Helene Bierne

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS ONE 7:e39080. 2012
  2. ncbi Internalins: a complex family of leucine-rich repeat-containing proteins in Listeria monocytogenes
    H Bierne
    Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC2020, Institut Pasteur, F 75015 Paris, France
    Microbes Infect 9:1156-66. 2007
  3. pmc Listeria monocytogenes surface proteins: from genome predictions to function
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Microbiol Mol Biol Rev 71:377-97. 2007
  4. pmc The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosis
    Nicolas Personnic
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Infect Immun 78:1979-89. 2010
  5. ncbi InlB, a surface protein of Listeria monocytogenes that behaves as an invasin and a growth factor
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Cell Sci 115:3357-67. 2002
  6. pmc Sortase B, a new class of sortase in Listeria monocytogenes
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    J Bacteriol 186:1972-82. 2004
  7. doi A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response
    Alice Lebreton
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Science 331:1319-21. 2011
  8. pmc Role of lipid rafts in E-cadherin-- and HGF-R/Met--mediated entry of Listeria monocytogenes into host cells
    Stephanie Seveau
    Unité des Interactions Bactéries Cellules, INSERM U604, Institut Pasteur, 75015 Paris Cedex 15, France
    J Cell Biol 166:743-53. 2004
  9. pmc LPXTG protein InlJ, a newly identified internalin involved in Listeria monocytogenes virulence
    Christophe Sabet
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, Paris, France
    Infect Immun 73:6912-22. 2005
  10. ncbi Species specificity of the Listeria monocytogenes InlB protein
    Nadia Khelef
    Institut Pasteur, Unité des Interactions Bactéries Cellules, 25 28 Rue du Docteur Roux, Paris, F 75015 France
    Cell Microbiol 8:457-70. 2006

