Genevieve Almouzni

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. pmc HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes
    Jerome Jullien
    The Welcome Trust Cancer Research UK Gurdon Institute, The Henry Welcome building of Cancer and Developmental Biology, and Department of Zoology, Cambridge, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Epigenetics Chromatin 5:17. 2012
  2. doi request reprint International symposium on the physicochemical field for genetic activities. Awaji Island, Japan, January 24–26, 2011
    Genevieve Almouzni
    Institut Curie Section de Recherche, 26 Rue d Ulm, Paris Cedex 05, France
    Nucleus 2:253-7. 2011
  3. pmc A unified phylogeny-based nomenclature for histone variants
    Paul B Talbert
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    Epigenetics Chromatin 5:7. 2012
  4. ncbi request reprint Regulation of replication fork progression through histone supply and demand
    Anja Groth
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Science 318:1928-31. 2007
  5. ncbi request reprint Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component
    Christèle Maison
    Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Genet 30:329-34. 2002
  6. ncbi request reprint The histone chaperone Asf1 is dispensable for direct de novo histone deposition in Xenopus egg extracts
    Dominique Ray-Gallet
    Section de Recherche, UMR 218 du CNRS, Institut Curie, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Chromosoma 116:487-96. 2007
  7. ncbi request reprint New histone incorporation marks sites of UV repair in human cells
    Sophie E Polo
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 5, France
    Cell 127:481-93. 2006
  8. ncbi request reprint Chromatin challenges during DNA replication and repair
    Anja Groth
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 5, France
    Cell 128:721-33. 2007
  9. pmc The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?
    Angela Taddei
    Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 6:520-4. 2005
  10. doi request reprint Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information
    Armelle Corpet
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 Centre National de la Recherche Scientifique and Institut Curie, 26 Rue d Ulm, Paris Cedex 05, France
    Trends Cell Biol 19:29-41. 2009

