N Nighoghossian

Summary

Affiliation: Hospices Civils de Lyon
Country: France

Publications

  1. ncbi request reprint USPIO-enhanced MRI of neuroinflammation at the sub-acute stage of ischemic stroke: preliminary data
    Tae Hee Cho
    Hospices Civils de Lyon, Cerebrovascular Unit, Hopital Neurologique, Lyon, France
    Cerebrovasc Dis 24:544-6. 2007
  2. ncbi request reprint Magnetic resonance imaging: significance of early ischemic changes on computed tomography
    Laurent Derex
    Cerebrovascular Disease Center, Hopital Neurologique, Hospices Civils de Lyon, Lyon, France
    Cerebrovasc Dis 18:232-5. 2004
  3. ncbi request reprint The vulnerable carotid artery plaque: current imaging methods and new perspectives
    Norbert Nighoghossian
    Cerebrovascular Unit, Hospital Neurologique Pierre Wertheimer, Lyon, France
    Stroke 36:2764-72. 2005
  4. ncbi request reprint [Reversible acute postpartum cerebral angiopathy]
    N Nighoghossian
    Service de Neurologie B, PR P Trouillas, Hopital Neurologique Pierre Wertheimer, Bron, France
    Rev Neurol (Paris) 162:1014-8. 2006
  5. ncbi request reprint Inflammatory response after ischemic stroke: a USPIO-enhanced MRI study in patients
    Norbert Nighoghossian
    Hospices Civils de Lyon, Cerebrovascular Unit, Hopital Neurologique, Lyon, France
    Stroke 38:303-7. 2007
  6. pmc Spontaneous reperfusion after in situ thromboembolic stroke in mice
    Anne Durand
    Universite de Lyon, CREATIS, CNRS UMR5220, INSERM U1044, INSA Lyon, Universite Lyon 1, Hospices Civils de Lyon, Lyon, France
    PLoS ONE 7:e50083. 2012
  7. pmc In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
    Fabien Chauveau
    CREATIS, CNRS UMR 5220, INSERM U 630, , France
    Exp Transl Stroke Med 2:4. 2010
  8. ncbi request reprint Baseline magnetic resonance imaging parameters and stroke outcome in patients treated by intravenous tissue plasminogen activator
    N Nighoghossian
    Cerebrovascular Disease Center, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    Stroke 34:458-63. 2003
  9. ncbi request reprint Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study
    N Nighoghossian
    Cerebrovascular Disease Center, and CREATIS UMR CNRS 5515, Lyon, France
    Stroke 33:735-42. 2002
  10. ncbi request reprint Silent coronaropathy: usefulness of dobutamine stress echocardiography in ischemic stroke
    Norbert Nighoghossian
    Cerebrovascular Unit, Hospital Pierre Wertheimer, Lyon, France
    Eur Neurol 56:211-6. 2006

Detail Information

Publications89

  1. ncbi request reprint USPIO-enhanced MRI of neuroinflammation at the sub-acute stage of ischemic stroke: preliminary data
    Tae Hee Cho
    Hospices Civils de Lyon, Cerebrovascular Unit, Hopital Neurologique, Lyon, France
    Cerebrovasc Dis 24:544-6. 2007
  2. ncbi request reprint Magnetic resonance imaging: significance of early ischemic changes on computed tomography
    Laurent Derex
    Cerebrovascular Disease Center, Hopital Neurologique, Hospices Civils de Lyon, Lyon, France
    Cerebrovasc Dis 18:232-5. 2004
    ..The significance of early ischemic changes (EICs) on CT remains controversial. MRI may provide relevant information in patients with EICs...
  3. ncbi request reprint The vulnerable carotid artery plaque: current imaging methods and new perspectives
    Norbert Nighoghossian
    Cerebrovascular Unit, Hospital Neurologique Pierre Wertheimer, Lyon, France
    Stroke 36:2764-72. 2005
    ..The traditional risk assessment relies on clinical, biological, and conventional imaging tools. However, these tools fall short in predicting near-future events in patients with vulnerable carotid artery plaque...
  4. ncbi request reprint [Reversible acute postpartum cerebral angiopathy]
    N Nighoghossian
    Service de Neurologie B, PR P Trouillas, Hopital Neurologique Pierre Wertheimer, Bron, France
    Rev Neurol (Paris) 162:1014-8. 2006
    ..This review aimed 1) to describe, epidemiologic, clinical and diagnostic features of this pathological condition. 2) To put in perspective this condition within the scope of neurovascular clinical syndrome of pregnancy...
  5. ncbi request reprint Inflammatory response after ischemic stroke: a USPIO-enhanced MRI study in patients
    Norbert Nighoghossian
    Hospices Civils de Lyon, Cerebrovascular Unit, Hopital Neurologique, Lyon, France
    Stroke 38:303-7. 2007
    ..Ultra-small superparamagnetic particles of iron oxide (USPIO) may enable assessment of neuroinflammation. We aimed to assess whether the intensity of the inflammatory response might be related to the subacute ischemic lesion volume...
