Rene Jean Bensadoun

Summary

Affiliation: Institut Paoli-Calmettes
Country: France

Publications

  1. ncbi request reprint Chemotherapy- and radiotherapy-induced mucositis in head and neck cancer patients: new trends in pathophysiology, prevention and treatment
    R J Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
    Eur Arch Otorhinolaryngol 258:481-7. 2001
  2. pmc The effect of low-level laser irradiation (In-Ga-Al-AsP - 660 nm) on melanoma in vitro and in vivo
    Lucio Frigo
    Laboratory of Pharmacology and Phototherapy of Inflammation, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo São Paulo 05508 900 SP Brasil
    BMC Cancer 9:404. 2009
  3. ncbi request reprint [Radiation-induced mucositis of the aerodigestive tract: prevention and treatment. MASCC/ISOO mucositis group's recommendations]
    Rene Jean Bensadoun
    Centre Antoine Lacassagne, Departement de Radiotherapie, 33, Avenue de Valombrose, 06189 Nice Cedex 2
    Bull Cancer 93:201-11. 2006
  4. ncbi request reprint Amifostine in the management of radiation-induced and chemo-induced mucositis
    Rene Jean Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, 33 av de Valombrose, 06189, Nice, Cedex 2, France
    Support Care Cancer 14:566-72. 2006
  5. ncbi request reprint Low level laser therapy (LLLT): a new paradigm in the management of cancer therapy-induced mucositis ?
    Rene Jean Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice Cedex, France
    Indian J Med Res 124:375-8. 2006
  6. ncbi request reprint French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: Results at 2 years (FNCLCC-GORTEC)
    Rene Jean Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
    Int J Radiat Oncol Biol Phys 64:983-94. 2006
  7. doi request reprint Free-flap head and neck reconstruction and quality of life: a 2-year prospective study
    Alexandre Bozec
    Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, Nice, France
    Laryngoscope 118:874-80. 2008
  8. ncbi request reprint Quality of life after oral and oropharyngeal reconstruction with a radial forearm free flap: prospective study
    Alexandre Bozec
    Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice 06189, France
    J Otolaryngol Head Neck Surg 38:401-8. 2009
  9. doi request reprint Head and neck squamous cell carcinoma in patients aged > or = 80 years: patterns of care and survival
    Antoine Italiano
    Department of Medical Oncology, Antoine Lacassagne Center, Nice, France
    Cancer 113:3160-8. 2008
  10. ncbi request reprint [2003 Update of Standards, Options and Recommendations for management of patients with salivary gland malignant tumors (excluding lymphoma, sarcoma and melanoma) (summary report)]
    Rene Jean Bensadoun
    Centre Antoine Lacassagne, Nice, France
    Bull Cancer 90:629-42. 2003

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Chemotherapy- and radiotherapy-induced mucositis in head and neck cancer patients: new trends in pathophysiology, prevention and treatment
    R J Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
    Eur Arch Otorhinolaryngol 258:481-7. 2001
    ..The efficacy of low-level laser therapy in the management of such toxicity could hence yield important developments with this method in the field of oncology...
  2. pmc The effect of low-level laser irradiation (In-Ga-Al-AsP - 660 nm) on melanoma in vitro and in vivo
    Lucio Frigo
    Laboratory of Pharmacology and Phototherapy of Inflammation, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo São Paulo 05508 900 SP Brasil
    BMC Cancer 9:404. 2009
    ..The aim of the present study is to analyze the behavior of melanoma cells (B16F10) in vitro and the in vivo development of melanoma in mice after laser irradiation...
  3. ncbi request reprint [Radiation-induced mucositis of the aerodigestive tract: prevention and treatment. MASCC/ISOO mucositis group's recommendations]
    Rene Jean Bensadoun
    Centre Antoine Lacassagne, Departement de Radiotherapie, 33, Avenue de Valombrose, 06189 Nice Cedex 2
    Bull Cancer 93:201-11. 2006
    ..MASCC/ISOO mucositis group's recommendations for the management of acute radiation-induced mucositis are here summarized...