Collaborators

Detail Information

Publications21

  1. pmc HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes
    Jerome Jullien
    The Welcome Trust Cancer Research UK Gurdon Institute, The Henry Welcome building of Cancer and Developmental Biology, and Department of Zoology, Cambridge, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Epigenetics Chromatin 5:17. 2012
    ..abstract:..
  2. doi request reprint International symposium on the physicochemical field for genetic activities. Awaji Island, Japan, January 24–26, 2011
    Genevieve Almouzni
    Institut Curie Section de Recherche, 26 Rue d Ulm, Paris Cedex 05, France
    Nucleus 2:253-7. 2011
    ..The meeting was organized by Professors Yasushi Hiraoka, Hitoshi Kurumizaka and Akatsuki Kimura...
  3. pmc A unified phylogeny-based nomenclature for histone variants
    Paul B Talbert
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    Epigenetics Chromatin 5:7. 2012
    ..For clarity and searchability, we encourage the use of descriptors that are separate from the phylogeny-based variant name to indicate developmental and other properties of variants that may be independent of structure...
  4. ncbi request reprint Regulation of replication fork progression through histone supply and demand
    Anja Groth
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Science 318:1928-31. 2007
    ....
  5. ncbi request reprint Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component
    Christèle Maison
    Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Genet 30:329-34. 2002
    ..In addition, we identify an RNA- and histone modification-dependent structure that brings methylated H3-K9 tails together in a specific configuration required for the accumulation of HP1 proteins in these domains...
  6. ncbi request reprint The histone chaperone Asf1 is dispensable for direct de novo histone deposition in Xenopus egg extracts
    Dominique Ray-Gallet
    Section de Recherche, UMR 218 du CNRS, Institut Curie, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Chromosoma 116:487-96. 2007
    ..Based on our results, it becomes important to consider the implications for Asf1 function during early development in Xenopus...
  7. ncbi request reprint New histone incorporation marks sites of UV repair in human cells
    Sophie E Polo
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 5, France
    Cell 127:481-93. 2006
    ..We conclude that chromatin restoration after damage cannot rely simply on histone recycling. New histone incorporation at repair sites both challenges epigenetic stability and possibly contributes to damage memory...
  8. ncbi request reprint Chromatin challenges during DNA replication and repair
    Anja Groth
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 5, France
    Cell 128:721-33. 2007
    ..The aim of this Review is to describe how these pathways operate and to highlight how the epigenetic landscape may be stably maintained even in the face of dramatic changes in chromatin structure...
  9. pmc The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?
    Angela Taddei
    Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 6:520-4. 2005
    ..Here, we discuss the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome...
  10. doi request reprint Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information
    Armelle Corpet
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 Centre National de la Recherche Scientifique and Institut Curie, 26 Rue d Ulm, Paris Cedex 05, France
    Trends Cell Biol 19:29-41. 2009
    ....
  11. pmc The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen
    Annabelle Gérard
    Institut Curie, Section de Recherche, UMR218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 7:817-23. 2006
    ..Conversely, CAF1 recruitment is reduced in a PCNA/DNA loading assay using Cdc7-depleted extracts. Our data define p150 as a new target for this kinase with implications for the coordination between DNA replication and CAF1 functions...
  12. ncbi request reprint Histone chaperones, a supporting role in the limelight
    Alejandra Loyola
    Institut Curie Section de Recherche, UMR 21826, rue d Ulm, 75231 Paris Cedex 05, France
    Biochim Biophys Acta 1677:3-11. 2004
    ..Finally, we discuss how these chaperones may have more than a supporting role in a histone metabolic pathway...
  13. ncbi request reprint HP1 and the dynamics of heterochromatin maintenance
    Christèle Maison
    Unité Mixte de Reserche 218, Centre National de la Recherche Scientifique Institut Curie Section de Recherche, 26 Rue d Ulm, 75231 Paris Cedex 05, France
    Nat Rev Mol Cell Biol 5:296-304. 2004
  14. doi request reprint Heterochromatin maintenance and establishment: lessons from the mouse pericentromere
    Genevieve Almouzni
    Institut Curie, Centre de Recherche, 26 Rue d Ulm, Paris F 75248, France
    Nucleus 2:332-8. 2011
    ..Comparison with heterochromatin maintenance in fission yeast will enable discussions of the common basic principles and various mechanisms exploited in the distinct organisms...
  15. doi request reprint An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
    Rhys S Allan
    Institut Curie Research Center, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nature 487:249-53. 2012
    ..These results establish a link between the SUV39H1–H3K9me3–HP1α pathway and the stability of TH2 cells, and they identify potential targets for therapeutic intervention in TH2-cell-mediated inflammatory diseases...
  16. pmc Tumor aromatase expression as a prognostic factor for local control in young breast cancer patients after breast-conserving treatment
    Marc A Bollet
    Department of Radiation Oncology, Institut Curie, 26 Rue d Ulm, 75248 Paris, France
    Breast Cancer Res 11:R54. 2009
    ..We sought to determine whether the levels of expression of 17 candidate genes were associated with locoregional control after breast-conserving treatments of early-stage breast cancers in young, premenopausal women...
  17. doi request reprint Nucleosome dynamics and histone variants
    Dominique Ray-Gallet
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Essays Biochem 48:75-87. 2010
    ..Finally, we provide working models to explain how H3 variants, deposited on to DNA using different histone chaperone machineries, can be transmitted or lost through cell divisions...
  18. pmc Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology
    Leanne de Koning
    Laboratory of Nuclear Dynamics and Genome Plasticity UMR218, Institut Curie CNRS UPMC, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Mol Med 1:178-91. 2009
    ..The overexpression of HP1alpha constitutes a new example of a potential epigenetic contribution to tumourigenesis that is of clinical interest for cancer prognosis...
  19. ncbi request reprint Histone chaperones: an escort network regulating histone traffic
    Leanne de Koning
    Laboratory of Nuclear Dynamics and Genome Plasticity UMR 218, Institut Curie, 26 Rue d Ulm, 75248 Paris, France
    Nat Struct Mol Biol 14:997-1007. 2007
    ..Given the current interest in chromatin as a source of epigenetic marks, we address the potential contributions of histone chaperones to epigenetic memory and genome stability...
  20. pmc Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway
    Jill A Mello
    Institut Curie, Research Section, UMR 218 du Centre National de la Recherche Scientifique CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 3:329-34. 2002
    ..A model is proposed in which the synergism between hAsf1 and CAF-1 for nucleosome formation during DNA repair is achieved through a transient physical interaction allowing histone delivery from Asf1 to CAF-1...
  21. ncbi request reprint Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote
    Aline V Probst
    Laboratory of Nuclear Dynamics and Nuclear Plasticity, UMR218 CNRS Institut Curie, 75248, Paris Cedex 05, France
    Chromosoma 116:403-15. 2007
    ..Our findings highlight the importance of ensuring a proper centromere function while preserving the distinction of parental genome origin during the return to totipotency in the zygote...