  6. pmc Spontaneous reperfusion after in situ thromboembolic stroke in mice
    Anne Durand
    Universite de Lyon, CREATIS, CNRS UMR5220, INSERM U1044, INSA Lyon, Universite Lyon 1, Hospices Civils de Lyon, Lyon, France
    PLoS ONE 7:e50083. 2012
    ..The study confirmed the value of the model for evaluating new thrombolytic treatments, but calls for extended MRI follow-up at the acute stage in therapeutic studies...
  7. pmc In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure
    Fabien Chauveau
    CREATIS, CNRS UMR 5220, INSERM U 630, , France
    Exp Transl Stroke Med 2:4. 2010
    ..No lesion was visible after temporal muscle incision or craniotomy. Early MRI monitoring is useful to identify non-specific brain injury that could hamper neuroprotective drugs assessment...
  8. ncbi request reprint Baseline magnetic resonance imaging parameters and stroke outcome in patients treated by intravenous tissue plasminogen activator
    N Nighoghossian
    Cerebrovascular Disease Center, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    Stroke 34:458-63. 2003
    ....
  9. ncbi request reprint Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study
    N Nighoghossian
    Cerebrovascular Disease Center, and CREATIS UMR CNRS 5515, Lyon, France
    Stroke 33:735-42. 2002
    ..MBs might be a potential risk factor for early cerebral bleeding (CB) after ischemic stroke. Therefore, we assessed the impact of MBs on the occurrence of CB after cerebral infarction...
  10. ncbi request reprint Silent coronaropathy: usefulness of dobutamine stress echocardiography in ischemic stroke
    Norbert Nighoghossian
    Cerebrovascular Unit, Hospital Pierre Wertheimer, Lyon, France
    Eur Neurol 56:211-6. 2006
    ..Most studies concerned patients with known or suspected CAD who have a high pretest probability of disease. We aimed to perform a preliminary evaluation of DSE in atherothrombotic stroke...
  11. doi request reprint Novel applications of magnetic resonance imaging to image tissue inflammation after stroke
    Norbert Nighoghossian
    Hospices Civils de Lyon, Cerebrovascular Unit, Hopital Neurologique, Lyon, France
    J Neuroimaging 18:349-52. 2008
    ..In this context, noninvasive imaging of inflammation associated with ischemic stroke lesions could have a predictive value and may be helpful for the development of cytoprotective drugs...
  12. pmc Clinical and imaging predictors of intracerebral haemorrhage in stroke patients treated with intravenous tissue plasminogen activator
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    J Neurol Neurosurg Psychiatry 76:70-5. 2005
    ..To evaluate clinical, biological, and pretreatment imaging variables for predictors of tissue plasminogen activator (tPA) related intracerebral haemorrhage (ICH) in stroke patients...
  13. ncbi request reprint Intravenous r-TPA in vertebrobasilar acute infarcts
    A Montavont
    Cerebrovascular Disease Center, CNRS, and Biostatistical Unit, HCL, France
    Neurology 62:1854-6. 2004
    ..At 3 months, 10 patients were independent (modified Rankin Scale [mRS] score = 0 to 2), whereas 8 patients showed a poor outcome (mRs = 3 to 6). IV r-TPA in VB ischemia in a 7-hour window may be safe and efficient...
  14. ncbi request reprint Early diagnosis of hemorrhagic transformation: diffusion/perfusion-weighted MRI versus CT scan
    N Nighoghossian
    Cerebrovascular Disease and Ataxia Research Center, Lyon, France
    Cerebrovasc Dis 11:151-6. 2001
    ..Day 7 CT confirmed HT in all patients who had early suspicion of bleeding according to DWI criteria. CONCLUSION: This study suggests that new MRI techniques may allow an early detection of HT, thus improving the management of stroke...
  15. ncbi request reprint Influence of the site of arterial occlusion on multiple baseline hemodynamic MRI parameters and post-thrombolytic recanalization in acute stroke
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, 59 Boulevard Pinel, 69003, Lyon, France
    Neuroradiology 46:883-7. 2004
    ..002). Our data suggest that CBF and peak height are the most relevant MRI parameters to assess the severity of hemodynamic impairment in regard to the site of occlusion...
  16. ncbi request reprint Hypointense leptomeningeal vessels at T2*-weighted MRI in acute ischemic stroke
    M Hermier
    Department of Radiology, Hopital Neurologique, Hospices Civils de Lyon, Lyon, France
    Neurology 65:652-3. 2005
  17. ncbi request reprint Vasodilatory response of border zones to acetazolamide before and after endarterectomy : an echo planar imaging-dynamic susceptibility contrast-enhanced MRI study in patients with high-grade unilateral internal carotid artery stenosis
    M Wiart
    CREATIS, CNRS Research Unit UMR 5515, Lyon, France
    Stroke 31:1561-5. 2000
    ..The aim of this study was to search for any hemodynamic impact of carotid endarterectomy (CEA) on vasodilatory response, in particular, within the border zones, by means of multislice dynamic susceptibility contrast MRI...
  18. ncbi request reprint Acute stroke and heart attack management within a four-hour time window
    I C Ralea
    Cerebrovascular Unit, University Claude Bernard, Lyon, France
    J Stroke Cerebrovasc Dis 18:167-70. 2009
    ..Although brain embolism is a uncommon complication of myocardial infarction, sequential treatment of cerebral and coronary artery occlusion within a 4-hour time window is unusual...
  19. ncbi request reprint Pulmonary embolism: an unusual complication of cerebral venous thrombosis
    S Cakmak
    Neurology and Neurosurgery Hospital, INSERM U 630, Lyon, France
    Neurology 65:1136-7. 2005
  20. ncbi request reprint Plaque density on CT, a potential marker of ischemic stroke
    J M Serfaty
    Department of Radiology, University Hospital Center, Lyon, France
    Neurology 66:118-20. 2006
    ..They found an odds ratio for neurologic events associated with a 10-point decrease in density of 1.54 (p = 0.002), showing an association between plaque density and neurologic events...
  21. doi request reprint Brain stem diffusion-weighted imaging lesion score: a potential marker of outcome in acute basilar artery occlusion
    T H Cho
    Cerebrovascular Unit, Hopital Neurologique Pierre Wertheimer, Lyon, France
    AJNR Am J Neuroradiol 30:194-8. 2009
    ..The baseline extent of brain stem damage may also influence the outcome. We investigated whether a baseline diffusion-weighted imaging (DWI) score may provide additional prognostic value in BAO...
  22. ncbi request reprint Transient neurologic symptoms related to cerebral amyloid angiopathy: usefulness of T2*-weighted imaging
    J A Roch
    Cerebrovascular Unit, Prof P Trouillas, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Bron, France
    Cerebrovasc Dis 20:412-4. 2005
  23. ncbi request reprint Hyperthyroidism and cerebral venous thrombosis
    S Mouton
    Cerebrovascular Disease Center, Lyon, France
    Eur Neurol 54:78-80. 2005
    ..Hyperthyroidism may have an impact on FVIII level. Accordingly in patients with hyperthyroidism and neurological symptoms, the diagnosis of CVT should be considered and an exhaustive coagulation screening may be appropriate...
  24. ncbi request reprint Intravenous tPA in acute ischemic stroke related to internal carotid artery dissection
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    Neurology 54:2159-61. 2000
    ..Four patients of 11 (36.4%) made an excellent recovery (day 90 m-RS score: 0 to 1). This study demonstrates the feasibility of IV thrombolysis with tPA (0.8 mg/kg) in ischemic stroke related to ICA dissection within the first 7 hours...
  25. ncbi request reprint [Necrosis of a hypophyseal adenoma and ischemic cerebral vascular accident ]
    H Catenoix
    Service de Neurologie B, Hopital Neurologique, Pierre Wertheimer, Lyon
    Rev Neurol (Paris) 158:734-6. 2002
    ..Neuroophthalmologic examination and hormonal screening were normal. Though pituitary apoplexy and stroke might represent a fortuitous association, several mechanisms underlying such clinical picture are advanced...
  26. ncbi request reprint Cerebral venous thrombosis: clinical outcome and systematic screening of prothrombotic factors
    S Cakmak
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    Neurology 60:1175-8. 2003
    ..This screening was positive in 12 patients (75%). An acquired prothrombotic factor was identified in 9 of these 12 patients. Elevation of factor VIII plasma level was the most common coagulation disorder (8 patients)...
  27. ncbi request reprint MRI of acute post-ischemic cerebral hemorrhage in stroke patients: diagnosis with T2*-weighted gradient-echo sequences
    M Hermier
    Department of Radiology, Hĵpital Neurologique P. Wertheimer, Hospices Civils de Lyon, , France
    Neuroradiology 43:809-15. 2001
    ..In one case, hemorrhage was seen earlier on MRI than on CT scan. In conclusion, T2* GRE appeared to be at least as efficient as CT scan in the detection of early post-ischemic cerebral hemorrhage...
  28. doi request reprint Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: an update
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    J Neurol Neurosurg Psychiatry 79:1093-9. 2008
    ..The input of multimodal MRI and biological predictors of ICH deserves further investigation...
  29. ncbi request reprint Thrombolytic therapy in acute ischemic stroke patients with cardiac thrombus
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    Neurology 57:2122-5. 2001
    ..One patient had late recurrent cerebral embolism and died. These data suggest that the presence of a cardiac thrombus is not associated with a high risk of recurrent embolism in patients with stroke who are given IV tPA...
