J Blay

..Numerous clinical studies currently underway with trabectedin are aiming to resolve a variety of questions in order to optimize its use in clinical practice...

..Chemokines CCL19, CCL20 and CCL21 and their receptors CCR6 and CCR7, were assessed as potential biomarkers of metastatic dissemination in primary breast cancer...

..We aimed to validate prognostic scores for survival in patients undergoing chemotherapy for advanced or metastatic cancer after first-line treatment...

..We analyzed the outcome of patients with non metastatic locally advanced primary GIST treated with IM within the prospective BFR14 phase III trial...

..CD40L was found to reduce doxorubicin-induced apoptosis in non Hodgkin's lymphoma cell lines through caspase-3 dependent mechanism. Whether this represents a general mechanism for other tumor types is unknown...

..We prospectively assessed the medical management of all patients diagnosed with sarcoma in a European region over a one-year period to identify the quantity of first diagnosis compared to central expert review (CER)...

..Colorectal cancer (CRC) screening has been shown to decrease CRC mortality. Organised mass screening programs are being implemented in France. Its perception in the general population and by general practitioners is not well known...

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..Imatinib is the standard treatment of advanced GI stromal tumors (GISTs). It is not known whether imatinib may be stopped in patients in whom disease is controlled...

..In elderly and/or frail patients, conversely, single agent doxorubicin may be the preferred option...

..These observations point out the need to introduce translational research as a key element to schedule and evaluate the activity of novel targeted agents in the clinics...

..The objectives of this international consensus meeting were to describe the optimal management procedures for patients with GIST in localized and advanced stages, as well as research issues for the future...

..We conclude that adjuvant chemotherapy has not been proven to improve the outcome of an unselected population of patients. Several hypotheses are proposed to account for this observation...

..Blood was collected during cycle 1 for pharmacokinetic analyses. Adverse events, tumor response, and survival were assessed...

..The objectives of the Edifice study were to analyze a large cohort of patients and doctors in order to further characterize these parameters...

..Many patients exhibit intolerance or resistance to first-line therapy with imatinib mesylate. Sunitinib malate is approved multinationally for the treatment of advanced imatinib-refractory GIST...

..This article reviews the evidence underlying the updates to the ESMO recommendations on the management of GIST and discusses the implications of the changes...

..In this setting, the optimal duration of treatment is not known, and it is generally considered that treatment should be given until progression or intolerance...

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..Design: Reference sources were selected by the author for searches in PubMed and EMBASE, with search terms dependent on the particular subtopic...

..In addition, areas of consensus and points of divergence among the guidelines are highlighted along with any unresolved issues...

..Following progression on these agents, patients have limited treatment options. This critical unmet need is being addressed by the development of new TKIs and the use of novel regimens with approved agents...

..Long-term survivors are observed in all prognostic subgroups of patients, in particular those achieving a CR to first-line chemotherapy...

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..The role of high-dose chemotherapy (HDCT) with hematopoietic stem-cell support in this disease is not established...

..The impact of treatment options on survival and late neurologic toxicity was investigated in a series of patients with primary cerebral lymphoma (PCL) and no known cause of immunosuppression...

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..1) from those calculated in the model. This risk index could be useful to identify patients at high risk for chemotherapy-induced thrombocytopenia requiring platelet transfusions...

..Primary cerebral non-Hodgkin's lymphomas (NHL) in immunocompetent patients (PCL) are located exclusively in the central nervous system, the eye, or meninges. Clinical management of these patients remains controversial...

..Only one patient experienced febrile neutropenia. Raltitrexed as monotherapy is not an effective treatment for patients with ASTS who failed conventional chemotherapy with doxorubicin and ifosfamide...

..In conclusion, poor performance status and lymphopenia identify a subgroup of patients at high risk for early death after chemotherapy...

..Phase III studies are required to confirm that survival may be improved by HDCT in subgroups of patients with ASTS...

