Philippe Humbert

Summary

Country: France

Publications

  1. ncbi request reprint Skin manifestations associated with toxocariasis: a case-control study
    P Humbert
    Department of Dermatology, University Hospital, Besancon, France
    Dermatology 201:230-4. 2000
  2. ncbi request reprint [Induced acne]
    Philippe Humbert
    Service de Dermatologie, Hôpital Saint Jacques 25030 Besançon
    Rev Prat 52:838-40. 2002
  3. ncbi request reprint Age-related changes of the cutaneous microcirculation in vivo
    Li Li
    Cutaneous Engineering and Biology Laboratory and IFR 133 Cell and Tissue Engineering and Biology, University of Franche Comte, Besancon, France
    Gerontology 52:142-53. 2006
  4. pmc Efficacy of micronutrient supplementation on skin aging and seasonal variation: a randomized, placebo-controlled, double-blind study
    Ferial Fanian
    Center for Studies and Research on the Integument CERT, Department of Dermatology, University Hospital of Besancon, Besancon, France Clinical Investigation Center, CIC BT 506, CHRU Besançon, France
    Clin Interv Aging 8:1527-37. 2013
  5. pmc Assessment of cumulative exposure to UVA through the study of asymmetrical facial skin aging
    Sophie Mac-Mary
    Skinexigence SAS, Saint Jacques University Hospital, Besancon, France
    Clin Interv Aging 5:277-84. 2010
  6. doi request reprint Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial
    Philippe Humbert
    Service de Dermatologie, CHU de Besancon, Universite de Franche Comte, Besancon, France
    Int Wound J 10:159-66. 2013
  7. ncbi request reprint Toxic epidermal necrolysis
    Florence Castelain
    Department of Dermatology, Besancon University Hospital, France
    Curr Drug Saf 7:332-8. 2012
  8. doi request reprint In the shadow of the wrinkle: theories
    Philippe Humbert
    Engineering and Cutaneous Biology Team, INSERM UMR 645, IFR 133, University of Franche Comte, Besancon, France
    J Cosmet Dermatol 11:72-8. 2012
  9. doi request reprint In the shadow of the wrinkle: experimental models
    Philippe Humbert
    Engineering and Cutaneous Biology Team, INSERM UMR 645, IFR 133, University of Franche Comte, Besancon, France
    J Cosmet Dermatol 11:79-83. 2012
  10. doi request reprint [What's new in dermatological research?]
    P Humbert
    Service de Dermatologie, CHU Saint Jacques, Universite de Franche Comte, INSERM U645, Besancon, France
    Ann Dermatol Venereol 135:S326-34. 2008

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Skin manifestations associated with toxocariasis: a case-control study
    P Humbert
    Department of Dermatology, University Hospital, Besancon, France
    Dermatology 201:230-4. 2000
    ..Objective: The purpose of our study was to assess the risk of having a positive Toxocara ELISA test in patients with different cutaneous symptoms...
  2. ncbi request reprint [Induced acne]
    Philippe Humbert
    Service de Dermatologie, Hôpital Saint Jacques 25030 Besançon
    Rev Prat 52:838-40. 2002
    ..Sun exposure, PUVA therapy and ionizing radiation are potentially acneigenous. Finally acne caused by cosmetics includes acne cosmetica, brilliantine and oily creams acne and detergent acne...
  3. ncbi request reprint Age-related changes of the cutaneous microcirculation in vivo
    Li Li
    Cutaneous Engineering and Biology Laboratory and IFR 133 Cell and Tissue Engineering and Biology, University of Franche Comte, Besancon, France
    Gerontology 52:142-53. 2006
    ..The architectural frameworks of the skin microcirculation are rather complex and change continuously with aging. But these changes are yet poorly documented in vivo...
  4. pmc Efficacy of micronutrient supplementation on skin aging and seasonal variation: a randomized, placebo-controlled, double-blind study
    Ferial Fanian
    Center for Studies and Research on the Integument CERT, Department of Dermatology, University Hospital of Besancon, Besancon, France Clinical Investigation Center, CIC BT 506, CHRU Besançon, France
    Clin Interv Aging 8:1527-37. 2013
    ..The purpose of this study was to evaluate the efficacy of an oral micronutrient supplement in preventing the negative effects of winter weather on skin quality using noninvasive biometrologic instruments...
