Stephane Thobois

Summary

Affiliation: Hospices Civils de Lyon
Country: France

Publications

  1. ncbi request reprint [Advantages and limitations in the assessment of neuroprotective treatment of Parkinson's disease by functional imaging]
    S Thobois
    Service de Neurologie D, CERMEP et INSERM U534, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon
    Rev Neurol (Paris) 161:385-93. 2005
  2. doi request reprint Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil
    Stephane Thobois
    Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Neurologie C 59 Bd Pinel, 69677 Bron, France
    Brain 136:1568-77. 2013
  3. doi request reprint [Imaging non motor signs in Parkinson's disease]
    S Thobois
    CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron Cedex, France
    Rev Neurol (Paris) 168:576-84. 2012
  4. doi request reprint Globus pallidus stimulation reduces frontal hyperactivity in tardive dystonia
    Stephane Thobois
    Université Lyon I, Hospices Civils de Lyon, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Service de Neurologie C, Lyon, France
    J Cereb Blood Flow Metab 28:1127-38. 2008
  5. ncbi request reprint Functional anatomy of motor urgency
    Stephane Thobois
    Université Lyon I, Hospices Civils de Lyon, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Neurologie C, Lyon, France
    Neuroimage 37:243-52. 2007
  6. doi request reprint Pre-operative evaluations for DBS in dystonia
    Stephane Thobois
    Université Lyon I, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer and CNRS, UMR 5229, Lyon, France
    Mov Disord 26:S17-22. 2011
  7. ncbi request reprint Proposed dose equivalence for rapid switch between dopamine receptor agonists in Parkinson's disease: a review of the literature
    Stephane Thobois
    Hopital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France
    Clin Ther 28:1-12. 2006
  8. ncbi request reprint [Circumstances of Parkinson's disease diagnosis]
    Stephane Thobois
    Neurologie D, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, 69677 Bron Cedex
    Rev Prat 55:717-22. 2005
  9. ncbi request reprint Severe dysphagia after botulinum toxin injection for cervical dystonia in multiple system atrophy
    S Thobois
    Department of Neurology, Neurological Hospital Pierre Wertheimer, Lyon, France
    Mov Disord 16:764-5. 2001
  10. ncbi request reprint [Is SPECT of interest in parkinsonian syndromes?]
    S Thobois
    Service de Neurologie C, CERMEP et INSERM U864, Universite Claude Bernard Lyon I, Hopital Neurologique Pierre Wertheimer, Lyon
    Rev Neurol (Paris) 164:F17-25. 2008

Detail Information

Publications47

  1. ncbi request reprint [Advantages and limitations in the assessment of neuroprotective treatment of Parkinson's disease by functional imaging]
    S Thobois
    Service de Neurologie D, CERMEP et INSERM U534, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon
    Rev Neurol (Paris) 161:385-93. 2005
    ....
  2. doi request reprint Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil
    Stephane Thobois
    Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Neurologie C 59 Bd Pinel, 69677 Bron, France
    Brain 136:1568-77. 2013
    ..05). No significant side effects were observed. The present study provides a class II evidence of the efficacy of the dopamine agonist piribedil in the treatment of apathy in Parkinson's disease...
  3. doi request reprint [Imaging non motor signs in Parkinson's disease]
    S Thobois
    CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron Cedex, France
    Rev Neurol (Paris) 168:576-84. 2012
    ..In this paper, we present a review of the recent advances provided by functional imaging in this area...
  4. doi request reprint Globus pallidus stimulation reduces frontal hyperactivity in tardive dystonia
    Stephane Thobois
    Université Lyon I, Hospices Civils de Lyon, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Service de Neurologie C, Lyon, France
    J Cereb Blood Flow Metab 28:1127-38. 2008
    ..The results are as follows: (1) TD is related to an excess of brain activity notably in the prefrontal and premotor areas; (2) GPi stimulation reduces the activation of motor, premotor, and prefrontal cortex as well as cerebellum...
  5. ncbi request reprint Functional anatomy of motor urgency
    Stephane Thobois
    Université Lyon I, Hospices Civils de Lyon, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Neurologie C, Lyon, France
    Neuroimage 37:243-52. 2007
    ..In a second step, the anterior (i.e. uncrossed) corticospinal tract (ipsilateral SMC) and the contralateral cerebellum are recruited. This recruitment is akin to the strategy observed during recovery in patients with brain lesions...
