Guillaume Monneret

Summary

Affiliation: Hospices Civils de Lyon
Country: France

Publications

  1. pmc A dynamic view of mHLA-DR expression in management of severe septic patients
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hôpital E, Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Crit Care 15:198. 2011
  2. pmc mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance
    Fanny Turrel-Davin
    bioMerieux, Joint Unit Hospices Civils de Lyon, Hopital Edouard Herriot, 69003 Lyon, France
    Crit Care 15:R252. 2011
  3. doi request reprint ICU-acquired immunosuppression and the risk for secondary fungal infections
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, 5 Place d Arsonval, Lyon, France
    Med Mycol 49:S17-23. 2011
  4. ncbi request reprint Immunomodulatory cell therapy in sepsis: have we learnt lessons from the past?
    Guillaume Monneret
    Cellular Immunology Laboratory, Hopital E Herriot, Hospices Civils de Lyon, Pavillon E, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Expert Rev Anti Infect Ther 8:1109-12. 2010
  5. ncbi request reprint Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survival
    Guillaume Monneret
    Hospices Civils de Lyon, Hopital Neurologique, Laboratoire d Immunologie, Lyon, France
    Crit Care Med 35:1942-7. 2007
  6. pmc Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, Lyon, France
    Mol Med 14:64-78. 2008
  7. ncbi request reprint Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock
    Guillaume Monneret
    Immunology Laboratory, Hopital Neurologique, Lyon, France
    Intensive Care Med 32:1175-83. 2006
  8. ncbi request reprint Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis
    Guillaume Monneret
    Lyon Sud University Hospital, France
    Crit Care Med 31:2068-71. 2003
  9. ncbi request reprint Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: application to the monitoring of patients with septic shock
    Guillaume Monneret
    Immunology Laboratory and Intensive Care Units, Lyon Sud University Hospital, 69495 Pierre Benite, France
    Clin Chem 48:1589-92. 2002
  10. ncbi request reprint The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration
    Guillaume Monneret
    Immunology Laboratory GM, MEF, FV, ALD, JBi and Intensive Care Units Jbo, AL, Lyon Sud University Hospital, 69495 Pierre Benite, France
    Immunol Lett 95:193-8. 2004

Collaborators

Detail Information

Publications66

  1. pmc A dynamic view of mHLA-DR expression in management of severe septic patients
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hôpital E, Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Crit Care 15:198. 2011
    ....
  2. pmc mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance
    Fanny Turrel-Davin
    bioMerieux, Joint Unit Hospices Civils de Lyon, Hopital Edouard Herriot, 69003 Lyon, France
    Crit Care 15:R252. 2011
    ..Successful therapy depends on the identification of appropriate immunostimulatory drugs and on the development of suitable biomarkers that could be used to stratify patients and to follow response to treatment...
  3. doi request reprint ICU-acquired immunosuppression and the risk for secondary fungal infections
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, 5 Place d Arsonval, Lyon, France
    Med Mycol 49:S17-23. 2011
    ....
  4. ncbi request reprint Immunomodulatory cell therapy in sepsis: have we learnt lessons from the past?
    Guillaume Monneret
    Cellular Immunology Laboratory, Hopital E Herriot, Hospices Civils de Lyon, Pavillon E, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Expert Rev Anti Infect Ther 8:1109-12. 2010
    ..Therefore, in this article, we propose hypotheses explaining why the future of clinical trials in sepsis immunology will likely rely on stimulating immune functions for rebalancing immune homeostasis...
  5. ncbi request reprint Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survival
    Guillaume Monneret
    Hospices Civils de Lyon, Hopital Neurologique, Laboratoire d Immunologie, Lyon, France
    Crit Care Med 35:1942-7. 2007
    ..The main objective of the current study was to measure human leukocyte antigen-G (soluble and membrane proteins) in septic shock...
  6. pmc Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony
    Guillaume Monneret
    Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, Lyon, France
    Mol Med 14:64-78. 2008
    ..This constitutes a prerequisite to a staging system for individualized treatment for these hitherto deadly syndromes...
  7. ncbi request reprint Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock
    Guillaume Monneret
    Immunology Laboratory, Hopital Neurologique, Lyon, France
    Intensive Care Med 32:1175-83. 2006
    ..We assessed whether a low monocyte human leukocyte antigen-DR (mHLA-DR) expression, proposed as a marker of immunosuppression, is an independent predictor of mortality in patients who survived the initial 48 h of septic shock...
