Minou Adib-Conquy

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression
    Minou Adib-Conquy
    Cytokines and Inflammation Unit, Institut Pasteur, 75724 Paris, France
    J Biol Chem 277:27927-34. 2002
  2. ncbi Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation
    Minou Adib-Conquy
    UP Cytokines and Inflammation, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Am J Respir Crit Care Med 168:158-64. 2003
  3. ncbi Compensatory anti-inflammatory response syndrome
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Thromb Haemost 101:36-47. 2009
  4. ncbi Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients
    Minou Adib-Conquy
    Cytokines and Inflammation Unit, Institut Pasteur, Paris, France
    Crit Care Med 34:2377-85. 2006
  5. ncbi Adherence influences monocyte responsiveness to interleukin-10
    Anne France Petit-Bertron
    UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    J Leukoc Biol 73:145-54. 2003
  6. ncbi Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome
    Christophe Adrie
    Medical ICU, Cochin Hospital, Paris, France
    Circulation 106:562-8. 2002
  7. ncbi Adherence modifies the regulation of gene expression induced by interleukin-10
    Anne France Petit-Bertron
    UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Cytokine 29:1-12. 2005
  8. pmc Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation
    Oh Yoen Kim
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr, Roux, Paris, France
    Crit Care 14:R61. 2010
  9. ncbi Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists
    Jörg H Fritz
    Groupe d Immunité Innée et Signalisation, Institut Pasteur, Paris, France
    Eur J Immunol 35:2459-70. 2005
  10. pmc Neutrophils in cystic fibrosis display a distinct gene expression pattern
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Mol Med 14:36-44. 2008

