microplates in 96-well format...
  13. ncbi request reprint Experimental and theoretical study of mitotic spindle orientation
    Manuel Thery
    Institut Curie, CNRS UMR144, Compartimentation et Dynamique Cellulaire, 26 Rue d Ulm, 75248 Paris, France
    Nature 447:493-6. 2007
    ..We conclude that, on the basis of a few simple assumptions, we can provide a quantitative description of the spindle orientation of adherent cells...
  14. ncbi request reprint Cell distribution of stress fibres in response to the geometry of the adhesive environment
    Manuel Thery
    Biologie du cycle cellulaire et de la motilité, UMR144, CNRS, Institut Curie, Paris, France
    Cell Motil Cytoskeleton 63:341-55. 2006
    ..We conclude that cells of a given area can generate the same total sum of tractional forces but that these tractional forces are differently spaced depending on the spatial distribution of its adherence contacts...
  15. ncbi request reprint Centrioles resist forces applied on centrosomes during G2/M transition
    Miguel Abal
    Institut Curie, UMR 144 CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Biol Cell 97:425-34. 2005
    ..The structural stability of the centrosome core structure, the centriole pair, is correlated with a heavy polyglutamylation of centriole tubulin...
  16. doi request reprint Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy
    James E Sillibourne
    Institut Curie, UMR144, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Cytoskeleton (Hoboken) 68:619-27. 2011
    ..Our results demonstrate that both PALM and STORM imaging have great potential as alternatives to immuno-EM...
  17. pmc Autophosphorylation of polo-like kinase 4 and its role in centriole duplication
    James E Sillibourne
    Institut Curie, Centre de Recherche Unité Mixte de Recherche 144 du Centre Nationale de la Recherche Scientifique, 75248 Paris Cedex 05, France
    Mol Biol Cell 21:547-61. 2010
    ..These data suggest that PLK4 activity is restricted to the centrosome to prevent aberrant centriole assembly and sustained kinase activity is required for centriole duplication...
  18. pmc Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells
    Olivier Gavet
    Institut Curie, Section Recherche, Unité Mixte Recherche 144 du Centre National de la Recherche Scientifique, 75248 Paris, France
    Mol Biol Cell 14:1818-34. 2003
    ..Together, our present data suggest that centrin4p could be more specifically involved in basal bodies assembly or in a subsequent step of ciliogenesis...
  19. ncbi request reprint Kar9 asymmetrical loading on spindle poles mediates proper spindle alignment in budding yeast
    Anne Paoletti
    Institut Curie, UMR144 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Dev Cell 4:289-90. 2003
    ..Kar9 mediates alignment of the spindle with the cell polarity axis through a Myo2-dependent mechanism that reorients astral MTs toward the bud...
  20. doi request reprint Probabilistic density maps to study global endomembrane organization
    Kristine Schauer
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Institut Curie, Laboratory Molecular mechanisms of intracellular transport, Paris, France
    Nat Methods 7:560-6. 2010
    ..Thus, combining micropatterning with construction of endomembrane density maps allows the systematic study of intracellular trafficking determinants...
  21. pmc Primary ciliogenesis requires the distal appendage component Cep123
    James E Sillibourne
    Institut Curie, Centre de Recherche UMR144 du Centre Nationale de la Recherche Scientifique, 26 Rue d Ulm, F 75248 Paris Cedex 05, France
    Biol Open 2:535-45. 2013
    ..Together, the data implicate Cep123 as a new player in the primary ciliogenesis pathway and expand upon the role of the distal appendages in this process. ..
  22. ncbi request reprint The universal dynamics of cell spreading
    Damien Cuvelier
    Physical Chemistry Curie, UMR 168, Institut Curie, 75005 Paris, France
    Curr Biol 17:694-9. 2007
    ..Thus, although cell spreading is driven by well-identified biomolecular interactions, it is dynamically limited by its mesoscopic structure and material properties...
  23. pmc Dissociating the centrosomal matrix protein AKAP450 from centrioles impairs centriole duplication and cell cycle progression
    Guy Keryer
    Unité Mixte Recherche 144 Centre National de la Recherche Scientifique Institut Curie, F 75248, Paris, France
    Mol Biol Cell 14:2436-46. 2003
    ..Moreover, centriole duplication is interrupted. Our data show that the association between centrioles and the centrosomal matrix protein AKAP450 is critical for the integrity of the centrosome and for its reproduction...