  5. pmc Assessment of cumulative exposure to UVA through the study of asymmetrical facial skin aging
    Sophie Mac-Mary
    Skinexigence SAS, Saint Jacques University Hospital, Besancon, France
    Clin Interv Aging 5:277-84. 2010
    ..The aim of this study was to assess the visual impact on the skin of repeated ultraviolet-A (UVA) exposure through a window...
  6. doi request reprint Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial
    Philippe Humbert
    Service de Dermatologie, CHU de Besancon, Universite de Franche Comte, Besancon, France
    Int Wound J 10:159-66. 2013
    ..HA gauze pad, in local treatment of venous leg ulcers, was significantly more effective than the neutral vehicle on wound size reduction, healed ulcers rate and pain management with a good safety profile...
  7. ncbi request reprint Toxic epidermal necrolysis
    Florence Castelain
    Department of Dermatology, Besancon University Hospital, France
    Curr Drug Saf 7:332-8. 2012
    ..Supportive care consist of covering areas of cutaneous detachment. No other therapy has demonstrated its efficiency, but high-dose intravenous immunoglobulin might improve the prognosis...
  8. doi request reprint In the shadow of the wrinkle: theories
    Philippe Humbert
    Engineering and Cutaneous Biology Team, INSERM UMR 645, IFR 133, University of Franche Comte, Besancon, France
    J Cosmet Dermatol 11:72-8. 2012
    ..The numerous age-related changes in human skin that are supposed to be involved in wrinkling are briefly reviewed, and the current theories on wrinkle formation linked to these changes are also discussed...
  9. doi request reprint In the shadow of the wrinkle: experimental models
    Philippe Humbert
    Engineering and Cutaneous Biology Team, INSERM UMR 645, IFR 133, University of Franche Comte, Besancon, France
    J Cosmet Dermatol 11:79-83. 2012
    ....
  10. doi request reprint [What's new in dermatological research?]
    P Humbert
    Service de Dermatologie, CHU Saint Jacques, Universite de Franche Comte, INSERM U645, Besancon, France
    Ann Dermatol Venereol 135:S326-34. 2008
    ..Thus, many fields of dermatology were the object of research which opens new prospects for diagnosis and treatment...
  11. ncbi request reprint Gluten intolerance and skin diseases
    Philippe Humbert
    Department of Dermatology, University of Franche Comte, CHU Saint Jacques, 25030 Besancon, France
    Eur J Dermatol 16:4-11. 2006
    ..Intestinal biopsy is usually needed to establish the diagnosis of CD or GI. Thus, gluten intolerance gives rise to a variety of dermatological manifestations which may benefit from a gluten-free diet...
  12. ncbi request reprint [Functional consequences of cutaneous lipid perturbation]
    P Humbert
    Laboratoire d ingénierie et de biologie cutanées, Service de Dermatologie, CHU Saint Jacques, 25030 Besancon, France
    Pathol Biol (Paris) 51:271-4. 2003
    ..Its role in the skin biology appears to be less vital than that of the lipids constituting the permeability barrier of the stratum corneum...
  13. ncbi request reprint In vivo assessment of iron and ascorbic acid in psoriatic dermis
    Nathalie Leveque
    Laboratory of Cutaneous Bioengineering, Faculty of Medicine and Pharmacy, Besancon, France
    Acta Derm Venereol 84:2-5. 2004
    ..8 +/- 29.0 microg/ml) (p<0.05). These results demonstrate that psoriatic patients exhibit high iron and low ascorbic acid concentrations in the dermis, but there were no significant differences between involved and uninvolved skin...
  14. ncbi request reprint Evaluation of a sunscreen photoprotective effect by ascorbic acid assessment in human dermis using microdialysis and gas chromatography mass spectrometry
    Nathalie Leveque
    Laboratoire d ingénierie et de biologie cutanées, Faculte de Medecine et de Pharmacie, 25030 Besancon Cedex, France
    Exp Dermatol 14:176-81. 2005
    ..The assessment of ascorbic acid and its metabolites in human dermis could be an efficient tool to demonstrate the oxidative process and consequently to control the efficiency of sunscreen creams against undesirable UV effects...
