Genevieve Almouzni

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. ncbi request reprint Histone chaperones: assisting histone traffic and nucleosome dynamics
    Zachary A Gurard-Levin
    Institut Curie, Centre de Recherche CNRS UMR 3664 Equipe Labellisée, Ligue contre le Cancer and Université Pierre et Marie Curie, Paris F 75248, France email
    Annu Rev Biochem 83:487-517. 2014
  2. pmc Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology
    Leanne de Koning
    Laboratory of Nuclear Dynamics and Genome Plasticity UMR218, Institut Curie CNRS UPMC, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Mol Med 1:178-91. 2009
  3. pmc HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair
    Celine Baldeyron
    Institut Curie, Centre de Recherche, Paris, F 75248 France
    J Cell Biol 193:81-95. 2011
  4. pmc HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes
    Jerome Jullien
    The Welcome Trust Cancer Research UK Gurdon Institute, The Henry Welcome building of Cancer and Developmental Biology, and Department of Zoology, Cambridge, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Epigenetics Chromatin 5:17. 2012
  5. ncbi request reprint International symposium on the physicochemical field for genetic activities. Awaji Island, Japan, January 24–26, 2011
    Genevieve Almouzni
    Institut Curie Section de Recherche, 26 Rue d Ulm, Paris Cedex 05, France
    Nucleus 2:253-7. 2011
  6. pmc A unified phylogeny-based nomenclature for histone variants
    Paul B Talbert
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    Epigenetics Chromatin 5:7. 2012
  7. pmc Mouse centric and pericentric satellite repeats form distinct functional heterochromatin
    Mounia Guenatri
    Institut Curie Research section, UMR218 du Centre National pour la Recherche Scientifique, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Biol 166:493-505. 2004
  8. doi request reprint Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX
    Nicolas Lacoste
    Institut Curie, Centre de Recherche, Paris75248, France CNRS, UMR3664, Paris75248, France Equipe Labellisée Ligue Contre le Cancer, UMR3664, Paris 75248, France UPMC, UMR3664, Paris 75248, France
    Mol Cell 53:631-44. 2014
  9. ncbi request reprint Regulation of replication fork progression through histone supply and demand
    Anja Groth
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Science 318:1928-31. 2007
  10. pmc Compaction kinetics on single DNAs: purified nucleosome reconstitution systems versus crude extract
    Gaudeline Wagner
    Laboratoire Physicochimie Curie, Institut Curie, CNRS UMR 168, 75248 Paris, France
    Biophys J 89:3647-59. 2005

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Histone chaperones: assisting histone traffic and nucleosome dynamics
    Zachary A Gurard-Levin
    Institut Curie, Centre de Recherche CNRS UMR 3664 Equipe Labellisée, Ligue contre le Cancer and Université Pierre et Marie Curie, Paris F 75248, France email
    Annu Rev Biochem 83:487-517. 2014
    ..Finally, we discuss the importance of histone chaperones during development and describe how misregulation of the histone flow can link to disease. ..
  2. pmc Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology
    Leanne de Koning
    Laboratory of Nuclear Dynamics and Genome Plasticity UMR218, Institut Curie CNRS UPMC, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Mol Med 1:178-91. 2009
    ..The overexpression of HP1alpha constitutes a new example of a potential epigenetic contribution to tumourigenesis that is of clinical interest for cancer prognosis...
  3. pmc HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair
    Celine Baldeyron
    Institut Curie, Centre de Recherche, Paris, F 75248 France
    J Cell Biol 193:81-95. 2011
    ..Collectively, our data reveal that HP1α recruitment at early stages of the DDR involves p150CAF-1 and is critical for proper DNA damage signaling and repair...
  4. pmc HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes
    Jerome Jullien
    The Welcome Trust Cancer Research UK Gurdon Institute, The Henry Welcome building of Cancer and Developmental Biology, and Department of Zoology, Cambridge, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Epigenetics Chromatin 5:17. 2012
    ..abstract:..
  5. ncbi request reprint International symposium on the physicochemical field for genetic activities. Awaji Island, Japan, January 24–26, 2011
    Genevieve Almouzni
    Institut Curie Section de Recherche, 26 Rue d Ulm, Paris Cedex 05, France
    Nucleus 2:253-7. 2011
    ..The meeting was organized by Professors Yasushi Hiraoka, Hitoshi Kurumizaka and Akatsuki Kimura...
