Genomes and Genes
Jean Pierre Hugot
- CARD15/NOD2 analyses in spondylarthropathyCorinne Miceli-Richard
Foundation Jean Dausset CEPH, Paris, France
Arthritis Rheum 46:1405-6. 2002
- Familial and genetic aspects of spondyloarthropathyMaxime Breban
Department of Rheumatology, Medical University of Paris Ile de France Ouest, Hopital Ambroise Pare, 9 avenue Charles de Graulle, 92100 Boulogne Billancourt, Paris, France
Rheum Dis Clin North Am 29:575-94. 2003....
- Inflammatory bowel disease: a complex group of genetic disordersJean Pierre Hugot
Department of Paediatric Gastroenterology and Nutrition, Programme AVENIR, INSERM U458, Hopital Robert Debre, 48, bd Serurier, 75019 Paris, France
Best Pract Res Clin Gastroenterol 18:451-62. 2004..Because it is involved in the innate immunity, it allows to speculate that CD is the result of a defect in host-bacteria interaction. However, it is not known if CD is caused by specific bacteria or the gut flora as a whole...
- 12-month follow-up after successful infliximab therapy in pediatric crohn diseaseJan Wynands
AP HP, Hopital Necker Enfants Malades, Department of Pediatrics, Pediatric Gastroenterology, Paris, France
J Pediatr Gastroenterol Nutr 46:293-8. 2008..Given the increasing safety concerns about the concomitant and prolonged use of IFX and azathioprine in CD, we wanted to address the clinical outcome in pediatric CD patients who responded to IFX medication, once IFX was stopped...
- On the use of haplotype phylogeny to detect disease susceptibility lociClaire Bardel
Unité de Recherche en Génétique Epidémiologique et Structure des Populations Humaines, INSERM U535, Villejuif, France
BMC Genet 6:24. 2005..However, the performance of this approach for the study of the genetic factors involved in complex diseases has never been studied...
- Genetic origin of IBDJean Pierre Hugot
Fondation Jean Dausset and Hôpital Robert Debré, Assistance Publique Hopitaux de Paris, Paris, France
Inflamm Bowel Dis 10:S11-5. 2004
- Crohn's disease: the cold chain hypothesisJean Pierre Hugot
Laboratoire de Génétique des Maladies Inflammatoires de l Intestin, Projet Avenir INSERM, Fondation Jean Dausset CEPH, Paris, France
Lancet 362:2012-5. 2003....
- Ileal involvement is age dependent in pediatric Crohn's diseaseUlrich Meinzer
Department of Paediatric Gastroenterology, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
Inflamm Bowel Dis 11:639-44. 2005..In contrast, colonic LFs are isolated and undergo little change during life. As a result, if LFs play a role in the occurrence of CD lesions, the distribution of ileal and colonic lesions is expected to be altered in small children...
- CARD15/NOD2 is required for Peyer's patches homeostasis in miceFrederick Barreau
U843, INSERM, Paris, France UMR S843, Universite Paris Diderot, Paris, France
PLoS ONE 2:e523. 2007..Using a new mouse model invalidated for Card15/Nod2 (KO), we thus analysed the impact of the gene in these lymphoid formations together with the development of experimental colitis...
- A prospective study of the efficacy and tolerance of a chimeric antibody to tumor necrosis factors (remicade) in severe pediatric crohn diseaseJean Pierre Cezard
Pediatric Gastroenterology Unit, Hopital Robert Debre, dagger Pediatric Gastroenterology Unit, Hopital Necker Enfants Malades, and double dagger Laboratory of Coprology, Hopital Pitie Salpetriere, Paris, France
J Pediatr Gastroenterol Nutr 36:632-6. 2003..One patient received only one injection. Eighteen patients were corticosteroid dependent, and 6 were receiving parenteral nutrition. Three patients were corticoid resistant (1 mg/kg/d >15 days). Sixteen had perianal disease...
