Jean Marc Alessandri

Summary

Affiliation: Institut National de la Recherche Agronomique
Country: France

Publications

  1. doi Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females
    Jean Marc Alessandri
    Unité de Nutrition et Régulation Lipidique des Fonctions Cérébrales, Département Alimentation Humaine, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Eur J Nutr 51:199-209. 2012
  2. doi Ovariectomy and 17β-estradiol alter transcription of lipid metabolism genes and proportions of neo-formed n-3 and n-6 long-chain polyunsaturated fatty acids differently in brain and liver
    Jean Marc Alessandri
    Institut National de la Recherche Agronomique, Unité de Nutrition et Régulation Lipidique des Fonctions Cérébrales UR 909, Département Alimentation Humaine, F 78352 Jouy en Josas, France
    J Nutr Biochem 22:820-7. 2011
  3. ncbi Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells
    Jean Marc Alessandri
    Unit of Lipid Nutrition and Regulation of Brain Functions, Nu Re Li Ce, INRA, Jouy en Josas, France
    Lipids 43:19-28. 2008
  4. ncbi Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life
    Jean Marc Alessandri
    Neurobiologie des Lipides, Laboratoire de Nutrition et Securite Alimentaire, INRA, 78352 Jouy en Josas, France
    Reprod Nutr Dev 44:509-38. 2004
  5. doi Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion
    Audrey Extier
    Unit of Lipid Nutrition and Regulation of Brain Functions, NuReLice, UR909, INRA, F 78352 Jouy en Josas, France
    J Nutr Biochem 21:180-7. 2010
  6. ncbi Astrocytes in culture require docosahexaenoic acid to restore the n-3/n-6 polyunsaturated fatty acid balance in their membrane phospholipids
    Gaelle Champeil-Potokar
    Laboratoire de Nutrition et Securite Alimentaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Neurosci Res 75:96-106. 2004
  7. doi Long-chain n-3 fatty acid levels in baseline serum phospholipids do not predict later occurrence of depressive episodes: a nested case-control study within a cohort of middle-aged French men and women
    Pierre Astorg
    INRA UR909, Nutrition et Régulation Lipidique des Fonctions Cérébrales NuRéLiCe, Unité NuRéLiCe, bât 230, Domaine de Vilvert, F 78352 Jouy en Josas, France
    Prostaglandins Leukot Essent Fatty Acids 81:265-71. 2009
  8. doi n-3 long-chain fatty acids and regulation of glucose transport in two models of rat brain endothelial cells
    Fabien Pifferi
    INRA, UR909, Nutrition et Régulation Lipidique des fonctions Cérébrales, F 78352 Jouy en Josas, France
    Neurochem Int 56:703-10. 2010
  9. ncbi An (n-3) polyunsaturated fatty acid-deficient diet disturbs daily locomotor activity, melatonin rhythm, and striatal dopamine in Syrian hamsters
    Monique Lavialle
    INRA, UR 909 Nutrition et Régulation Lipidique des Fonctions Cérébrales, F 78352 Jouy en Josas, France
    J Nutr 138:1719-24. 2008
  10. ncbi Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid
    Bénédicte Langelier
    Nutrition and Food Safety, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Neurosci Res 74:134-41. 2003