  6. doi request reprint Pre-operative evaluations for DBS in dystonia
    Stephane Thobois
    Université Lyon I, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer and CNRS, UMR 5229, Lyon, France
    Mov Disord 26:S17-22. 2011
    ..The preoperative evaluation in dystonia aims at characterizing the severity and topography of motor symptoms in patients, who have previously been selected for deep brain stimulation (DBS)...
  7. ncbi request reprint Proposed dose equivalence for rapid switch between dopamine receptor agonists in Parkinson's disease: a review of the literature
    Stephane Thobois
    Hopital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France
    Clin Ther 28:1-12. 2006
    ..However, the equivalence of doses of dopamine receptor agonists before and after switching drugs remains empirical because few clinical trials have addressed this issue...
  8. ncbi request reprint [Circumstances of Parkinson's disease diagnosis]
    Stephane Thobois
    Neurologie D, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, 69677 Bron Cedex
    Rev Prat 55:717-22. 2005
    ..In the future, early recognition of the disease will become more and more important with the development of neuroprotective therapeutic strategies...
  9. ncbi request reprint Severe dysphagia after botulinum toxin injection for cervical dystonia in multiple system atrophy
    S Thobois
    Department of Neurology, Neurological Hospital Pierre Wertheimer, Lyon, France
    Mov Disord 16:764-5. 2001
    ..A few days later and persisting for the next 4 months, she developed a severe dysphagia, requiring nasogastric feeding. This implicates cautious use of BTX in a case of MSA...
  10. ncbi request reprint [Is SPECT of interest in parkinsonian syndromes?]
    S Thobois
    Service de Neurologie C, CERMEP et INSERM U864, Universite Claude Bernard Lyon I, Hopital Neurologique Pierre Wertheimer, Lyon
    Rev Neurol (Paris) 164:F17-25. 2008
  11. ncbi request reprint Subthalamic nucleus stimulation in Parkinson's disease: clinical evaluation of 18 patients
    S Thobois
    Service de Neurologie D, Hopital Neurologique Pierre Wertheimer, 59 Bd Pinel, 69003 Lyon, France
    J Neurol 249:529-34. 2002
    ..This study confirms the great value of subthalamic nucleus stimulation in the treatment of intractable PD. Some adverse events such as depression may be taken into account in the inclusion criteria and also in the post-operative outcome...
  12. ncbi request reprint Chronic subthalamic nucleus stimulation and striatal D2 dopamine receptors in Parkinson's disease--A [(11)C]-raclopride PET study
    S Thobois
    Dept of Neurology D Pr G Chazot and INSERM U 534, Hopital Neurologique Pierre Wertheimer, 59 Bd Pinel, 69003 Lyon, France
    J Neurol 250:1219-23. 2003
    ..Subthalamic nucleus (STN) stimulation mechanism of action remains a matter for debate. In animals, an increased striatal dopamine (DA) release due to STN stimulation has been reported...
  13. ncbi request reprint Young-onset Parkinson disease with and without parkin gene mutations: a fluorodopa F 18 positron emission tomography study
    Stephane Thobois
    Service de Neurologie D and Cycloton Unit, CERMEP, Hopital Neurologique Pierre Wertheimer, Lyon, France
    Arch Neurol 60:713-8. 2003
    ..Mutations of the parkin gene are frequently encountered in patients with young-onset Parkinson disease (YOPD), but the effects of this mutation on the nigrostriatal dopaminergic degeneration are not well established...
  14. ncbi request reprint Adrafinil-induced orofacial dyskinesia
    Stephane Thobois
    Department of Neurology, The Pierre Wertheimer Neurological Hospital, Lyon, France
    Mov Disord 19:965-6. 2004
    ..They were secondly dramatically improved by tetrabenazine, a presynaptic dopaminergic depleting drug which was introduced after the 4-month adrafinil-free period...