  24. pmc Fission yeast cdc31p is a component of the half-bridge and controls SPB duplication
    Anne Paoletti
    Institut Curie, UMR144 CNRS, 75248 Paris, France
    Mol Biol Cell 14:2793-808. 2003
    ....
  25. ncbi request reprint The extracellular matrix guides the orientation of the cell division axis
    Manuel Thery
    Biologie du cycle cellulaire et de la motilité, UMR144, CNRS, Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Nat Cell Biol 7:947-53. 2005
    ..This segregation is further maintained on the cortex of mitotic cells and used for spindle orientation...
  26. ncbi request reprint Comparative study and improvement of current cell micro-patterning techniques
    Jenny Fink
    Biologie du cycle cellulaire et de la motilité, Institut Curie, CNRS, UMR144, 26 Rue d Ulm, 75005 Paris, France
    Lab Chip 7:672-80. 2007
    ..Finally, we present a new method based on UV crosslinking of adhesion proteins with benzophenone to easily and rapidly produce highly reproducible micropatterns without the use of a microfabricated elastomeric stamp...
  27. doi request reprint [The evolutionary fates of the flagellum from the unicellular ancestral eukaryote]
    Michel Bornens
    UMR 144, CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Biol Aujourdhui 205:1-4. 2011
    ..The current efforts on human ciliopathies benefit directly from long lasting basic research on the flagellar assembly in experimental models like Chlamydomonas reinhardtii...
  28. ncbi request reprint The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus
    Karin Pernet-Gallay
    CNRS UMR 144, Institut Curie Section de Recherche, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Traffic 3:822-32. 2002
    ..The role of GMAP-210 on membrane processes at the interface between the endoplasmic reticulum and the Golgi apparatus is discussed in the light of the property of this protein to bind CGN membranes and microtubules...
  29. pmc Polo-like kinase 4: the odd one out of the family
    James E Sillibourne
    Institut Curie, UMR144, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Cell Div 5:25. 2010
    ..Here, we overview past and present data discussing the regulation and functions of PLK4...
  30. doi request reprint Organelle positioning and cell polarity
    Michel Bornens
    Compartimentation et Dynamique Cellulaires, UMR144 CNRS Institut Curie, 26 Rue d Ulm, 75 248, Paris Cedex 05, France
    Nat Rev Mol Cell Biol 9:874-86. 2008
    ..This organelle has a defined polarity that can be transmitted to the cell. Its conservative mode of duplication seems to be a core mechanism for the transmission of polarities through cell division...
  31. ncbi request reprint Centrosome inheritance: birthright or the privilege of maturity?
    Michel Bornens
    Institut Curie, UMR 144 du CNRS, 26 Rue d Ulm, 75248 Cedex 05, Paris, France
    Curr Biol 12:R71-3. 2002
    ..But it is the astral microtubule-cortex interaction which matters for controlling the asymmetric localization of Bfa1p/Bub2 at spindle pole bodies...
  32. ncbi request reprint The Golgi apparatus at the cell centre
    Rosa M Rios
    Departamento de Microbiologia, Facultad de Biologia, Universidad de Sevilla, Reina Mercedes 6, 41012 Sevilla, Spain
    Curr Opin Cell Biol 15:60-6. 2003
    ....
  33. ncbi request reprint Cell structure and dynamics
    Laura M Machesky
    Curr Opin Cell Biol 15:2-5. 2003
  34. ncbi request reprint PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression
    Angelique Augustin
    Unité 9003 du CNRS, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brant, 67400 Illkirch, France
    J Cell Sci 116:1551-62. 2003
    ..PARP-1 also resides for part of the cell cycle in the centrosome and interacts with hPARP-3. The presence of both PARP-1 and PARP-3 at the centrosome may link the DNA damage surveillance network to the mitotic fidelity checkpoint...
