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Genomes and Genes | Ivo Gomperts BonecaSummaryAffiliation: Institut Pasteur Country: France Publications
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Publications
The role of peptidoglycan in pathogenesisIvo G Boneca
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
Curr Opin Microbiol 8:46-53. 2005..Recent research highlights the role of peptidoglycan in the pathogenesis of different human pathogens such as Streptococcus pneumoniae, Listeria monocytogenes or Helicobacter pylori...- Peptidoglycan detection by mammals and fliesCatherine Chaput
Department of Cellular Microbiology, Max Planck Institute, Chariteplatz 1, D 10117 Berlin, Germany
Microbes Infect 9:637-47. 2007..The host exploits the peptidoglycan particular composition and uniqueness to bacteria for specific bacterial recognition. Insects and mammals accomplish this via receptors such as PGRP and Nod proteins... - Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanStephen E Girardin
Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28, rue du Dr Roux, 75724Paris Cedex 15, France
Science 300:1584-7. 2003..Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing... - Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracisEmmanuel Psylinakis
Department of Biology, Enzyme Biotechnology Group, University of Crete, P O Box 2208, Vasilika Vouton 714 09, Heraklion, Crete, Greece
J Biol Chem 280:30856-63. 2005..cereus by BC1960 and BC3618 resulted in increased resistance to lysozyme digestion. This is the first biochemical study of bacterial peptidoglycan N-acetylglucosamine deacetylases... - The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonistsMihai G Netea
Department of Internal Medicine, Radboud University Nijmegen Medical Center, The Netherlands
J Biol Chem 280:35859-67. 2005..Together, our results identified a cross-talk between the Nod1 and Nod2 pathways and suggested that down-regulation of Nod1/M-Tri(DAP) pathway may be associated with Crohn disease... 
Mammalian PGRPs in the spotlightIvo Gomperts Boneca
Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, Paris, France
Cell Host Microbe 5:109-11. 2009..In this issue of Cell Host & Microbe, Saha et al. (2009) report that the mammalian PGRP, PGLYRP-2, functions as a cytokine-like molecule in a PG-induced arthritis model...
A revised annotation and comparative analysis of Helicobacter pylori genomesIvo G Boneca
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France
Nucleic Acids Res 31:1704-14. 2003..113 of these differences were due to different start codon assignments, a common problem when constructing physical annotations...- Vancomycin resistance: occurrence, mechanisms and strategies to combat itIvo G Boneca
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
Expert Opin Ther Targets 7:311-28. 2003..Whilst most of these agents are still in clinical or preclinical development, some have entered the clinic and currently represent the only option for treating vancomycin-resistant enterococci (VRE)... - A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune systemIvo G Boneca
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 75724 Paris, France
Proc Natl Acad Sci U S A 104:997-1002. 2007..The presence of deacetylase genes in other pathogenic bacteria indicates that PG N-deacetylation could be a general mechanism used by bacteria to evade the host innate immune system... - Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pyloriIvo G Boneca
Groupe Biologie et Génétique de la Paroi Bactérienne, Unité de Pathogénie Bactérienne des Muqueuses, Department of Microbiology, Institut Pasteur, 75724 Paris, France
Appl Environ Microbiol 74:2095-102. 2008..pylori. Finally, we demonstrated that following in vitro methylation of the recombinant plasmids, these could be introduced into a large variety of H. pylori isolates with different genetic backgrounds... - Characterization of Helicobacter pylori lytic transglycosylases Slt and MltDCatherine Chaput
Unité de Pathogénie Bactérienne des Muqueuses, Department of Microbiology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Bacteriol 189:422-9. 2007..In this study, we determined the distinct roles of the lytic transglycosylases Slt and MltD in PG metabolism... - Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity islandJérôme Viala
Groupe d Immunité Innée et Signalisation, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
Nat Immunol 5:1166-74. 2004..pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens... 