  30. ncbi request reprint Effects of structural and functional cerebellar lesions on sensorimotor adaptation of saccades
    M Panouilleres
    INSERM U1028, CNRS UMR5292, IMPACT team, Lyon Neuroscience Research Center, 69000, Lyon, France
    Exp Brain Res 231:1-11. 2013
    ..We conclude that the medio-posterior cerebellum is critical for the adaptation of both saccade categories, whereas the supero-anterior cerebellum is specifically involved in the adaptation of voluntary saccades. ..
  31. doi request reprint Quantitative effects of cell internalization of two types of ultrasmall superparamagnetic iron oxide nanoparticles at 4.7 T and 7 T
    J C Brisset
    Universite de Lyon, Lyon 1, Lyon 69003, France
    Eur Radiol 20:275-85. 2010
    ..The purpose of the present study was to characterise the relaxation properties of macrophages labelled with two types of USPIOs, at 4.7 T and 7 T...
  32. ncbi request reprint Hemiplegia in posterior cerebral artery occlusion: acute MRI assessment
    A Montavont
    Cerebrovascular Disease Center, Lyon, France
    Cerebrovasc Dis 16:452-3. 2003
  33. ncbi request reprint Imaging inflammation in stroke using magnetic resonance imaging
    F Chauveau
    CNRS, UMR 5220, INSERM, U630, INSA de Lyon, CREATIS, Bron, France
    Int J Clin Pharmacol Ther 48:718-28. 2010
    ..Despite current limitations, MRI of inflammation may become an important tool for the investigation of novel ischemic stroke therapeutics targeting inflammation...
  34. ncbi request reprint Large-artery stroke in a young patient with Crohn's disease. Role of vitamin B6 deficiency-induced hyperhomocysteinemia
    S Younes-Mhenni
    Service d Urgences Neurovasculaires, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    J Neurol Sci 221:113-5. 2004
    ..Our case report stresses the importance of vitamin deficiency screening in patients with IBD in terms of stroke prevention...
  35. ncbi request reprint [Cerebral venous thrombosis presenting as subarachnoid hemorrhage]
    E Tidahy
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon
    Rev Neurol (Paris) 160:459-61. 2004
    ..Unfractionated intravenous heparin treatment resulted in resolution of subarachnoid hemorrhage on control brain CT scan and quick clinical recovery...
  36. ncbi request reprint [Delayed post-anoxic leukoencephalopathy]
    L Peter
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon
    Rev Neurol (Paris) 160:1085-8. 2004
    ..The onset of post-anoxic encephalopathies can be delayed after the acute hypoxic injury...
  37. ncbi request reprint Effects of thalamic hemorrhage on cortical hemodynamic parameters assessed by perfusion MR imaging: preliminary report
    Y Berthezene
    Department of Radiology, Creatis UMR CNRS 5515, Hôpital Neuro Cardiologique, Lyon, France
    J Neurol Sci 157:67-72. 1998
    ....
  38. ncbi request reprint Early magnetic resonance imaging prediction of arterial recanalization and late infarct volume in acute carotid artery stroke
    Marc Hermier
    Department of Radiology and MRI, Hospital Neurologique, Hospices Civils de Lyon, France
    J Cereb Blood Flow Metab 23:240-8. 2003
    ..The best predictors of late infarct size were day 0 lesion volume on DWI and day 1 recanalization. Early PWI and DWI studies and day 1 MRA provide relevant predictive information on stroke outcome...
  39. doi request reprint Synchrotron radiation X-ray phase micro-computed tomography as a new method to detect iron oxide nanoparticles in the brain
    M Marinescu
    Universite de Lyon, Lyon 1, France
    Mol Imaging Biol 15:552-9. 2013
    ....
  40. doi request reprint Multilevel assessment of atherosclerotic extent using a 40-section multidetector scanner after transient ischemic attack or ischemic stroke
    L Mechtouff
    From the Stroke Unit L M, L D, T H C, N N, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France
    AJNR Am J Neuroradiol 35:568-72. 2014
    ..The objective of the second part of this study was to assess the atherosclerotic extent by use of MDCT in these patients...
  41. doi request reprint [Subarachnoidal hemorrhage and multiple vascular cerebral abnormalities in β-thalassemia major]
    J Svahn
    Service d Urgences Neurovasculaires, Hopital Neurologique Pierre Wertheimer, 59, boulevard Pinel, 69003 Lyon, France
    Rev Neurol (Paris) 169:266-8. 2013
    ..Brain MRI revealed complex vascular abnormalities: intracranial carotid occlusion, carotid micro-aneurisms, abnormally developed deep perforators and cortical arteries...
