Matthew L Albert

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes
    Giovanna Barba-Spaeth
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:1179-84. 2005
  2. pmc Chikungunya virus-induced autophagy delays caspase-dependent cell death
    Pierre Emmanuel Joubert
    Unité Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, Paris, France
    J Exp Med 209:1029-47. 2012
  3. pmc Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Clementine Schilte
    Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 207:429-42. 2010
  4. pmc Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
    Jeremie Decalf
    The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 204:2423-37. 2007
  5. pmc Antigen Cross-Priming of Cell-Associated Proteins is Enhanced by Macroautophagy within the Antigen Donor Cell
    Pierre Emmanuel Joubert
    Laboratory of Dendritic Cell Immunobiology, Department of Immunology, INSERM U818, Institut Pasteur Paris, France
    Front Immunol 3:61. 2012
  6. pmc Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery
    Isabelle Bouvier
    Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur Paris, France
    Front Immunol 2:71. 2011
  7. doi request reprint Plasmacytoid dendritic cells move down on the list of suspects: in search of the immune pathogenesis of chronic hepatitis C
    Matthew L Albert
    The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France
    J Hepatol 49:1069-78. 2008
  8. ncbi request reprint Presence of functional dendritic cells in patients chronically infected with hepatitis C virus
    Randy S Longman
    Institut Pasteur, 25, rue du Dr Roux, Paris, France 75724
    Blood 103:1026-9. 2004
  9. ncbi request reprint Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
    Matthew L Albert
    INSERM AVEN0201, Laboratoire d Immunobiologie des Cellules Dendritiques, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Rev Immunol 4:223-31. 2004
  10. pmc A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte, Institut Pasteur, Paris, France
    PLoS Pathog 4:e29. 2008