  8. ncbi request reprint Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis
    Guillaume Monneret
    Lyon Sud University Hospital, France
    Crit Care Med 31:2068-71. 2003
    ..Because human peripheral blood CD4+CD25+ T cells have been characterized as suppressor T cells, we hypothesized they might be increased in sepsis-induced immunoparalysis...
  9. ncbi request reprint Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: application to the monitoring of patients with septic shock
    Guillaume Monneret
    Immunology Laboratory and Intensive Care Units, Lyon Sud University Hospital, 69495 Pierre Benite, France
    Clin Chem 48:1589-92. 2002
  10. ncbi request reprint The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration
    Guillaume Monneret
    Immunology Laboratory GM, MEF, FV, ALD, JBi and Intensive Care Units Jbo, AL, Lyon Sud University Hospital, 69495 Pierre Benite, France
    Immunol Lett 95:193-8. 2004
    ..They might constitute helpful indicators for staging patients and making a decision about whether to institute a therapy with molecules able of reversing sepsis-induced immunosuppression...
  11. ncbi request reprint Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils
    Guillaume Monneret
    Immunology Laboratory and Intensive Care Unit, Lyon Sud University Hospital, 69495, Pierre Benite, France
    Intensive Care Med 29:923-8. 2003
    ..This study examined whether CGRP and N-PCT modulate the LPS-induced expression of CD11b, which is one of the major integrins involved in monocyte and neutrophil chemotaxis during a response to microbial infections...
  12. doi request reprint [Reversing ICU-acquired immunosuppression: an innovative biomarker-guided therapeutic strategy for decreasing sepsis mortality and nosocomial infection rate]
    G Monneret
    Laboratoire d Immunologie Cellulaire, Hospices Civils de Lyon, Hopital E Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Pathol Biol (Paris) 59:329-33. 2011
    ..This review attempts to integrate these new facts into an up-to-date account of sepsis pathophysiology...
  13. ncbi request reprint Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism
    Fabienne Venet
    Immunology Laboratory, Hopital Neurologique, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677 Lyon Cedex, France
    J Immunol 177:6540-7. 2006
    ..This may be an important mechanism for septic shock-induced immunosuppression and may offer new perspectives for the treatment of this deadly disease...
  14. pmc Identification of biomarkers of response to IFNg during endotoxin tolerance: application to septic shock
    Florence Allantaz-Frager
    Joint Unit Hospices Civils de Lyon Biomérieux sepsis, Hopital Edouard Herriot, Lyon, France
    PLoS ONE 8:e68218. 2013
    ..Upon favorable results, they could serve as stratification tools prior to immunostimulatory treatment and to monitor drug efficacy. ..
  15. ncbi request reprint Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes
    Fabienne Venet
    Immunology Laboratory, Lyon Sud University Hospital, France
    Crit Care Med 32:2329-31. 2004
    ..The objective of the present study was to investigate whether this increased percentage was due to Treg proliferation...
  16. ncbi request reprint Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock
    Fabienne Venet
    Hospices Civils de Lyon, Hopital Neurologique, Laboratoire d Immunologie, Lyon, France
    Crit Care Med 35:1910-7. 2007
    ..The main objective of the current study was to characterize the appearance and the duration of low mHLA-DR expression after severe burn as well as to determine its correlation with mortality and septic complications...
  17. doi request reprint Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients
    Caroline Guignant
    Flow Cytometry Unit, Immunology Laboratory, Hopital E Herriot, Hospices Civils de Lyon, 5, Place d Arsonval, 69437, Lyon Cedex 03, France
    Intensive Care Med 35:1859-67. 2009
    ....
  18. ncbi request reprint Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients
    Alexandre Pachot
    Department of Human Genetics, bioMerieux, Parc Club du Moulin à Vent, 33, avenue du Docteur LEVY, 69693 Vénissieux Cedex, France
    Crit Care Med 33:31-8; discussion 236-7. 2005
    ....