  15. ncbi request reprint High iron and low ascorbic acid concentrations in the dermis of atopic dermatitis patients
    Nathalie Leveque
    Laboratoire d ingénierie et de biologie cutanées, Faculte de Medecine et de Pharmacie, Place Saint Jacques, Besancon, France
    Dermatology 207:261-4. 2003
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease in which reactive oxygen species (ROS) may be involved. Iron catalyses ROS formation and ascorbic acid (AA) scavenges these species...
  16. ncbi request reprint Contractile forces generated by striae distensae fibroblasts embedded in collagen lattices
    Celine Viennet
    Engineering and Cutaneous Biology Laboratory, IFR 133, School of Medicine and Pharmacy, 25000 Besancon, France
    Arch Dermatol Res 297:10-7. 2005
    ..The contractile properties of fibroblasts from striae distensae varies depending on the stage of the disease. In early striae distensae, fibroblasts acquire a more contractile phenotype, corresponding to that of myofibroblasts...
  17. ncbi request reprint Assessment of spray application of Saint GERVAIS water effects on skin wettability by contact angle measurement comparison with bidistilled water
    Ahmed Elkhyat
    Laboratoire d ingénierie, Hopital Saint Jacques, Besancon, France
    Skin Res Technol 10:283-6. 2004
    ..Dry skin is a common form of skin damage. Contact angle 0 between a surface and water is a good indicator of hydrophobic or hydrophilic tendency of surfaces...
  18. ncbi request reprint Age-related changes in skin topography and microcirculation
    Li Li
    Cutaneous Engineering and Biology Laboratory and IFR 133 Cell and Tissue Engineering and Biology, University of Franche Comte, 25030, Besancon, France
    Arch Dermatol Res 297:412-6. 2006
    ..The interference fringe profilometry associated with videocapillaroscopy may be useful and accurate to measure the efficacy of medical or cosmetic products to delay skin aging...
  19. ncbi request reprint Assessment of principal parabens used in cosmetics after their passage through human epidermis-dermis layers (ex-vivo study)
    Sawsan El Hussein
    Cutaneous Engineering and Biology Laboratory EA 3183, IFR 133, University of Franche Comte, Besancon, France
    Exp Dermatol 16:830-6. 2007
    ..This situation provokes the accumulation of these molecules which were considered by some authors as the cause of skin toxicities and carcinogenicity...
  20. ncbi request reprint Iron and ascorbic acid concentrations in human dermis with regard to age and body sites
    Nathalie Leveque
    Laboratoire d ingénierie et de biologie cutanées, Faculte de Medecine et de Pharmacie, Universite de Franche Comte, Besancon, France
    Gerontology 49:117-22. 2003
    ..Reactive oxygen species (ROS) contribute to processes relating to cutaneous aging. Iron catalyses ROS formation whereas ascorbic acid (AA) plays a fundamental role in defending the organism against undesirable ROS action...
  21. doi request reprint Increased levels of circulating microparticles are associated with increased procoagulant activity in patients with cutaneous malignant melanoma
    Claire Laresche
    Service de Dermatologie, Centre Hospitalier Universitaire Jean Minjoz, Besancon, France
    J Invest Dermatol 134:176-82. 2014
    ..In addition, we observed an inverse correlation between PMPs, AV(+)MPs, and clotting times. Our data suggest that MPs are involved in the progression of melanoma and may be associated to melanoma-associated thrombogenesis. ..
  22. doi request reprint Development and characterization of a human dermal equivalent with physiological mechanical properties
    Gwenaël Rolin
    Inserm UMR 645 Engineering and Cutaneous Biology Team, Besancon, France
    Skin Res Technol 18:251-8. 2012
    ..Indeed, human skin is naturally under tension. Taking into account these features, the purpose of this work was to obtain a cellularized dermal equivalent (CDE), composed of collagen and dermal fibroblasts...