Collaborators

Detail Information

Publications43

  1. pmc Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes
    Giovanna Barba-Spaeth
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:1179-84. 2005
    ..These findings offer insight into the immunologic mechanisms associated with the highly capable YF17D vaccine that may guide effective vaccine design...
  2. pmc Chikungunya virus-induced autophagy delays caspase-dependent cell death
    Pierre Emmanuel Joubert
    Unité Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, Paris, France
    J Exp Med 209:1029-47. 2012
    ..Our study suggests that inducers of autophagy may limit the pathogenesis of acute Chikungunya disease...
  3. pmc Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Clementine Schilte
    Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 207:429-42. 2010
    ..This study defines an essential role for type I IFN, produced via cooperation between multiple host sensors and acting directly on nonhematopoietic cells, in the control of CHIKV...
  4. pmc Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
    Jeremie Decalf
    The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 204:2423-37. 2007
    ..Furthermore, this work will help evaluate the therapeutic application of pDC agonists in diseases such as chronic HCV infection...
  5. pmc Antigen Cross-Priming of Cell-Associated Proteins is Enhanced by Macroautophagy within the Antigen Donor Cell
    Pierre Emmanuel Joubert
    Laboratory of Dendritic Cell Immunobiology, Department of Immunology, INSERM U818, Institut Pasteur Paris, France
    Front Immunol 3:61. 2012
    ..Further examination of this point of immune regulation is warranted and may contribute to a better understanding of how to optimize immunotherapy for treatment of cancer and chronic infectious disease...
  6. pmc Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery
    Isabelle Bouvier
    Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur Paris, France
    Front Immunol 2:71. 2011
    ....
  7. doi request reprint Plasmacytoid dendritic cells move down on the list of suspects: in search of the immune pathogenesis of chronic hepatitis C
    Matthew L Albert
    The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France
    J Hepatol 49:1069-78. 2008
    ..Thus, instead of being the culprit, pDCs may in fact represent a novel therapeutic target in order to improve upon existing therapies for treating HCV patients...
  8. ncbi request reprint Presence of functional dendritic cells in patients chronically infected with hepatitis C virus
    Randy S Longman
    Institut Pasteur, 25, rue du Dr Roux, Paris, France 75724
    Blood 103:1026-9. 2004
    ..This finding is consistent with clinical and immunologic data that the deficit in the patient's immune repertoire is HCV-specific and suggests that refined models are required for understanding the role of DCs in HCV pathogenesis...
  9. ncbi request reprint Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
    Matthew L Albert
    INSERM AVEN0201, Laboratoire d Immunobiologie des Cellules Dendritiques, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Rev Immunol 4:223-31. 2004
  10. pmc A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte, Institut Pasteur, Paris, France
    PLoS Pathog 4:e29. 2008
    ..The development of a permissive small animal model will expedite the testing of future vaccines and therapeutic candidates...
  11. doi request reprint Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy
    Pierre Emmanuel Joubert
    Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France
    Autophagy 8:1261-3. 2012
    ....
  12. doi request reprint Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles
    Zacarias Garcia
    Institut Pasteur, Dynamics of Immune Responses Unit, Paris, France
    Blood 120:4744-50. 2012
    ..Our results identify SCS macrophages as primary mediators of NK cell activation in response to lymph-borne viral particles suggesting that they act as early sensors of local infection or delivery of viral-based vaccines...
  13. doi request reprint Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection
    Clementine Schilte
    Unité d Immunobiologie des Cellules Dendritiques, Departement d Immunologie, Institut Pasteur, Paris 75724, France
    J Immunol 188:2967-71. 2012
    ..These results highlight the interplay between nonimmune and immune cells during Chikungunya virus infection and suggest an important role for nonhematopoietic cells as a critical source of IFN-α/β...
  14. doi request reprint Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation
    Hélène Beuneu
    Institut Pasteur, Dynamics of Immune Responses Unit, F 75015 Paris, France
    J Immunol 187:2084-8. 2011
    ..Our results suggest that type I IFNs produced following viral infection simultaneously target accessory cells for IL-15 transpresentation and NK cells themselves and that these two pathways cooperate for NK cell priming...
  15. doi request reprint Visualizing the functional diversification of CD8+ T cell responses in lymph nodes
    Hélène Beuneu
    Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Departement d Immunologie, Paris, France
    Immunity 33:412-23. 2010
    ..Thus, the early set of T cell-DC interactions in lymph nodes largely contribute to the heterogeneity of T cell responses through the generation of functionally divergent clonal progenies...
  16. doi request reprint Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer
    Claire Biot
    Unité d Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, F 75724 Paris, France
    Sci Transl Med 4:137ra72. 2012
    ....
  17. doi request reprint Tracking antigen-specific CD8⁺ T cells using MHC class I multimers
    Cécile Alanio
    Immunobiologie des cellules dendritiques, Unité Mixte Pasteur Inserm U818, Institut Pasteur and Centre d Immunologie Humaine, Institut Pasteur, Paris, France
    Methods Mol Biol 960:309-26. 2013
    ..Future developments in cytometric systems (e.g., mass spectroscopy-based cytometry) and gene expression studies (e.g., single cell PCR) will extend these approaches and provide an unprecedented assessment of the immune repertoire...
  18. ncbi request reprint The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis
    Darragh Duffy
    Laboratory of Dendritic Cells Immunobiology, Institut Pasteur, Paris, France Inserm U818, Paris, France
    Hepatology 59:1273-82. 2014
    ..The identification of hepatitis virus specific signatures provides a foundation for functional studies and the identification of potential correlates of viral clearance...
  19. pmc Characterization of reemerging chikungunya virus
    Marion Sourisseau
    Department of Virology, Unité Virus et Immunite, Institut Pasteur, Paris, France
    PLoS Pathog 3:e89. 2007
    ..CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host...
  20. doi request reprint Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis
    Kym R Garrod
    Institut Pasteur, Dynamics of Immune Responses Unit, 75015 Paris, France Inserm U668, 75015 Paris, France
    Cell Rep 2:1438-47. 2012
    ..Our results offer insight into a poorly explored phase of immunity and provide a versatile methodology to study apoptosis during the development or function of a variety of immune cells in vivo...
  21. pmc Innate sensing of HIV-infected cells
    Alice Lepelley
    Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
    PLoS Pathog 7:e1001284. 2011
    ..Characterization of the mechanisms of innate recognition of HIV-infected cells allows a better understanding of the pathogenic and exacerbated immunologic events associated with HIV infection...