  42. ncbi request reprint Multiple intracerebral hemorrhages and vasospasm following antimigrainous drug abuse
    N Nighoghossian
    Centre de Recherches sur I'Ataxie, , Lyon, France
    Headache 38:478-80. 1998
    ..Multiple intracerebral hemorrhages in migraine may exceptionally be related to vasospasm leading to arterial wall injury. Intracranial arterial vasospasm could be precipitated by excessive vasoactive therapy...
  43. ncbi request reprint [Knowledge about stroke in patients admitted in a French Stroke Unit]
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    Rev Neurol (Paris) 160:331-7. 2004
    ..Educational campaigns must stress the risk factors and symptoms of stroke and the appropriate response in the hopes of reducing admission delay and improving stroke prevention...
  44. ncbi request reprint Perfusion-based segmentation of the human brain using similarity mapping
    M Wiart
    CREATIS, CNRS Research Unit (affiliated with INSERM, Lyon, France
    Magn Reson Med 45:261-8. 2001
    ..Therefore, this approach might allow the segmentation of pathological regions, and combined with an indicator-dilution analysis might offer new possibilities for characterizing a brain pathology. Magn Reson Med 45:261-268, 2001...
  45. ncbi request reprint [Cerebral amyloid angiopathy revealed by transient ischemic events: contribution of MRI to diagnosis and pathophysiology study]
    S Peysson
    Service d Urgences Neurovasculaires, Lyon, France
    Rev Neurol (Paris) 159:203-5. 2003
    ..The association of ischemic suffering, petechial haemorrhage and meningeal enhancement as demonstrated by multisequence MRI highly suggest a cerebral amyloid angiopathy...
  46. doi request reprint Combined intravenous recombinant-tissular plasminogen activator and endovascular treatment of spontaneous occlusive internal carotid dissection with tandem intracranial artery occlusion
    Alain Lekoubou
    Hôpital Neurologique et Neurochirurgical P Wertheimer, Lyon, France
    Eur Neurol 63:211-4. 2010
    ..Endovascular treatment was feasible and safe. All our patients had a good clinical outcome. This potential effective approach may need further validation...
  47. ncbi request reprint [Long-term outcome in patients with symptomatic low-grade oligodendrogliomatous tumors treated by cytotoxic agents]
    H Catenoix
    Service de Neurologie B, Hopital Neurologique, Lyon
    Rev Neurol (Paris) 162:1069-75. 2006
    ..However, symptomatic low-grade gliomas require prompt therapeutic intervention because of neurological impairment, uncontrolled seizures, and deterioration of life quality...
  48. ncbi request reprint [Cerebral amyloid angiopathy]
    J A Roch
    Unité Cérébrovasculaire, PR P Trouillas, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Bron
    Rev Neurol (Paris) 163:134-7. 2007
    ..It is the main contributing factor to cerebral hemorrhage after hypertension in the elderly. We aimed to review epidemiological, pathophysiological and clinical and MRI imaging data in CAA...
  49. ncbi request reprint Danaparoid in the prevention of ischemic stroke in paroxysmal nocturnal hemoglobinuria
    J Zyss
    Cerebrovascular Unit, Hôpital P Wertheimer, Lyon, France
    Cerebrovasc Dis 23:462-3. 2007
  50. ncbi request reprint [Anterior choroidal artery infarction revealing polyarteritis nodosa]
    R Marignier
    Service d Urgences Neurovasculaires, Hospital Neurologique Pierre Wertheimer, Lyon, France
    Rev Neurol (Paris) 158:221-4. 2002
    ..Twenty months later, the patient had recovered normal cognitive function and was able to carry out all usual activities. We describe the CNS complications of PAN and the therapeutic options...
  51. ncbi request reprint [Vertebro-basilar ischemic strokes and aseptic meningitis, late complications of Fabry's disease]
    X Perrot
    Service de Neurologie B, Urgences Cerebrovasculaires, France
    Rev Neurol (Paris) 158:596-8. 2002
    ..Biological tests showed the presence of an aseptic meningitis and a biological inflammatory syndrome, suggesting a particularly progressive illness. The possible mechanisms involved in this exceptional association are discussed...
  52. ncbi request reprint [Neurological manifestations in the vertebro-basilar system suggesting pregnancy toxemia]
    N Nighoghossian
    Service de Neurologie B, Hopital Neurologique, Lyon
    Rev Fr Gynecol Obstet 86:119-22. 1991
    ..CT scan performed three weeks after the onset was normal. These finding suggest a vasospasm; in this case betasympathomimetic agents given two weeks before the onset of toxemia for preterm labor could lead to the vasospasm...
  53. ncbi request reprint Interaction between cortical control of vestibular function and spatial representation in man
    J Ventre-Dominey
    Cognitive Sciences Institute, CNRS, Bron, France
    Ann N Y Acad Sci 1039:494-7. 2005
    ....