..They are composed of a connective tissue stroma and epithelial elements. Pathological presentation ranges from grade I to malignant phyllodes tumours (grade III) where the stromal component clearly exhibits a sarcoma pattern...

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..This study evaluates histological response, long-term outcome, and toxicity in an intensive chemotherapy program given before surgery...

..This could have important therapeutic implications with regard to endostatin therapy and raises the question of a possible role of this humoral reaction against endostatin in the neoplastic process...

..To evaluate the safety, pharmacokinetics, and efficacy of three different dose levels of pegylated granulocyte colony-stimulating factor (Ro 25-8315) on progenitor cell mobilization and hematologic recovery in cancer patients...

..Thus, if age does not seem to modify the potential for response to IL2 therapy, cardiac toxicity appears as a limiting factor for intravenous schedules of IL2...

..This prospective multicentric phase II study aimed to confirm the results of the C5R protocol of high-dose methotrexate (MTX)-based chemotherapy (CT) for immunocompetent primary central nervous system lymphoma...

..Vascular endothelial growth factor serum and plasma levels are not useful indicators of prognosis for these patients...

..CNB is accurate, not misleading for s-t-M diagnosis, avoids open biopsy complications, and allows one-surgery or neo-adjuvant chemotherapy planning when combined with appropriate imaging...

..v.) infusion, and vinorelbine (VNB) was delivered at a dose of 6 mg i.v. bolus followed by VNB, 6 mg/m2/day, in continuous i.v. infusion (Days 1-5) every 21 days...

..Because sarcomas are relatively uncommon yet comprise a wide variety of different entities, second opinion was systematically performed for all included cases...

..Three patients were alive, free of disease 30 months after completion of the study. Such therapy allows for high-dose intensity and high cumulative doses on a short period of time with manageable toxicity...

..The primary management of adult soft tissue sarcomas (STS) is characterized by heterogeneity across centers. Several studies suggest that it is improved when coordinated by specialized sarcoma centers...

..IL-2 and INF-alpha given by this schedule can be safely administered in an outpatient setting. The objective response rate was similar to our previous treatments with high-dose IL-2 given as a continuous infusion...

..To assess the outcome and the prognosis of adults with a neoplasm related to the Ewing's sarcoma family of tumors...

..There are only scarce data about the benefit of adjunctive chemotherapy in patients with localized synovial sarcoma (SS)...

..Unfortunately, recent studies showed no optimal management for majority of patients treated for sarcomas...

..This study clearly evidences the selection of the patients receiving immunotherapy and the modification in referrals of a disease induced by a new available therapy. This emphasises the need for prospective studies in this setting...

..Taken together, these results demonstrate that IL-4 and IL-13 reverse the inhibitory effect of tumor cells on DC differentiation...

..The 'day 1' model identifies a small population of patients at high risk for FN, but has a lower sensitivity than the day 5 model...

..These results indicate that RCCs induce IL-10, PGE2 and TNF-alpha production by monocytes, which down-regulate the expression of cell-surface molecules involved in antigen presentation as well as their endocytic capacity...

..008). Thus, these results suggest that, in vivo, IL-2 may enhance cellular-mediated immunity against a tumour antigen and that some MHC molecules are more efficient than others for endogenous tumour antigen presentation...

..We sought to investigate the molecular epidemiology of sarcomas, including GIST, in the Rhone-Alpes region in France...

..Target therapies and antiangiogenic treatment have also begun to show results. It is advisable from now on to distinguish the different sub-type of sarcomas in order to assess cytotoxic activity...

..The patient is in complete remission six months after the end of treatment. Liposomal daunorubicin is a promising treatment in the non HIV patient with visceral KS...

..Imatinib induces responses and disease stabilisations in non-resectable patients with aggressive fibromatosis (AF). The precise target of imatinib in AF and predictive factors for response to treatment are unknown...

..We must also improve our understanding of the in vivo mechanisms of action of antibody to develop more efficient antibody constructs...

