Jean Pierre Hugot

Summary

Country: France

Publications

  1. ncbi request reprint CARD15/NOD2 analyses in spondylarthropathy
    Corinne Miceli-Richard
    Foundation Jean Dausset CEPH, Paris, France
    Arthritis Rheum 46:1405-6. 2002
  2. ncbi request reprint Familial and genetic aspects of spondyloarthropathy
    Maxime Breban
    Department of Rheumatology, Medical University of Paris Ile de France Ouest, Hopital Ambroise Pare, 9 avenue Charles de Graulle, 92100 Boulogne Billancourt, Paris, France
    Rheum Dis Clin North Am 29:575-94. 2003
  3. ncbi request reprint Inflammatory bowel disease: a complex group of genetic disorders
    Jean Pierre Hugot
    Department of Paediatric Gastroenterology and Nutrition, Programme AVENIR, INSERM U458, Hopital Robert Debre, 48, bd Serurier, 75019 Paris, France
    Best Pract Res Clin Gastroenterol 18:451-62. 2004
  4. doi request reprint 12-month follow-up after successful infliximab therapy in pediatric crohn disease
    Jan Wynands
    AP HP, Hopital Necker Enfants Malades, Department of Pediatrics, Pediatric Gastroenterology, Paris, France
    J Pediatr Gastroenterol Nutr 46:293-8. 2008
  5. pmc On the use of haplotype phylogeny to detect disease susceptibility loci
    Claire Bardel
    Unité de Recherche en Génétique Epidémiologique et Structure des Populations Humaines, INSERM U535, Villejuif, France
    BMC Genet 6:24. 2005
  6. ncbi request reprint Genetic origin of IBD
    Jean Pierre Hugot
    Fondation Jean Dausset and Hôpital Robert Debré, Assistance Publique Hopitaux de Paris, Paris, France
    Inflamm Bowel Dis 10:S11-5. 2004
  7. ncbi request reprint Crohn's disease: the cold chain hypothesis
    Jean Pierre Hugot
    Laboratoire de Génétique des Maladies Inflammatoires de l Intestin, Projet Avenir INSERM, Fondation Jean Dausset CEPH, Paris, France
    Lancet 362:2012-5. 2003
  8. ncbi request reprint Ileal involvement is age dependent in pediatric Crohn's disease
    Ulrich Meinzer
    Department of Paediatric Gastroenterology, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
    Inflamm Bowel Dis 11:639-44. 2005
  9. pmc CARD15/NOD2 is required for Peyer's patches homeostasis in mice
    Frederick Barreau
    U843, INSERM, Paris, France UMR S843, Universite Paris Diderot, Paris, France
    PLoS ONE 2:e523. 2007
  10. ncbi request reprint A prospective study of the efficacy and tolerance of a chimeric antibody to tumor necrosis factors (remicade) in severe pediatric crohn disease
    Jean Pierre Cezard
    Pediatric Gastroenterology Unit, Hopital Robert Debre, dagger Pediatric Gastroenterology Unit, Hopital Necker Enfants Malades, and double dagger Laboratory of Coprology, Hopital Pitie Salpetriere, Paris, France
    J Pediatr Gastroenterol Nutr 36:632-6. 2003

Detail Information

Publications49

  1. ncbi request reprint CARD15/NOD2 analyses in spondylarthropathy
    Corinne Miceli-Richard
    Foundation Jean Dausset CEPH, Paris, France
    Arthritis Rheum 46:1405-6. 2002
  2. ncbi request reprint Familial and genetic aspects of spondyloarthropathy
    Maxime Breban
    Department of Rheumatology, Medical University of Paris Ile de France Ouest, Hopital Ambroise Pare, 9 avenue Charles de Graulle, 92100 Boulogne Billancourt, Paris, France
    Rheum Dis Clin North Am 29:575-94. 2003
    ....
  3. ncbi request reprint Inflammatory bowel disease: a complex group of genetic disorders
    Jean Pierre Hugot
    Department of Paediatric Gastroenterology and Nutrition, Programme AVENIR, INSERM U458, Hopital Robert Debre, 48, bd Serurier, 75019 Paris, France
    Best Pract Res Clin Gastroenterol 18:451-62. 2004
    ..Because it is involved in the innate immunity, it allows to speculate that CD is the result of a defect in host-bacteria interaction. However, it is not known if CD is caused by specific bacteria or the gut flora as a whole...
