Andres Alcover

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses
    Andres Alcover
    Institut Pasteur, Unite de Biologie Cellulaire des Lymphocytes, Departement d Immunologie, CNRS, URA1961, F 75724, Paris Cedex 15, France
    Curr Top Microbiol Immunol 340:191-207. 2010
  2. pmc Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse
    Helena Soares
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, F 75724 Paris, France
    J Exp Med 210:2415-33. 2013
  3. ncbi request reprint Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
    Maria Isabel Thoulouze
    Unite de Biologie Cellulaire des Lymphocytes, Centre National de la Recherche Scientifique Unité de Recherche Associée 1930, Institut Pasteur, 25 28 rue Dr Roux, 75724 Paris Cedex 15, France
    Immunity 24:547-61. 2006
  4. pmc Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation
    Rémi Lasserre
    Lymphocyte Cell Biology Unit, Department of Immunology, Imagopole, Institut Pasteur, F 75015 Paris, Cedex 15, France
    J Cell Biol 195:839-53. 2011
  5. pmc Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse
    Rémi Lasserre
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France
    EMBO J 29:2301-14. 2010
  6. ncbi request reprint Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia
    Beatrice Payelle-Brogard
    Unité d Immuno Hématologie et d Immunopathologie, CNRS URA 1960, Paris, France
    Br J Haematol 118:976-85. 2002
  7. ncbi request reprint Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor
    Robert Weil
    Unité de Biologie Moléculaire de l Expression Génique, FRE 2364 Centre National de la Recherche Scientifique CNRS, 75724 Paris Cedex 15, France
    Immunity 18:13-26. 2003
  8. ncbi request reprint Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses
    Helena Soares
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France CNRS, URA 1961, Paris, France
    Immunol Rev 256:118-32. 2013
  9. ncbi request reprint T-lymphocyte activation induced by staphylococcal enterotoxin superantigens. Analysis of protein tyrosine phosphorylation
    Anne Roumier
    Unite de Biologie des Interactions Cellulaires, Institut Pasteur, Paris, France
    Methods Mol Biol 214:127-35. 2003
  10. doi request reprint Can viruses form biofilms?
    Maria Isabel Thoulouze
    Institut Pasteur, Lymphocyte Cell Biology Unit, Department of Immunology, 28 rue du Dr Roux, F 75724 Paris, France
    Trends Microbiol 19:257-62. 2011

