Philippe Humbert

..Objective: The purpose of our study was to assess the risk of having a positive Toxocara ELISA test in patients with different cutaneous symptoms...

..Sun exposure, PUVA therapy and ionizing radiation are potentially acneigenous. Finally acne caused by cosmetics includes acne cosmetica, brilliantine and oily creams acne and detergent acne...

..Videocapillaroscopy associated to an image processing and laser Doppler flowmetry revealed different vascular layers. So the combination of both instruments offers an easy way to observe the architectural frameworks in vivo...

..HA gauze pad, in local treatment of venous leg ulcers, was significantly more effective than the neutral vehicle on wound size reduction, healed ulcers rate and pain management with a good safety profile...

..Supportive care consist of covering areas of cutaneous detachment. No other therapy has demonstrated its efficiency, but high-dose intravenous immunoglobulin might improve the prognosis...

..The numerous age-related changes in human skin that are supposed to be involved in wrinkling are briefly reviewed, and the current theories on wrinkle formation linked to these changes are also discussed...

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..Its role in the skin biology appears to be less vital than that of the lipids constituting the permeability barrier of the stratum corneum...

..Intestinal biopsy is usually needed to establish the diagnosis of CD or GI. Thus, gluten intolerance gives rise to a variety of dermatological manifestations which may benefit from a gluten-free diet...

..Thus, many fields of dermatology were the object of research which opens new prospects for diagnosis and treatment...

..The contractile properties of fibroblasts from striae distensae varies depending on the stage of the disease. In early striae distensae, fibroblasts acquire a more contractile phenotype, corresponding to that of myofibroblasts...

..In oncology, dermal equivalent may be indicated to cover losses of substance related to skin tumors or after the removal of skin flaps...

..This situation provokes the accumulation of these molecules which were considered by some authors as the cause of skin toxicities and carcinogenicity...

..Indeed, human skin is naturally under tension. Taking into account these features, the purpose of this work was to obtain a cellularized dermal equivalent (CDE), composed of collagen and dermal fibroblasts...

..Since the introduction of sentinel lymph node biopsy (SLNB), its use as a standard of care for patients with clinically node-negative cutaneous melanoma remains controversial. We wished to evaluate our experience of SLNB for melanoma...

..The aim of this study was to validate an optic device used to measure the quantity of light reflected by the skin, which depends on the brightness of the skin...

..The aim of this study was to assess the visual impact on the skin of repeated ultraviolet-A (UVA) exposure through a window...

..The assessment of ascorbic acid and its metabolites in human dermis could be an efficient tool to demonstrate the oxidative process and consequently to control the efficiency of sunscreen creams against undesirable UV effects...

..The limits of detection and quantification were respectively 0.12 and 0.4 ng/ml for GSH and 0.2 and 0.5 ng/ml for GSSG. Intra-day and inter-day accuracy and precision were determined and the variability was less than 6.2% (R.S.D.)...

..20 and 0.08, respectively and did not vary significantly from 1980-1984 to 2000-2003. Five-year survival was 64.5% for PCL patients similar to MF patients. Our results provide updated data on the incidence of PCL in France...

..This work is based on light scattering phenomena and in-vivo measurements of the skin profile and of the skin Bi-directional Reflection Distribution Function (BRDF)...

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..We have evaluated the differences in the skin surface properties of three ethnic groups: Black, African or Caribbean Mixed-race and Caucasian women living in defined climatic conditions...

..Other than interferon therapy, sarcoidosis or granulomatosis reactions rarely have been reported in malignant melanoma. We discuss and review the literature on the physiopathology of sarcoidosis brought on by interferon therapy...

..Cutaneous psoriasis is an example, of which several cases have been reported...

..Post-menopausal skin aging has intrinsic as well as extrinsic origins, and this process induces important disparities of appearance and feeling within an age range...

..In this review, we focus on these particular skin manifestations regarding their clinical description, diagnosis, and treatment...

..Auto-immune disorders are frequently observed. Among them, it is very rare to observe cutaneous PAN associated with positive ANCA. The pathophysiological mechanisms are discussed...

..The latter limit the long-term use of thalidomide and imply strict rules for its prescription and surveillance (efficient contraception, clinical neurological examinations, electroneurophysiological controls)...

..AM transplantation may thus be considered to be an alternative method for treating chronic leg ulcers...

..On the contrary, patients with psoriasis had a very high level of perceived stress and a deeply altered quality of life...

..CONCLUSION: This neural filter system is capable of real-time processing; it recognizes capillaries anywhere in an image, and operates successfully under wide range of lighting and noisy conditions...

..The eruption cleared after oral and topical metronidazole therapy. Demodicidosis should be included in the differential diagnosis of facial eruption in immunosuppressed children...

..The algorithm has been used successfully to unwrap phase images generated in a three-dimensional shape measurement for noninvasive quantification of human skin structure in dermatology, cosmetology, and plastic surgery...

..Moreover, the contact angle measurement with bidistilled water illustrated the increased wettability of the skin...

..Research on this new sensor was carried out to allow the quantification of the thermal properties of the made-up skin...

..7 +/- 0.6 vs. 176.8 +/- 14.5 microg/ml, respectively). CONCLUSION: These results suggest that iron and AA dermis levels could be indicators of inflammatory tissues and might be implicated in dermatological diseases such as AD...

..In association with an example-based detection system, this method can be generalized to other stimuli in the same conditions...

..These results suggest that AF and FF do not respond to UVB by the same pathway...

..The interference fringe profilometry associated with videocapillaroscopy may be useful and accurate to measure the efficacy of medical or cosmetic products to delay skin aging...

..8 +/- 29.0 microg/ml) (p<0.05). These results demonstrate that psoriatic patients exhibit high iron and low ascorbic acid concentrations in the dermis, but there were no significant differences between involved and uninvolved skin...

..The results demonstrated that the association of microdialysis with the GC-MS method was an efficient procedure to collect and assess 8-MOP in human dermis, in vivo...