..Translational research is and will be an essential tool for the development of new treatments and the identification of the mechanisms of answer and resistance set up by these tumors...

..The aim of this study was to analyse practices and factors influencing vaccination in a single centre, in the light of recent literature data...

..These experimental data may be of importance for the design of clinical trials that currently use multiple DC injections...

..Our objective was to analyze the prognostic value of circulating vascular endothelial growth factor (VEGF), interleukin-10 (IL-10), and interleukin-6 (IL-6)...

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..Combining doxorubicin with standard-dose ifosfamide has not been shown to improve survival and is associated with a significantly increased toxicity; it is not known whether higher dose single-agent ifosfamide is superior to doxorubicin...

..This review article focuses on recent developments in the use of angiogenesis inhibitors for the treatment of breast, lung, and colorectal cancers...

..This is a review of the major biological and clinical data available on the critical role of angiogenesis in breast cancer. We will also review the different clinical studies reported to date in this area...

..We review the current data regarding the activity of imatinib in solid tumors, including GIST...

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..Imatinib mesilate, which was approved in 2002 for the treatment of patients with advanced GIST, has dramatically changed the course of the disease...

..Based on a report showing a specific overexpression of HER-1 in SyS, we investigated an HER-1 inhibitor, gefitinib, in refractory SyS...

..This article presents a short version of the Recommendations updated in 2007...

..This review summarises treatment strategies in the context of advanced disease and discusses new compounds being developed for patients with soft tissue sarcomas...

..In 2 patients (0.2%) a possible cardiotoxic effect of imatinib could not fully be excluded. The current analysis of a large randomised prospective study could not confirm previous suggestions of imatinib induced cardiac toxicity...

..1% of patients were still alive and progression free one year after cross-over. We conclude that a cross-over to high-dose imatinib is feasible and safe in GIST patients who progress on low-dose therapy...

..If confirmed in predictive models, the identification of prognostic subgroups, based on KPS and lymphopenia, among patients with BM from breast cancer would help physicians select patients for future clinical trials...

..The study indicates that the information available from reported clinical trials needs to be upgraded and homogenised in order to improve the decision making process in oncology...

..The present paper reviews examples of targeted cancer therapies and their results...

..CONCLUSIONS: Infiltration by pDC of primary localized breast tumor correlates with an adverse outcome, suggesting their contribution in the progression of breast cancer...

..Indeed, this case study shows that the quality of decisions does not only rely on the collective deliberation, but also on the individual and specific competencies of some members of the committee that other members admit...

..Simultaneous treatment with imatinib mesylate and rituximab was given, yielded response for both tumors and was well tolerated...

..CONCLUSIONS: A low CD4 count was an independent risk factor for febrile neutropenia and early death in patients receiving cytotoxic chemotherapy...

..Imatinib is approved worldwide for use in gastrointestinal stromal tumours (GIST). We aimed to assess dose dependency of response and progression-free survival with imatinib for metastatic GIST...

..These data point to a novel mode of antitumor action for Gleevec...

..Additional follow-up is necessary. Glivec treatment of GIST is the first example of an efficient targeted treatment in a solid tumor...

..In addition, anemia could relieve of specific treatment such as blood transfusion or preventive treatment with recombinant erythropoietin...

..Numerous question regarding the integration of this treatment with surgery and the long term outcome of these patients still remain to be answered however...

..Further clinical trials are needed to gain clear insight into the precise role of those promising strategies for the management of solid tumours...

..A national consensus meeting was therefore organized in order to identify the optimal management procedures for patients with GIST in localized and advanced stages...

..Synergy was reported in vitro with doxorubicin and cisplatin; phase I combination studies are in progress...

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..This article is meant to inform patients and relatives about the disease and its treatments. It also offers health professionals a synthetic evidence-based patient information source which facilitates discussions with the patient...

..In the non-GIST group, this PFS is in the range of other agents considered active in STS, and may predict for more substantial first line activity. Further investigation in STS other than GIST appears warranted...