Ivo Gomperts Boneca

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint The role of peptidoglycan in pathogenesis
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
    Curr Opin Microbiol 8:46-53. 2005
  2. ncbi request reprint Peptidoglycan detection by mammals and flies
    Catherine Chaput
    Department of Cellular Microbiology, Max Planck Institute, Chariteplatz 1, D 10117 Berlin, Germany
    Microbes Infect 9:637-47. 2007
  3. ncbi request reprint Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28, rue du Dr Roux, 75724Paris Cedex 15, France
    Science 300:1584-7. 2003
  4. ncbi request reprint Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis
    Emmanuel Psylinakis
    Department of Biology, Enzyme Biotechnology Group, University of Crete, P O Box 2208, Vasilika Vouton 714 09, Heraklion, Crete, Greece
    J Biol Chem 280:30856-63. 2005
  5. ncbi request reprint The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
    Mihai G Netea
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    J Biol Chem 280:35859-67. 2005
  6. doi request reprint Mammalian PGRPs in the spotlight
    Ivo Gomperts Boneca
    Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, Paris, France
    Cell Host Microbe 5:109-11. 2009
  7. pmc A revised annotation and comparative analysis of Helicobacter pylori genomes
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France
    Nucleic Acids Res 31:1704-14. 2003
  8. ncbi request reprint Vancomycin resistance: occurrence, mechanisms and strategies to combat it
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Expert Opin Ther Targets 7:311-28. 2003
  9. pmc A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 104:997-1002. 2007
  10. pmc Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori
    Ivo G Boneca
    Groupe Biologie et Génétique de la Paroi Bactérienne, Unité de Pathogénie Bactérienne des Muqueuses, Department of Microbiology, Institut Pasteur, 75724 Paris, France
    Appl Environ Microbiol 74:2095-102. 2008