- Significant linkage to spondyloarthropathy on 9q31-34Corinne Miceli-Richard
Laboratoire de Génétique des Maladies Inflammatoires de l Intestin et Fondation Jean Dausset CEPH, Paris, France
Hum Mol Genet 13:1641-8. 2004..87, LOD=5.15, P=0.00002). This result provides evidence for the presence of a non-MHC susceptibility locus for SpA mapping to 9q31-34...
- Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patchesFrederick Barreau
INSERM, U843, Paris, France
Gut 59:207-17. 2010..It thus appears that Nod2 modulates the cross-talk between CD4(+) T cells and the epithelium recovering PP and that it downregulates the pro-inflammatory effect driven by the ileal microflora, likely by inhibiting the TLR pathways...
- Lessons to be learned from the NOD2 gene in Crohn's diseaseJean Pierre Hugot
Fondation Jean Dausset CEPH, Paris, France
Eur J Gastroenterol Hepatol 15:593-7. 2003....
- Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphismsCamille Jung
Universite Paris Diderot, UMR843, Paris, France
PLoS ONE 7:e52223. 2012..However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and phenotypes for the main 53 CD-associated polymorphisms...
- Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signalingCamille Jung
Universite Paris Diderot, UMR843, Paris, France
J Clin Invest 122:2239-51. 2012..Therefore, Y. pseudotuberculosis subverts intestinal barrier function by altering the interplay between immune and epithelial cells during infection...
- Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunctionUlrich Meinzer
Universite Paris Diderot, Paris, France
Cell Host Microbe 11:337-51. 2012..Thus, YopJ alters intestinal permeability and promotes the dissemination of Yersinia as well as commensal bacteria by exploiting the mucosal inflammatory response...
- Clustering of Crohn's disease within affected sibshipsJean Pierre Hugot
Fondation Jean Dausset CEPH, Paris, France
Eur J Hum Genet 11:179-84. 2003..More generally, the CAST statistics may be widely applicable to estimate the involvement of environmental factors in the aetiology of other binary traits which may be observed in multiple members of the same sibship...
- Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort studyLaurent Beaugerie
Department of Gastroenterology, Assistance Publique Hopitaux de Paris AP HP, Hopital Saint Antoine, Universite Pierre et Marie Curie Paris VI, Paris, France
Lancet 374:1617-25. 2009..Reports of an increased risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease are controversial. We assessed this risk in a prospective observational cohort study...
- CARD15/NOD2 is not a predisposing factor for necrotizing enterocolitisHabib Zouali
Fondation Jean Dausset CEPH, Universite, Paris, France
Dig Dis Sci 50:1684-7. 2005..Our results suggest that CARD15/NOD2 does not play a major role in genetic susceptibility to NEC...
- CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel diseaseSuzanne Lesage
Fondation Jean Dausset CEPH, 27 rue Juliette Dodu, 75010 Paris, France
Am J Hum Genet 70:845-57. 2002..These findings provide tools for a DNA-based test of susceptibility and for genetic counseling in inflammatory bowel disease...
- Estimating the odds ratios of Crohn disease for the main CARD15/NOD2 mutations using a conditional maximum likelihood method in pedigrees collected via affected family membersLeigh Pascoe
Fondation Jean Dausset CEPH, Paris, France
Eur J Hum Genet 15:864-71. 2007..This last observation illustrates the power of this approach, especially for alleles with low or moderate frequency in the general population...
- Defective IL10 signaling defining a subgroup of patients with inflammatory bowel diseaseBernadette Begue
INSERM U989, Paris, France
Am J Gastroenterol 106:1544-55. 2011..Thus, we aimed to further elaborate the hypothesis of defective anti-inflammatory responses in patients with IBD...
- Nod2 and Crohn's disease: many connected highwaysUlrich Meinzer
INSERM U458, Department of Paediatric Gastroenterology, Hopital Robert Debre, 75019 Paris, France
Lancet 365:1752-4. 2005
- CARD15/NOD2 mutations in Crohn's diseaseJean Pierre Hugot
INSERM Avenir U458, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
Ann N Y Acad Sci 1072:9-18. 2006..Despite a large amount of work, a consensus model explaining the effect of Card 15/NoD2 mutations did not emerge, and the disease mechanisms are still subject to debate...
- Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensingStephen E Girardin
Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris, France
Trends Immunol 24:652-8. 2003..Together, studies on Nod2 (Card15) provide a conceptual link between inflammatory disorders, such as Crohn's disease and Blau syndrome, and bacterial sensing...
- Microvillous inclusion disease: how to improve the prognosis of a severe congenital enterocyte disorderUgur Halac
Pediatric Gastroenterology, Hepatology and Nutrition Unit, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, France
J Pediatr Gastroenterol Nutr 52:460-5. 2011....
- Nod2 mediates susceptibility to Yersinia pseudotuberculosis in miceUlrich Meinzer
INSERM, U843, Universite Paris 7, Hopital Robert Debre, Paris, France
PLoS ONE 3:e2769. 2008..This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice...
- Prevalence of CARD15/NOD2 mutations in Caucasian healthy peopleJean Pierre Hugot
INSERM Avenir U763 AP HP Université Paris 7, Hopital Robert Debre, Paris, France
Am J Gastroenterol 102:1259-67. 2007..This high risk may support the opinion that CARD15/NOD2 variants are strong CD risk factors at the individual and population levels...
- Implication of phylogenetic systematics of rodent-borne hantaviruses allows understanding of their distributionVincent Herbreteau
Institut de Recherche pour le Developpement, Paris, France
Ann N Y Acad Sci 1081:39-56. 2006..New viruses, different hosts, and different human syndromes may be discovered in the future mainly in Southeastern Asia and in Africa where Muridae rodents are present and highly diversified...
- Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxinJoao Gamelas Magalhaes
Unité de Pathogénie Microbienne Moléculaire INSERM U389, Paris, France
EMBO Rep 6:1201-7. 2005..This study thereby identifies Nod1 as the long sought after sensor of TCT in mammals...
- A remarkable case of micro-endemism in Laonastes aenigmamus (Diatomyidae, Rodentia) revealed by nuclear and mitochondrial DNA sequence dataViolaine Nicolas
UMR CNRS 7205, Departement Systematique et Evolution, Museum national d histoire naturelle, Paris, France
PLoS ONE 7:e48145. 2012..This work increases the necessity for a strict protection of this rare animal and its habitat and provides exclusive information, essential to the organization of its protection...
- Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's diseaseElodie Thachil
Univ Paris Diderot, Sorbonne Paris Cité, France
Gastroenterology 142:1097-1099.e4. 2012..These observations might account for the disorganization of secretory granules previously reported in Paneth cells from patients with CD...
- Prolonged enteral feeding is often required to avoid long-term nutritional and metabolic complications after esophagogastric dissociationChrystele Madre
Assistance Publique Hopitaux de Paris, Universite Paris Diderot, Hopital Robert Debre, Paris, France
J Pediatr Gastroenterol Nutr 50:280-6. 2010..Although the long-term results in terms of GERD control have been previously reported, those regarding the nutritional and metabolic status have never been documented...
- Inflammatory bowel diseases: the paediatric gastroenterologist's perspectiveJean Pierre Hugot
INSERM U843, Universite Paris VII, 48 Bd Serurier, Paris, 75019, France
Pediatr Radiol 37:1065-70. 2007..Finally, new imaging methods are useful during patient follow-up for assessing disease activity and for the diagnosis of complications...
- Ontogeny of the cranial system in Laonastes aenigmamusAnthony Herrel
UMR CNRS MNHN 7179, Mécanismes adaptatifs des organismes aux communautés, Paris, France
J Anat 221:128-37. 2012..Our data suggest a functional signal in the development of the unusual cranial morphology, possibly associated with the folivorous trophic ecology of the species...
- Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free dietJacques Cosnes
Service de Gastroenterologie et Nutrition, Hôpital St Antoine and Université Pierre and Marie Curie, Paris, France
Clin Gastroenterol Hepatol 6:753-8. 2008..Celiac disease may be associated with autoimmune diseases. The aims of the present study were to determine in celiac patients which factors modulate the risk of autoimmune disease and to evaluate the effect of the gluten-free diet...