Collaborators

Detail Information

Publications17

  1. doi request reprint Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses
    Andres Alcover
    Institut Pasteur, Unite de Biologie Cellulaire des Lymphocytes, Departement d Immunologie, CNRS, URA1961, F 75724, Paris Cedex 15, France
    Curr Top Microbiol Immunol 340:191-207. 2010
    ..We discuss how some lymphotropic viruses target the vesicle traffic in T lymphocytes, inhibiting the formation of immunological synapses and modulating the response of infected T cells...
  2. pmc Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse
    Helena Soares
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, F 75724 Paris, France
    J Exp Med 210:2415-33. 2013
    ..This mechanism is required for priming IL-2 and IFN-γ production and may contribute to fine-tuning T cell activation breadth in response to different stimulatory conditions. ..
  3. ncbi request reprint Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
    Maria Isabel Thoulouze
    Unite de Biologie Cellulaire des Lymphocytes, Centre National de la Recherche Scientifique Unité de Recherche Associée 1930, Institut Pasteur, 25 28 rue Dr Roux, 75724 Paris Cedex 15, France
    Immunity 24:547-61. 2006
    ..Alteration of endocytic and signaling networks at the immunological synapse likely impacts the function and fate of HIV-1-infected cells...
  4. pmc Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation
    Rémi Lasserre
    Lymphocyte Cell Biology Unit, Department of Immunology, Imagopole, Institut Pasteur, F 75015 Paris, Cedex 15, France
    J Cell Biol 195:839-53. 2011
    ..These results demonstrate that serine/threonine phosphorylation of multiple TCR-proximal effectors controls the stability of signaling microclusters, thereby determining the intensity of T cell responses...
  5. pmc Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse
    Rémi Lasserre
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France
    EMBO J 29:2301-14. 2010
    ..Moreover, they underscore the importance of ezrin and Dlg1 in the regulation of NF-AT activation through p38...
  6. ncbi request reprint Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia
    Beatrice Payelle-Brogard
    Unité d Immuno Hématologie et d Immunopathologie, CNRS URA 1960, Paris, France
    Br J Haematol 118:976-85. 2002
    ..These findings demonstrated that a post-transcriptional defect located at the BCR intracellular assembly and/or trafficking levels could be involved in its low surface expression in B-CLL...
  7. ncbi request reprint Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor
    Robert Weil
    Unité de Biologie Moléculaire de l Expression Génique, FRE 2364 Centre National de la Recherche Scientifique CNRS, 75724 Paris Cedex 15, France
    Immunity 18:13-26. 2003
    ..This study shows that the localization of NEMO to the immunological synapse is important for TCR-induced NF-kappaB activation and offers a powerful system to dissect the NF-kappaB cascade in T cells...
  8. ncbi request reprint Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses
    Helena Soares
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France CNRS, URA 1961, Paris, France
    Immunol Rev 256:118-32. 2013
    ..We also discuss how the human immunodeficiency virus (HIV-1) hijacks some of these processes impairing immunological synapse generation and function. ..
  9. ncbi request reprint T-lymphocyte activation induced by staphylococcal enterotoxin superantigens. Analysis of protein tyrosine phosphorylation
    Anne Roumier
    Unite de Biologie des Interactions Cellulaires, Institut Pasteur, Paris, France
    Methods Mol Biol 214:127-35. 2003
  10. doi request reprint Can viruses form biofilms?
    Maria Isabel Thoulouze
    Institut Pasteur, Lymphocyte Cell Biology Unit, Department of Immunology, 28 rue du Dr Roux, F 75724 Paris, France
    Trends Microbiol 19:257-62. 2011
    ....
  11. ncbi request reprint Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells
    Laurent Mascarell
    Unité de Biologie des Populations Lymphocytaires, CNRS 2582, Institut Pasteur, Paris, France
    J Biol Chem 279:10556-63. 2004
    ..These data reveal a new mechanism of action for CSA, which involves up-regulation of a gene whose products are sorted to mitochondria and depolarize the mitochondrial membrane...
  12. doi request reprint Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses
    Ana Monica Pais-Correia
    Institut Pasteur, Unite de Biologie Cellulaire des Lymphocytes, Centre National de Recherche Scientifique CNRS, Unité de Recherche Associée 1961, Paris, France
    Nat Med 16:83-9. 2010
    ..HTLV-1 biofilm-like structures represent a major route for virus transmission from cell to cell...
  13. doi request reprint Cytoskeletal cross-talk in the control of T cell antigen receptor signaling
    Rémi Lasserre
    Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France
    FEBS Lett 584:4845-50. 2010
    ..Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine-tuning of T cell signaling...
  14. pmc ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation
    Nathalie Sol-Foulon
    Groupe Virus et Immunité, Institut Pasteur, CNRS URA1930, France
    EMBO J 26:516-26. 2007
    ..These results bring novel insights into the links that exist between T-cell activation and HIV spread, and suggest that HIV usurps components of the immunological synapse machinery to ensure its own spread through cell-to-cell contacts...
  15. ncbi request reprint Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling
    Stephanie Charrin
    Unite de Biologie Cellulaire des Lymphocytes, Institut Pasteur, 25, rue Dr Roux, 75724 Paris Cedex 15, France
    Front Biosci 11:1987-97. 2006
    ....
  16. pmc Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment
    Franck Coumailleau
    Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Biol Cell 15:4444-56. 2004
    ..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane...
  17. pmc The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression
    Josiane Ragimbeau
    Unité de Signalisation des Cytokines, CNRS URA 1961, Unite de Biologie des Interactions Cellulaires, CNRS URA 1960, Institut Pasteur, Paris 75724 Cedex 15, France
    EMBO J 22:537-47. 2003
    ..This function is distinct from the previously reported effect of other Jak proteins on receptor exit from the endoplasmic reticulum...