  19. doi request reprint Delayed increase of S100A9 messenger RNA predicts hospital-acquired infection after septic shock
    Mathieu Fontaine
    Intensive Care Unit, Hospices Civils de Lyon, CHU Lyon Sud, Pierre Benite, France
    Crit Care Med 39:2684-90. 2011
    ..The aim of this study was to assess the capability of S100A9 messenger RNA in whole blood from patients with septic shock to predict survival and the occurrence of hospital-acquired infection...
  20. doi request reprint Proatrial natriuretic peptide is a better predictor of 28-day mortality in septic shock patients than proendothelin-1
    Caroline Guignant
    Hospices Civils de Lyon, Hopital E Herriot, Laboratoire d Immunologie, Lyon, France
    Clin Chem Lab Med 48:1813-20. 2010
    ....
  21. doi request reprint Assessment of a novel flow cytometry technique of one-step intracellular staining: example of FOXP3 in clinical samples
    Julie Demaret
    Hospices Civils de Lyon, Hopital Edouard Herriot, Laboratoire d Immunologie, Lyon F 69003, France
    Cytometry B Clin Cytom 84:187-93. 2013
    ..The objective of our study was thus to assess this new method in comparison with the reference technique by focusing on FOXP3 staining in clinical samples...
  22. ncbi request reprint The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock
    Fabienne Venet
    Flow Cytometry Unit, Immunology Laboratory and Intensive Care Units, Lyon Sud University Hospital, CEDEX F 69495 Pierre Bénite, France
    Clin Immunol 113:278-84. 2004
    ..Importantly, the persistence over time of low levels of CRTH2 or CCR3 expression was found in nonsurvivors. We hypothesize that the restoration of CRTH2/CCR3 expression may be an indicator for optimal recovery after septic shock...
  23. pmc Early interleukin-6 and slope of monocyte human leukocyte antigen-DR: a powerful association to predict the development of sepsis after major trauma
    Aurélie Gouel-Chéron
    Service de Reanimation, Hôpital Edouard Herriot Hospices Civils de Lyon, Lyon, France
    PLoS ONE 7:e33095. 2012
    ....
  24. doi request reprint Persistent high level of circulating midregional-proadrenomedullin and increased risk of nosocomial infections after septic shock
    Caroline Guignant
    Immunology Laboratory, E Herriot Hospital, Hospices Civils de Lyon, France
    J Trauma Acute Care Surg 72:293-6. 2012
    ....
  25. ncbi request reprint Metabolic phenotyping of traumatized patients reveals a susceptibility to sepsis
    Benjamin J Blaise
    Hospices Civils de Lyon, Service de Reanimation, Hopital Edouard Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Anal Chem 85:10850-5. 2013
    ..A larger cohort is necessary to validate and complete this study, understand biochemical mechanisms promoting sepsis development, and identify patients at risk. ..
  26. ncbi request reprint Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression
    Alexandre Pachot
    Joint Unit Hospices Civils de Lyon bioMérieux, Hopital Edouard Herriot, 5 Place d Arsonval, Lyon, France
    J Immunol 180:6421-9. 2008
    ..This could represent an important new feature of sepsis-induced immunosuppression...
  27. pmc Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients
    Fanny Turrel-Davin
    Joint Unit Hospices Civils de Lyon bioMérieux, Hopital Edouard Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Crit Care 14:R133. 2010
    ..However, no routine biomarkers of apoptosis are so far available in patients. Thus, the aim of our study was to assess the different biomarkers of apoptosis putatively usable on a routine basis in septic shock...
  28. doi request reprint [Interleukin-7, a new immunoadjuvant for the treatment of septic shock]
    Guillaume Monneret
    Hospices Civils de Lyon, Hopital Edouard Herriot, Laboratoire d Immunologie Cellulaire, 5, Place d Arsonval, 69437 Lyon Cedex 03, France EAM 4174 Hémostase, Sepsis, Inflammation, Hospices Civils de Lyon, Université Lyon I, Lyon, France
    Med Sci (Paris) 30:160-5. 2014
    ..Of them, the case of interleukin-7 is more specifically envisaged. ..
  29. doi request reprint Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock
    Caroline Landelle
    Laboratoire de Biometrie et Biologie Evolutive, Epidémiologie et Santé Publique, CNRS, UMR 5558, Universite Lyon, Lyon, France
    Intensive Care Med 36:1859-66. 2010
    ....