  6. pmc A unified phylogeny-based nomenclature for histone variants
    Paul B Talbert
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    Epigenetics Chromatin 5:7. 2012
    ..For clarity and searchability, we encourage the use of descriptors that are separate from the phylogeny-based variant name to indicate developmental and other properties of variants that may be independent of structure...
  7. pmc Mouse centric and pericentric satellite repeats form distinct functional heterochromatin
    Mounia Guenatri
    Institut Curie Research section, UMR218 du Centre National pour la Recherche Scientifique, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Biol 166:493-505. 2004
    ..Thus, we define functionally independent centromeric subdomains, which spatio-temporal isolation is proposed to be important for centromeric cohesion and dissociation during chromosome segregation...
  8. doi request reprint Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX
    Nicolas Lacoste
    Institut Curie, Centre de Recherche, Paris75248, France CNRS, UMR3664, Paris75248, France Equipe Labellisée Ligue Contre le Cancer, UMR3664, Paris 75248, France UPMC, UMR3664, Paris 75248, France
    Mol Cell 53:631-44. 2014
    ..Our findings illustrate how changes in histone variant levels can disrupt chromatin dynamics and suggests a possible mechanism for cell resistance to anticancer treatments. ..
  9. ncbi request reprint Regulation of replication fork progression through histone supply and demand
    Anja Groth
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Science 318:1928-31. 2007
    ....
  10. pmc Compaction kinetics on single DNAs: purified nucleosome reconstitution systems versus crude extract
    Gaudeline Wagner
    Laboratoire Physicochimie Curie, Institut Curie, CNRS UMR 168, 75248 Paris, France
    Biophys J 89:3647-59. 2005
    ..Data are discussed and models proposed to account for the kinetics obtained in our single-molecule assay...
  11. ncbi request reprint New histone incorporation marks sites of UV repair in human cells
    Sophie E Polo
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 5, France
    Cell 127:481-93. 2006
    ..We conclude that chromatin restoration after damage cannot rely simply on histone recycling. New histone incorporation at repair sites both challenges epigenetic stability and possibly contributes to damage memory...
  12. ncbi request reprint The HP1-p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells
    Jean Pierre Quivy
    lnstitut Curie, Centre de Recherche, UMR218 du CNRS, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Nat Struct Mol Biol 15:972-9. 2008
    ..Notably, in cells lacking the histone methylases Suv39h, in which pericentric domains do not show HP1 accumulation, p150 is dispensable for S-phase progression...
  13. doi request reprint Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity
    Dominique Ray-Gallet
    Centre de Recherche, Institut Curie, 75248 Paris, France
    Mol Cell 44:928-41. 2011
    ..3, and HIRA association with Pol II ensures local H3.3 enrichment at specific sites. We discuss the importance of this H3.3 deposition as a salvage pathway to maintain chromatin integrity...
  14. pmc A CAF-1 dependent pool of HP1 during heterochromatin duplication
    Jean Pierre Quivy
    Institut Curie, Section de Recherche, UMR218 du CNRS, 26, Paris, France
    EMBO J 23:3516-26. 2004
    ....
  15. ncbi request reprint Histone metabolic pathways and chromatin assembly factors as proliferation markers
    Sophie E Polo
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 5, France
    Cancer Lett 220:1-9. 2005
    ..On the basis of recent data, we discuss the potential use of chromatin-associated factors as new proliferation markers of interest for cancer diagnosis and prognosis...
  16. pmc The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen
    Annabelle Gérard
    Institut Curie, Section de Recherche, UMR218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 7:817-23. 2006
    ..Conversely, CAF1 recruitment is reduced in a PCNA/DNA loading assay using Cdc7-depleted extracts. Our data define p150 as a new target for this kinase with implications for the coordination between DNA replication and CAF1 functions...
  17. ncbi request reprint Chromatin assembly factor-1, a marker of clinical value to distinguish quiescent from proliferating cells
    Sophie E Polo
    Laboratories of Nuclear Dynamics and Genome Plasticity, Curie Institute CNRS, Paris, France
    Cancer Res 64:2371-81. 2004
    ..Our data highlight the precise association of CAF-1 expression with the proliferative state and validate the use of this factor as a useful proliferation marker and prognostic indicator in malignant and benign breast lesions...