  4. ncbi request reprint Amifostine in the management of radiation-induced and chemo-induced mucositis
    Rene Jean Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, 33 av de Valombrose, 06189, Nice, Cedex 2, France
    Support Care Cancer 14:566-72. 2006
    ..The goal of this literature review is to update previously published guidelines for the management of mucositis...
  5. ncbi request reprint Low level laser therapy (LLLT): a new paradigm in the management of cancer therapy-induced mucositis ?
    Rene Jean Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice Cedex, France
    Indian J Med Res 124:375-8. 2006
  6. ncbi request reprint French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: Results at 2 years (FNCLCC-GORTEC)
    Rene Jean Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
    Int J Radiat Oncol Biol Phys 64:983-94. 2006
    ..Unresectable carcinomas of the oropharynx and hypopharynx still have a poor long-term prognosis. Following a previous phase II study, this phase III multicenter trial was conducted between November 1997 and March 2002...
  7. doi request reprint Free-flap head and neck reconstruction and quality of life: a 2-year prospective study
    Alexandre Bozec
    Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, Nice, France
    Laryngoscope 118:874-80. 2008
    ..This prospective study was designed to evaluate quality of life (QOL) after free-flap head and neck reconstruction...
  8. ncbi request reprint Quality of life after oral and oropharyngeal reconstruction with a radial forearm free flap: prospective study
    Alexandre Bozec
    Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice 06189, France
    J Otolaryngol Head Neck Surg 38:401-8. 2009
    ..To evaluate quality of life (QOL) after radial forearm free flap (RFFF) reconstruction of the oral cavity and oropharynx in head and neck cancer patients...
  9. doi request reprint Head and neck squamous cell carcinoma in patients aged > or = 80 years: patterns of care and survival
    Antoine Italiano
    Department of Medical Oncology, Antoine Lacassagne Center, Nice, France
    Cancer 113:3160-8. 2008
    ..Scarce data exist concerning the outcome of very elderly patients with head and neck squamous cell carcinoma (HNSCC)...
  10. ncbi request reprint [2003 Update of Standards, Options and Recommendations for management of patients with salivary gland malignant tumors (excluding lymphoma, sarcoma and melanoma) (summary report)]
    Rene Jean Bensadoun
    Centre Antoine Lacassagne, Nice, France
    Bull Cancer 90:629-42. 2003
    ..The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients...
  11. doi request reprint Oral cavity squamous cell carcinoma in 260 patients aged 80years or more
    Cecile Ortholan
    Department of Radiotherapy, Centre Antoine Lacassagne, Nice, France
    Radiother Oncol 93:516-23. 2009
    ..We report the experience of two French cancer centers in the treatment of oral cavity squamous cell carcinoma (SCC) in patients aged 80 years...
  12. doi request reprint Randomized clinical trial of post-operative radiotherapy versus concomitant carboplatin and radiotherapy for head and neck cancers with lymph node involvement
    Severine Racadot
    Centre Leon Berard, Department of Radiation Oncology, Lyon, France
    Radiother Oncol 87:164-72. 2008
    ..We report the results of a randomized trial testing post-operative radiotherapy alone versus concomitant carboplatin and radiotherapy for head and neck cancers with lymph node involvement...
  13. ncbi request reprint Contrasted outcomes to gefitinib on tumoral IGF1R expression in head and neck cancer patients receiving postoperative chemoradiation (GORTEC trial 2004-02)
    Juliette Thariat
    University of Nice Sophia Antipolis, Department of Pathology, Centre Antoine Lacassagne Institut Universitaire de la Face et du Cou IUFC, Centre Antoine Lacassagne, Nice, France
    Clin Cancer Res 18:5123-33. 2012
    ..This study was designed to assess improved outcomes and identify predictive biomarkers...
  14. doi request reprint Intensity-modulated radiotherapy in head and neck cancer: results of the prospective study GORTEC 2004-03
    Ivan Toledano
    Department of Radiation Oncology, Centre Jean Perrin, Clermont Ferrand, France
    Radiother Oncol 103:57-62. 2012
    ....