  4. doi request reprint 12-month follow-up after successful infliximab therapy in pediatric crohn disease
    Jan Wynands
    AP HP, Hopital Necker Enfants Malades, Department of Pediatrics, Pediatric Gastroenterology, Paris, France
    J Pediatr Gastroenterol Nutr 46:293-8. 2008
    ..Given the increasing safety concerns about the concomitant and prolonged use of IFX and azathioprine in CD, we wanted to address the clinical outcome in pediatric CD patients who responded to IFX medication, once IFX was stopped...
  5. pmc On the use of haplotype phylogeny to detect disease susceptibility loci
    Claire Bardel
    Unité de Recherche en Génétique Epidémiologique et Structure des Populations Humaines, INSERM U535, Villejuif, France
    BMC Genet 6:24. 2005
    ..However, the performance of this approach for the study of the genetic factors involved in complex diseases has never been studied...
  6. ncbi request reprint Genetic origin of IBD
    Jean Pierre Hugot
    Fondation Jean Dausset and Hôpital Robert Debré, Assistance Publique Hopitaux de Paris, Paris, France
    Inflamm Bowel Dis 10:S11-5. 2004
  7. ncbi request reprint Crohn's disease: the cold chain hypothesis
    Jean Pierre Hugot
    Laboratoire de Génétique des Maladies Inflammatoires de l Intestin, Projet Avenir INSERM, Fondation Jean Dausset CEPH, Paris, France
    Lancet 362:2012-5. 2003
    ....
  8. ncbi request reprint Ileal involvement is age dependent in pediatric Crohn's disease
    Ulrich Meinzer
    Department of Paediatric Gastroenterology, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
    Inflamm Bowel Dis 11:639-44. 2005
    ..In contrast, colonic LFs are isolated and undergo little change during life. As a result, if LFs play a role in the occurrence of CD lesions, the distribution of ileal and colonic lesions is expected to be altered in small children...
  9. pmc CARD15/NOD2 is required for Peyer's patches homeostasis in mice
    Frederick Barreau
    U843, INSERM, Paris, France UMR S843, Universite Paris Diderot, Paris, France
    PLoS ONE 2:e523. 2007
    ..Using a new mouse model invalidated for Card15/Nod2 (KO), we thus analysed the impact of the gene in these lymphoid formations together with the development of experimental colitis...
  10. ncbi request reprint A prospective study of the efficacy and tolerance of a chimeric antibody to tumor necrosis factors (remicade) in severe pediatric crohn disease
    Jean Pierre Cezard
    Pediatric Gastroenterology Unit, Hopital Robert Debre, dagger Pediatric Gastroenterology Unit, Hopital Necker Enfants Malades, and double dagger Laboratory of Coprology, Hopital Pitie Salpetriere, Paris, France
    J Pediatr Gastroenterol Nutr 36:632-6. 2003
    ..One patient received only one injection. Eighteen patients were corticosteroid dependent, and 6 were receiving parenteral nutrition. Three patients were corticoid resistant (1 mg/kg/d >15 days). Sixteen had perianal disease...
  11. ncbi request reprint Significant linkage to spondyloarthropathy on 9q31-34
    Corinne Miceli-Richard
    Laboratoire de Génétique des Maladies Inflammatoires de l Intestin et Fondation Jean Dausset CEPH, Paris, France
    Hum Mol Genet 13:1641-8. 2004
    ..87, LOD=5.15, P=0.00002). This result provides evidence for the presence of a non-MHC susceptibility locus for SpA mapping to 9q31-34...
  12. doi request reprint Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches
    Frederick Barreau
    INSERM, U843, Paris, France
    Gut 59:207-17. 2010
    ..It thus appears that Nod2 modulates the cross-talk between CD4(+) T cells and the epithelium recovering PP and that it downregulates the pro-inflammatory effect driven by the ileal microflora, likely by inhibiting the TLR pathways...