  23. doi request reprint Exploratory study of the typology of various grades of mature skin
    Jean Marie Sainthillier
    Skinexigence, Besancon, France
    Skin Res Technol 19:e507-14. 2013
    ..Post-menopausal skin aging has intrinsic as well as extrinsic origins, and this process induces important disparities of appearance and feeling within an age range...
  24. ncbi request reprint Comparison of ultraviolet B-induced imbalance of antioxidant status in foreskin- and abdominal skin-derived human fibroblasts
    Thibaut Saguet
    Laboratoire d ingénierie et de biologie cutanées, EA 3183, IFR 133 Ingénierie cellulaire et tissulaire, Universite de Franche Comte, 25041 Besançon cedex France
    Eur J Dermatol 16:368-74. 2006
    ..These results suggest that AF and FF do not respond to UVB by the same pathway...
  25. ncbi request reprint Skin capillary network recognition and analysis by means of neural algorithms
    Jean Marie Sainthillier
    Laboratoire d ingénierie et de biologie cutanées, Dermatology Department, University Hospital, Besancon Cedex, France
    Skin Res Technol 11:9-16. 2005
    ..Nevertheless, finding capillary loops automatically in an image is a difficult yet important first step in order to achieve microcirculation analysis...
  26. doi request reprint Cutaneous differences between Black, African or Caribbean Mixed-race and Caucasian women: biometrological approach of the hydrolipidic film
    Corinne Fotoh
    Department of Dermatology and Laboratory of Engineering and Cutaneous Biology LIBC, INSERM U645, University Hospital of Besancon, Besancon, France
    Skin Res Technol 14:327-35. 2008
    ..We have evaluated the differences in the skin surface properties of three ethnic groups: Black, African or Caribbean Mixed-race and Caucasian women living in defined climatic conditions...
  27. ncbi request reprint Skin radiance: how to quantify? Validation of an optical method
    Adeline Petitjean
    Cutaneous Engineering and Biology Laboratory, EA3183 and IFR 133 Cell and Tissue Engineering and Biology, CHU, Besancon, France
    Skin Res Technol 13:2-8. 2007
    ..The aim of this study was to validate an optic device used to measure the quantity of light reflected by the skin, which depends on the brightness of the skin...
  28. doi request reprint Dermal equivalents in oncology: benefit of one-stage procedure
    Julien Pauchot
    Orthopedic, Traumatology, Plastic Reconstructive, and Hand Surgery Unit, University Hospital of Besancon, Besancon, France
    Dermatol Surg 39:43-50. 2013
    ..In oncology, dermal equivalent may be indicated to cover losses of substance related to skin tumors or after the removal of skin flaps...
  29. ncbi request reprint A skin substitute based on human amniotic membrane
    Hélène Tauzin
    UMR 1098, SFR FED 4234, University of Franche Comte, 25000, Besancon, France
    Cell Tissue Bank 15:257-65. 2014
    ..As re-epithelialization is an important step for ulcer closure, a model of epidermized HAM could be used to speed up the healing of such wounds. ..
  30. pmc Assessment of the efficacy and safety of a new treatment for head lice
    Sophie Mac-Mary
    Skinexigence, Pavillon Sainte Lucienne, Saint Jacques University Hospital, 25030 Besancon, France
    ISRN Dermatol 2012:460467. 2012
    ....
  31. doi request reprint LC-MS determination of oxidized and reduced glutathione in human dermis: a microdialysis study
    Sophie Robin
    SARL BIOEXIGENCE, Besancon, France
    J Chromatogr B Analyt Technol Biomed Life Sci 879:3599-606. 2011
    ..The limits of detection and quantification were respectively 0.12 and 0.4 ng/ml for GSH and 0.2 and 0.5 ng/ml for GSSG. Intra-day and inter-day accuracy and precision were determined and the variability was less than 6.2% (R.S.D.)...
  32. ncbi request reprint Minocycline-induced cutaneous polyarteritis nodosa with antineutrophil cytoplasmic antibodies
    Fabien Pelletier
    Department of Dermatology, University Hospital, 2 Place Saint Jacques, 25030 Besancon, France
    Eur J Dermatol 13:396-8. 2003
    ..Auto-immune disorders are frequently observed. Among them, it is very rare to observe cutaneous PAN associated with positive ANCA. The pathophysiological mechanisms are discussed...