  15. doi request reprint Modeling of salivary production recovery after radiotherapy using mixed models: determination of optimal dose constraint for IMRT planning and construction of convenient tools to predict salivary function
    Cecile Ortholan
    Department of Radiotherapy, Centre Antoine Lacassagne, Canceropôle PACA, Nice, France
    Int J Radiat Oncol Biol Phys 73:178-86. 2009
    ..This study, which included data from patients included in a French prospective study assessing the benefit of intensity-modulated radiotherapy (RT), sought to elaborate a convenient and original model of salivary recovery...
  16. ncbi request reprint Concomitant twice-a-day radiotherapy and chemotherapy in unresectable head and neck cancer patients: A long-term quality of life analysis
    N Magne
    Department of Head and Neck Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France
    Head Neck 23:678-82. 2001
    ....
  17. ncbi request reprint Prognostic significance of computed tomography in tumors of the oral cavity and oropharynx treated with neoadjuvant chemotherapy
    H P Verschuur
    Department of Otorhinolaryngology, Centre Antoine Lacassagne, Nice, France
    Am J Otolaryngol 18:190-6. 1997
    ..Despite its high response rate, the use of neoadjuvant chemotherapy remains controversial. Pretherapeutic identification of subgroups of patients who are likely to respond to chemotherapy is of the utmost importance...
  18. ncbi request reprint [Concomitant bifractionated radiotherapy and chemotherapy with cisplatin and 5-fluorouracil in locally progressive, non-resectable epidermoid carcinomas of the pharynx: ten years experience at the Antoine Lacassagne center]
    N Magne
    Centre Antoine Lacassagne, 33, Avenue de Valombrose, 06189 Nice, France
    Cancer Radiother 5:413-24. 2001
    ..Evaluation was based on analysis of the toxicity, the response rates, the survival, and the clinical prognostic factors...
  19. ncbi request reprint In vivo measurements with MOSFET detectors in oropharynx and nasopharynx intensity-modulated radiation therapy
    Serge Marcie
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
    Int J Radiat Oncol Biol Phys 61:1603-6. 2005
    ..To evaluate the feasibility of in vivo measurements with metal oxide semiconductor field effect transistor (MOSFET) dosimeters for oropharynx and nasopharynx intensity-modulated radiation therapy (IMRT)...
  20. ncbi request reprint Impact of intensity-modulated radiotherapy on health-related quality of life for head and neck cancer patients: matched-pair comparison with conventional radiotherapy
    Pierre Graff
    Department of Radiation Oncology, Alexis Vautrin Center, Vandoeuvre les Nancy, France
    Int J Radiat Oncol Biol Phys 67:1309-17. 2007
    ..To assess the benefit of intensity-modulated radiotherapy (IMRT) compared with conventional RT for the quality of life (QOL) of head and neck cancer survivors...
  21. ncbi request reprint Low level laser therapy: a real hope in the management of chemo-induced and radiation-induced mucositis?
    Rene Jean Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
    Cancer J 8:236-8. 2002
  22. ncbi request reprint Concomitant b.i.d. radiotherapy and chemotherapy with cisplatin and 5-fluorouracil in unresectable squamous-cell carcinoma of the pharynx: clinical and pharmacological data of a French multicenter phase II study
    R J Bensadoun
    Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France
    Int J Radiat Oncol Biol Phys 42:237-45. 1998
    ..i.d.) continuous nonaccelerated radiotherapy with concomitant cisplatin (CP)-5-fluorouracil (5-FU) chemotherapy, both given at full dose. Feasibility, efficacy, survival, and pharmacokinetic-pharmacodynamic relationships were analyzed...
  23. doi request reprint Radical ablative surgery and radial forearm free flap (RFFF) reconstruction for patients with oral or oropharyngeal cancer: postoperative outcomes and oncologic and functional results
    Alexandre Bozec
    Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice, France
    Acta Otolaryngol 129:681-7. 2009
    ..Radical ablative surgery and radial forearm free flap (RFFF) reconstruction provide promising oncologic and functional results in patients with oral or oropharyngeal cancer...
  24. ncbi request reprint [Upper aerodigestive tract carcinoma: therapeutic management]
    Gilles Poissonnet
    Institut universitaire de la face et du cou de Nice et Centre Antoine Lacassagne, Nice
    Presse Med 36:1634-42. 2007
    ..Conservative treatment strategies must be favored. Treatment is essentially surgical and radiological. Prognosis for survival is poor. For all stages and sites together, 5-year survival remains between 30 and 40%...