  13. ncbi request reprint Lessons to be learned from the NOD2 gene in Crohn's disease
    Jean Pierre Hugot
    Fondation Jean Dausset CEPH, Paris, France
    Eur J Gastroenterol Hepatol 15:593-7. 2003
    ....
  14. pmc Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms
    Camille Jung
    Universite Paris Diderot, UMR843, Paris, France
    PLoS ONE 7:e52223. 2012
    ..However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and phenotypes for the main 53 CD-associated polymorphisms...
  15. pmc Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling
    Camille Jung
    Universite Paris Diderot, UMR843, Paris, France
    J Clin Invest 122:2239-51. 2012
    ..Therefore, Y. pseudotuberculosis subverts intestinal barrier function by altering the interplay between immune and epithelial cells during infection...
  16. doi request reprint Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction
    Ulrich Meinzer
    Universite Paris Diderot, Paris, France
    Cell Host Microbe 11:337-51. 2012
    ..Thus, YopJ alters intestinal permeability and promotes the dissemination of Yersinia as well as commensal bacteria by exploiting the mucosal inflammatory response...
  17. ncbi request reprint Clustering of Crohn's disease within affected sibships
    Jean Pierre Hugot
    Fondation Jean Dausset CEPH, Paris, France
    Eur J Hum Genet 11:179-84. 2003
    ..More generally, the CAST statistics may be widely applicable to estimate the involvement of environmental factors in the aetiology of other binary traits which may be observed in multiple members of the same sibship...
  18. doi request reprint Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
    Laurent Beaugerie
    Department of Gastroenterology, Assistance Publique Hopitaux de Paris AP HP, Hopital Saint Antoine, Universite Pierre et Marie Curie Paris VI, Paris, France
    Lancet 374:1617-25. 2009
    ..Reports of an increased risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease are controversial. We assessed this risk in a prospective observational cohort study...
  19. ncbi request reprint CARD15/NOD2 is not a predisposing factor for necrotizing enterocolitis
    Habib Zouali
    Fondation Jean Dausset CEPH, Universite, Paris, France
    Dig Dis Sci 50:1684-7. 2005
    ..Our results suggest that CARD15/NOD2 does not play a major role in genetic susceptibility to NEC...
  20. pmc CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
    Suzanne Lesage
    Fondation Jean Dausset CEPH, 27 rue Juliette Dodu, 75010 Paris, France
    Am J Hum Genet 70:845-57. 2002
    ..These findings provide tools for a DNA-based test of susceptibility and for genetic counseling in inflammatory bowel disease...
  21. ncbi request reprint Estimating the odds ratios of Crohn disease for the main CARD15/NOD2 mutations using a conditional maximum likelihood method in pedigrees collected via affected family members
    Leigh Pascoe
    Fondation Jean Dausset CEPH, Paris, France
    Eur J Hum Genet 15:864-71. 2007
    ..This last observation illustrates the power of this approach, especially for alleles with low or moderate frequency in the general population...
  22. doi request reprint Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease
    Bernadette Begue
    INSERM U989, Paris, France
    Am J Gastroenterol 106:1544-55. 2011
    ..Thus, we aimed to further elaborate the hypothesis of defective anti-inflammatory responses in patients with IBD...
  23. ncbi request reprint Nod2 and Crohn's disease: many connected highways
    Ulrich Meinzer
    INSERM U458, Department of Paediatric Gastroenterology, Hopital Robert Debre, 75019 Paris, France
    Lancet 365:1752-4. 2005
  24. ncbi request reprint CARD15/NOD2 mutations in Crohn's disease
    Jean Pierre Hugot
    INSERM Avenir U458, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Ann N Y Acad Sci 1072:9-18. 2006
    ..Despite a large amount of work, a consensus model explaining the effect of Card 15/NoD2 mutations did not emerge, and the disease mechanisms are still subject to debate...
  25. ncbi request reprint Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris, France
    Trends Immunol 24:652-8. 2003
    ..Together, studies on Nod2 (Card15) provide a conceptual link between inflammatory disorders, such as Crohn's disease and Blau syndrome, and bacterial sensing...
