Research Topics
| Rene Jean BensadounSummaryAffiliation: Institut Paoli-Calmettes Country: France Publications
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Detail Information
Publications
The effect of low-level laser irradiation (In-Ga-Al-AsP - 660 nm) on melanoma in vitro and in vivoLucio Frigo
Laboratory of Pharmacology and Phototherapy of Inflammation, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo São Paulo 05508 900 SP Brasil
BMC Cancer 9:404. 2009..The aim of the present study is to analyze the behavior of melanoma cells (B16F10) in vitro and the in vivo development of melanoma in mice after laser irradiation...
Chemotherapy- and radiotherapy-induced mucositis in head and neck cancer patients: new trends in pathophysiology, prevention and treatmentR J Bensadoun
Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
Eur Arch Otorhinolaryngol 258:481-7. 2001..The efficacy of low-level laser therapy in the management of such toxicity could hence yield important developments with this method in the field of oncology...- French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: Results at 2 years (FNCLCC-GORTEC)Rene Jean Bensadoun
Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
Int J Radiat Oncol Biol Phys 64:983-94. 2006..Unresectable carcinomas of the oropharynx and hypopharynx still have a poor long-term prognosis. Following a previous phase II study, this phase III multicenter trial was conducted between November 1997 and March 2002... - [Radiation-induced mucositis of the aerodigestive tract: prevention and treatment. MASCC/ISOO mucositis group's recommendations]Rene Jean Bensadoun
Centre Antoine Lacassagne, Departement de Radiotherapie, 33, Avenue de Valombrose, 06189 Nice Cedex 2
Bull Cancer 93:201-11. 2006..MASCC/ISOO mucositis group's recommendations for the management of acute radiation-induced mucositis are here summarized... - Low level laser therapy (LLLT): a new paradigm in the management of cancer therapy-induced mucositis ?Rene Jean Bensadoun
Department of Radiation Oncology, Centre Antoine Lacassagne, Nice Cedex, France
Indian J Med Res 124:375-8. 2006 - Amifostine in the management of radiation-induced and chemo-induced mucositisRene Jean Bensadoun
Department of Radiation Oncology, Centre Antoine Lacassagne, 33 av de Valombrose, 06189, Nice, Cedex 2, France
Support Care Cancer 14:566-72. 2006..The goal of this literature review is to update previously published guidelines for the management of mucositis. RESULTS: This article reports the findings of the subgroup charged with reviewing the literature related to amifostine... 
Free-flap head and neck reconstruction and quality of life: a 2-year prospective studyAlexandre Bozec
Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, Nice, France
Laryngoscope 118:874-80. 2008..This prospective study was designed to evaluate quality of life (QOL) after free-flap head and neck reconstruction...- Quality of life after oral and oropharyngeal reconstruction with a radial forearm free flap: prospective studyAlexandre Bozec
Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice 06189, France
J Otolaryngol Head Neck Surg 38:401-8. 2009..To evaluate quality of life (QOL) after radial forearm free flap (RFFF) reconstruction of the oral cavity and oropharynx in head and neck cancer patients... - Head and neck squamous cell carcinoma in patients aged > or = 80 years: patterns of care and survivalAntoine Italiano
Department of Medical Oncology, Antoine Lacassagne Center, Nice, France
Cancer 113:3160-8. 2008..Scarce data exist concerning the outcome of very elderly patients with head and neck squamous cell carcinoma (HNSCC)... - [2003 Update of Standards, Options and Recommendations for management of patients with salivary gland malignant tumors (excluding lymphoma, sarcoma and melanoma) (summary report)]Rene Jean Bensadoun
Centre Antoine Lacassagne, Nice, France
Bull Cancer 90:629-42. 2003..The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients... - Oral cavity squamous cell carcinoma in 260 patients aged 80years or moreCecile Ortholan
Department of Radiotherapy, Centre Antoine Lacassagne, Nice, France