  54. ncbi request reprint Comparison of primary angioplasty and pre-hospital fibrinolysis in acute myocardial infarction (CAPTIM) trial: a 5-year follow-up
    Eric Bonnefoy
    UMR 5558, Univeristé Lyon 1 et Centre d Investigation Clinique, Hôpital Cardio Vasculaire et Pneumologique, Hospices Civils de Lyon, 69394 Lyon Cedex 03, France
    Eur Heart J 30:1598-606. 2009
    ..The present analysis was designed to compare both strategies at 5 years...
  55. doi request reprint Thrombolysis, stroke-unit admission and early rehabilitation in elderly patients
    Laurent Derex
    Department of Neurology, Neurological Hospital, Lyon, France
    Nat Rev Neurol 5:506-11. 2009
    ..In this article, we review the literature regarding the effect of thrombolysis, stroke-unit care, and rehabilitation in patients over 80 years of age with stroke...
  56. doi request reprint Ipsilateral ptosis as main feature of tuberothalamic artery infarction
    Eric Azabou
    Cerebrovascular Unit, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Universite Lyon 1, 59 Boulevard Pinel, 69003 Lyon, France
    Neurol Sci 30:69-70. 2009
    ..Here, we report a case of TTAI with an ipsilateral ptosis as main clinical manifestation. This finding suggests that a Horner's syndrome can be the main feature of TTAI when neuropsychological manifestations are inconspicuous...
  57. doi request reprint Symptomatic Moyamoya disease: clinical features and outcome after indirect bypass surgery in four French adults
    Laurent Derex
    Department of Neurology, Neurological Hospital, University of Lyon, France
    J Neurol Sci 288:92-5. 2010
    ..We present the clinical manifestations, the neuroradiological aspects, the treatment, and the outcome after surgical revascularization of four French patients with MMD...
  58. doi request reprint Acute headache followed by focal neuropsychological impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    François Ducray
    Department of Neurology B, Cerebrovascular Unit, Universite Lyon 1, Lyon, France
    J Stroke Cerebrovasc Dis 19:75-6. 2010
    ..We report the atypical presentation of two patients in whom CADASIL was revealed by an episode of headache followed by focal neuropsychological impairment...
  59. ncbi request reprint Influence of pretreatment MRI parameters on clinical outcome, recanalization and infarct size in 49 stroke patients treated by intravenous tissue plasminogen activator
    Laurent Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    J Neurol Sci 225:3-9. 2004
    ..003). In conclusion, a severe baseline NIHSS score, a critical level of pretreatment DWI/PWI parameters and a proximal site of occlusion are predictive of a worse outcome after IV rt-PA for acute ischemic stroke...
  60. ncbi request reprint Thrombolysis for ischemic stroke in patients with old microbleeds on pretreatment MRI
    Laurent Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Hospices Civils de Lyon, Lyon, France
    Cerebrovasc Dis 17:238-41. 2004
    ..They may be a marker of increased risk of intracerebral hemorrhage (ICH) following thrombolysis. However, data regarding this potential risk are limited...
  61. ncbi request reprint Hypointense transcerebral veins at T2*-weighted MRI: a marker of hemorrhagic transformation risk in patients treated with intravenous tissue plasminogen activator
    Marc Hermier
    Department of Radiology and MRI, Hopital Neurologique, Hospices Civils de Lyon, Lyon, France
    J Cereb Blood Flow Metab 23:1362-70. 2003
    ..At multiple regression analysis, two baseline MRI factors had an independent predictive value for HT risk during the first week: the AVV and the cerebral blood volume ratio (Nagelkerke R2 = 0.48)...
  62. ncbi request reprint Early fibrinogen degradation coagulopathy is predictive of parenchymal hematomas in cerebral rt-PA thrombolysis: a study of 157 cases
    Paul Trouillas
    Cerebrovascular Unit, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    Stroke 35:1323-8. 2004
    ..Little is known about the coagulation factors as predictors of cerebral bleeding in rt-PA thrombolysis. The aim of this study was to determine what early coagulation parameters could predict early hemorrhagic lesions...
  63. ncbi request reprint Optimizing therapy of seizures in stroke patients
    Philippe Ryvlin
    Service de Neurologie Fonctionnelle et d Epileptologie and CTRS IDEE, Hospices Civils de Lyon et Université Claude Bernard Lyon 1, Lyon, France
    Neurology 67:S3-9. 2006
    ..However, low-dose extended-release carbamazepine might be a reasonable and less expensive option in patients with appropriate bone health who do not requiring anticoagulation...
  64. ncbi request reprint Evolution of lesion volume in acute stroke treated by intravenous t-PA
    Jean Baptiste Pialat
    Laboratoire CREATIS, Unité Médicale de Recherche CNRS 5515 Unité 630 INSERM, Lyon, France
    J Magn Reson Imaging 22:23-8. 2005
    ..To determine the evolution of the ischemic lesion volumes in a population treated with tissue plasminogen activator (t-PA), MRIs were performed before treatment and 24 hours later; final infarct size was evaluated 60 days later...