  30. doi request reprint Decreased T-cell repertoire diversity in sepsis: a preliminary study
    Fabienne Venet
    Cellular Immunology Laboratory, Hopital E Herriot, Lyon, France
    Crit Care Med 41:111-9. 2013
    ..The objective of this study was to investigate T-cell receptor diversity, an important feature of T-cell response, in patients with septic shock...
  31. doi request reprint IL-7 restores lymphocyte functions in septic patients
    Fabienne Venet
    Hospices Civils de Lyon, Laboratoire d Immunologie Cellulaire, Hopital E Herriot, 69003 Lyon, France
    J Immunol 189:5073-81. 2012
    ..To our knowledge, this constitutes the first report of rhIL-7 ability to restore normal lymphocyte functions in septic patients. These results support the rational for initiating a clinical trial testing rhIL-7 in septic shock...
  32. ncbi request reprint Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock
    Alexandre Pachot
    Department of Human Genetics, bioMerieux, 69280 Marcy l Etoile, France
    Clin Immunol 114:61-9. 2005
    ..These results illustrate both the potential of whole blood mRNA quantification assays and the interest of a multiparametric strategy to better stratify septic patients...
  33. doi request reprint Flow cytometry developments and perspectives in clinical studies: examples in ICU patients
    Fabienne Venet
    Laboratoire d Immunologie, Hopital E Herriot, Hospices Civils de Lyon, 69437, Lyon Cedex 03, France
    Methods Mol Biol 761:261-75. 2011
    ..Importantly, many other markers of immune dysfunction are currently under development that could further enable the administration of targeted individualized therapy in ICU patients...
  34. pmc Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients
    Caroline Guignant
    Hospices Civils de Lyon, Hôpital E, Herriot, Laboratoire d Immunologie, 5 Place d Arsonval, 69003 Lyon, France
    Crit Care 15:R99. 2011
    ..It has recently been shown that PD-1 knock-out mice exhibited a lower mortality in response to experimental sepsis. The objective of the present study was to investigate PD-1-related molecule expressions in septic shock patients...
  35. ncbi request reprint Both percentage of gammadelta T lymphocytes and CD3 expression are reduced during septic shock
    Fabienne Venet
    Immunology Laboratory, Lyon Sud University Hospital, France
    Crit Care Med 33:2836-40. 2005
    ..The objective of the present study was to investigate whether two characteristics of T cells were altered in this situation: the percentage of circulating gammadelta T lymphocytes and the level of CD3 expression on T lymphocytes...
  36. ncbi request reprint Increased MerTK expression in circulating innate immune cells of patients with septic shock
    Caroline Guignant
    Laboratoire d Immunologie, Hopital E Herriot, Hospices Civils de Lyon, 5 Place d Arsonval, 69437, Lyon Cedex 03, France
    Intensive Care Med 39:1556-64. 2013
    ..The objective of this prospective, observational, clinical study was to investigate the expression patterns of TAM receptors in circulating white blood cells collected from patients with septic shock...
  37. doi request reprint Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients
    Fabienne Venet
    Hospices Civils de Lyon, Immunology Laboratory, Hop E Herriot, 69437 Lyon, France
    Int Immunopharmacol 11:2086-90. 2011
    ..These results need to be confirmed in a larger cohort of patients...
  38. doi request reprint Early assessment of leukocyte alterations at diagnosis of septic shock
    Fabienne Venet
    Hospices Civils de Lyon, CRB Sepsis, France
    Shock 34:358-63. 2010
    ..No significant variation could be detected within the first 48 h. This should be taken into account in the forthcoming clinical trials testing immunomodulating therapies in septic shock patients...
  39. pmc Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions
    Fabienne Venet
    Hospices Civils de Lyon, Immunology Laboratory, Hôpital E, Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Crit Care 15:231. 2011
    ..The next critical step would be to use these standardized flow cytometry protocols in large multicentric clinical trials testing individualized immunotherapy...
  40. doi request reprint CD4+CD25+CD127- assessment as a surrogate phenotype for FOXP3+ regulatory T cells in HIV-1 infected viremic and aviremic subjects
    Julien Saison
    Hospices Civils de Lyon, Hopital Edouard Herriot, Laboratoire d Immunologie, Lyon, F 69003, France
    Cytometry B Clin Cytom 84:50-4. 2013
    ..Therefore, the objective of the present study was to assess the correlation between frequencies of CD4+CD25+CD127- and CD4+CD25+FOXP3+ lymphocytes in viremic and matched aviremic HIV-infected patients...