  18. ncbi request reprint HIRA is critical for a nucleosome assembly pathway independent of DNA synthesis
    Dominique Ray-Gallet
    Section de Recherche, Institut Curie, UMR 218 du CNRS, Paris, France
    Mol Cell 9:1091-100. 2002
    ..Furthermore, this defect was largely corrected by reintroduction of HIRA along with (H3-H4)(2) tetramers. We thus delineate a nucleosome assembly pathway that depends on HIRA...
  19. doi request reprint CAF-1 is required for efficient replication of euchromatic DNA in Drosophila larval endocycling cells
    Benjamin Klapholz
    CNRS, Institut Curie, Pavillon Pasteur, Paris, France
    Chromosoma 118:235-48. 2009
    ....
  20. pmc Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer
    Armelle Corpet
    Institut Curie, UMR218, Nuclear Dynamics and Genome Plasticity, Paris, France
    EMBO J 30:480-93. 2011
    ..We discuss the implications of these results for breast cancer diagnosis and prognosis...
  21. ncbi request reprint DNA synthesis-dependent and -independent chromatin assembly pathways in Xenopus egg extracts
    Dominique Ray-Gallet
    Institut Curie, Section de Recherche, F 75248, Paris, France
    Methods Enzymol 375:117-31. 2004
  22. doi request reprint An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
    Rhys S Allan
    Institut Curie Research Center, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nature 487:249-53. 2012
    ..These results establish a link between the SUV39H1–H3K9me3–HP1α pathway and the stability of TH2 cells, and they identify potential targets for therapeutic intervention in TH2-cell-mediated inflammatory diseases...
  23. ncbi request reprint Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component
    Christèle Maison
    Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Genet 30:329-34. 2002
    ..In addition, we identify an RNA- and histone modification-dependent structure that brings methylated H3-K9 tails together in a specific configuration required for the accumulation of HP1 proteins in these domains...
  24. ncbi request reprint Analysis of DNA repair and chromatin assembly in vitro using immobilized damaged DNA substrates
    Jill A Mello
    Research Section, Institut Curie, UMR218 du Centre National de la Recherche Scientifique, Paris, France
    Methods Mol Biol 281:271-81. 2004
    ....
  25. doi request reprint Developmental roles of histone H3 variants and their chaperones
    Dan Filipescu
    Institut Curie, Centre de Recherche, Paris F 75248 cedex 05, France CNRS, UMR218, Paris F 75248 cedex 05, France
    Trends Genet 29:630-40. 2013
    ..Future challenges will be to gain a comprehensive picture of H3 variants and their chaperones during development and differentiation. ..
  26. ncbi request reprint Chromatin challenges during DNA replication and repair
    Anja Groth
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 5, France
    Cell 128:721-33. 2007
    ..The aim of this Review is to describe how these pathways operate and to highlight how the epigenetic landscape may be stably maintained even in the face of dramatic changes in chromatin structure...
  27. pmc Differential contribution of HP1 proteins to DNA end resection and homology-directed repair
    Gaston Soria
    Laboratory of Chromatin Dynamics, Institut Curie Section Recherche, Paris, France
    Cell Cycle 12:422-9. 2013
    ..Altogether, our findings provide mechanistic insight into how human HP1 proteins participate in the recombination process, emerging as important chromatin regulators during HDR...
  28. pmc Local action of the chromatin assembly factor CAF-1 at sites of nucleotide excision repair in vivo
    Catherine M Green
    UMR218, Institut Curie Section de Recherche, 26 Rue d Ulm, 75248 Paris 05, France
    EMBO J 22:5163-74. 2003
    ..This in vivo demonstration of the local role of CAF-1, depending directly on NER, supports the hypothesis that CAF-1 ensures the maintenance of epigenetic information by acting locally at repair sites...
  29. ncbi request reprint The histone chaperone Asf1 is dispensable for direct de novo histone deposition in Xenopus egg extracts
    Dominique Ray-Gallet
    Section de Recherche, UMR 218 du CNRS, Institut Curie, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Chromosoma 116:487-96. 2007
    ..Based on our results, it becomes important to consider the implications for Asf1 function during early development in Xenopus...