Radiother Oncol 93:516-23. 2009..We report the experience of two French cancer centers in the treatment of oral cavity squamous cell carcinoma (SCC) in patients aged 80 years... - Randomized clinical trial of post-operative radiotherapy versus concomitant carboplatin and radiotherapy for head and neck cancers with lymph node involvementSeverine Racadot
Centre Leon Berard, Department of Radiation Oncology, Lyon, France
Radiother Oncol 87:164-72. 2008..We report the results of a randomized trial testing post-operative radiotherapy alone versus concomitant carboplatin and radiotherapy for head and neck cancers with lymph node involvement... - Contrasted outcomes to gefitinib on tumoral IGF1R expression in head and neck cancer patients receiving postoperative chemoradiation (GORTEC trial 2004-02)Juliette Thariat
University of Nice Sophia Antipolis, Department of Pathology, Centre Antoine Lacassagne Institut Universitaire de la Face et du Cou IUFC, Centre Antoine Lacassagne, Nice, France
Clin Cancer Res 18:5123-33. 2012..This study was designed to assess improved outcomes and identify predictive biomarkers... - Low level laser therapy: a real hope in the management of chemo-induced and radiation-induced mucositis?Rene Jean Bensadoun
Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
Cancer J 8:236-8. 2002 - Intensity-modulated radiotherapy in head and neck cancer: results of the prospective study GORTEC 2004-03Ivan Toledano
Department of Radiation Oncology, Centre Jean Perrin, Clermont Ferrand, France
Radiother Oncol 103:57-62. 2012.... - In vivo measurements with MOSFET detectors in oropharynx and nasopharynx intensity-modulated radiation therapySerge Marcie
Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
Int J Radiat Oncol Biol Phys 61:1603-6. 2005..To evaluate the feasibility of in vivo measurements with metal oxide semiconductor field effect transistor (MOSFET) dosimeters for oropharynx and nasopharynx intensity-modulated radiation therapy (IMRT)... - Impact of intensity-modulated radiotherapy on health-related quality of life for head and neck cancer patients: matched-pair comparison with conventional radiotherapyPierre Graff
Department of Radiation Oncology, Alexis Vautrin Center, Vandoeuvre les Nancy, France
Int J Radiat Oncol Biol Phys 67:1309-17. 2007..To assess the benefit of intensity-modulated radiotherapy (IMRT) compared with conventional RT for the quality of life (QOL) of head and neck cancer survivors... - Modeling of salivary production recovery after radiotherapy using mixed models: determination of optimal dose constraint for IMRT planning and construction of convenient tools to predict salivary functionCecile Ortholan
Department of Radiotherapy, Centre Antoine Lacassagne, Canceropôle PACA, Nice, France
Int J Radiat Oncol Biol Phys 73:178-86. 2009..This study, which included data from patients included in a French prospective study assessing the benefit of intensity-modulated radiotherapy (RT), sought to elaborate a convenient and original model of salivary recovery... - Concomitant twice-a-day radiotherapy and chemotherapy in unresectable head and neck cancer patients: A long-term quality of life analysisN Magne
Department of Head and Neck Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France
Head Neck 23:678-82. 2001.... - [Concomitant bifractionated radiotherapy and chemotherapy with cisplatin and 5-fluorouracil in locally progressive, non-resectable epidermoid carcinomas of the pharynx: ten years experience at the Antoine Lacassagne center]N Magne
Centre Antoine Lacassagne, 33, Avenue de Valombrose, 06189 Nice, France
Cancer Radiother 5:413-24. 2001..Evaluation was based on analysis of the toxicity, the response rates, the survival, and the clinical prognostic factors... - Prognostic significance of computed tomography in tumors of the oral cavity and oropharynx treated with neoadjuvant chemotherapyH P Verschuur
Department of Otorhinolaryngology, Centre Antoine Lacassagne, Nice, France
Am J Otolaryngol 18:190-6. 1997..Despite its high response rate, the use of neoadjuvant chemotherapy remains controversial. Pretherapeutic identification of subgroups of patients who are likely to respond to chemotherapy is of the utmost importance... - Concomitant b.i.d. radiotherapy and chemotherapy with cisplatin and 5-fluorouracil in unresectable squamous-cell carcinoma of the pharynx: clinical and pharmacological data of a French multicenter phase II studyR J Bensadoun
Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
Int J Radiat Oncol Biol Phys 42:237-45. 1998..i.d.) continuous nonaccelerated radiotherapy with concomitant cisplatin (CP)-5-fluorouracil (5-FU) chemotherapy, both given at full dose. Feasibility, efficacy, survival, and pharmacokinetic-pharmacodynamic relationships were analyzed... - [2008 Update of Standards, Options: recommendations for management of patients with salivary gland malignant tumours (excluding lymphoma, sarcoma and melanoma), summary report]Rene Jean Bensadoun
Oncologue radiothérapeute, Centre Antoine Lacassagne, Nice, Boulogne Billancourt Cedex, France
Bull Cancer 95:735-49. 2008..g. last generation hadrontherapy)... - Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharyngeal candidiasis: a prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients Rene Jean Bensadoun
Department of Radiation Oncology, Antoine Lacassagne Center, Nice, France
Cancer 112:204-11. 2008..The objective of the current study was to compare MBT with miconazole 500-mg oral gel (MOG) in patients with head and neck cancer... - [Upper aerodigestive tract carcinoma: therapeutic management]Gilles Poissonnet
Institut universitaire de la face et du cou de Nice et Centre Antoine Lacassagne, Nice
Presse Med 36:1634-42. 2007..Conservative treatment strategies must be favored. Treatment is essentially surgical and radiological. Prognosis for survival is poor. For all stages and sites together, 5-year survival remains between 30 and 40%... - Clinical prognostic factors for patients with recurrent head and neck cancer: implications for randomized trialsX Pivot
Centre Antoine Lacassagne, Nice, France
Oncology 61:197-204. 2001..The advantages of taking into account such prognostic factors are to eliminate the patient selection bias and to ensure a fairer comparative evaluation of new or already existing agents in recurrent head and neck cancer... - The relationship of epidermal growth factor receptor levels to the prognosis of unresectable pharyngeal cancer patients treated by chemo-radiotherapyN Magne
Department of Radiotherapy, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France
Eur J Cancer 37:2169-77. 2001..EGFR determination appears to be a powerful prognostic parameter in unresectable pharyngeal cancer patients treated by concomitant chemo-radiotherapy... - A comparison between distal and proximal port device insertion in head and neck cancerP Y Marcy
Department of Radiodiagnostics and Interventional Radiology, Antoine Lacassagne Anticancer Research Institute, Nice Cedex 1, France
Eur J Surg Oncol 34:1262-9. 2008.... - Systematic percutaneous fluoroscopic gastrostomy for concomitant radiochemotherapy of advanced head and neck cancer: optimization of therapyP Y Marcy
Centre Antoine Lacassagne, Nice, France
Support Care Cancer 8:410-3. 2000..The overall procedure-related mortality rate was nil. Further prospective investigations are necessary to determine whether treatment of wasting improves patient survival... - Low-energy He/Ne laser in the prevention of radiation-induced mucositis. A multicenter phase III randomized study in patients with head and neck cancerR J Bensadoun
External Radiotherapy Unit, Centre Antoine Lacassagne, Nice, France
Support Care Cancer 7:244-52. 1999..In addition, there is a tremendous potential for using LEL in combined treatment protocols utilizing concomitant chemotherapy and radiotherapy... - [Study of theoretical cases of intensity-modulated beams with step-and-shoot technique]S Marcie
Departement de Radiotherapie, Centre Antoine Lacassagne, 33, Avenue de Valombrose, 06189 cedex 2, Nice, France
Cancer Radiother 7:179-83. 2003..These theoretical cases provide a first step on the way towards treatments with intensity modulation... - [Intensity modulated radiotherapy (IMRT) in France: The boost of the national funding for the new expensive innovative technologies (STIC 2001 and 2002)]C Marchal
Departement de Radiotherapie, Centre Alexis Vautrin, 54511 Vandaeuvre les Nancy, France
Cancer Radiother 7:44s-48s. 2003.... - [Propositions for the selection and the delineation of peritumoral microscopic disease volumes in oral cavity and oropharyngeal cancers (lymph nodes excluded)]M Lapeyre