  25. ncbi request reprint [Propositions for the selection and the delineation of peritumoral microscopic disease volumes in oral cavity and oropharyngeal cancers (lymph nodes excluded)]
    M Lapeyre
    Departement de Radiotherapie, Centre Alexis Vautrin, Avenue de Bourgogne, 54511 Vandoeuvre les Nancy, France
    Cancer Radiother 9:261-70. 2005
    ..These propositions are for the delineation of microscopic peritumoral target volumes when external beam irradiation is required. CTVs are illustrated on CT sections...
  26. ncbi request reprint Clinical prognostic factors for patients with recurrent head and neck cancer: implications for randomized trials
    X Pivot
    Centre Antoine Lacassagne, Nice, France
    Oncology 61:197-204. 2001
    ..The advantages of taking into account such prognostic factors are to eliminate the patient selection bias and to ensure a fairer comparative evaluation of new or already existing agents in recurrent head and neck cancer...
  27. ncbi request reprint Systematic percutaneous fluoroscopic gastrostomy for concomitant radiochemotherapy of advanced head and neck cancer: optimization of therapy
    P Y Marcy
    Centre Antoine Lacassagne, Nice, France
    Support Care Cancer 8:410-3. 2000
    ..The overall procedure-related mortality rate was nil. Further prospective investigations are necessary to determine whether treatment of wasting improves patient survival...
  28. doi request reprint [Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies]
    A Bozec
    Departement de Chirurgie, Institut Universitaire de la Face et Du Cou, Centre Antoine Lacassagne, 33, Avenue de Valombrose, Nice, France
    Cancer Radiother 12:14-24. 2008
    ..Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy...
  29. ncbi request reprint Low-energy He/Ne laser in the prevention of radiation-induced mucositis. A multicenter phase III randomized study in patients with head and neck cancer
    R J Bensadoun
    External Radiotherapy Unit, Centre Antoine Lacassagne, Nice, France
    Support Care Cancer 7:244-52. 1999
    ..In addition, there is a tremendous potential for using LEL in combined treatment protocols utilizing concomitant chemotherapy and radiotherapy...
  30. ncbi request reprint A comparison between distal and proximal port device insertion in head and neck cancer
    P Y Marcy
    Department of Radiodiagnostics and Interventional Radiology, Antoine Lacassagne Anticancer Research Institute, Nice Cedex 1, France
    Eur J Surg Oncol 34:1262-9. 2008
    ....
  31. ncbi request reprint [Study of theoretical cases of intensity-modulated beams with step-and-shoot technique]
    S Marcie
    Departement de Radiotherapie, Centre Antoine Lacassagne, 33, Avenue de Valombrose, 06189 cedex 2, Nice, France
    Cancer Radiother 7:179-83. 2003
    ..These theoretical cases provide a first step on the way towards treatments with intensity modulation...
  32. ncbi request reprint [Intensity modulated radiotherapy (IMRT) in France: The boost of the national funding for the new expensive innovative technologies (STIC 2001 and 2002)]
    C Marchal
    Departement de Radiotherapie, Centre Alexis Vautrin, 54511 Vandaeuvre les Nancy, France
    Cancer Radiother 7:44s-48s. 2003
    ....
  33. ncbi request reprint The relationship of epidermal growth factor receptor levels to the prognosis of unresectable pharyngeal cancer patients treated by chemo-radiotherapy
    N Magne
    Department of Radiotherapy, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France
    Eur J Cancer 37:2169-77. 2001
    ..EGFR determination appears to be a powerful prognostic parameter in unresectable pharyngeal cancer patients treated by concomitant chemo-radiotherapy...
  34. doi request reprint [Advances in radiation oncology for metastatic bone disease]
    Juliette Thariat
    Centre Antoine Lacassagne Institut universitaire de la face et du cou, université Nice Sophia Antipolis, Department of Radiation Oncology, 33, Avenue Valombrose, 06300 Nice Cedex 2, France
    Bull Cancer 100:1187-97. 2013
    ..The higher doses and more conformal dose distribution achievable while saving healthy tissue with new irradiation techniques have induced a paradigm shift in the management of bone metastases in a growing number of clinical situations...