  30. ncbi request reprint Interplay between chromatin and cell cycle checkpoints in the context of ATR/ATM-dependent checkpoints
    Stephane Koundrioukoff
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Curie Institute, 26 Rue d Ulm, 75248 Paris, Cedex 5, France
    DNA Repair (Amst) 3:969-78. 2004
    ....
  31. ncbi request reprint Chromatin assembly: a basic recipe with various flavours
    Sophie E Polo
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 5, France
    Curr Opin Genet Dev 16:104-11. 2006
    ..New data highlight the importance of histone dimers as deposition entities for de novo nucleosome assembly and identify dedicated machineries involved in histone variant deposition...
  32. ncbi request reprint Heterochromatin reorganization during early mouse development requires a single-stranded noncoding transcript
    Miguel Casanova
    Institut Curie, Centre de Recherche, Paris F 75248, France CNRS, UMR218, Paris F 75248, France
    Cell Rep 4:1156-67. 2013
    ..Finally, our discovery that only reverse pericentric transcripts are required for both the nuclear reorganization of PHC and development beyond the two-cell stage challenges current views on heterochromatin organization...
  33. doi request reprint A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain
    Adam J L Cook
    Institut Curie, Centre de Recherche, Paris F 75248, France
    Mol Cell 44:918-27. 2011
    ..These insights into NASP function and the existence of a tunable reservoir in mammalian cells demonstrate that contingency is integrated into the histone supply chain to respond to unexpected changes in demand...
  34. ncbi request reprint PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state
    Alejandra Loyola
    CNRS UMR 218, Institut Curie, Paris 75248, France
    Mol Cell 24:309-16. 2006
    ..Although the set of initial modifications present on H3.1 is permissive for further modifications, in H3.3 a subset cannot be K9me3. Thus, initial modifications impact final PTMs within chromatin...
  35. ncbi request reprint Methods for studying chromatin assembly coupled to DNA repair
    Annabelle Gérard
    Laboratory of Nuclear Dynamics and Genome Plasticity, Institut Curie, UMR 218, CNRS, Paris, France
    Methods Enzymol 409:358-74. 2006
    ..Combination of these approaches provides powerful tools to gain insights into the mechanism by which chromatin organization can be restored after repair of DNA lesions...
  36. ncbi request reprint HP1 and the dynamics of heterochromatin maintenance
    Christèle Maison
    Unité Mixte de Reserche 218, Centre National de la Recherche Scientifique Institut Curie Section de Recherche, 26 Rue d Ulm, 75231 Paris Cedex 05, France
    Nat Rev Mol Cell Biol 5:296-304. 2004
  37. ncbi request reprint Rad53: a controller ensuring the fine-tuning of histone levels
    Jean Pierre Quivy
    Institut Curie, Research Section, UMR 218 du CNRS, 75218 Paris cedex 05, France
    Cell 115:508-10. 2003
    ..Their function is believed to depend largely on the detection of the DNA damage or defects occurring during replication fork progression...
  38. doi request reprint A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus
    Emmanuelle Szenker
    Institut Curie, Centre de Recherche, Paris F 75248 France
    Cell Rep 1:730-40. 2012
    ..3 incorporation into chromatin comparable to H3.3 depletion. We discuss how specific HIRA-dependent H3.3 deposition is required for chromatin dynamics during gastrulation...
  39. ncbi request reprint Analysis of DNA repair and chromatin assembly in vitro using immobilized damaged DNA substrates
    Jill A Mello
    Research Section, Institut Curie, Paris, France
    Methods Mol Biol 314:477-87. 2006
    ....
  40. doi request reprint The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin
    Christèle Maison
    Institut Curie, Centre de Recherche, Paris, France
    Nat Struct Mol Biol 19:458-60. 2012
    ..Depletion of SENP7 delocalizes HP1α from pericentric heterochromatin without affecting H3K9me3 levels. We propose that following targeting of HP1α, a subsequent deSUMOylation event enables HP1α retention at these domains...
  41. doi request reprint Clinical significance and prognostic value of chromatin assembly factor-1 overexpression in human solid tumours
    Sophie E Polo
    UMR218 Curie CNRS, Paris, France
    Histopathology 57:716-24. 2010
    ..The aim was to investigate CAF-1 as a proliferation marker in a wide variety of solid tumours, and to assess its potential value in predicting clinical outcome...