Collaborators

Detail Information

Publications41

  1. ncbi Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression
    Minou Adib-Conquy
    Cytokines and Inflammation Unit, Institut Pasteur, 75724 Paris, France
    J Biol Chem 277:27927-34. 2002
    ....
  2. ncbi Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation
    Minou Adib-Conquy
    UP Cytokines and Inflammation, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Am J Respir Crit Care Med 168:158-64. 2003
    ..In conclusion, the immunodysregulation described for patients with trauma is not a generalized phenomenon but depends on the stimulus and the signaling pathway...
  3. ncbi Compensatory anti-inflammatory response syndrome
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Thromb Haemost 101:36-47. 2009
    ..Thus, CARS may be considered as an adapted compartmentalized response with the aim to silence some acute proinflammatory genes, and to maintain the possible expression of certain genes involved in the anti-infectious process...
  4. ncbi Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients
    Minou Adib-Conquy
    Cytokines and Inflammation Unit, Institut Pasteur, Paris, France
    Crit Care Med 34:2377-85. 2006
    ..In this study, we addressed the specificity of this hyporeactivity and investigated some of the possible associated mechanistic events...
  5. ncbi Adherence influences monocyte responsiveness to interleukin-10
    Anne France Petit-Bertron
    UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    J Leukoc Biol 73:145-54. 2003
    ..Altogether, these data illustrate that adherence modulates the properties and the anti-inflammatory effects of IL-10...
  6. ncbi Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome
    Christophe Adrie
    Medical ICU, Cochin Hospital, Paris, France
    Circulation 106:562-8. 2002
    ..We investigated the immunoinflammatory profile of patients successfully resuscitated after cardiac arrest, representing a model of whole-body ischemia/reperfusion syndrome...
  7. ncbi Adherence modifies the regulation of gene expression induced by interleukin-10
    Anne France Petit-Bertron
    UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Cytokine 29:1-12. 2005
    ..Furthermore, the inhibition of the expression of SOCS1 by IL-10 in the absence of adherence, may explain its priming effects on a subsequent LPS stimulation that we previously described...
  8. pmc Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation
    Oh Yoen Kim
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr, Roux, Paris, France
    Crit Care 14:R61. 2010
    ..So far, the analyses were mainly performed without taking into account monocytes subpopulations...
  9. ncbi Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists
    Jörg H Fritz
    Groupe d Immunité Innée et Signalisation, Institut Pasteur, Paris, France
    Eur J Immunol 35:2459-70. 2005
    ....
  10. pmc Neutrophils in cystic fibrosis display a distinct gene expression pattern
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Mol Med 14:36-44. 2008
    ..Altogether, this study clearly demonstrates that blood PMNs from CF patients display a profound modification of gene expression profile associated with the disease, suggesting a state of activation of these cells...
  11. pmc The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response
    Aurelia Delaune
    Institut Pasteur, Biology of Gram Positive Pathogens, Department of Microbiology, Paris, France
    Infect Immun 80:3438-53. 2012
    ..Taken together, our results indicate that WalKR play an important role in virulence and eliciting the host inflammatory response by controlling autolytic activity...
  12. doi CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis
    Marianna Parlato
    Unit of Cytokines and Inflammation, Department of Infection and Epidemiology, Institut Pasteur, 75015 Paris, France
    J Immunol 192:2449-59. 2014
    ..Our results suggest a novel aspect of CD24-mediated immunoregulation and represent, to our knowledge, the first report showing the role of CD24 in the delayed/defective cell death in sepsis. ..
  13. ncbi Cytokine cascade in sepsis
    Jean Marc Cavaillon
    UP Cytokine and Inflammation, Institut Pasteur, Paris, France
    Scand J Infect Dis 35:535-44. 2003
    ..Although TNF contributes towards favouring the production of many other cytokines within a complex cascade, there are numerous examples to illustrate that its presence is not a prerequisite for these productions...
  14. pmc Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages
    Ronan Kapetanovic
    Cytokines and Inflammation Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Infect Immun 75:830-7. 2007
    ..Taken together, these results show the contribution of phagocytosis and Nod molecules to the response to HKSA in macrophages and also identify possible cross talk between Nod1 and Nod2...
  15. ncbi Determining the degree of immunodysregulation in sepsis
    Jean Marc Cavaillon
    Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Contrib Nephrol 156:101-11. 2007
    ..Thus, the immune dysregulation observed in sepsis corresponds to a reprogramming of circulating leukocytes...
  16. doi NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis
    Fernando Souza-Fonseca-Guimarães
    Institut Pasteur, Unité Cytokines et Inflammation, Département Infection et Epidémiologie, F 75015 Paris, France
    J Immunol 188:5850-8. 2012
    ..We show that this tolerance is associated with a reduction of the CD27(+)CD11b(-) subset in the spleen related to the presence of regulatory T cells and mainly mediated by TGF-β...
  17. doi Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytes
    Cristina D Ciornei
    Unité Cytokines and Inflammation, Institut Pasteur, Paris, France
    Innate Immun 16:288-301. 2010
    ..Our results, therefore, show that P. aeruginosa biofilm LPS undergoes structural modifications that only partially contribute to an increased inflammatory response from human monocytes...
  18. ncbi Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection
    Minou Adib-Conquy
    Cytokines and Inflammation Unit, Institute Pasteur, Paris, France
    Shock 28:406-10. 2007
    ..In conclusion, sTREM-1 and PCT are not specific for infection and can increase markedly in acute inflammation without infection...
  19. doi Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia
    Ronan Kapetanovic
    Institut Pasteur, Unité Cytokines and Inflammation, Département Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
    Microbes Infect 12:759-67. 2010
    ..aureus-induced pneumonia, but that it contributes to the inflammatory response in the lungs. Interestingly, the absence of NOD2 led to a lesser inflammation and was finally beneficial for the animal recovery...
  20. doi Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes
    Ronan Kapetanovic
    Institut Pasteur, Cytokines and Inflammation Unit, Paris, France
    Am J Physiol Cell Physiol 300:C850-9. 2011
    ..The influence of the compartments on cell properties and behavior should be taken into account, to better understand cell physiology and host-pathogen interaction, and to define efficient strategies to fight infection...
  21. pmc DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patients
    Catherine Fitting