  65. ncbi request reprint Factors influencing early admission in a French stroke unit
    Laurent Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    Stroke 33:153-9. 2002
    ..We sought to determine the factors associated with early admission in a French stroke unit...
  66. ncbi request reprint [Pseudo-dementia as presentation of a dural arteriovenous fistula]
    M Belo
    Service de Neurologie B, Hopital Neurologique, Lyon, France
    Rev Neurol (Paris) 160:347-9. 2004
    ..We describe a case of a 70-Year-old man who presented subacute pseudo-dementia due to a dural fistula. Neurological assessment and the reversibility of the symptoms after embolization support the originality of this observation...
  67. ncbi request reprint MRI monitoring of neuroinflammation in mouse focal ischemia
    Marlene Wiart
    Universite de Lyon, Lyon, F 69003, France
    Stroke 38:131-7. 2007
    ..The aim of the present study was to monitor phagocytic activity after focal cerebral ischemia in mice...
  68. doi request reprint Early-stage investigations of ultrasmall superparamagnetic iron oxide-induced signal change after permanent middle cerebral artery occlusion in mice
    Virginie Desestret
    Universite Lyon, Lyon, France
    Stroke 40:1834-41. 2009
    ..Here, we compared MR signal changes after intravenous USPIO injection with the histological iron and macrophage distribution during the first 24 hours in a rodent model of acute stroke...
  69. doi request reprint Effect of long-term oral treatment with L-arginine and idebenone on the prevention of stroke-like episodes in an adult MELAS patient
    A Lekoubou
    Cerebrovascular Unit, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59, boulevard Pinel, 69677 Bron, France
    Rev Neurol (Paris) 167:852-5. 2011
    ..There are very few reports on long-term prevention of SLEs with oral L-arginine and idebenone treatment in MELAS adult patients...
  70. ncbi request reprint High-resolution MRI of isolated intraluminal clot of the common carotid artery
    L Boussel
    Lyon, France
    Neurology 68:788. 2007
  71. ncbi request reprint Magnetic resonance imaging (MRI) of inflammation in stroke
    Marlene Wiart
    Universite de Lyon, Creatis LRMN, UMR CNRS 5220, INSERM U630, INSA de Lyon, Lyon, France
    Conf Proc IEEE Eng Med Biol Soc 2007:4316-9. 2007
    ..Despite current limitations, MRI of inflammation may become an important tool for the investigation of novel ischemic stroke therapeutics targeted at inflammation...
  72. ncbi request reprint Contribution of susceptibility-weighted imaging to acute stroke assessment
    Marc Hermier
    Department of Neuroradiology and MRI, and the Cerebrovascular Disease Center, CREATIS, CNRS UMR 5515, INSERM U630 Hôpital Neurologique P Wertheimer, Claude Bernard Lyon I University, Lyon, France
    Stroke 35:1989-94. 2004
    ..Susceptibility-weighted (SW) MRI provides insight into the pathophysiology of acute stroke. We report on the use of SW imaging (SWI) sequences in clinical practice and highlight the future applications...
  73. ncbi request reprint [Sequential MRI imaging of progressive bilateral rostro-caudal medullary infarction]
    S Boulogne
    Service de Neurologie Vasculaire, Hopital Neurologique Pierre Wertheimer, 35, boulevard Pinel, 69500 Bron, France
    Rev Neurol (Paris) 170:277-9. 2014
    ..We report two patients who presented progressive quadriplegia, anarthia and dysphagia. Sequential MRI showed progressive constitution of the characteristic "heart appearance" sign. ..
  74. ncbi request reprint Evidence for interacting cortical control of vestibular function and spatial representation in man
    J Ventre-Dominey
    INSERM and CNRS Cognitive Sciences Institute UMR 5015, 67 Bd Pinel, 69500, Bron, France
    Neuropsychologia 41:1884-98. 2003
    ..e. in right cortical lesions with hemi-neglect syndrome. These results demonstrate in man, the existence of a cortical influence on vestibular function related to the mechanisms of spatial representation...
  75. ncbi request reprint Separate neural substrates in the human cerebellum for sensory-motor adaptation of reactive and of scanning voluntary saccades
    N Alahyane
    INSERM, U864, Espace et Action, Bron, France
    Cerebellum 7:595-601. 2008
    ..Brain Res 1135:107-121 (2007))...
  76. doi request reprint Nocturnal urine melatonin and 6-sulphatoxymelatonin excretion at the acute stage of ischaemic stroke
    Thomas Ritzenthaler
    Cerebrovascular Unit, Hospices Civils de Lyon, Lyon, France
    J Pineal Res 46:349-52. 2009
    ..001 and P = 0.03 respectively). The impact of melatonin at the acute stage of stroke on clinical severity and lesion size needs further assessment, as melatonin may have potential neuroprotective effects...