Collaborators

Detail Information

Publications29

  1. pmc Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS ONE 7:e39080. 2012
    ..In addition, the feto-placental tissue was responsive to IFN-λ2. Together, these results suggest that IFN-λ may be an important modulator of the immune response to Gram-positive intracellular bacteria in epithelial tissues...
  2. ncbi Internalins: a complex family of leucine-rich repeat-containing proteins in Listeria monocytogenes
    H Bierne
    Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC2020, Institut Pasteur, F 75015 Paris, France
    Microbes Infect 9:1156-66. 2007
    ....
  3. pmc Listeria monocytogenes surface proteins: from genome predictions to function
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Microbiol Mol Biol Rev 71:377-97. 2007
    ..This diversity offers new clues about the molecular bases of Listeria pathogenesis...
  4. pmc The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosis
    Nicolas Personnic
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Infect Immun 78:1979-89. 2010
    ..These results strongly suggest that InlH is a stress-induced surface protein that facilitates pathogen survival in tissues by tempering the inflammatory response...
  5. ncbi InlB, a surface protein of Listeria monocytogenes that behaves as an invasin and a growth factor
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Cell Sci 115:3357-67. 2002
    ..Therefore, studies of InlB may help us to analyze the previously noticed similarities between growth factor receptor activation and phagocytosis...
  6. pmc Sortase B, a new class of sortase in Listeria monocytogenes
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    J Bacteriol 186:1972-82. 2004
    ..SrtB-mediated anchoring could therefore be required to anchor surface proteins involved in the adaptation of this microorganism to different environmental conditions...
  7. doi A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response
    Alice Lebreton
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Science 331:1319-21. 2011
    ..Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host...
  8. pmc Role of lipid rafts in E-cadherin-- and HGF-R/Met--mediated entry of Listeria monocytogenes into host cells
    Stephanie Seveau
    Unité des Interactions Bactéries Cellules, INSERM U604, Institut Pasteur, 75015 Paris Cedex 15, France
    J Cell Biol 166:743-53. 2004
    ..Our work, in addition to documenting for the first time the role of lipid rafts in Listeria entry, provides the first evidence that E-cadherin and HGF-R require lipid domain integrity for their full activity...
  9. pmc LPXTG protein InlJ, a newly identified internalin involved in Listeria monocytogenes virulence
    Christophe Sabet
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, Paris, France
    Infect Immun 73:6912-22. 2005
    ..In conclusion, this postgenomic approach identified InlJ as a new virulence factor among the proteins belonging to the internalin family in L. monocytogenes...
  10. ncbi Species specificity of the Listeria monocytogenes InlB protein
    Nadia Khelef
    Institut Pasteur, Unité des Interactions Bactéries Cellules, 25 28 Rue du Docteur Roux, Paris, F 75015 France
    Cell Microbiol 8:457-70. 2006
    ..These results unravel a second L. monocytogenes species specificity critical for understanding human listeriosis and emphasize the need for developing new animal models for studying InlA and InlB functions in the same animal model...
  11. ncbi Listeria monocytogenes: a multifaceted model
    Mélanie Hamon
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris 75015, France
    Nat Rev Microbiol 4:423-34. 2006
    ..Moreover, the vast amount of knowledge that has been gathered through in-depth comparative genomic analyses and in vivo studies makes L. monocytogenes one of the most well-studied bacterial pathogens...
  12. pmc Regulated shift from helical to polar localization of Listeria monocytogenes cell wall-anchored proteins
    Serawit Bruck
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    J Bacteriol 193:4425-37. 2011
    ..This dynamic control would distribute virulence factors at specific sites during the infectious process...
  13. doi Spatial positioning of cell wall-anchored virulence factors in Gram-positive bacteria
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015, France
    Curr Opin Microbiol 15:715-23. 2012
    ..The results indicate that deployment of virulence factors by pathogenic bacteria is a dynamic process tightly connected to secretion, cell morphogenesis, cell division rate and gene expression levels...
  14. pmc The Listeria monocytogenes virulence factor InlJ is specifically expressed in vivo and behaves as an adhesin
    Christophe Sabet
    UIBC, Institut Pasteur, INSERM, U604, INRA, USC2020, 25 rue du Dr Roux, Paris F 75015, France
    Infect Immun 76:1368-78. 2008
    ..innocua promotes bacterial adherence to human cells in vitro. Taken together, these results strongly suggest that InlJ acts as a novel L. monocytogenes sortase-anchored adhesin specifically expressed during infection in vivo...
  15. pmc Epigenetics and bacterial infections
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Cold Spring Harb Perspect Med 2:a010272. 2012
    ..Their effects might generate specific, long-lasting imprints on host cells, leading to a memory of infection that influences immunity and might be at the origin of unexplained diseases...
  16. doi When bacteria target the nucleus: the emerging family of nucleomodulins
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015, France
    Cell Microbiol 14:622-33. 2012
    ....
  17. doi Bacteria tune interferon responses by playing with chromatin
    Alice Lebreton
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Virulence 3:87-91. 2012
    ..Here, we further document the current knowledge about chromatin mechanisms modulating interferon responses during host-bacteria interplay, and discuss their physiological consequences...
  18. ncbi A role for Ral GTPase-activating protein subunit β in mitotic regulation
    Nicolas Personnic
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France INSERM, U604, Paris, France INRA, USC2020, Paris, France
    FEBS J 281:2977-89. 2014
    ..Deregulation of RalGAPβ might cause genomic instability, leading to human carcinogenesis...
  19. pmc Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses
    Yu Huan Tsai
    Institut Pasteur, Biology of Infection Unit, Paris, France
    PLoS Pathog 9:e1003381. 2013
    ..These results challenge the relevance of using InlA(m)-expressing Lm to study human listeriosis and in vivo host responses to this human pathogen...
  20. ncbi WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Cell Sci 118:1537-47. 2005
    ....
  21. ncbi Sorting sortases: a nomenclature proposal for the various sortases of Gram-positive bacteria
    Shaynoor Dramsi
    Unité de Biologie des Bactéries Pathogènes à Gram Positif, URA CNRS 2172, 25, rue du Dr Roux, 75724 Paris, France
    Res Microbiol 156:289-97. 2005
    ..We propose the classification of sortases into 4 classes designated A, B, C and D. This classification should help to discriminate between sortases in the future...
  22. ncbi The use of host cell machinery in the pathogenesis of Listeria monocytogenes
    P Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Curr Opin Immunol 13:96-103. 2001
    ..Increasing evidence shows that many cellular genes are up- or down-regulated during infection and probably play a role in the establishment of infection, inflammation and induction of the host immune response...
  23. pmc The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons
    Olivier Dussurget
    Unité des Interactions Bactéries Cellules, Institut Pasteur Paris, France INSERM, U604 Paris, France INRA, USC2020 Paris, France University of Paris Diderot, Sorbonne Paris Cité Paris, France
    Front Cell Infect Microbiol 4:50. 2014
    ....
  24. ncbi The New Microbiology: a conference at the Institut de France
    Lilliana Radoshevich
    INSERM U604, INRA USC2020, Institut Pasteur, Unité des Interactions Bactéries Cellules, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    C R Biol 335:514-9. 2012
    ..The conference took place in the historical Palais de l'Institut de France in Paris with the strong support of Jean-François Bach, Secrétaire Perpétuel of the Académie des sciences...
  25. pmc Human BAHD1 promotes heterochromatic gene silencing
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC2020, Paris, F 75015, France
    Proc Natl Acad Sci U S A 106:13826-31. 2009
    ..Collectively, these findings provide evidence that BAHD1 acts as a silencer by recruiting at specific promoters a set of proteins that coordinate heterochromatin assembly...
  26. ncbi Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002
    ..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
  27. pmc A role for cofilin and LIM kinase in Listeria-induced phagocytosis
    H Bierne
    , Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Biol 155:101-12. 2001
    ..We propose a model in which cofilin is involved in the formation and disruption of the phagocytic cup as a result of its local progressive enrichment...
  28. ncbi InlB: an invasion protein of Listeria monocytogenes with a novel type of surface association
    L Braun
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Mol Microbiol 25:285-94. 1997
    ..This motif may have important consequences for the release of surface proteins involved in interactions with eukaryotic cells...
  29. pmc Enterococcal leucine-rich repeat-containing protein involved in virulence and host inflammatory response
    Sophie Brinster
    Unité des Bactéries Lactiques et Pathogènes Opportunistes, INRA, Domaine de Vilvert, 78350 Jouy en Josas, France
    Infect Immun 75:4463-71. 2007
    ..Altogether, these results demonstrate a role for ElrA in the E. faecalis infectious process in vivo and suggest that this surface protein may contribute to E. faecalis virulence by stimulating the host inflammatory response...