  26. doi request reprint Microvillous inclusion disease: how to improve the prognosis of a severe congenital enterocyte disorder
    Ugur Halac
    Pediatric Gastroenterology, Hepatology and Nutrition Unit, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, France
    J Pediatr Gastroenterol Nutr 52:460-5. 2011
    ....
  27. pmc Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice
    Ulrich Meinzer
    INSERM, U843, Universite Paris 7, Hopital Robert Debre, Paris, France
    PLoS ONE 3:e2769. 2008
    ..This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice...
  28. ncbi request reprint Prevalence of CARD15/NOD2 mutations in Caucasian healthy people
    Jean Pierre Hugot
    INSERM Avenir U763 AP HP Université Paris 7, Hopital Robert Debre, Paris, France
    Am J Gastroenterol 102:1259-67. 2007
    ..This high risk may support the opinion that CARD15/NOD2 variants are strong CD risk factors at the individual and population levels...
  29. ncbi request reprint Implication of phylogenetic systematics of rodent-borne hantaviruses allows understanding of their distribution
    Vincent Herbreteau
    Institut de Recherche pour le Developpement, Paris, France
    Ann N Y Acad Sci 1081:39-56. 2006
    ..New viruses, different hosts, and different human syndromes may be discovered in the future mainly in Southeastern Asia and in Africa where Muridae rodents are present and highly diversified...
  30. pmc Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
    Joao Gamelas Magalhaes
    Unité de Pathogénie Microbienne Moléculaire INSERM U389, Paris, France
    EMBO Rep 6:1201-7. 2005
    ..This study thereby identifies Nod1 as the long sought after sensor of TCT in mammals...
  31. pmc A remarkable case of micro-endemism in Laonastes aenigmamus (Diatomyidae, Rodentia) revealed by nuclear and mitochondrial DNA sequence data
    Violaine Nicolas
    UMR CNRS 7205, Departement Systematique et Evolution, Museum national d histoire naturelle, Paris, France
    PLoS ONE 7:e48145. 2012
    ..This work increases the necessity for a strict protection of this rare animal and its habitat and provides exclusive information, essential to the organization of its protection...
  32. doi request reprint Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease
    Elodie Thachil
    Univ Paris Diderot, Sorbonne Paris Cité, France
    Gastroenterology 142:1097-1099.e4. 2012
    ..These observations might account for the disorganization of secretory granules previously reported in Paneth cells from patients with CD...
  33. doi request reprint Prolonged enteral feeding is often required to avoid long-term nutritional and metabolic complications after esophagogastric dissociation
    Chrystele Madre
    Assistance Publique Hopitaux de Paris, Universite Paris Diderot, Hopital Robert Debre, Paris, France
    J Pediatr Gastroenterol Nutr 50:280-6. 2010
    ..Although the long-term results in terms of GERD control have been previously reported, those regarding the nutritional and metabolic status have never been documented...
  34. ncbi request reprint Inflammatory bowel diseases: the paediatric gastroenterologist's perspective
    Jean Pierre Hugot
    INSERM U843, Universite Paris VII, 48 Bd Serurier, Paris, 75019, France
    Pediatr Radiol 37:1065-70. 2007
    ..Finally, new imaging methods are useful during patient follow-up for assessing disease activity and for the diagnosis of complications...
  35. pmc Ontogeny of the cranial system in Laonastes aenigmamus
    Anthony Herrel
    UMR CNRS MNHN 7179, Mécanismes adaptatifs des organismes aux communautés, Paris, France
    J Anat 221:128-37. 2012
    ..Our data suggest a functional signal in the development of the unusual cranial morphology, possibly associated with the folivorous trophic ecology of the species...
  36. doi request reprint Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet
    Jacques Cosnes
    Service de Gastroenterologie et Nutrition, Hôpital St Antoine and Université Pierre and Marie Curie, Paris, France
    Clin Gastroenterol Hepatol 6:753-8. 2008
    ..Celiac disease may be associated with autoimmune diseases. The aims of the present study were to determine in celiac patients which factors modulate the risk of autoimmune disease and to evaluate the effect of the gluten-free diet...