  41. ncbi request reprint Innovative therapeutic strategies for restoring lymphocyte functions in septic patients
    Fanny Turrel
    Joint Unit Civils de Lyon bioMérieux, Hopital Edouard Herriot, Lyon, France
    Inflamm Allergy Drug Targets 7:181-6. 2008
    ..This review focuses on lymphocyte dysfunctions described so far in patients and on potential new therapeutic strategies aimed at restoring a functional lymphocytic response after sepsis...
  42. pmc S100A8/A9 mRNA Induction in an Ex Vivo Model of Endotoxin Tolerance: Roles of IL-10 and IFNγ
    Mathieu Fontaine
    Hospices Civils de Lyon Intensive Care Unit, Centre Hospitalier Lyon Sud, Pierre Benite, France Joint Unit Hospices Civils de Lyon bioMérieux, Hopital Edouard Herriot, Lyon, France EAM 4174 Hemostasis, inflammation and sepsis Hospices Civils de Lyon Université Claude Bernard Lyon I, Lyon, France
    PLoS ONE 9:e100909. 2014
    ..Importantly, a delayed S100A9 mRNA increase predicts hospital-acquired infection in patients. The aim of this study was to investigate the regulation of S100A8 and S100A9 mRNA expression in an ex vivo model of ET...
  43. ncbi request reprint FcgammaRIIIb and complement component C7 codeficiency in a patient with recurrence of fulminant meningococcal septic shock
    Anne Lise Debard
    Immunology Laboratory, Lyon Sud University Hospital, Pierre Benite, France
    Clin Infect Dis 40:1679-83. 2005
    ..We found a total deficiency of FcgammaRIIIb on neutrophils, which could partially explain the unusually severe clinical presentation...
  44. doi request reprint Percentage of regulatory T cells CD4+CD25+CD127- in HIV-infected patients is not reduced after cryopreservation
    Fabienne Venet
    Hospices Civils de Lyon, Hopital E Herriot, Pavillon E, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    J Immunol Methods 357:55-8. 2010
    ..Ours results indicate that cryopreservation does not affect this specific T lymphocyte subset...
  45. ncbi request reprint Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study
    Alexandre Pachot
    Joint Unit bioMérieux, Hospices Civils de Lyon, Hopital Edouard Herriot, France
    Immunol Lett 106:63-71. 2006
    ....
  46. doi request reprint Nosocomial infection after septic shock among intensive care unit patients
    Caroline Landelle
    Service d Hygiène, Epidémiologie et Prévention, Hopital Edouard Herriot, and the Centre d Investigation Clinique de Lyon, CIC201, INSERM, France
    Infect Control Hosp Epidemiol 29:1054-65. 2008
    ..To measure the incidence of nosocomial infection (NI) among patients with septic shock according to the place of septic shock acquisition and to evaluate the increase in the risk of pulmonary infection associated with septic shock...
  47. ncbi request reprint Comparative inflammatory properties of staphylococcal superantigenic enterotoxins SEA and SEG: implications for septic shock
    Olivier Dauwalder
    Universite Claude Bernard, INSERM E230, IFR 62, Lyon, France
    J Leukoc Biol 80:753-8. 2006
    ..These results suggest that the association of SEA with the severity of S. aureus septic shock, characterized by a deleterious, inflammatory cascade, may be explained partly by the specific proinflammatory properties of this superantigen...
  48. doi request reprint Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples
    Julie Demaret
    Hospices Civils de Lyon, Hopital Edouard Herriot, Laboratoire d Immunologie, Lyon F 69003, France
    Cytometry B Clin Cytom 84:59-62. 2013
    ..The objective of the present work was to test, in an inter-laboratory clinical study, a standardized protocol for mHLA-DR measurement by flow cytometry...
  49. pmc Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma
    Aurélie Cheron
    Hospices Civils de Lyon, Service de Reanimation, Hopital Edouard Herriot, 5 place d Arsonval 69437 Lyon Cedex 03, France
    Crit Care 14:R208. 2010
    ..The main objective of this study was to determine the relation between mHLA-DR expression in severe trauma patients and the development of sepsis...