  33. pmc Sentinel lymph node biopsy in melanoma: our 8-year clinical experience in a single French institute (2002-2009)
    Caroline Biver-Dalle
    Department of Dermatology, Besancon University Hospital, Besancon, France
    BMC Dermatol 12:21. 2012
    ..Since the introduction of sentinel lymph node biopsy (SLNB), its use as a standard of care for patients with clinically node-negative cutaneous melanoma remains controversial. We wished to evaluate our experience of SLNB for melanoma...
  34. ncbi request reprint Use of amniotic membrane transplantation in the treatment of venous leg ulcers
    Isabelle Mermet
    Universite de Franche Comte, Department of Dermatology, University Hospital and Medical School, Besancon, France
    Wound Repair Regen 15:459-64. 2007
    ..AM transplantation may thus be considered to be an alternative method for treating chronic leg ulcers...
  35. doi request reprint Primary cutaneous lymphomas: a population-based descriptive study of 71 consecutive cases diagnosed between 1980 and 2003
    Marie Odile Riou-Gotta
    Service de Dermatologie, CHU de Besancon, France
    Leuk Lymphoma 49:1537-44. 2008
    ..20 and 0.08, respectively and did not vary significantly from 1980-1984 to 2000-2003. Five-year survival was 64.5% for PCL patients similar to MF patients. Our results provide updated data on the incidence of PCL in France...
  36. ncbi request reprint Towards objective evaluation of the skin aspect: principles and instrumentation
    Patrick Sandoz
    Département d Optique PM Duffieux, Institut FEMTO ST, UMR CNRS 6174, Universite de Franche Comte, Besancon, France
    Skin Res Technol 10:263-70. 2004
    ..This work is based on light scattering phenomena and in-vivo measurements of the skin profile and of the skin Bi-directional Reflection Distribution Function (BRDF)...
  37. ncbi request reprint Indication of fibroblast apoptosis during the maturation of disc-shaped mechanically stressed collagen lattices
    Jacqueline Bride
    Laboratoire d ingénierie et de biologie cutanées, UFR Medecine Pharmacie, 25030 Besancon, France
    Arch Dermatol Res 295:312-7. 2004
    ....
  38. ncbi request reprint [City/hospital networks for leg ulcers and treatment with ialuset]
    Philippe Humbert
    Service de Dermatologie, Hôpital Universitaire de Franche Comté, Besancon, France
    Ann Dermatol Venereol 129:1231-4. 2002
  39. ncbi request reprint Pulmonary and cutaneous sarcoidosis associated with interferon therapy for melanoma
    Fabien Pelletier
    Department of Dermatology, Centre Hospitalier Universitaire de Besancon, l Université de Franche Comté, France
    Cutis 80:441-5. 2007
    ..Other than interferon therapy, sarcoidosis or granulomatosis reactions rarely have been reported in malignant melanoma. We discuss and review the literature on the physiopathology of sarcoidosis brought on by interferon therapy...
  40. ncbi request reprint Validation of a microdialysis-gas chromatographic-mass spectrometric method to assess 8-methoxypsoralen in psoriatic patient dermis
    Nathalie Leveque
    Laboratoire d ingénierie et de biologie cutanées, Faculte de Medecine et de Pharmacie, Hopital Saint Jacques, Place Saint Jacques, 25030, Cedex, Besancon, France
    J Chromatogr B Analyt Technol Biomed Life Sci 780:119-27. 2002
    ..The results demonstrated that the association of microdialysis with the GC-MS method was an efficient procedure to collect and assess 8-MOP in human dermis, in vivo...
  41. ncbi request reprint Demodicidosis in a child with xantholeukaemia associated with type 1 neurofibromatosis
    Mouna Benessahraoui
    Department of Dermatology, 2 Place Saint Jacques, 25030 Besancon Cedex, France
    Eur J Dermatol 13:311-2. 2003
    ..The eruption cleared after oral and topical metronidazole therapy. Demodicidosis should be included in the differential diagnosis of facial eruption in immunosuppressed children...