  15. ncbi request reprint The timing of antiparkinsonian treatment reduction after subthalamic nucleus stimulation
    S Thobois
    Neurological Department D, Neurological Hospital Pierre Wertheimer, Lyon, France
    Eur Neurol 49:59-63. 2003
    ..In conclusion, STN stimulation allows a major reduction and simplification of antiparkinsonian treatment which can usually be achieved during the early postoperative period...
  16. ncbi request reprint Role of dopaminergic treatment in dopamine receptor down-regulation in advanced Parkinson disease: a positron emission tomographic study
    Stephane Thobois
    Neurological Department D, The Pierre Wertheimer Neurological Hospital and INSERM U 534, Lyon, France
    Arch Neurol 61:1705-9. 2004
    ....
  17. ncbi request reprint Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: three years follow-up
    Jing Gan
    Hospices Civils de Lyon, Claude Bernard Lyon I University, Hopital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France
    J Neurol 254:99-106. 2007
    ..To assess the long-term efficacy and safety of chronic bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced Parkinson's disease (PD)...
  18. ncbi request reprint Chorea induced by globus pallidus externus stimulation in a dystonic patient
    Servane Mouton
    Service de Neurologie C, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Claude Bernard Lyon I University, INSERM U 534, Lyon, France
    Mov Disord 21:1771-3. 2006
    ..This has never been described in dystonia. We report here a case of abnormal movements induced by the stimulation of GPe in a dystonic patient and discuss the pathophysiological mechanisms...
  19. doi request reprint Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation
    Stephane Thobois
    Universitée Lyon I, Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France
    Brain 133:1111-27. 2010
    ..A varying extent of mesolimbic dopaminergic denervation and differences in dopaminergic treatment largely determine mood, anxiety and motivation in patients with Parkinson's disease, contributing to different non-motor phenotypes...
  20. ncbi request reprint Effect of sensory stimulus on striatal dopamine release in humans and cats: a [(11)C]raclopride PET study
    Stephane Thobois
    Service de Neurologie D and INSERM U 534, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    Neurosci Lett 368:46-51. 2004
    ..Sensory stimulation of the forelimb extremities constitutes a well-established experimental model that has consistently shown to activate dopamine (DA) neurotransmission in the mammals' forebrain...
  21. doi request reprint Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: five year follow-up
    Hélène Gervais-Bernard
    Claude Bernard Lyon I, Universite de Lyon, Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France
    J Neurol 256:225-33. 2009
    ..To assess the long-term efficacy and safety of bilateral subthalamic nucleus (STN) stimulation in patients with advanced Parkinson's disease (PD)...
  22. pmc Deep brain stimulation of the subthalamic nucleus, but not dopaminergic medication, improves proactive inhibitory control of movement initiation in Parkinson's disease
    Emilie Favre
    Universite de Lyon, 69622, Lyon, France
    Neurotherapeutics 10:154-67. 2013
    ..This conclusion is discussed with regard to the role the STN may play as an interface between non-DA executive and DA motor systems in cortico-basal ganglia loops...
  23. ncbi request reprint Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns
    Véronique Boulenger
    L2C2 Institut des Sciences Cognitives, UMR 5230 CNRS Université Claude Bernard Lyon I, 67 Boulevard Pinel, 69675 Bron Cedex, France
    Neuropsychologia 46:743-56. 2008
    ..Overall, this study thus brings compelling evidence that processing lexico-semantic information about action words depends on the integrity of the motor system...
  24. doi request reprint Do the effects measured by intraoperative and postoperative STN macrostimulation in Parkinson's disease match?
    Jing Xie
    Service de Neurologie C, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59 Bd Pinel, Bron Cedex, France
    J Neurol 257:1453-6. 2010
    ..Differences between the type of electrodes used, the stimulation parameters employed and the conditions of the assessment could explain these discrepancies...
  25. doi request reprint Effects of dopamine and serotonin antagonist injections into the striatopallidal complex of asymptomatic MPTP-treated monkeys
    Sara Neumane
    Centre Nationale de la Recherche Scientifique, Centre de Neurosciences Cognitives, UMR 5229, Bron, France
    Neurobiol Dis 48:27-39. 2012
    ..Furthermore, these results support the notion that the residual DA in the different striatal territories and the GPe could be involved in important mechanisms of compensation in PD...