  50. ncbi request reprint Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils
    Guillaume Monneret
    Immunology Laboratory, Lyon Sud University Hospital, Pierre Bénite Lyon, France
    J Pharmacol Exp Ther 312:627-34. 2005
    ..The balance between DP(1) and DP(2) receptors may be important in determining the magnitude of basophil responses to this prostaglandin...
  51. ncbi request reprint Monitoring of basophil activation using CD63 and CCR3 in allergy to muscle relaxant drugs
    Guillaume Monneret
    Immunology Laboratory, Lyon Sud University Hospital, Pierre Benite, France
    Clin Immunol 102:192-9. 2002
    ..Furthermore, the CD63 protocol showed good specificity (100%). We conclude that our flow cytometry protocol is a promising tool in allergy diagnosis since it is specific and complementary to specific IgE detection...
  52. pmc Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies
    Fabienne Venet
    Hospices Civils de Lyon, Immunology Laboratory, Hôpital E, Herriot, 5, Place d Arsonval, Lyon Cedex 03, France
    Curr Opin Immunol 25:477-83. 2013
    ..Such biomarkers of immune functionality will enable a novel approach in the design of clinical trials evaluating immunostimulating therapies in sepsis at the right time and in the right patient. ..
  53. ncbi request reprint Assessment of cellular immune parameters in paediatric toxic shock syndrome: a report of five cases
    Olivier Dauwalder
    Centre National de Références des Staphylocoques, Faculté de médecine Lyon Est, Universite de Lyon, France
    FEMS Immunol Med Microbiol 66:116-9. 2012
    ..Future studies must isolate and better characterize the phenotypic and functional properties of Treg subsets during TSS to understand the mechanisms sustaining their increase, especially the putative role of superantigens...
  54. ncbi request reprint Alveolar and serum procalcitonin: diagnostic and prognostic value in ventilator-associated pneumonia
    Frederic Duflo
    Department of Anesthesiology, hôpital de l Hôtel dieu, Lyon, France
    Anesthesiology 96:74-9. 2002
    ..The potential role of serum and alveolar procalcitonin as early markers of ventilator-associated pneumonia (VAP) and its prognostic value were investigated...
  55. ncbi request reprint Dear PCT, you are not a specific marker of bacterial infection
    Guillaume Monneret
    Intensive Care Med 28:377-8. 2002
  56. ncbi request reprint 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils
    Guillaume Monneret
    Department of Medicine, Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Pharmacol Exp Ther 304:349-55. 2003
    ....
  57. ncbi request reprint High serum procalcitonin levels do not predict bacteremia in adult patients with acute fever
    Anne Lise Debard
    Clin Infect Dis 36:825-6; author reply 826-7. 2003
  58. ncbi request reprint Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study
    Wolf Dietrich Döcke
    Institute of Medical Immunology, Charite Campus Mitte, Humboldt University of Berlin, and University Hospital, Charite Berlin, Germany
    Clin Chem 51:2341-7. 2005
    ..Single-center trials have shown that monocytic HLA-DR is a good marker for monitoring the severity of temporary immunodepression after trauma, major surgery, or sepsis. A new test for measuring monocytic HLA-DR is now available...
  59. ncbi request reprint 5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytes
    Panagiota B Stamatiou
    Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain Street, Montreal, Quebec H2X 2P2, Canada
    J Biol Chem 279:28159-64. 2004
    ....
  60. ncbi request reprint Statins and sepsis: do we really need to further decrease monocyte HLA-DR expression to treat septic patients?
    Guillaume Monneret
    Lancet Infect Dis 7:697-9. 2007
  61. ncbi request reprint Regulatory T cell populations in sepsis and trauma
    Fabienne Venet
    Division of Surgical Research, Rhode Island Hospital Brown University, 593 Eddy Street, Providence, RI 02903, USA
    J Leukoc Biol 83:523-35. 2008
    ....
  62. doi request reprint Consider delayed immunosuppression into the concept of sepsis
    Joerg C Schefold
    Crit Care Med 36:3118. 2008
  63. ncbi request reprint 15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils
    Guillaume Monneret
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Immunol 168:3563-9. 2002
    ....