Departement de Radiotherapie, Centre Alexis Vautrin, Avenue de Bourgogne, 54511 Vandoeuvre les Nancy, France
Cancer Radiother 9:261-70. 2005..These propositions are for the delineation of microscopic peritumoral target volumes when external beam irradiation is required. CTVs are illustrated on CT sections... - [Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies]A Bozec
Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, 33, Avenue de Valombrose, Nice, France
Cancer Radiother 12:14-24. 2008..Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy... - Radical ablative surgery and radial forearm free flap (RFFF) reconstruction for patients with oral or oropharyngeal cancer: postoperative outcomes and oncologic and functional resultsAlexandre Bozec
Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice, France
Acta Otolaryngol 129:681-7. 2009..Radical ablative surgery and radial forearm free flap (RFFF) reconstruction provide promising oncologic and functional results in patients with oral or oropharyngeal cancer... - Comparison between nasogastric tube feeding and percutaneous fluoroscopic gastrostomy in advanced head and neck cancer patientsN Magne
Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France
Eur Arch Otorhinolaryngol 258:89-92. 2001..PFG is a safe and effective method of providing enteral nutrition during treatment to patients with advanced head and neck cancer and offers important advantages over NG... - A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracilM C Etienne
Centre Antoine Lacassagne, Nice, France
Br J Cancer 79:1864-9. 1999..68 for T staging and 2.65 for EGFR. Overall, EGFR remained an independent prognostic factor when response to treatment and T staging were considered in the multivariate analysis... - [2003 update of Standards, Options and Recommandations for radiotherapy for patients with salivary gland malignant tumors (excluding lymphona, sarcoma and melanoma)]R J Bensadoun
Centre Antoine-Lacassagne, Nice
Cancer Radiother 7:280-95. 2003.... - Pharmacokinetics of low-dose carboplatin and applicability of a method of calculation for estimating individual drug clearanceM C Etienne
Centre Antoine Lacassagne, Nice, France
Ann Oncol 14:643-7. 2003..CONCLUSIONS: The Chatelut carboplatin clearance model established for conventional carboplatin dosages (>100 mg/m(2)) is not applicable for targeting low AUC (<1 mg x min/ml)... - [Teeth and irradiation: dental care and treatment of osteoradionecrosis after irradiation in head and neck cancer]J Thariat
Service de Radiotherapie, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice, France
Cancer Radiother 14:137-44. 2010..New irradiation techniques are changing dose distributions and therefore require close collaboration between odonto-stomatologists and radiation oncologists to define the best dental care... - [Teeth and irradiation in head and neck cancer]J Thariat
Service de Radiotherapie, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice, France
Cancer Radiother 14:128-36. 2010..Osteoradionecrosis occurs spontaneously (35%), mostly involves the mandibula (85%)... - [Osteonecrosis of the jaw and bisphophonates in oncology]Thierry Facon
Departement de Radiotherapie, Centre Antoine Lacassagne, Nice
Bull Cancer 95:413-8. 2008..Studies are currently underway in an attempt to answer this issue... - [Normal tissue tolerance to external beam radiation therapy: salivary glands]C Ortholan
Service de Radiotherapie, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice Cedex 2, France
Cancer Radiother 14:290-4. 2010..Clinical benefit of submandibular gland sparing is more controversial. A mean dose less than 39 Gy could preserve submandibular gland function. This paper aims to review main studies evaluating tolerance dose of salivary glands... - Analysis of the dinucleotide repeat polymorphism in the epidermal growth factor receptor (EGFR) gene in head and neck cancer patientsM C Etienne-Grimaldi
Laboratoire d Oncopharmacologie, Centre Antoine Lacassagne, Nice, France
Ann Oncol 16:934-41. 2005..The first intron of EGFR gene is polymorphic (9-23 CA repeats) and transcription declines when the number of repeats increases...