Collaborators

Detail Information

Publications21

  1. doi Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females
    Jean Marc Alessandri
    Unité de Nutrition et Régulation Lipidique des Fonctions Cérébrales, Département Alimentation Humaine, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Eur J Nutr 51:199-209. 2012
    ..The ω3 ∆4-desaturation index was drawn from the DHA to docosapentaenoic acid (ω3DPA) ratio in liver phospholipids...
  2. doi Ovariectomy and 17β-estradiol alter transcription of lipid metabolism genes and proportions of neo-formed n-3 and n-6 long-chain polyunsaturated fatty acids differently in brain and liver
    Jean Marc Alessandri
    Institut National de la Recherche Agronomique, Unité de Nutrition et Régulation Lipidique des Fonctions Cérébrales UR 909, Département Alimentation Humaine, F 78352 Jouy en Josas, France
    J Nutr Biochem 22:820-7. 2011
    ..In conclusion, E2 sustained the transcription of lipid metabolism genes and proportions of neo-formed DHA and n-6DPA differently in brain and liver...
  3. ncbi Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells
    Jean Marc Alessandri
    Unit of Lipid Nutrition and Regulation of Brain Functions, Nu Re Li Ce, INRA, Jouy en Josas, France
    Lipids 43:19-28. 2008
    ..Enhanced synthesis of ALA-elongation products in neuroblastoma cells treated with E2 supports the hypothesis that neurosteroids could modulate the metabolism of PUFA...
  4. ncbi Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life
    Jean Marc Alessandri
    Neurobiologie des Lipides, Laboratoire de Nutrition et Securite Alimentaire, INRA, 78352 Jouy en Josas, France
    Reprod Nutr Dev 44:509-38. 2004
    ....
  5. doi Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion
    Audrey Extier
    Unit of Lipid Nutrition and Regulation of Brain Functions, NuReLice, UR909, INRA, F 78352 Jouy en Josas, France
    J Nutr Biochem 21:180-7. 2010
    ..Our results support the hypothesis on hormonal regulation of PUFA metabolism, which should be taken into account for specific nutritional recommendations...
  6. ncbi Astrocytes in culture require docosahexaenoic acid to restore the n-3/n-6 polyunsaturated fatty acid balance in their membrane phospholipids
    Gaelle Champeil-Potokar
    Laboratoire de Nutrition et Securite Alimentaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Neurosci Res 75:96-106. 2004
    ..This reliable method of altering membrane phospholipid composition promises to be useful for studying the influence of n-6/n-3 imbalance on astrocyte function...
  7. doi Long-chain n-3 fatty acid levels in baseline serum phospholipids do not predict later occurrence of depressive episodes: a nested case-control study within a cohort of middle-aged French men and women
    Pierre Astorg
    INRA UR909, Nutrition et Régulation Lipidique des Fonctions Cérébrales NuRéLiCe, Unité NuRéLiCe, bât 230, Domaine de Vilvert, F 78352 Jouy en Josas, France
    Prostaglandins Leukot Essent Fatty Acids 81:265-71. 2009
    ..This study does not support the hypothesis of a predictive value of n-3 PUFA status for depression in population settings...
  8. doi n-3 long-chain fatty acids and regulation of glucose transport in two models of rat brain endothelial cells
    Fabien Pifferi
    INRA, UR909, Nutrition et Régulation Lipidique des fonctions Cérébrales, F 78352 Jouy en Josas, France
    Neurochem Int 56:703-10. 2010
    ..Physiological doses of n-3 LC-PUFA have a direct and positive effect on glucose transport and GLUT1 density in RBEC that could partly explain decreased brain glucose utilization in n-3 PUFA-deprived rats...
  9. ncbi An (n-3) polyunsaturated fatty acid-deficient diet disturbs daily locomotor activity, melatonin rhythm, and striatal dopamine in Syrian hamsters
    Monique Lavialle
    INRA, UR 909 Nutrition et Régulation Lipidique des Fonctions Cérébrales, F 78352 Jouy en Josas, France
    J Nutr 138:1719-24. 2008
    ..We suggest that an (n-3) PUFA-deficient diet lessens the melatonin rhythm, weakens endogenous functioning of the circadian clock, and plays a role in nocturnal sleep disturbances as described in attention deficit/hyperactivity disorder...
  10. ncbi Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid
    Bénédicte Langelier
    Nutrition and Food Safety, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Neurosci Res 74:134-41. 2003
    ....
  11. ncbi Incorporation of docosahexaenoic acid into nerve membrane phospholipids: bridging the gap between animals and cultured cells
    Jean Marc Alessandri