- Peyer's Patches: The Immune Sensors of the IntestineCamille Jung
UMR843 INSERM, Université Sorbonne Paris Cité Diderot, Hopital Robert Debre, 75019 Paris, France
Int J Inflam 2010:823710. 2010..Two human disorders, Crohn's disease and graft-versus-host disease are thought to be driven by an abnormal response toward the commensal flora. They have been associated with NOD2 mutations and PP dysfunction...
- Genetic analysis of Thailand hantavirus in Bandicota indica trapped in ThailandJean Pierre Hugot
OSEB, UMR 5202 du CNRS, Museum national d histoire naturelle, Paris, France
Virol J 3:72. 2006..On the phylogenetic trees they formed a well-supported cluster within the group of Murinae-associated hantaviruses and shared a recent common ancestor with Seoul virus...
- Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseasesMathias Chamaillard
Fondation Jean Dausset, Centre d Etude du Polymorphisme Humain, 27 rue Juliette Dodu, 75010 Paris, France
Proc Natl Acad Sci U S A 100:3455-60. 2003....
- NOD2/CARD15 does not influence response to infliximab in Crohn's diseaseSeverine Vermeire
Department of Gastroenterology, UZ Gasthuisberg, Leuven, Belgium
Gastroenterology 123:106-11. 2002..It is not clear which factors influence treatment outcome. We assessed whether variants in NOD2/CARD15 are predictive for differences in clinical response...
- [Role of NOD2 gene in Crohn's disease]Jean Pierre Hugot
Gastroenterol Clin Biol 26:13-5. 2002
- The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interactionMarie Pierik
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Inflamm Bowel Dis 11:1-7. 2005..To further characterize this locus, we assessed gene-environment interaction (IBD4 x smoking) and phenotypic heterogeneity in a large cohort of IBD-affected sibling pairs as part of an ongoing international collaborative effort...
- Inflammatory bowel disease: causes and consequencesJean Pierre Hugot
Best Pract Res Clin Gastroenterol 18:447-9. 2004
- The NOD2-RICK complex signals from the plasma membranePatrick Lecine
Centre de Recherche en Cancerologie de Marseille, UMR 599 INSERM Institut Paoli Calmettes Universitédela Méditerranée, 27 Boulevard LeïRoure, 13009 Marseille, France
J Biol Chem 282:15197-207. 2007..Thus, our data suggest that NOD2 is responsible for the membrane recruitment of RICK to induce a regulated NF-kappaB signaling and production of proinflammatory cytokines...
- Phylogenetic systematics and evolution of primate-derived Pneumocystis based on mitochondrial or nuclear DNA sequence comparisonJean Pierre Hugot
Museum national d histoire naturelle, Departement Systematique et Evolution, UMS Origine, Structure et Evolution de la Biodiversité, 75 231 Paris Cedex 05, France
Syst Biol 52:735-44. 2003..This study also provides support for the hypothesis that the different Pneumocystis species are genetically independent organisms, helping to clarify their taxonomic status...
- Sporadic Blau syndrome with a double CARD15 mutation. Report of a case with lifelong follow-upRoberta Priori
Cattedra di Reumatologia, Dipartimento di Terapia Medica Applicata, Universita La Sapienza, Rome, Italy
Sarcoidosis Vasc Diffuse Lung Dis 21:228-31. 2004..An extensive radiologic, histologic and laboratory evaluation and a life-long clinical follow-up is available for this patient who presented skin, joint, epididimal and eye involvement...
- NOD2: a potential target for regulating liver injuryMathilde Body-Malapel
INSERM U795, Lille, France
Lab Invest 88:318-27. 2008..Taken together, our results indicate that NOD2 may represent a new therapeutic target in liver diseases...
- PPAR and Crohn's disease: another piece of the puzzle?Jean Pierre Hugot
Gastroenterology 128:500-3. 2005
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseJeffrey C Barrett
Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Genet 40:955-62. 2008..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...