  22. ncbi request reprint Cutting edge: cross-presented intracranial antigen primes CD8+ T cells
    Lisa Walter
    Department of Immunology, Laboratory of Dendritic Cell Immunobiology, Institut Pasteur, Paris, France
    J Immunol 178:6038-42. 2007
    ..Our findings have important implications for the initiation of T cell immune responses toward CNS Ags...
  23. pmc Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone
    Emmanuelle Coutanceau
    Unite de Genetique Moleculaire Bacterienne, Genomes and Genetics Department, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 204:1395-403. 2007
    ..Moreover, they highlight a potential interest in mycolactone as a novel immunosuppressive agent...
  24. pmc Identification of a novel neuropathogenic Theiler's murine encephalomyelitis virus
    Matthew R Buckwalter
    Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, Cedex 15, France
    J Virol 85:6893-905. 2011
    ....
  25. ncbi request reprint Simultaneous assessment of autophagy and apoptosis using multispectral imaging cytometry
    Claire de la Calle
    Centre d Immunologie Humaine, Departement d Immunologie, Institut Pasteur, Paris, France
    Autophagy 7:1045-51. 2011
    ..We report a novel method that enables high-throughput, high-content assessment of LC3 puncta and caspase-3 cleavage at the single cell level...
  26. pmc A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation
    Deborah Braun
    Institut Pasteur, Paris, France
    Blood 106:2375-81. 2005
    ....
  27. pmc Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study
    Clementine Schilte
    Unité Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 7:e2137. 2013
    ..Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya...
  28. pmc A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes
    Mariana Mesel-Lemoine
    Unité de Génomique Virale et Vaccination, Department of Virology, Institut Pasteur, CNRS URA 3015, Paris, France
    J Virol 86:7577-87. 2012
    ....
  29. ncbi request reprint Biology and pathogenesis of chikungunya virus
    Olivier Schwartz
    Institut Pasteur, 28 rue du Dr Roux, Paris 75724 Cedex 15, France
    Nat Rev Microbiol 8:491-500. 2010
    ..This Review highlights some of the most recent advances in our understanding of the biology of CHIKV and its interactions with the host...
  30. pmc Gamma c cytokines condition the progressive differentiation of CD4+ T cells
    Guillemette X Masse
    Cytokines and Lymphoid Development Unit, Immunology Department, Institut Pasteur, F 75724 Paris, France
    Proc Natl Acad Sci U S A 104:15442-7. 2007
    ..These results define a late checkpoint in T cell differentiation in the tissues where gamma(c) cytokines, including IL-15, authenticate CD4(+) T cell effector functions...
  31. doi request reprint Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies
    Cécile Alanio
    Centre d Immunologie Humaine, Institut Pasteur, 75724 Paris, France
    Blood 115:3718-25. 2010
    ..Development of a procedure for direct assessment of T-cell precursor frequency in humans has important implications, with particular relevance to vaccine development and monitoring of tumor and self-reactive T cells...
  32. pmc Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation
    Nathalie E Blachere
    Laboratoire d Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France
    PLoS Biol 3:e185. 2005
    ..In vivo data suggest that in situations of stress (e.g., viral infection), this latter pathway may be more efficient, illustrating that dying cells may preselect immunologically important antigenic determinants...
  33. doi request reprint CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients
    Dina Ragab
    Laboratory of Dendritic Cell Immunobiology, Institut Pasteur, Paris, France Faculty of Medicine, Aim Shams University, Cairo, Egypt
    Cytokine 63:105-12. 2013
    ..These findings generalize the observation of chemokine antagonism as a mechanism of immune modulation in chronic HCV patients and may help guide the use of new therapeutic immune modulators...
  34. ncbi request reprint The impact of macroautophagy on CD8(+) T-cell-mediated antiviral immunity
    Brieuc P Perot
    Unité d Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France
    Immunol Rev 255:40-56. 2013
    ..In sum, our review highlights the interplay between viruses and three integrated host response pathways - autophagy, innate and adaptive immunity - providing a framework for future mechanistic and pathogenesis-based research. ..
  35. ncbi request reprint Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli
    Darragh Duffy
    Center for Human Immunology, Institut Pasteur, 75015 Paris, France Inserm U818, 75015 Paris, France Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 75015 Paris, France
    Immunity 40:436-50. 2014
    ..The implementation of a general solution for assessment of functional immune responses will help support harmonization of clinical studies and data sharing...
  36. pmc Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV
    Armanda Casrouge
    The Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, Paris, France
    J Clin Invest 121:308-17. 2011
    ..These data offer what we believe to be the first evidence for CXCL10 antagonism in human disease and identify a possible factor contributing to the inability of patients to clear HCV...
  37. doi request reprint Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy
    Susanna Celli
    Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Departement d Immunologie, Paris, France
    Nat Med 17:744-9. 2011
    ....
  38. ncbi request reprint IL-2 is required for the activation of memory CD8+ T cells via antigen cross-presentation
    Nathalie E Blachere
    The Rockefeller University, New York, NY 10021, USA
    J Immunol 176:7288-300. 2006
    ..Thus, these data support a combined role for Ag-specific, cognate interactions at the CD4(+) T cell/DC as well as the DC/CD8(+) T cell interface, with the helper effect mediated by soluble noncognate signals...
  39. ncbi request reprint Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming
    Hélène Jusforgues-Saklani
    Immunology Department, Institut Pasteur, Paris France
    J Immunol 181:3067-76. 2008
    ..These findings imply that long-lived Ag is critical for efficient vaccination protocols in which the CD8(+) T cell response is helper-dependent...
  40. ncbi request reprint Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation
    Randy S Longman
    Rockefeller University, New York, NY, USA
    Blood 109:1113-22. 2007
    ..These data provide evidence for a molecular switch in signaling pathways concomitant with DC maturation that offers a novel mechanism by which DCs modulate the integration of signals from the surrounding environment...
  41. ncbi request reprint Immune response against dying tumor cells
    Laurence Zitvogel
    Institut Gustave Roussy Villejuif, France
    Adv Immunol 84:131-79. 2004
  42. ncbi request reprint Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C
    Randy S Longman
    The Rockefeller University, The Cornell Rockefeller Sloan Kettering Tri Institutional MD PhD Program, New York, New York, USA
    J Infect Dis 192:497-503. 2005
    ..These results are encouraging for DC-based HCV immunotherapy trials...
  43. ncbi request reprint The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells
    Shin Akakura
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 07103, Newark, NJ, USA
    Exp Cell Res 292:403-16. 2004
    ....