  35. ncbi request reprint Structure and duplication of the centrosome
    Juliette Azimzadeh
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    J Cell Sci 120:2139-42. 2007
  36. ncbi request reprint [Cell adhesion guides cell polarity]
    Manuel Thery
    Med Sci (Paris) 23:230-2. 2007
  37. ncbi request reprint [Mitosis: entry, exit and emergency issues]
    Michel Bornens
    Med Sci (Paris) 19:259-61. 2003
  38. ncbi request reprint The centrosome-nucleus complex and microtubule organization in the Drosophila oocyte
    Jens Januschke
    Institut Jacques Monod, Unité Mixte Recherche 7592, CNRS, Université Paris 6 et Paris 7, 2 place Jussieu, 75251 Paris Cedex 05, France
    Development 133:129-39. 2006
    ....
  39. pmc Microtubule release from the centrosome in migrating cells
    Miguel Abal
    Institut Curie UMR 144 du Centre National de la Recherche Scientifique, 75248 Paris, France
    J Cell Biol 159:731-7. 2002
    ..We thus propose that the balance between MT minus-end capture and release from the centrosome is critical for efficient cell migration...
  40. ncbi request reprint Nucleokinesis in tangentially migrating neurons comprises two alternating phases: forward migration of the Golgi/centrosome associated with centrosome splitting and myosin contraction at the rear
    Arnaud Bellion
    Unité 616, Institut National de la Sante et de la Recherche Medicale, Universite Paris 6, Institut Fédératif de Recherche des Sciences 70, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
    J Neurosci 25:5691-9. 2005
    ..During this phase of nuclear translocation, the leading growth cone either stops migrating or divides, showing a tight correlation between leading edge movements and nuclear movements...
  41. pmc The Rho-associated protein kinase p160ROCK is required for centrosome positioning
    Véronique Chevrier
    Institut National de la Santé et de la Recherche Médicale U366, Département de Biologie Moléculaire et Structurale Cytosqulette, Commissariat a l Energie Atomique, de Grenoble, 38054 Grenoble Cedex 9, France
    J Cell Biol 157:807-17. 2002
    ..p160ROCK inhibition late after anaphase in mitosis triggered MC migration to the midbody followed by completion of cell division. Thus, p160ROCK is required for centrosome positioning and centrosome-dependent exit from mitosis...
  42. ncbi request reprint Dynamic modes of the cortical actomyosin gel during cell locomotion and division
    Ewa Paluch
    Laboratoire Physicochimie Curie, UMR168 Institut Curie CNRS, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France
    Trends Cell Biol 16:5-10. 2006
    ..We go on to analyze the implications of spontaneous cortical contractile behaviors on cell locomotion and division and we particularly emphasize that variations in actomyosin contractility can account for a variety of migration modes...
  43. ncbi request reprint GMAP-210 recruits gamma-tubulin complexes to cis-Golgi membranes and is required for Golgi ribbon formation
    Rosa M Rios
    Departamento de Microbiologia, Facultad de Biologia, Universidad de Sevilla, Apdo 1095, 41080, Spain
    Cell 118:323-35. 2004
    ..All our experiments suggest that GMAP-210 displays microtubule anchoring and membrane fusion activities, thus contributing to the assembly and maintenance of the Golgi ribbon around the centrosome...
  44. pmc Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends
    Leticia Peris
    Laboratoire du Cytosquelette, Institut National de la Santé et de la Recherche Médicale U366, Département Réponse et Dynamique Cellulaire, Commisariat a l Energie Atomique Grenoble, 38054 Grenoble, France
    J Cell Biol 174:839-49. 2006
    ....
  45. ncbi request reprint Cell shape and cell division
    Manuel Thery
    CEA, DSV, DRDC, Laboratoire Biopuces, Grenoble, F38054 France
    Curr Opin Cell Biol 18:648-57. 2006
    ..From these data, cell division appears to be a continuous transformation ensuring the maintenance of tissue mechanical integrity...
  46. pmc Cortical actomyosin breakage triggers shape oscillations in cells and cell fragments
    Ewa Paluch
    Laboratoire Physicochimie Curie, UMR168 Institut Curie CNRS, 75231 Paris Cedex 05, France
    Biophys J 89:724-33. 2005
    ..Our observations suggest a mechanism based on active gel dynamics and inspired by symmetry breaking of actin gels growing around beads. The proposed mechanism for breakage of the actomyosin cortex may be used for cell polarization...