    Unit Cytokines and Inflammation, Department of Infection and Epidemiology, Institut Pasteur, Paris, France
    PLoS ONE 7:e38916. 2012
    ..The concordance in bacterial identification between microbiology and the VYOO® test was 46.2%. This study demonstrates that these new technologies offer great hopes, but improvements are still needed...
  22. pmc LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis
    Jennifer Dahan
    Unité d Oncogenèse et Virologie Moléculaire, Institut Pasteur, Paris, France
    Mol Cell Biol 33:3299-308. 2013
    ..Our findings demonstrate FHL2 as a positive regulator of NF-κB activity in liver regeneration and carcinogenesis and highlight the importance of FHL2 in both hepatocytes and hepatic immune cells. ..
  23. ncbi Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10
    Anne France Petit-Bertron
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Cytokine 41:54-60. 2008
    ....
  24. ncbi Endotoxin tolerance: is there a clinical relevance?
    Jean Marc Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    J Endotoxin Res 9:101-7. 2003
    ..In conclusion, in vitro and in vivo endotoxin tolerance, either experimental or due to clinical status, are similar but not identical...
  25. pmc Translocation of bacterial NOD2 agonist and its link with inflammation
    Oh Yoen Kim
    Cytokines and Inflammation Unit, Institut Pasteur, 28 rue Dr, Roux, 75015 Paris, France
    Crit Care 13:R124. 2009
    ..The process could be more frequently identified if peptidoglycan, derived from both Gram-negative and Gram-positive bacteria, was measured...
  26. pmc Resilience to bacterial infection: difference between species could be due to proteins in serum
    H Shaw Warren
    Infectious Disease Unit, Institut Pasteur, Paris, France
    J Infect Dis 201:223-32. 2010
    ..The involvement of circulating proteins as key molecules raises hope that the process might be manipulated to create better animal models and potentially new drug targets...
  27. pmc Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection
    Charlène Blanchet
    Institut Pasteur, Cytokines and Inflammation, Département Infection et Epidémiologie, Paris, France
    PLoS ONE 9:e87927. 2014
    ..Their presence is protective for local pulmonary infection, whereas it becomes detrimental in the peritoneal infection. ..
  28. pmc Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis
    Jean Marc Cavaillon
    Cytokines and Inflammation Unit, Institut Pasteur, rue Dr Roux, 75015 Paris, France
    Crit Care 10:233. 2006
    ..The term 'cellular reprogramming', which has been proposed to qualify the process of endotoxin tolerance, defines well the immune status of circulating leukocytes in septic and SIRS patients...
  29. pmc Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING)
    Fernando Souza-Fonseca-Guimarães
    Institut Pasteur, Unit of Cytokines and Inflammation, Department Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
    J Biol Chem 288:10715-21. 2013
    ..Our study thereby allows us to gain insight into the mechanisms of synergy between accessory cytokines and CpG-ODN in NK cells. It also identifies a new and alternative signaling pathway for CpG-ODN in murine NK cells...
  30. ncbi Mechanisms of immunodysregulation in sepsis
    Jean Marc Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    Contrib Nephrol 144:76-93. 2004
  31. pmc Immune status in sepsis: the bug, the site of infection and the severity can make the difference
    Jean Marc Cavaillon
    Département Infection et Epidémiologie, Unité Cytokines and Inflammation, Institut Pasteur, 28 rue Dr, Roux F 75015 Paris, France
    Crit Care 14:167. 2010
    ..Their study illustrates the heterogeneity of patients with sepsis and points out that numerous key parameters of severe infection influence immune status...
  32. ncbi Stress molecules in sepsis and systemic inflammatory response syndrome
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    FEBS Lett 581:3723-33. 2007
    ..g. High mobility group box-1); that share some properties with PAMPs. Thus, numerous similarities occur during infectious and non-infectious systemic inflammation...
  33. pmc In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis
    Oumaima Ibrahim-Granet
    Unité de Recherche Cytokines and Inflammation, Institut Pasteur Paris France
    BMC Microbiol 10:105. 2010
    ..Studies on the pathogenesis of IA have been limited by the difficulty to monitor disease progression in real-time. For real-time monitoring of the infection, we recently engineered a bioluminescent A. fumigatus strain...
  34. pmc The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}
    Edith Gouin
    Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, Institut Pasteur, F 75015 Paris, France
    Proc Natl Acad Sci U S A 107:17333-8. 2010
    ..Together, these results demonstrate that InlC, by interacting with IKKα, dampens the host innate response induced by Listeria during the infection process...
  35. ncbi Monocytes/macrophages and sepsis
    Jean Marc Cavaillon
    UP Cytokines and Inflammation, Institut Pasteur, Paris, France
    Crit Care Med 33:S506-9. 2005
  36. doi TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals
    Minou Adib-Conquy
    Institut Pasteur, Unité Cytokines and Inflammation, Département Infection et Epidémiologie, Paris, France
    Immunol Cell Biol 92:256-62. 2014
    ....
  37. pmc Natural killer (NK) cells in antibacterial innate immunity: angels or devils?
    Fernando Souza-Fonseca-Guimarães
    Institut Pasteur, Cytokines and Inflammation Unit, Department of Infection and Epidemiology, Paris, France
    Mol Med 18:270-85. 2012
    ..Accordingly, as the main source of IFN-γ in the early phase of infection, NK cells display both beneficial and deleterious effects, depending on the circumstances...
  38. doi Regulatory role of UvrY in adaptation of Photorhabdus luminescens growth inside the insect
    Evelyne Krin
    Unite de Genetique des Genomes Bacteriens URA2171, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Environ Microbiol 10:1118-34. 2008
    ..As a consequence, the uvrY-deficient strain exhibited a decreased killing of insect cells and a reduced growth on insect cells culture, suggesting a UvrY role in the adaptation of P. luminescens inside the insect...
  39. ncbi Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB
    Lynn Verstrepen
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, Ghent, Belgium
    J Cell Mol Med 12:316-29. 2008
    ..Altogether, these data indicate an important role for NF-kappaB-dependent gene expression of ABIN-3 in the negative feedback regulation of TNF receptor and toll-like receptor 4 induced NF-kappaB activation...
  40. pmc Simple method for repurification of endotoxins for biological use
    Alina Tirsoaga
    Equipe Endotoxines, UMR 8619 du CNRS, IBBMC, Universite de Paris Sud, 91405 Orsay, France
    Appl Environ Microbiol 73:1803-8. 2007
    ..Applied to different lipopolysaccharides, the method also improved their mass spectra, thus facilitating their structural analysis...
  41. ncbi LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation
    Andy Wullaert
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    J Biol Chem 282:81-90. 2007
    ..Taken together, these results implicate ABIN-3 as a novel negative feedback regulator of LPS-induced NF-kappaB activation...