  26. doi request reprint Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's disease
    Benedicte Ballanger
    CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France
    Mov Disord 27:84-9. 2012
    ..The present imaging study suggests that abnormalities in serotonin 1A receptor neurotransmission in the limbic system may be involved in the neural mechanisms underlying depression in patients with Parkinson's disease...
  27. ncbi request reprint Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson's disease
    S Thobois
    CERMEP et service de neurologie D, , 59, boulevard Pinel, Lyon, France
    Neurophysiol Clin 31:321-40. 2001
    ....
  28. pmc A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease
    Alice Poisson
    Universite de Lyon, Faculté de Médecine Lyon Sud Charles Mérieux, Lyon, France
    PLoS ONE 8:e66910. 2013
    ..The concomitant overactivation of a proactive inhibitory network (including the posterior cingulate cortex and precuneus) could reflect a compensatory inhibition of mirror movements. ..
  29. ncbi request reprint Effects of subthalamic nucleus stimulation on actual and imagined movement in Parkinson's disease : a PET study
    Stephane Thobois
    Service de Neurologie D, Hopital Neurologique Pierre Wertheimer, Lyon
    J Neurol 249:1689-98. 2002
    ..PET studies in moderately affected Parkinson's disease (PD) patients reveal abnormal cerebral activation during motor execution and imagery, but the effects of subthalamic nucleus (STN) stimulation are not well established...
  30. ncbi request reprint Treatment of motor dysfunction in Parkinson's disease: an overview
    Stephane Thobois
    Service de Neurologie, Hopital Neurologique Pierre Wertheimer, Lyon, France
    Clin Neurol Neurosurg 107:269-81. 2005
    ..Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation...
  31. doi request reprint Functional imaging of non-motor signs in Parkinson's disease
    Benedicte Ballanger
    CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France
    J Neurol Sci 315:9-14. 2012
    ..The present paper covers the recent advances provided by functional imaging in this area...
  32. ncbi request reprint Subthalamic nucleus stimulation in Parkinson's disease : anatomical and electrophysiological localization of active contacts
    F Godinho
    Department of Functional Neurosurgery, Hopital Neurologique et Neurochirurgical, Pierre Wertheimer, 9 Bd Pinel, 69003, Lyon, France
    J Neurol 253:1347-55. 2006
    ..2 - To analyze the stereotactic spatial distribution of the active contacts in relation to the dorsal and the ventral electrophysiologically-defined borders of the STN and the stereotactic theoretical target...
  33. doi request reprint A common optimization principle for motor execution in healthy subjects and parkinsonian patients
    Pierre Baraduc
    Cognitive Neuroscience Centre, CNRS UMR 5229, 69675 Bron, France
    J Neurosci 33:665-77. 2013
    ....
  34. doi request reprint Risk factors for spinal cord lesions in dystonic cerebral palsy and generalised dystonia
    Emilie Guettard
    AP HP, Department of Neurology, Groupe Hospitalier Pitie Salpetriere, Paris, France
    J Neurol Neurosurg Psychiatry 83:159-63. 2012
    ..The aim of this study is to identify the risk factors and clinical characteristics of CM in patients with generalised dystonia, including dystonic CP...
  35. doi request reprint Surgery for tardive dyskinesia
    Stephane Thobois
    Université Lyon I Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France
    Int Rev Neurobiol 98:289-96. 2011
    ..All of them have shown a marked improvement of motor symptoms without any major psychiatric side effects...
  36. ncbi request reprint Contribution of Jules Froment to the study of parkinsonian rigidity
    Emmanuel Broussolle
    Universite de Lyon, Universite Claude Bernard Lyon I, Faculté de médecine Lyon Sud, Lyon, France
    Mov Disord 22:909-14. 2007
    ..In their number, breadth, and originality, Froment's contributions to the study of parkinsonian rigidity remain currently relevant to clinical and neurophysiological issues of PD...
  37. ncbi request reprint Epilepsia partialis continua with dystonic hand movement in a patient with a malformation of cortical development
    Julie Zyss
    Universite de Lyon, Hospices Civils de Lyon, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Service de Neurologie C, Lyon, France
    Mov Disord 22:1793-6. 2007
    ..We conclude that the dystonic movement is part of the partial seizure...