Role of AmiA in the morphological transition of Helicobacter pylori and in immune escapeCatherine Chaput
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France
PLoS Pathog 2:e97. 2006..pylori infection...- Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2Stephen E Girardin
Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Biol Chem 278:41702-8. 2003..By defining the PG structural requirements for Nod1 and Nod2 sensing, this study reveals how PG processing and modifications, either by host or bacterial enzymes, may affect innate immune responses... - From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphomaJean Michel Thiberge
Institut Pasteur, Unité postulante de Pathogenèse de Helicobacter, Paris, France
BMC Genomics 11:368. 2010..To determine whether certain combinations of genetic markers can be used to predict the clinical source of the infection, we analyzed well documented and geographically homogenous clinical isolates using a comparative genomics approach... - New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureusSarah Dubrac
Unité de Biologie des Bactéries Pathogènes à Gram Positif, CNRS URA 2172, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Bacteriol 189:8257-69. 2007..Taken together, our results now define this signal transduction pathway as a master regulatory system for cell wall metabolism, which we have accordingly renamed WalK/WalR to reflect its true function... - Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognitionLeonardo H Travassos
, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France
EMBO Rep 5:1000-6. 2004.... - HobA--a novel protein involved in initiation of chromosomal replication in Helicobacter pyloriAnna Zawilak-Pawlik
Institut Pasteur, Unité de Pathogénie Bactérienne des Muqueuses, 75724 Paris Cedex 15, France
Mol Microbiol 65:979-94. 2007..pylori, whereas depletion of HobA led to growth arrest and failure to initiate replication. In conclusion, HobA may be the first identified of a new group of initiation factors common to epsilon proteobacteria... - Prediction, assessment and validation of protein interaction maps in bacteriaJerome Wojcik
Hybrigenics, SA, 3 5 Impasse Reille, Paris, France
J Mol Biol 323:763-70. 2002..coli and C.jejuni led to the proposition of new functional assignments. Finally, the prediction of protein-protein interaction maps across organisms enabled us to validate some of the interactions on the original experimental map... - A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cellsNadia Chaouche-Drider
Institut Pasteur, Unité de Pathogénie Bactérienne des Muqueuses, Paris, France
PLoS ONE 4:e5396. 2009..We suggest that H. muridarum may act as a confounding factor in colitis model studies in rodents... - Bacteria and MAMP-induced morphogenesis of the immune systemGerard Eberl
Institut Pasteur, Development of Lymphoid Tissues Unit, Paris 75724, France
Curr Opin Immunol 22:448-54. 2010.... - Detailed structural analysis of the peptidoglycan of the human pathogen Neisseria meningitidisAude Antignac
, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Biol Chem 278:31521-8. 2003..This suggests that reduced susceptibility to penicillin G in N. meningitidis is associated with a decrease in d,d-carboxypeptidase activity and/or D,D-transpeptidase activity... - Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detectionStephen E Girardin
Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris Cedex 15, France
J Biol Chem 278:8869-72. 2003..Additionally, the characterization of Nod2 as the first pathogen-recognition molecule that detects MDP will help to unravel the well known biological activities of this immunomodulatory compound... - Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteriaVincent Bischoff
Institut de Biologie Moleculaire et Cellulaire, CNRS UPR 9022, 15 rue Rene Descartes, Universite Louis Pasteur, 67084 Strasbourg Cedex, France
Nat Immunol 5:1175-80. 2004..These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex... - Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathwayCarolyn R Stenbak
, Gif-sur-Yvette, France
J Immunol 173:7339-48. 2004..Altogether, these results indicate multiple requirements for efficient PG-mediated activation of the Imd pathway and demonstrate that PG is a complex immune elicitor... - Nod1 participates in the innate immune response to Pseudomonas aeruginosaLeonardo H Travassos
Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ CEP 21 941 590, Brazil
J Biol Chem 280:36714-8. 2005..aeruginosa. Finally, we demonstrate that the cytokine secretion kinetics and bacterial killing are altered in Nod1-deficient cells infected with P. aeruginosa in the early stages of infection... - Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2Vincent Bischoff
Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, Strasbourg, France
PLoS Pathog 2:e14. 2006..We further show that a strict control of IMD-pathway activation is essential to prevent bacteria-induced developmental defects and larval death...