Sylvie Bonvalot

..This is a review of diagnostic and therapeutic improvements which have allowed quality of life of patients with soft tissue sarcoma...

..Adequate management at the time of primary presentation is likely to afford the best chance for long-term survival...

..To define the optimal initial management and the best extent of surgery that would optimize margins on primary retroperitoneal sarcomas (RPS)...

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..To assess the efficacy of isolated pelvic perfusion (IPP) with tumor necrosis factor (TNF)-α and melphalan in patients with locally advanced cancers in the pelvic and groin area requiring mutilating surgery...

..New blockers of the tyrosine-kinase activity are currently in development in cases of resistance...

..Surgery is being evaluated in the other responding patients. The majority of responses being limited to partial responses, best indications of surgery are when complete resection may be expected (< 10%)...

..A phase 3 EORTC study will start and will randomise this secondary surgery after 6 to 12 months of imatinib in responding patients...

..The 5-year probability of local control is approximately 50%. The role of adjuvant therapy is evolving and at present should not be used outside the investigational setting...

..The optimal dose of TNF-alpha delivered by isolated limb perfusion (ILP) in patients with locally advanced soft tissue sarcoma is still unknown...

..In order to decrease loco-regional relapse after complete resection of peritoneal sarcomatosis (PS), the role of intraperitoneal chemotherapy (IPEC) was prospectively evaluated...

..Efficacy and safety of low-dose TNFalpha could greatly facilitate ILP procedures in the near future...

..An ongoing phase III EORTC randomises this secondary surgery after 6 to 12 months of imatinib in responding patients...

..The objective of this retrospective study was to evaluate the feasibility and benefit of this secondary surgery...

..Additional study of the molecular determinants of desmoid behaviour is needed to guide treatment...

..To evaluate the impact of surgery as first-line treatment on event-free survival (EFS) of primary aggressive fibromatosis...

..Isolated pelvic perfusion exposes tissue to high drug doses and may benefit patients with advanced malignancy. However, leakage is a limit to this technique...

..The aim of this retrospective study was to assess the advantages of free-lap reconstruction in locally advanced soft tissue sarcomas...

..A randomized study will start soon...

..To prospectively analyze the evolution of hepatic and peritoneal unresectable metastases from gastrointestinal stromal tumors (GIST) under imatinib mesylate, a new targeted treatment, which induces changes in lesion structure...

..Isolated limb perfusion and free flap reconstruction permitted more extensive tumor excision. Amputation was avoided in 78% of our 37 patients, and early postoperative radiotherapy was possible in 25 cases...

..To define computed tomography (CT) criteria for evaluating the response of patients with gastrointestinal stromal tumors (GIST) who are receiving Imatinib (tyrosine-kinase inhibitor therapy)...

..The objective of the present study was to confirm these data on a larger sample size of locally advanced or recurrent extremity soft tissue sarcomas with low-dose TNF-alpha...

..The purpose of this study was to evaluate contrast-enhanced Doppler sonography with perfusion software as a predictor of early tumor response to imatinib (Glivec) in c-kit-positive gastrointestinal stromal tumors (GISTs)...

..A sizeable population of elderly patients with STS is unfit for conventional doxorubicin- or ifosfamide-based chemotherapy. We assessed the feasibility of metronomic oral cyclophosphamide (CPM) in this population...

..Doxorubicin and ifosfamide are highly active drugs for the treatment of high-grade sarcomas, but little is known on the optimal management of young patients who develop such malignancies during pregnancy...

..This phase II study evaluated masitinib as a first-line treatment of advanced GIST...

..We sought to assess morbidity and mortality in primary retroperitoneal soft tissue sarcomas (RSTS) treated by a frontline aggressive surgical approach...

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..A randomized trial is warranted. Because of its rarity, and the risk of recurrence both local and metastatic, treatment should preferentially be discussed with a multimodality specialized approach...

..The aim of this article is to expose imaging protocols and useful radiological signs, to show the core biopsy technique for diagnosis, to precise imaging key points before treatment and for survey...

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..This work is based on the methodology developed in the "Standards, Options and Recommendations" (SOR) project...

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..Cytogenetic and molecular genetic analyses contribute to the diagnosis and can be performed at the same time with a core biopsy...

..The purpose of this study is to report tolerance and preliminary results in patients with liver metastases synchronous to moderate PC, treated with hepatectomy, complete cytoreductive surgery, and IPIC...

..However, despite progress, surgery alone is rarely curative, and analysis of the causes of failures and of other prognostic factors are warranted to ascertain treatment orientations...

..5 mg/m(2) as a 24-hour continuous infusion every 3 weeks in patients with pretreated advanced soft tissue sarcoma...

..A peri-tumoral resection confers a high risk of local recurrence and should be avoided. Lymphadenectomy is not systematic. Grade is the main prognostic factor for OS and can be a decision marker for adjuvant treatment with Gleevec...

..The relationship between p53 status and response to TNF-alpha and melphalan in patients undergoing ILP is unknown...

..Focal bone marrow abnormalities, detected on MRI examinations and mimicking bone metastases in patients who were otherwise responding, should be considered as probable bone marrow necrosis...

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..Primitive cutaneous neuroendocrine carcinoma or Merkel cell carcinoma is a rare tumor. It may be large since diagnosis is frequently delayed. The usual treatment is extensive surgical removal and radiotherapy...

..This rare case illustrates the potential for jejunal metastasis and complete response to chemotherapy, proven histologically at 33 months...

..5 months. Surgery was the primary treatment and the best salvage modality. The role of chemotherapy and radiation therapy as true adjuvant or post-salvage-surgery adjunctive treatments remains unclear...

..Here we tested the ability of TNF-α to directly induce apoptosis of sarcoma cells. In addition, we investigated the impact of p53 in the regulation of such effect...

..CONCLUSION: Color Doppler US is highly effective for the follow-up of patients with recurrent melanoma of the limbs. It provides prognostic factors of treatment failure, which may lead to early modification of the treatment strategy...

..There are no known molecular biomarkers of local recurrence. We searched for beta-catenin mutations in a European multicentre series of fibromatosis tumours to relate beta-catenin mutational status to disease outcome...

..Introduction of anaesthesia in 1846 and asepsis in 1870 have strongly allowed this development...

..The management of GIST in these cases required a coordinated, multidisciplinary approach involving medical oncologists, diagnostic radiologists, gastroenterologists, surgeons, and pathologists...

..A national consensus meeting was therefore organized in order to identify the optimal management procedures for patients with GIST in localized and advanced stages...

..In elderly and/or frail patients, conversely, single agent doxorubicin may be the preferred option...