  77. ncbi request reprint Stenting of symptomatic basilar and vertebral artery stenosis in patients resistant to optimal medical prevention: the lyon stroke unit experience
    Ionela Camelia Ralea
    Cerebrovascular Unit, Hopital Neurologique Pierre Wertheimer, Lyon, France
    Eur Neurol 60:127-31. 2008
    ..Intracranial angioplasty stenting may be an efficient therapy in patients with intracranial atherosclerotic symptomatic vertebrobasilar artery stenosis unresponsive to optimal medical therapy. We present our experience in this setting...
  78. ncbi request reprint Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact
    Fabien Chauveau
    Universite de Lyon, Lyon 1, Lyon F 69003, France
    Curr Neurovasc Res 8:95-102. 2011
    ..03). MRI-based assessment demonstrated the neuroprotective effect of DHA in the MCAO model. Results further highlighted the therapeutic potential of engineered brain-targeting forms of omega-3 fatty acids for acute stroke treatment...
  79. ncbi request reprint Ethical issues of informed consent in acute stroke. Analysis of the modalities of consent in 56 patients enrolled in urgent therapeutic trials
    Genevieve Demarquay
    Service d Urgences Neurovasculaires, Hôpital Neurologique de Lyon, Lyon, France
    Cerebrovasc Dis 19:65-8. 2005
    ....
  80. ncbi request reprint Auditory and electrophysiological patterns of a unilateral lesion of the lateral lemniscus
    Tae Hee Cho
    Department of Clinical Neurophysiology and UCB EA1880, Hopital Neurologique et Neurochirurgical, Lyon, France
    Audiol Neurootol 10:153-8. 2005
    ..The dysfunction of auditory pathways is associated with specific electrophysiological abnormalities that can be assessed by evoked potential recording...
  81. ncbi request reprint Saccadic lateropulsion in Wallenberg syndrome: a window to access cerebellar control of saccades?
    Caroline Tilikete
    Neuro Ophthalmology Department, Universite Claude Bernard Lyon I, Hospices Civils de Lyon, 59 Bd Pinel, 69 677 Bron Cedex, France
    Exp Brain Res 174:555-65. 2006
    ..Thus we conclude that the cerebellum might be involved both in controlling the motor execution of saccades and in determining the visuo-spatial information about their goal...
  82. doi request reprint Recurrent cerebral venous thrombosis revealing paraneoplastic angiitis in Hodgkin's lymphoma
    Stephanie Roggerone
    Cerebrovascular Unit, Hopital Neurologique Pierre Wertheimer, 59 Boulevard Pinel, 69677, Bron Cedex, France
    J Neurooncol 89:195-8. 2008
    ..This case of CVT due to paraneoplastic cerebral angiitis is a rare condition and represents a new, very rare manifestation of nodular lymphocyte predominant Hodgkin's disease...
  83. ncbi request reprint Concordance rate differences of 3 noninvasive imaging techniques to measure carotid stenosis in clinical routine practice: results of the CARMEDAS multicenter study
    Michel Nonent
    Department of Radiology, University Hospital Center, Brest, France
    Stroke 35:682-6. 2004
    ..Our purpose is to compare the concordance rates of contrast-enhanced MR angiography (CEMRA) and CT angiography (CTA) with Doppler ultrasound (DUS) in clinical routine practice...
  84. ncbi request reprint tPA in daily clinical practice
    Norbert Nighoghossian
    Stroke 34:1106-13. 2003
  85. ncbi request reprint MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice
    Jean Baptiste Pialat
    Universite Lyon 1, Laboratoire CREATIS, INSA de Lyon, CNRS UMR 5515, INSERM U630, Villeurbanne, France
    NMR Biomed 20:335-42. 2007
    ..These data validate high-resolution MRI for monitoring cerebral ischemic lesions, and confirm the neuroprotective role of PPARalpha and PPARbeta in the brain...
  86. ncbi request reprint Warning compulsive behavior preceding acute ischemic stroke
    Norbert Nighoghossian
    Eur Neurol 56:39-40. 2006
  87. ncbi request reprint Altered awareness of voluntary action after damage to the parietal cortex
    Angela Sirigu
    Institut des Sciences Cognitives CNRS, 67 Blv Pinel, 69675 Bron, France
    Nat Neurosci 7:80-4. 2004
    ..This model might form the neural correlate of motor awareness...
  88. ncbi request reprint Simultaneous subarachnoid hemorrhage and cerebellar infarct revealing vertebral artery aneurysm: acute magnetic resonance imaging assessment
    Geraldine Androdias
    Arch Neurol 62:1158-9. 2005
  89. doi request reprint Oculopalatal tremor and severe late-onset cerebellar ataxia
    Caroline Tilikete
    UMR S864, Espace et Action, 16 Avenue du doyen Lépine, 69 676 BRON Cedex, France
    Neurology 71:301. 2008