  42. doi request reprint Characterization of chromatin domains by 3D fluorescence microscopy: An automated methodology for quantitative analysis and nuclei screening
    Sylvain Cantaloube
    Institut Curie, Centre National de la Recherche Scientifique, Unité Mixte de Recherche UMR 218, Laboratory of Nuclear Dynamics and Genome Plasticity, Paris Cedex, France
    Bioessays 34:509-17. 2012
    ..By adapting a few parameters, it could be extended to other nuclear structures and the benefit of using available software will permit its use in many biological labs...
  43. doi request reprint Cell cycle dynamics of histone variants at the centromere, a model for chromosomal landmarks
    Ekaterina Boyarchuk
    Institut Curie, Centre de Recherche, Paris, F 75248, France
    Curr Opin Cell Biol 23:266-76. 2011
    ..Finally, we highlight the importance of histone variants in the crosstalk between centric and pericentric domains for maintaining centromere identity...
  44. pmc The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?
    Angela Taddei
    Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 6:520-4. 2005
    ..Here, we discuss the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome...
  45. pmc When repair meets chromatin. First in series on chromatin dynamics
    Catherine M Green
    UMR 218, Pavillion Pasteur, Institut Curie Section de Recherche, 26, rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 3:28-33. 2002
    ....
  46. doi request reprint Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information
    Armelle Corpet
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 Centre National de la Recherche Scientifique and Institut Curie, 26 Rue d Ulm, Paris Cedex 05, France
    Trends Cell Biol 19:29-41. 2009
    ....
  47. ncbi request reprint Histone chaperones, a supporting role in the limelight
    Alejandra Loyola
    Institut Curie Section de Recherche, UMR 21826, rue d Ulm, 75231 Paris Cedex 05, France
    Biochim Biophys Acta 1677:3-11. 2004
    ..Finally, we discuss how these chaperones may have more than a supporting role in a histone metabolic pathway...
  48. ncbi request reprint Phosphorylation and DNA Binding of HJURP Determine Its Centromeric Recruitment and Function in CenH3(CENP-A) Loading
    Sebastian Müller
    Institut Curie, Centre de Recherche, Paris 75248, France CNRS, UMR3664, Paris 75248, France Equipe Labellisée Ligue Contre le Cancer, UMR3664, Paris 75248, France UPMC, UMR3664, Paris 75248, France Sorbonne University, Paris 75005, France
    Cell Rep 8:190-203. 2014
    ....
  49. doi request reprint SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin
    Christèle Maison
    Institut Curie, Centre de Recherche, Paris, France
    Nat Genet 43:220-7. 2011
    ..We propose that SUMO-HP1, through a specific association with major forward transcript, is guided at the pericentric heterochromatin domain to seed further HP1 localization...
  50. ncbi request reprint Repairing DNA damage in chromatin
    Alisson M de M C Gontijo
    UMR 218 Institute Curie, Recherche, 26 Rue d Ulm, 75248 Paris 5, France
    Biochimie 85:1133-47. 2003
    ..Finally, we will comment on the way in which chromatin assembly factors can participate in the maintenance of chromatin structures during DNA repair...
  51. ncbi request reprint [Variations on the topic of the "histone code"]
    Dominique Ray-Gallet
    Section de Recherche, CNRS UMR 218, Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Med Sci (Paris) 21:384-9. 2005
    ..We will next describe core histone variants, insisting on their mode of incorporation into chromatin to discuss their epigenetic function and inheritance...
  52. doi request reprint Heterochromatin maintenance and establishment: lessons from the mouse pericentromere
    Genevieve Almouzni
    Institut Curie, Centre de Recherche, 26 Rue d Ulm, Paris F 75248, France
    Nucleus 2:332-8. 2011
    ..Comparison with heterochromatin maintenance in fission yeast will enable discussions of the common basic principles and various mechanisms exploited in the distinct organisms...
  53. ncbi request reprint Chromatin assembly of DNA templates microinjected into Xenopus oocytes
    Daniele Roche
    Research Section, Institute Curie, UMR218 du Centre National de la Recherche Scientifique, Paris, France
    Methods Mol Biol 322:139-47. 2006
    ..This method allows in vivo chromatin formation in a nuclear environment. We provide the experimental procedures for oocyte preparation, DNA injection, and analysis of the assembled chromatin...