  42. doi request reprint Onset or exacerbation of cutaneous psoriasis during TNFalpha antagonist therapy
    Daniel Wendling
    Rheumatology Department, CHU Jean Minjoz, Minjoz Teaching Hospital, Franche Comte University, Boulevard Fleming, 25030 Besancon Cedex, France
    Joint Bone Spine 75:315-8. 2008
    ..Cutaneous psoriasis is an example, of which several cases have been reported...
  43. doi request reprint Cutaneous manifestations of human toxocariasis
    Béatrice Gavignet
    Department of Parasitology and Mycology, Jean Minjoz University Hospital, Besancon, France
    J Am Acad Dermatol 59:1031-42. 2008
    ..In this review, we focus on these particular skin manifestations regarding their clinical description, diagnosis, and treatment...
  44. ncbi request reprint Influence of the hydrophobic and hydrophilic characteristics of sliding and slider surfaces on friction coefficient: in vivo human skin friction comparison
    Ahmed Elkhyat
    Laboratoire d ingénierie et de biologie cutanée, Universite de Franche Comte, Besancon, France
    Skin Res Technol 10:215-21. 2004
    ....
  45. ncbi request reprint Lack of expression of an alternative CD20 transcript variant in circulating B cells from patients with pemphigus
    Clémentine Gamonet
    Inserm UMR 1098, Etablissement Français du Sang Bourgogne Franche Comté, Besancon, France
    Exp Dermatol 23:66-7. 2014
    ..Further study of RTX non-responders or non-escaping PV patients is thus still required to appreciate whether D393-CD20 expression may be detected under the pressure of RTX therapy...
  46. ncbi request reprint [Exanthem, erythrodermia]
    Eve Puzenat
    Service de Dermatologie, CHU Saint Jacques, 25030 Besancon Cedex
    Rev Prat 58:783-8. 2008
  47. ncbi request reprint [Management of a patient receiving thalidomide]
    Hélène Brocvielle
    Laboratoire d ingénierie et de biologie cutanées, Faculte de Medecine et de Pharmacie, Besancon
    Presse Med 32:1894-8. 2003
    ..The latter limit the long-term use of thalidomide and imply strict rules for its prescription and surveillance (efficient contraception, clinical neurological examinations, electroneurophysiological controls)...
  48. doi request reprint Comparative study of stress and quality of life in outpatients consulting for different dermatoses in 5 academic departments of dermatology
    Laurent Misery
    Service de Dermatologie, CHU Brest, Brest, France
    Eur J Dermatol 18:412-5. 2008
    ..On the contrary, patients with psoriasis had a very high level of perceived stress and a deeply altered quality of life...
  49. ncbi request reprint Phase-unwrapping algorithm for images with high noise content based on a local histogram
    Jaime Meneses
    Grupo de Óptica y Tratamiento de Señales, Escuela de Fisica, Universidad Industrial de Santander, A A 678 Bucaramanga, Colombia
    Appl Opt 44:1207-15. 2005
    ..The algorithm has been used successfully to unwrap phase images generated in a three-dimensional shape measurement for noninvasive quantification of human skin structure in dermatology, cosmetology, and plastic surgery...
  50. ncbi request reprint Effects of cigarette smoking on the skin of women
    Adeline Petitjean
    J Dermatol Sci 42:259-61. 2006
  51. ncbi request reprint Development of a new sensor based on micro-electro-mechanical systems for objective in vivo measurement of the cutaneous temperature: application to foundations
    Rodolphe Korichi
    LVMH Recherche, 45804 Saint Jean de Braye, France
    Skin Res Technol 12:206-10. 2006
    ..Research on this new sensor was carried out to allow the quantification of the thermal properties of the made-up skin...
  52. ncbi request reprint Geometrical capillary network analysis
    Jean Marie Sainthillier
    LIBC Laboratoire d Ingénierie et de Biologie Cutanées, Service de Dermatologie 1, Centre Hospitalo Universitaire, Besancon Cedex, France
    Skin Res Technol 9:312-20. 2003
    ..For characterizing capillary ensembles, the statistical and geometrical properties of the network need to be explored...
  53. ncbi request reprint Low incidence of polymorphous light eruption in renal transplant recipients
    Bouteina Benanni
    Acta Derm Venereol 87:372-4. 2007