Research Topics
Genomes and Genes | Andres AlcoverSummaryAffiliation: Institut Pasteur Country: France Publications
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Detail Information
Publications
Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic virusesAndres Alcover
Institut Pasteur, Unite de Biologie Cellulaire des Lymphocytes, Departement d Immunologie, CNRS, URA1961, F 75724, Paris Cedex 15, France
Curr Top Microbiol Immunol 340:191-207. 2010..We discuss how some lymphotropic viruses target the vesicle traffic in T lymphocytes, inhibiting the formation of immunological synapses and modulating the response of infected T cells...
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activationRémi Lasserre
Lymphocyte Cell Biology Unit, Department of Immunology, Imagopole, Institut Pasteur, F 75015 Paris, Cedex 15, France
J Cell Biol 195:839-53. 2011..These results demonstrate that serine/threonine phosphorylation of multiple TCR-proximal effectors controls the stability of signaling microclusters, thereby determining the intensity of T cell responses...- Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapseRémi Lasserre
Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France
EMBO J 29:2301-14. 2010..Moreover, they underscore the importance of ezrin and Dlg1 in the regulation of NF-AT activation through p38... 
Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemiaBeatrice Payelle-Brogard
Unité d Immuno Hématologie et d Immunopathologie, CNRS URA 1960, Paris, France
Br J Haematol 118:976-85. 2002..These findings demonstrated that a post-transcriptional defect located at the BCR intracellular assembly and/or trafficking levels could be involved in its low surface expression in B-CLL...- Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptorRobert Weil
Unité de Biologie Moléculaire de l Expression Génique, FRE 2364 Centre National de la Recherche Scientifique CNRS, 75724 Paris Cedex 15, France
Immunity 18:13-26. 2003..This study shows that the localization of NEMO to the immunological synapse is important for TCR-induced NF-kappaB activation and offers a powerful system to dissect the NF-kappaB cascade in T cells... - Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapseMaria Isabel Thoulouze
, , Institut Pasteur, 25-28 rue Dr Roux, 75724 Paris Cedex 15, France
Immunity 24:547-61. 2006..Alteration of endocytic and signaling networks at the immunological synapse likely impacts the function and fate of HIV-1-infected cells... - Can viruses form biofilms?Maria Isabel Thoulouze
Institut Pasteur, Lymphocyte Cell Biology Unit, Department of Immunology, 28 rue du Dr Roux, F 75724 Paris, France
Trends Microbiol 19:257-62. 2011.... - Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cellsLaurent Mascarell
Unité de Biologie des Populations Lymphocytaires, CNRS 2582, Institut Pasteur, Paris, France
J Biol Chem 279:10556-63. 2004..These data reveal a new mechanism of action for CSA, which involves up-regulation of a gene whose products are sorted to mitochondria and depolarize the mitochondrial membrane... - T-lymphocyte activation induced by staphylococcal enterotoxin superantigens. Analysis of protein tyrosine phosphorylationAnne Roumier
, Institut Pasteur, Paris, France
Methods Mol Biol 214:127-35. 2003 - ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formationNathalie Sol-Foulon
Groupe Virus et Immunité, Institut Pasteur, CNRS URA1930, France
EMBO J 26:516-26. 2007..These results bring novel insights into the links that exist between T-cell activation and HIV spread, and suggest that HIV usurps components of the immunological synapse machinery to ensure its own spread through cell-to-cell contacts... - Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapsesAna Monica Pais-Correia
Institut Pasteur, Unite de Biologie Cellulaire des Lymphocytes, Centre National de Recherche Scientifique CNRS, Unité de Recherche Associée 1961, Paris, France
Nat Med 16:83-9. 2010..HTLV-1 biofilm-like structures represent a major route for virus transmission from cell to cell... - Cytoskeletal cross-talk in the control of T cell antigen receptor signalingRémi Lasserre
Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France
FEBS Lett 584:4845-50. 2010..Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine-tuning of T cell signaling... - Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signalingStephanie Charrin
Unite de Biologie Cellulaire des Lymphocytes, Institut Pasteur, 25, rue Dr Roux, 75724 Paris Cedex 15, France
Front Biosci 11:1987-97. 2006.... - The tyrosine kinase Tyk2 controls IFNAR1 cell surface expressionJosiane Ragimbeau
Unité de Signalisation des Cytokines, CNRS URA 1961, Unite de Biologie des Interactions Cellulaires, CNRS URA 1960, Institut Pasteur, Paris 75724 Cedex 15, France
EMBO J 22:537-47. 2003..This function is distinct from the previously reported effect of other Jak proteins on receptor exit from the endoplasmic reticulum... - Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartmentFranck Coumailleau
Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Mol Biol Cell 15:4444-56. 2004..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane...