Research Topics
Genomes and Genes | Guillaume MonneretSummaryAffiliation: Hospices Civils de Lyon Country: France Publications
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Publications
A dynamic view of mHLA-DR expression in management of severe septic patientsGuillaume Monneret
Hospices Civils de Lyon, Immunology Laboratory, Hôpital E, Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
Crit Care 15:198. 2011....- mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin toleranceFanny Turrel-Davin
bioMerieux, Joint Unit Hospices Civils de Lyon, Hopital Edouard Herriot, 69003 Lyon, France
Crit Care 15:R252. 2011..Successful therapy depends on the identification of appropriate immunostimulatory drugs and on the development of suitable biomarkers that could be used to stratify patients and to follow response to treatment... 
Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophilsGuillaume Monneret
Immunology Laboratory and Intensive Care Unit, Lyon Sud University Hospital, 69495, Pierre Benite, France
Intensive Care Med 29:923-8. 2003..This study examined whether CGRP and N-PCT modulate the LPS-induced expression of CD11b, which is one of the major integrins involved in monocyte and neutrophil chemotaxis during a response to microbial infections...- Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremonyGuillaume Monneret
Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, Lyon, France
Mol Med 14:64-78. 2008..This constitutes a prerequisite to a staging system for individualized treatment for these hitherto deadly syndromes... - Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shockGuillaume Monneret
Immunology Laboratory, Hopital Neurologique, Lyon, France
Intensive Care Med 32:1175-83. 2006..We assessed whether a low monocyte human leukocyte antigen-DR (mHLA-DR) expression, proposed as a marker of immunosuppression, is an independent predictor of mortality in patients who survived the initial 48 h of septic shock... 
ICU-acquired immunosuppression and the risk for secondary fungal infectionsGuillaume Monneret
Hospices Civils de Lyon, Immunology Laboratory, Hopital E Herriot, 5 Place d Arsonval, Lyon, France
Med Mycol 49:S17-23. 2011....- Immunomodulatory cell therapy in sepsis: have we learnt lessons from the past?Guillaume Monneret
Cellular Immunology Laboratory, Hopital E Herriot, Hospices Civils de Lyon, Pavillon E, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
Expert Rev Anti Infect Ther 8:1109-12. 2010..Therefore, in this article, we propose hypotheses explaining why the future of clinical trials in sepsis immunology will likely rely on stimulating immune functions for rebalancing immune homeostasis... - Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survivalGuillaume Monneret
Hospices Civils de Lyon, Hopital Neurologique, Laboratoire d Immunologie, Lyon, France
Crit Care Med 35:1942-7. 2007..The main objective of the current study was to measure human leukocyte antigen-G (soluble and membrane proteins) in septic shock... - The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentrationGuillaume Monneret
Immunology Laboratory GM, MEF, FV, ALD, JBi and Intensive Care Units Jbo, AL, Lyon Sud University Hospital, 69495 Pierre Benite, France
Immunol Lett 95:193-8. 2004..They might constitute helpful indicators for staging patients and making a decision about whether to institute a therapy with molecules able of reversing sepsis-induced immunosuppression... - Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysisGuillaume Monneret
Lyon Sud University Hospital, France
Crit Care Med 31:2068-71. 2003..Because human peripheral blood CD4+CD25+ T cells have been characterized as suppressor T cells, we hypothesized they might be increased in sepsis-induced immunoparalysis... - Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: application to the monitoring of patients with septic shockGuillaume Monneret
Immunology Laboratory and Intensive Care Units, Lyon-Sud University Hospital, , France
Clin Chem 48:1589-92. 2002 - [Reversing ICU-acquired immunosuppression: an innovative biomarker-guided therapeutic strategy for decreasing sepsis mortality and nosocomial infection rate]G Monneret
Laboratoire d Immunologie Cellulaire, Hospices Civils de Lyon, Hopital E Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
Pathol Biol (Paris) 59:329-33. 2011..This review attempts to integrate these new facts into an up-to-date account of sepsis pathophysiology... - Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shockFabienne Venet
Hospices Civils de Lyon, Hopital Neurologique, Laboratoire d Immunologie, Lyon, France
Crit Care Med 35:1910-7. 2007..The main objective of the current study was to characterize the appearance and the duration of low mHLA-DR expression after severe burn as well as to determine its correlation with mortality and septic complications... - Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanismFabienne Venet
Immunology Laboratory, , Hospices Civils de Lyon, 59 Boulevard Pinel, 69677 Lyon Cedex, France
J Immunol 177:6540-7. 2006..This may be an important mechanism for septic shock-induced immunosuppression and may offer new perspectives for the treatment of this deadly disease... - Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patientsCaroline Guignant
Flow Cytometry Unit, Immunology Laboratory, Hopital E Herriot, Hospices Civils de Lyon, 5, Place d Arsonval, 69437, Lyon Cedex 03, France
Intensive Care Med 35:1859-67. 2009.... - Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patientsAlexandre Pachot
Department of Human Genetics, bioMerieux, Parc Club du Moulin à Vent, 33, avenue du Docteur LEVY, 69693 Vénissieux Cedex, France
Crit Care Med 33:31-8; discussion 236-7. 2005.... - Delayed increase of S100A9 messenger RNA predicts hospital-acquired infection after septic shockMathieu Fontaine
Intensive Care Unit, Hospices Civils de Lyon, CHU Lyon Sud, Pierre Benite, France
Crit Care Med 39:2684-90. 2011..The aim of this study was to assess the capability of S100A9 messenger RNA in whole blood from patients with septic shock to predict survival and the occurrence of hospital-acquired infection... - Proatrial natriuretic peptide is a better predictor of 28-day mortality in septic shock patients than proendothelin-1Caroline Guignant
Hospices Civils de Lyon, Hopital E Herriot, Laboratoire d Immunologie, Lyon, France
Clin Chem Lab Med 48:1813-20. 2010.... - Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytesFabienne Venet
Immunology Laboratory, Lyon-Sud University Hospital, France
Crit Care Med 32:2329-31. 2004..We hypothesize that it might be due to a resistance of Treg to apoptosis processes occurring during septic shock... - The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shockFabienne Venet
Flow Cytometry Unit, Immunology Laboratory and Intensive Care Units, Lyon Sud University Hospital, CEDEX F 69495 Pierre Bénite, France
Clin Immunol 113:278-84. 2004..Importantly, the persistence over time of low levels of CRTH2 or CCR3 expression was found in nonsurvivors. We hypothesize that the restoration of CRTH2/CCR3 expression may be an indicator for optimal recovery after septic shock... - Early interleukin-6 and slope of monocyte human leukocyte antigen-DR: a powerful association to predict the development of sepsis after major traumaAurélie Gouel-Chéron
Service de Reanimation, Hôpital Edouard Herriot Hospices Civils de Lyon, Lyon, France
PLoS ONE 7:e33095. 2012.... - Persistent high level of circulating midregional-proadrenomedullin and increased risk of nosocomial infections after septic shockCaroline Guignant
Immunology Laboratory, E Herriot Hospital, Hospices Civils de Lyon, France
J Trauma Acute Care Surg 72:293-6. 2012.... - Upregulation of the pro-apoptotic genes BID and FAS in septic shock patientsFanny Turrel-Davin
Joint Unit Hospices Civils de Lyon bioMérieux, Hopital Edouard Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
Crit Care 14:R133. 2010..However, no routine biomarkers of apoptosis are so far available in patients. Thus, the aim of our study was to assess the different biomarkers of apoptosis putatively usable on a routine basis in septic shock... - IL-7 restores lymphocyte functions in septic patientsFabienne Venet
Hospices Civils de Lyon, Laboratoire d Immunologie Cellulaire, Hopital E Herriot, 69003 Lyon, France
J Immunol 189:5073-81. 2012..To our knowledge, this constitutes the first report of rhIL-7 ability to restore normal lymphocyte functions in septic patients. These results support the rational for initiating a clinical trial testing rhIL-7 in septic shock... - Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppressionAlexandre Pachot
Joint Unit Hospices Civils de Lyon bioMérieux, Hopital Edouard Herriot, 5 Place d Arsonval, Lyon, France
J Immunol 180:6421-9. 2008..This could represent an important new feature of sepsis-induced immunosuppression... - Flow cytometry developments and perspectives in clinical studies: examples in ICU patientsFabienne Venet
Laboratoire d Immunologie, Hopital E Herriot, Hospices Civils de Lyon, 69437, Lyon Cedex 03, France
Methods Mol Biol 761:261-75. 2011..Importantly, many other markers of immune dysfunction are currently under development that could further enable the administration of targeted individualized therapy in ICU patients... - Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shockAlexandre Pachot
Department of Human Genetics, bioMerieux, 69280 Marcy l Etoile, France
Clin Immunol 114:61-9. 2005..These results illustrate both the potential of whole blood mRNA quantification assays and the interest of a multiparametric strategy to better stratify septic patients... - Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patientsCaroline Guignant
Hospices Civils de Lyon, Hôpital E, Herriot, Laboratoire d Immunologie, 5 Place d Arsonval, 69003 Lyon, France
Crit Care 15:R99. 2011..It has recently been shown that PD-1 knock-out mice exhibited a lower mortality in response to experimental sepsis. The objective of the present study was to investigate PD-1-related molecule expressions in septic shock patients... - Both percentage of gammadelta T lymphocytes and CD3 expression are reduced during septic shockFabienne Venet
Immunology Laboratory, Lyon-Sud University Hospital, France
Crit Care Med 33:2836-40. 2005..These two observations constitute additional pieces of the complex puzzle of sepsis-induced immunosuppression... - Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctionsFabienne Venet
Hospices Civils de Lyon, Immunology Laboratory, Hôpital E, Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
Crit Care 15:231. 2011..The next critical step would be to use these standardized flow cytometry protocols in large multicentric clinical trials testing individualized immunotherapy... - Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shockCaroline Landelle
Laboratoire de Biometrie et Biologie Evolutive, Epidémiologie et Santé Publique, CNRS, UMR 5558, Universite Lyon, Lyon, France
Intensive Care Med 36:1859-66. 2010.... - Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patientsFabienne Venet
Hospices Civils de Lyon, Immunology Laboratory, Hop E Herriot, 69437 Lyon, France
Int Immunopharmacol 11:2086-90. 2011..These results need to be confirmed in a larger cohort of patients... - Innovative therapeutic strategies for restoring lymphocyte functions in septic patientsFanny Turrel
Joint Unit Civils de Lyon bioMérieux, Hopital Edouard Herriot, Lyon, France
Inflamm Allergy Drug Targets 7:181-6. 2008..This review focuses on lymphocyte dysfunctions described so far in patients and on potential new therapeutic strategies aimed at restoring a functional lymphocytic response after sepsis... - Early assessment of leukocyte alterations at diagnosis of septic shockFabienne Venet
Hospices Civils de Lyon, CRB Sepsis, France
Shock 34:358-63. 2010..No significant variation could be detected within the first 48 h. This should be taken into account in the forthcoming clinical trials testing immunomodulating therapies in septic shock patients... - FcgammaRIIIb and complement component C7 codeficiency in a patient with recurrence of fulminant meningococcal septic shockAnne Lise Debard
Immunology Laboratory, Lyon Sud University Hospital, Pierre Benite, France
Clin Infect Dis 40:1679-83. 2005..We found a total deficiency of FcgammaRIIIb on neutrophils, which could partially explain the unusually severe clinical presentation... - Percentage of regulatory T cells CD4+CD25+CD127- in HIV-infected patients is not reduced after cryopreservationFabienne Venet
Hospices Civils de Lyon, Hopital E Herriot, Pavillon E, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
J Immunol Methods 357:55-8. 2010..Ours results indicate that cryopreservation does not affect this specific T lymphocyte subset... - Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary studyAlexandre Pachot
Joint Unit bioMérieux, Hospices Civils de Lyon, Hopital Edouard Herriot, France
Immunol Lett 106:63-71. 2006.... - Nosocomial infection after septic shock among intensive care unit patientsCaroline Landelle
Service d Hygiène, Epidémiologie et Prévention, Hopital Edouard Herriot, and the Centre d Investigation Clinique de Lyon, CIC201, INSERM, France
Infect Control Hosp Epidemiol 29:1054-65. 2008..To measure the incidence of nosocomial infection (NI) among patients with septic shock according to the place of septic shock acquisition and to evaluate the increase in the risk of pulmonary infection associated with septic shock... - Comparative inflammatory properties of staphylococcal superantigenic enterotoxins SEA and SEG: implications for septic shockOlivier Dauwalder
, INSERM E230, IFR-62, Lyon, France
J Leukoc Biol 80:753-8. 2006..These results suggest that the association of SEA with the severity of S. aureus septic shock, characterized by a deleterious, inflammatory cascade, may be explained partly by the specific proinflammatory properties of this superantigen... - CD4+CD25+CD127- assessment as a surrogate phenotype for FOXP3+ regulatory T cells in HIV-1 infected viremic and aviremic subjectsJulien Saison
Hospices Civils de Lyon, Hopital Edouard Herriot, Laboratoire d Immunologie, Lyon, F 69003, France
Cytometry B Clin Cytom 84:50-4. 2013..Therefore, the objective of the present study was to assess the correlation between frequencies of CD4+CD25+CD127- and CD4+CD25+FOXP3+ lymphocytes in viremic and matched aviremic HIV-infected patients... - Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major traumaAurélie Cheron
Hospices Civils de Lyon, Service de Reanimation, Hopital Edouard Herriot, 5 place d Arsonval 69437 Lyon Cedex 03, France
Crit Care 14:R208. 2010..The main objective of this study was to determine the relation between mHLA-DR expression in severe trauma patients and the development of sepsis... - Decreased T-cell repertoire diversity in sepsis: a preliminary studyFabienne Venet
Cellular Immunology Laboratory, Hopital E Herriot, Lyon, France
Crit Care Med 41:111-9. 2013..The objective of this study was to investigate T-cell receptor diversity, an important feature of T-cell response, in patients with septic shock... - Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophilsGuillaume Monneret
Immunology Laboratory, Lyon-Sud University Hospital, , France
J Pharmacol Exp Ther 312:627-34. 2005..The balance between DP(1) and DP(2) receptors may be important in determining the magnitude of basophil responses to this prostaglandin... - Monitoring of basophil activation using CD63 and CCR3 in allergy to muscle relaxant drugsGuillaume Monneret
Immunology Laboratory, Lyon-Sud University Hospital, , France
Clin Immunol 102:192-9. 2002..Furthermore, the CD63 protocol showed good specificity (100%). We conclude that our flow cytometry protocol is a promising tool in allergy diagnosis since it is specific and complementary to specific IgE detection... - Assessment of cellular immune parameters in paediatric toxic shock syndrome: a report of five casesOlivier Dauwalder
Centre National de Références des Staphylocoques, Faculté de médecine Lyon Est, Universite de Lyon, France
FEMS Immunol Med Microbiol 66:116-9. 2012..Future studies must isolate and better characterize the phenotypic and functional properties of Treg subsets during TSS to understand the mechanisms sustaining their increase, especially the putative role of superantigens... - Alveolar and serum procalcitonin: diagnostic and prognostic value in ventilator-associated pneumoniaFrederic Duflo
Department of Anesthesiology, hôpital de l Hôtel dieu, Lyon, France
Anesthesiology 96:74-9. 2002..The potential role of serum and alveolar procalcitonin as early markers of ventilator-associated pneumonia (VAP) and its prognostic value were investigated... - Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samplesJulie Demaret
Hospices Civils de Lyon, Hopital Edouard Herriot, Laboratoire d Immunologie, Lyon F 69003, France
Cytometry B Clin Cytom 84:59-62. 2013..The objective of the present work was to test, in an inter-laboratory clinical study, a standardized protocol for mHLA-DR measurement by flow cytometry... - Statins and sepsis: do we really need to further decrease monocyte HLA-DR expression to treat septic patients?Guillaume Monneret
Lancet Infect Dis 7:697-9. 2007 - Dear PCT, you are not a specific marker of bacterial infectionGuillaume Monneret
Intensive Care Med 28:377-8. 2002 - Regulatory T cell populations in sepsis and traumaFabienne Venet
Division of Surgical Research, Rhode Island Hospital Brown University, 593 Eddy Street, Providence, RI 02903, USA
J Leukoc Biol 83:523-35. 2008.... - Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized studyWolf Dietrich Döcke
Institute of Medical Immunology, Charite Campus Mitte, Humboldt University of Berlin, and University Hospital, Charite Berlin, Germany
Clin Chem 51:2341-7. 2005..Single-center trials have shown that monocytic HLA-DR is a good marker for monitoring the severity of temporary immunodepression after trauma, major surgery, or sepsis. A new test for measuring monocytic HLA-DR is now available... - 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophilsGuillaume Monneret
Department of Medicine, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada
J Pharmacol Exp Ther 304:349-55. 2003.... - High serum procalcitonin levels do not predict bacteremia in adult patients with acute feverAnne-Lise Debard
Clin Infect Dis 36:825-6; author reply 826-7. 2003 - 5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytesPanagiota B Stamatiou
Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain Street, Montreal, Quebec H2X 2P2, Canada
J Biol Chem 279:28159-64. 2004.... - 15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophilsGuillaume Monneret
Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
J Immunol 168:3563-9. 2002.... - Consider delayed immunosuppression into the concept of sepsisJoerg C Schefold
Crit Care Med 36:3118. 2008