  37. pmc Peyer's Patches: The Immune Sensors of the Intestine
    Camille Jung
    UMR843 INSERM, Université Sorbonne Paris Cité Diderot, Hopital Robert Debre, 75019 Paris, France
    Int J Inflam 2010:823710. 2010
    ..Two human disorders, Crohn's disease and graft-versus-host disease are thought to be driven by an abnormal response toward the commensal flora. They have been associated with NOD2 mutations and PP dysfunction...
  38. pmc Genetic analysis of Thailand hantavirus in Bandicota indica trapped in Thailand
    Jean Pierre Hugot
    OSEB, UMR 5202 du CNRS, Museum national d histoire naturelle, Paris, France
    Virol J 3:72. 2006
    ..On the phylogenetic trees they formed a well-supported cluster within the group of Murinae-associated hantaviruses and shared a recent common ancestor with Seoul virus...
  39. pmc Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases
    Mathias Chamaillard
    Fondation Jean Dausset, Centre d Etude du Polymorphisme Humain, 27 rue Juliette Dodu, 75010 Paris, France
    Proc Natl Acad Sci U S A 100:3455-60. 2003
    ....
  40. ncbi request reprint NOD2/CARD15 does not influence response to infliximab in Crohn's disease
    Severine Vermeire
    Department of Gastroenterology, UZ Gasthuisberg, Leuven, Belgium
    Gastroenterology 123:106-11. 2002
    ..It is not clear which factors influence treatment outcome. We assessed whether variants in NOD2/CARD15 are predictive for differences in clinical response...
  41. ncbi request reprint [Role of NOD2 gene in Crohn's disease]
    Jean Pierre Hugot
    Gastroenterol Clin Biol 26:13-5. 2002
  42. ncbi request reprint The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction
    Marie Pierik
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Inflamm Bowel Dis 11:1-7. 2005
    ..To further characterize this locus, we assessed gene-environment interaction (IBD4 x smoking) and phenotypic heterogeneity in a large cohort of IBD-affected sibling pairs as part of an ongoing international collaborative effort...
  43. ncbi request reprint Inflammatory bowel disease: causes and consequences
    Jean Pierre Hugot
    Best Pract Res Clin Gastroenterol 18:447-9. 2004
  44. ncbi request reprint The NOD2-RICK complex signals from the plasma membrane
    Patrick Lecine
    Centre de Recherche en Cancerologie de Marseille, UMR 599 INSERM Institut Paoli Calmettes Universitédela Méditerranée, 27 Boulevard LeïRoure, 13009 Marseille, France
    J Biol Chem 282:15197-207. 2007
    ..Thus, our data suggest that NOD2 is responsible for the membrane recruitment of RICK to induce a regulated NF-kappaB signaling and production of proinflammatory cytokines...
  45. ncbi request reprint Phylogenetic systematics and evolution of primate-derived Pneumocystis based on mitochondrial or nuclear DNA sequence comparison
    Jean Pierre Hugot
    Museum national d histoire naturelle, Departement Systematique et Evolution, UMS Origine, Structure et Evolution de la Biodiversité, 75 231 Paris Cedex 05, France
    Syst Biol 52:735-44. 2003
    ..This study also provides support for the hypothesis that the different Pneumocystis species are genetically independent organisms, helping to clarify their taxonomic status...
  46. ncbi request reprint Sporadic Blau syndrome with a double CARD15 mutation. Report of a case with lifelong follow-up
    Roberta Priori
    Cattedra di Reumatologia, Dipartimento di Terapia Medica Applicata, Universita La Sapienza, Rome, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 21:228-31. 2004
    ..An extensive radiologic, histologic and laboratory evaluation and a life-long clinical follow-up is available for this patient who presented skin, joint, epididimal and eye involvement...
  47. doi request reprint NOD2: a potential target for regulating liver injury
    Mathilde Body-Malapel
    INSERM U795, Lille, France
    Lab Invest 88:318-27. 2008
    ..Taken together, our results indicate that NOD2 may represent a new therapeutic target in liver diseases...
  48. ncbi request reprint PPAR and Crohn's disease: another piece of the puzzle?
    Jean Pierre Hugot
    Gastroenterology 128:500-3. 2005
  49. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
    ..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...