  38. doi request reprint The ability to assess muscular force in asymmetrical Parkinson's disease
    Gilles Lafargue
    Centre de Neuroscience Cognitive, CNRS, Bron, France
    Cortex 44:82-9. 2008
    ..Our findings suggest that PD patients present a deficit in sensing motor effort. Effort awareness might be mediated by the basal ganglia...
  39. ncbi request reprint [Initial management of Parkinson disease]
    Stephane Thobois
    Service de Neurologie C, Cermep et Inserm U 534, Universite Claude Bernard Lyon I, Hopital Neurologique Pierre Wertheimer, Lyon
    Presse Med 36:86-91. 2007
    ..Initial prescription and subsequent modifications depend on functional problems and must be progressive. Regular physical exercise and physical therapy must be encouraged...
  40. ncbi request reprint Atypical propriospinal myoclonus with possible relationship to alpha interferon therapy
    Isabelle Benatru
    Service de Neurologie D, Hopital Neurologique Pierre Wertheimer, Lyon, France
    Mov Disord 18:1564-8. 2003
    ..No antineuronal antibodies were found. Although the mechanism of interferon neurotoxicity remains unclear, the possible responsibility of interferon was considered, as no focal lesion or paraneoplastic pathology were disclosed...
  41. doi request reprint C9orf72 repeat expansions are a rare genetic cause of parkinsonism
    Suzanne Lesage
    Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, UMR S975 Inserm, U975, CNRS, UMR 7225, 75013 Paris, France
    Brain 136:385-91. 2013
    ..This study also provides the tools for identifying parkinsonian patients with C9orf72 expansions, with important consequences for genetic counselling...
  42. doi request reprint Possible Parkinson's disease revealed by a pure head resting tremor
    J Gan
    Université Lyon I, Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France
    J Neurol Sci 279:121-3. 2009
    ..The tremor was responsive to levodopa and had a 4.7 Hz frequency. A [(123)I]FP-CIT SPECT imaging confirmed a reduction of tracer uptake in the right striatum consistent with PD, that should be confirmed by long-term follow-up...
  43. doi request reprint [Behavioral disorders in Parkinson's disease: from pathophysiology to the mastery of dopaminergic treatment]
    S Thobois
    Service de Neurologie C, Université Lyon I, Hospices Civils, Hopital Neurologique Pierre Wertheimer, 69500 Bron, France
    Rev Neurol (Paris) 166:816-21. 2010
    ....
  44. ncbi request reprint Clozapine improves dyskinesias in Parkinson disease: a double-blind, placebo-controlled study
    F Durif
    Department of Neurology, Hopital Gabriel Montpied, Clermont Ferrand, France
    Neurology 62:381-8. 2004
    ..To investigate the efficacy and safety of clozapine in the treatment of levodopa-induced dyskinesias (LID) in patients with severe Parkinson disease (PD)...
  45. doi request reprint Patient profile, indications, efficacy and safety of duodenal levodopa infusion in advanced Parkinson's disease
    David Devos
    Department of Neurology, EA2683 IFR114 IMPRT, Hopital R Salengro, CHU Lille, France
    Mov Disord 24:993-1000. 2009
    ..Technical problems were commonplace. Duodenal levodopa infusion seems to be an effective last-line therapy for motor complications in Parkinson's disease. Hence, technical improvements and earlier introduction should be considered...
  46. ncbi request reprint [Genetics and environmental factors of Parkinson disease]
    E Broussolle
    Service de Neurologie D, Hopital Neurologique Pierre Wertheimer, 69003 Lyon
    Rev Neurol (Paris) 158:S11-23. 2002
    ..In conclusion, the aetiology of Parkinson's disease remains unknown. There are probably several types or causes of Parkinson's disease. In most cases, this heterogeneity could be attributed both to genetic and environmental factors...
  47. doi request reprint [Postural tremor as first symptom of Huntington disease]
    E Bernard
    Service de Neurologie C, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Université Lyon I, 59 Boulevard Pinel, 69677 Bron, France
    Rev Neurol (Paris) 166:841-3. 2010
    ..Initial manifestations of Huntington's disease (HD) are varied and chorea is not always the first motor symptom...