  35. doi request reprint [2008 Update of Standards, Options: recommendations for management of patients with salivary gland malignant tumours (excluding lymphoma, sarcoma and melanoma), summary report]
    Rene Jean Bensadoun
    Oncologue radiothérapeute, Centre Antoine Lacassagne, Nice, Boulogne Billancourt Cedex, France
    Bull Cancer 95:735-49. 2008
    ..g. last generation hadrontherapy)...
  36. pmc A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracil
    M C Etienne
    Centre Antoine Lacassagne, Nice, France
    Br J Cancer 79:1864-9. 1999
    ..68 for T staging and 2.65 for EGFR. Overall, EGFR remained an independent prognostic factor when response to treatment and T staging were considered in the multivariate analysis...
  37. ncbi request reprint Comparison between nasogastric tube feeding and percutaneous fluoroscopic gastrostomy in advanced head and neck cancer patients
    N Magne
    Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France
    Eur Arch Otorhinolaryngol 258:89-92. 2001
    ..PFG is a safe and effective method of providing enteral nutrition during treatment to patients with advanced head and neck cancer and offers important advantages over NG...
  38. ncbi request reprint [2003 update of Standards, Options and Recommandations for radiotherapy for patients with salivary gland malignant tumors (excluding lymphona, sarcoma and melanoma)]
    R J Bensadoun
    Centre Antoine Lacassagne, Nice
    Cancer Radiother 7:280-95. 2003
    ..and specialists from French public universities,general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients...
  39. ncbi request reprint Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharyngeal candidiasis: a prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients
    Rene Jean Bensadoun
    Department of Radiation Oncology, Antoine Lacassagne Center, Nice, France
    Cancer 112:204-11. 2008
    ..The objective of the current study was to compare MBT with miconazole 500-mg oral gel (MOG) in patients with head and neck cancer...
  40. ncbi request reprint Pharmacokinetics of low-dose carboplatin and applicability of a method of calculation for estimating individual drug clearance
    M C Etienne
    Centre Antoine Lacassagne, Nice, France
    Ann Oncol 14:643-7. 2003
    ....
  41. doi request reprint [Teeth and irradiation in head and neck cancer]
    J Thariat
    Service de Radiotherapie, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice, France
    Cancer Radiother 14:128-36. 2010
    ..Osteoradionecrosis occurs spontaneously (35%), mostly involves the mandibula (85%)...
  42. doi request reprint [Teeth and irradiation: dental care and treatment of osteoradionecrosis after irradiation in head and neck cancer]
    J Thariat
    Service de Radiotherapie, Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice, France
    Cancer Radiother 14:137-44. 2010
    ..New irradiation techniques are changing dose distributions and therefore require close collaboration between odonto-stomatologists and radiation oncologists to define the best dental care...
  43. doi request reprint [Osteonecrosis of the jaw and bisphophonates in oncology]
    Thierry Facon
    Departement de Radiotherapie, Centre Antoine Lacassagne, Nice
    Bull Cancer 95:413-8. 2008
    ..Studies are currently underway in an attempt to answer this issue...
  44. doi request reprint [Normal tissue tolerance to external beam radiation therapy: salivary glands]
    C Ortholan
    Service de Radiotherapie, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice Cedex 2, France
    Cancer Radiother 14:290-4. 2010
    ..Clinical benefit of submandibular gland sparing is more controversial. A mean dose less than 39 Gy could preserve submandibular gland function. This paper aims to review main studies evaluating tolerance dose of salivary glands...
  45. ncbi request reprint Analysis of the dinucleotide repeat polymorphism in the epidermal growth factor receptor (EGFR) gene in head and neck cancer patients
    M C Etienne-Grimaldi
    Laboratoire d Oncopharmacologie, Centre Antoine Lacassagne, Nice, France
    Ann Oncol 16:934-41. 2005
    ..The first intron of EGFR gene is polymorphic (9-23 CA repeats) and transcription declines when the number of repeats increases...