Collaborators

Detail Information

Publications27

  1. ncbi request reprint The role of peptidoglycan in pathogenesis
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
    Curr Opin Microbiol 8:46-53. 2005
    ..Recent research highlights the role of peptidoglycan in the pathogenesis of different human pathogens such as Streptococcus pneumoniae, Listeria monocytogenes or Helicobacter pylori...
  2. ncbi request reprint Peptidoglycan detection by mammals and flies
    Catherine Chaput
    Department of Cellular Microbiology, Max Planck Institute, Chariteplatz 1, D 10117 Berlin, Germany
    Microbes Infect 9:637-47. 2007
    ..The host exploits the peptidoglycan particular composition and uniqueness to bacteria for specific bacterial recognition. Insects and mammals accomplish this via receptors such as PGRP and Nod proteins...
  3. ncbi request reprint Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28, rue du Dr Roux, 75724Paris Cedex 15, France
    Science 300:1584-7. 2003
    ..Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing...
  4. ncbi request reprint Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis
    Emmanuel Psylinakis
    Department of Biology, Enzyme Biotechnology Group, University of Crete, P O Box 2208, Vasilika Vouton 714 09, Heraklion, Crete, Greece
    J Biol Chem 280:30856-63. 2005
    ..cereus by BC1960 and BC3618 resulted in increased resistance to lysozyme digestion. This is the first biochemical study of bacterial peptidoglycan N-acetylglucosamine deacetylases...
  5. ncbi request reprint The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
    Mihai G Netea
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    J Biol Chem 280:35859-67. 2005
    ..Together, our results identified a cross-talk between the Nod1 and Nod2 pathways and suggested that down-regulation of Nod1/M-Tri(DAP) pathway may be associated with Crohn disease...
  6. doi request reprint Mammalian PGRPs in the spotlight
    Ivo Gomperts Boneca
    Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, Paris, France
    Cell Host Microbe 5:109-11. 2009
    ..In this issue of Cell Host & Microbe, Saha et al. (2009) report that the mammalian PGRP, PGLYRP-2, functions as a cytokine-like molecule in a PG-induced arthritis model...
  7. pmc A revised annotation and comparative analysis of Helicobacter pylori genomes
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France
    Nucleic Acids Res 31:1704-14. 2003
    ..113 of these differences were due to different start codon assignments, a common problem when constructing physical annotations...
  8. ncbi request reprint Vancomycin resistance: occurrence, mechanisms and strategies to combat it
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Expert Opin Ther Targets 7:311-28. 2003
    ..Whilst most of these agents are still in clinical or preclinical development, some have entered the clinic and currently represent the only option for treating vancomycin-resistant enterococci (VRE)...
  9. pmc A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 104:997-1002. 2007
    ..The presence of deacetylase genes in other pathogenic bacteria indicates that PG N-deacetylation could be a general mechanism used by bacteria to evade the host innate immune system...
  10. pmc Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori
    Ivo G Boneca
    Groupe Biologie et Génétique de la Paroi Bactérienne, Unité de Pathogénie Bactérienne des Muqueuses, Department of Microbiology, Institut Pasteur, 75724 Paris, France
    Appl Environ Microbiol 74:2095-102. 2008
    ..pylori. Finally, we demonstrated that following in vitro methylation of the recombinant plasmids, these could be introduced into a large variety of H. pylori isolates with different genetic backgrounds...
  11. pmc Characterization of Helicobacter pylori lytic transglycosylases Slt and MltD
    Catherine Chaput
    Unité de Pathogénie Bactérienne des Muqueuses, Department of Microbiology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Bacteriol 189:422-9. 2007
    ..In this study, we determined the distinct roles of the lytic transglycosylases Slt and MltD in PG metabolism...
  12. ncbi request reprint Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    Jérôme Viala
    Groupe d Immunité Innée et Signalisation, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    Nat Immunol 5:1166-74. 2004
    ..pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens...
  13. pmc Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape
    Catherine Chaput
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France
    PLoS Pathog 2:e97. 2006
    ..pylori infection...
  14. ncbi request reprint Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 278:41702-8. 2003
    ..By defining the PG structural requirements for Nod1 and Nod2 sensing, this study reveals how PG processing and modifications, either by host or bacterial enzymes, may affect innate immune responses...
  15. pmc From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma
    Jean Michel Thiberge
    Institut Pasteur, Unité postulante de Pathogenèse de Helicobacter, Paris, France
    BMC Genomics 11:368. 2010
    ..To determine whether certain combinations of genetic markers can be used to predict the clinical source of the infection, we analyzed well documented and geographically homogenous clinical isolates using a comparative genomics approach...
  16. pmc New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus
    Sarah Dubrac
    Unité de Biologie des Bactéries Pathogènes à Gram Positif, CNRS URA 2172, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Bacteriol 189:8257-69. 2007
    ..Taken together, our results now define this signal transduction pathway as a master regulatory system for cell wall metabolism, which we have accordingly renamed WalK/WalR to reflect its true function...
  17. pmc Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
    Leonardo H Travassos
    Groupe d Immunité Innée et Signalisation, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO Rep 5:1000-6. 2004
    ....
  18. ncbi request reprint HobA--a novel protein involved in initiation of chromosomal replication in Helicobacter pylori
    Anna Zawilak-Pawlik
    Institut Pasteur, Unité de Pathogénie Bactérienne des Muqueuses, 75724 Paris Cedex 15, France
    Mol Microbiol 65:979-94. 2007
    ..pylori, whereas depletion of HobA led to growth arrest and failure to initiate replication. In conclusion, HobA may be the first identified of a new group of initiation factors common to epsilon proteobacteria...
  19. ncbi request reprint Prediction, assessment and validation of protein interaction maps in bacteria
    Jerome Wojcik
    Hybrigenics, SA, 3 5 Impasse Reille, Paris, France
    J Mol Biol 323:763-70. 2002
    ..coli and C.jejuni led to the proposition of new functional assignments. Finally, the prediction of protein-protein interaction maps across organisms enabled us to validate some of the interactions on the original experimental map...
  20. pmc A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells
    Nadia Chaouche-Drider
    Institut Pasteur, Unité de Pathogénie Bactérienne des Muqueuses, Paris, France
    PLoS ONE 4:e5396. 2009
    ..We suggest that H. muridarum may act as a confounding factor in colitis model studies in rodents...
  21. doi request reprint Bacteria and MAMP-induced morphogenesis of the immune system
    Gerard Eberl
    Institut Pasteur, Development of Lymphoid Tissues Unit, Paris 75724, France
    Curr Opin Immunol 22:448-54. 2010
    ....
  22. ncbi request reprint Detailed structural analysis of the peptidoglycan of the human pathogen Neisseria meningitidis
    Aude Antignac
    Unité des Neisseria and Centre National de Référence des Méningocoques, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 278:31521-8. 2003
    ..This suggests that reduced susceptibility to penicillin G in N. meningitidis is associated with a decrease in d,d-carboxypeptidase activity and/or D,D-transpeptidase activity...
  23. ncbi request reprint Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris Cedex 15, France
    J Biol Chem 278:8869-72. 2003
    ..Additionally, the characterization of Nod2 as the first pathogen-recognition molecule that detects MDP will help to unravel the well known biological activities of this immunomodulatory compound...
  24. ncbi request reprint Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
    Vincent Bischoff
    Institut de Biologie Moleculaire et Cellulaire, CNRS UPR 9022, 15 rue Rene Descartes, Universite Louis Pasteur, 67084 Strasbourg Cedex, France
    Nat Immunol 5:1175-80. 2004
    ..These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex...
  25. ncbi request reprint Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway
    Carolyn R Stenbak
    Centre de Genetique Moleculaire du Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Immunol 173:7339-48. 2004
    ..Altogether, these results indicate multiple requirements for efficient PG-mediated activation of the Imd pathway and demonstrate that PG is a complex immune elicitor...
  26. ncbi request reprint Nod1 participates in the innate immune response to Pseudomonas aeruginosa
    Leonardo H Travassos
    Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ CEP 21 941 590, Brazil
    J Biol Chem 280:36714-8. 2005
    ..aeruginosa. Finally, we demonstrate that the cytokine secretion kinetics and bacterial killing are altered in Nod1-deficient cells infected with P. aeruginosa in the early stages of infection...
  27. pmc Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2
    Vincent Bischoff
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, Strasbourg, France
    PLoS Pathog 2:e14. 2006
    ..We further show that a strict control of IMD-pathway activation is essential to prevent bacteria-induced developmental defects and larval death...