    Nutrition and Food Safety Laboratory, Neurobiology of Lipids, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Am J Clin Nutr 78:702-10. 2003
    ..The molecular effects of DHA are commonly studied in cultured cells, but questions remain about the physiologic connection between animal and cell models...
  12. doi n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: effect of rest and neuronal activation in the rat
    Emilie Harbeby
    INRA, Nutrition et Régulation Lipidique des fonctions Cérébrales, Jouy en Josas, France
    Prostaglandins Leukot Essent Fatty Acids 86:211-20. 2012
    ..We conclude that n-3 deficiency repressed GLUT1 gene expression in the cerebral cortex, while DHA supplementation improved the mitochondrial ATP generation in the CA1 area of the hippocampus...
  13. doi Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells
    Audrey Extier
    Unit of Lipid Nutrition and Regulation of Brain Functions, Nu Re Li Ce, UR909, INRA, Domaine de Vilvert, F 78352 Jouy en Josas, France
    Neurochem Int 55:295-301. 2009
    ..These results help our understanding of the regulation of brain PUFA metabolism by steroid hormones...
  14. ncbi Changes of the transcriptional and fatty acid profiles in response to n-3 fatty acids in SH-SY5Y neuroblastoma cells
    Bénédicte Langelier
    Nutrition and Food Safety, Neurobiology of Lipids, INRA l Institut National de la Recherche Agronomique, Jouy en Josas, France
    Lipids 40:719-28. 2005
    ..We conclude that the critical precursor- concentration window of responsiveness may originate from the low basal expression level of peroxisomal enzymes...
  15. doi Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations
    Philippe Guesnet
    INRA, UR909 Unité de Nutrition et Régulation Lipidique des Fonctions Cérébrales Nurélice, CRJ, F 78352 Jouy en Josas Cedex, France
    Biochimie 93:7-12. 2011
    ....
  16. doi Gene expression of fatty acid transport and binding proteins in the blood-brain barrier and the cerebral cortex of the rat: differences across development and with different DHA brain status
    Hélène Pélerin
    INRA, Nutrition et Régulation Lipidique des fonctions Cérébrales, 78352 Jouy en Josas, France Electronic address
    Prostaglandins Leukot Essent Fatty Acids 91:213-20. 2014
    ....
  17. ncbi (n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats
    Fabien Pifferi
    Nutrition and Food Safety Laboratory Unit, Neurobiology of Lipids, Institut National de la Recherche Agronomique INRA, Jouy en Josas, 78352 Cedex, France
    J Nutr 135:2241-6. 2005
    ..These results suggest that the decreased glucose utilization in the cerebral cortex of (n-3) PUFA-deficient rats is due to reduced amounts of the 2 isoforms of GLUT1, indicating post-transcriptional regulation of GLUT1 synthesis...
  18. ncbi Analysis of the 2nd symposium "Anomalies of fatty acids, ageing and degenerating pathologies"
    Philippe Guesnet
    Neurobiology of Lipids, The Nutrition and Food Safety Laboratory, Institut National de la Recherche Agronomique, CRJ, 78352 Jouy en Josas Cedex, France
    Reprod Nutr Dev 44:263-71. 2004
    ....
  19. doi Association of fish and long-chain n-3 polyunsaturated fatty acid intakes with the occurrence of depressive episodes in middle-aged French men and women
    Pierre Astorg
    Unité Nutrition et Régulation Lipidique des Fonctions Cérébrales NuRéLiCe, UR 909, Institut National de la Recherche Agronomique INRA, Centre de Recherche de Jouy, Jouy en Josas, France
    Prostaglandins Leukot Essent Fatty Acids 78:171-82. 2008
    ..In contrast, smokers eating fatty fish had an increased risk of recurrent depression. These results suggest that a usual intake of fatty fish or long-chain n-3 PUFA may decrease the risk of recurrent depression in non-smokers...
  20. ncbi Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids
    Adriana Ximenes da Silva
    Laboratoire de Neurobiologie des Fonctions Vegetatives, INRA, Jouy en Josas, France
    J Neurochem 81:1328-37. 2002
    ..The present results suggest that changes in energy metabolism induced by n-3 deficiency could result from functional alteration in glucose transporters...
  21. ncbi Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity
    Gerard Ailhaud
    ISDBC, Centre de Biochimie UMR 6543 CNRS, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    Prog Lipid Res 45:203-36. 2006
    ..If prevention of obesity is a key issue for future generations, agricultural and food industry policies should be thoroughly reevaluated...