  54. ncbi request reprint Bromodomains in living cells participate in deciphering the histone code
    Alejandra Loyola
    UMR 218 CNRS Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Trends Cell Biol 14:279-81. 2004
  55. pmc Tumor aromatase expression as a prognostic factor for local control in young breast cancer patients after breast-conserving treatment
    Marc A Bollet
    Department of Radiation Oncology, Institut Curie, 26 Rue d Ulm, 75248 Paris, France
    Breast Cancer Res 11:R54. 2009
    ..We sought to determine whether the levels of expression of 17 candidate genes were associated with locoregional control after breast-conserving treatments of early-stage breast cancers in young, premenopausal women...
  56. doi request reprint Nucleosome dynamics and histone variants
    Dominique Ray-Gallet
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Essays Biochem 48:75-87. 2010
    ..Finally, we provide working models to explain how H3 variants, deposited on to DNA using different histone chaperone machineries, can be transmitted or lost through cell divisions...
  57. doi request reprint A strand-specific burst in transcription of pericentric satellites is required for chromocenter formation and early mouse development
    Aline V Probst
    Laboratory of Nuclear Dynamics and Genome Plasticity, Unite Mixte de Recherche, 218 Centre National de la Recherche Scientifique Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Dev Cell 19:625-38. 2010
    ..We conclude that the exquisite strand-specific expression dynamics at major satellites during the 2-cell stage, with both up and downregulation, are necessary events for proper chromocenter organization and developmental progression...
  58. doi request reprint A network of players in H3 histone variant deposition and maintenance at centromeres
    Sebastian Müller
    Institut Curie Section de Recherche, UMR218, 26 Rue d Ulm, 75231 Paris Cedex 05, France
    Biochim Biophys Acta 1839:241-50. 2014
    ..This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development. ..
  59. pmc Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway
    Jill A Mello
    Institut Curie, Research Section, UMR 218 du Centre National de la Recherche Scientifique CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 3:329-34. 2002
    ..A model is proposed in which the synergism between hAsf1 and CAF-1 for nucleosome formation during DNA repair is achieved through a transient physical interaction allowing histone delivery from Asf1 to CAF-1...
  60. pmc The double face of the histone variant H3.3
    Emmanuelle Szenker
    Institut Curie, Centre de Recherche, Paris F 75248, France
    Cell Res 21:421-34. 2011
    ..Finally, we discuss the functional significance of the use of this H3 variant, in particular during germline formation and early development in different species...
  61. ncbi request reprint Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote
    Aline V Probst
    Laboratory of Nuclear Dynamics and Nuclear Plasticity, UMR218 CNRS Institut Curie, 75248, Paris Cedex 05, France
    Chromosoma 116:403-15. 2007
    ..Our findings highlight the importance of ensuring a proper centromere function while preserving the distinction of parental genome origin during the return to totipotency in the zygote...
  62. ncbi request reprint Histone chaperones: an escort network regulating histone traffic
    Leanne de Koning
    Laboratory of Nuclear Dynamics and Genome Plasticity UMR 218, Institut Curie, 26 Rue d Ulm, 75248 Paris, France
    Nat Struct Mol Biol 14:997-1007. 2007
    ..Given the current interest in chromatin as a source of epigenetic marks, we address the potential contributions of histone chaperones to epigenetic memory and genome stability...
  63. ncbi request reprint How to restore chromatin structure and function in response to DNA damage--let the chaperones play: delivered on 9 July 2013 at the 38th FEBS Congress in St Petersburg, Russia
    Salome Adam
    Institut Curie, Centre de Recherche, Paris, France Centre National de la Recherche Scientifique, UMR3664, Paris, France Equipe Labellisée Ligue Contre le Cancer, Paris, France Institut de Formation Doctorale, University Pierre and Marie Curie, Paris, France Sorbonne University, PSL, Paris, France Epigenetics and Cell Fate Centre, UMR7216, Centre National de la Recherche Scientifique Paris Diderot University, Paris, France
    FEBS J 281:2315-23. 2014
    ..Finally, we discuss how, in addition to restoring chromatin integrity, the cellular networks that signal and repair DNA damage may also provide a window of opportunity for modulating the information conveyed by chromatin. ..