G Millat

Summary

Affiliation: Hospices Civils de Lyon
Country: France

Publications

  1. pmc A human MYBPC3 mutation appearing about 10 centuries ago results in a hypertrophic cardiomyopathy with delayed onset, moderate evolution but with a risk of sudden death
    Carolien H Teirlinck
    Laboratoire Cardiogénétique, Centre de biologie et pathologie est, Groupe Hospitalier Est, 59 Boulevard Pinel, Bron, Lyon, 69677, France
    BMC Med Genet 13:105. 2012
  2. doi request reprint Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Eur J Med Genet 54:e570-5. 2011
  3. doi request reprint Development of a high resolution melting method for the detection of genetic variations in Long QT Syndrome
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Clin Chim Acta 412:203-7. 2011
  4. doi request reprint Development of a high resolution melting method for the detection of genetic variations in hypertrophic cardiomyopathy
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Clin Chim Acta 411:1983-91. 2010
  5. doi request reprint Prevalence and spectrum of mutations in a cohort of 192 unrelated patients with hypertrophic cardiomyopathy
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Eur J Med Genet 53:261-7. 2010
  6. doi request reprint Contribution of long-QT syndrome genetic variants in sudden infant death syndrome
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, Bron Cedex, France
    Pediatr Cardiol 30:502-9. 2009
  7. doi request reprint Validation of high-resolution DNA melting analysis for mutation scanning of the LMNA gene
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Bron, France
    Clin Biochem 42:892-8. 2009
  8. doi request reprint Rapid, sensitive and inexpensive detection of SCN5A genetic variations by high resolution melting analysis
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, Bron Cedex, France
    Clin Biochem 42:491-9. 2009
  9. ncbi request reprint Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome
    G Millat
    Laboratoire de Biochimie et Biologie Moleculaire, Hopital CardioVasculaire et Pneumologique L Pradel, Bron, France, and Unidad de neonatología Servicio de pediatría, Hospital Universitario Rio Hortega, Valladolid, Spain
    Clin Genet 70:214-27. 2006
  10. doi request reprint Molecular characterization of a large MYBPC3 rearrangement in a cohort of 100 unrelated patients with hypertrophic cardiomyopathy
    V Chanavat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Eur J Med Genet 55:163-6. 2012

Collaborators

Detail Information

Publications13

  1. pmc A human MYBPC3 mutation appearing about 10 centuries ago results in a hypertrophic cardiomyopathy with delayed onset, moderate evolution but with a risk of sudden death
    Carolien H Teirlinck
    Laboratoire Cardiogénétique, Centre de biologie et pathologie est, Groupe Hospitalier Est, 59 Boulevard Pinel, Bron, Lyon, 69677, France
    BMC Med Genet 13:105. 2012
    ..Hypertrophic Cardiomyopathy (HCM) is a genetically heterogeneous disease. One specific mutation in the MYBPC3 gene is highly prevalent in center east of France giving an opportunity to define the clinical profile of this specific mutation...
  2. doi request reprint Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Eur J Med Genet 54:e570-5. 2011
    ..The discovery of novel DCM mutations is crucial for clinical management of patients and their families because pre-symptomatic diagnosis is possible and precocious intervention could prevent or ameliorate the prognosis...
  3. doi request reprint Development of a high resolution melting method for the detection of genetic variations in Long QT Syndrome
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Clin Chim Acta 412:203-7. 2011
    ..Due to large cohorts to investigate, the size of the 3 prevalent mutated genes, and the presence of a large spectrum of private mutations, mutational screening requires an extremely sensitive and specific scanning method...
  4. doi request reprint Development of a high resolution melting method for the detection of genetic variations in hypertrophic cardiomyopathy
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Clin Chim Acta 411:1983-91. 2010
    ....
  5. doi request reprint Prevalence and spectrum of mutations in a cohort of 192 unrelated patients with hypertrophic cardiomyopathy
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Eur J Med Genet 53:261-7. 2010
    ..No single or cumulative genetic modifier effect could be evidenced in this HCM cohort...
  6. doi request reprint Contribution of long-QT syndrome genetic variants in sudden infant death syndrome
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, Bron Cedex, France
    Pediatr Cardiol 30:502-9. 2009
    ..Identification of more LQTS mutations in SIDS cases could provide new insights into the pathophysiology of SIDS and, consequently, reduce the number of unexplained sudden infant deaths...
  7. doi request reprint Validation of high-resolution DNA melting analysis for mutation scanning of the LMNA gene
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Bron, France
    Clin Biochem 42:892-8. 2009
    ..LMNA mutations lead to a wide spectrum of disorders now called laminopathies. Due to large cohorts to investigate, mutational screening must be performed using an extremely sensitive and specific scanning method...
  8. doi request reprint Rapid, sensitive and inexpensive detection of SCN5A genetic variations by high resolution melting analysis
    Gilles Millat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, Bron Cedex, France
    Clin Biochem 42:491-9. 2009
    ..SCN5A mutations lead to a wide spectrum of cardiovascular disorders. Due to large cohorts to investigate and the large gene size, mutational screening must be performed using an extremely sensitive and specific scanning method...
  9. ncbi request reprint Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome
    G Millat
    Laboratoire de Biochimie et Biologie Moleculaire, Hopital CardioVasculaire et Pneumologique L Pradel, Bron, France, and Unidad de neonatología Servicio de pediatría, Hospital Universitario Rio Hortega, Valladolid, Spain
    Clin Genet 70:214-27. 2006
    ..Most of our patients (84%) showed complex molecular pattern with one mutation (and even two for four patients) associated with several SNPs located in several LQTS genes...
  10. doi request reprint Molecular characterization of a large MYBPC3 rearrangement in a cohort of 100 unrelated patients with hypertrophic cardiomyopathy
    V Chanavat
    Laboratoire de Cardiogénétique Moléculaire, Centre de biologie et pathologie est, Hospices Civils de Lyon, Lyon, France
    Eur J Med Genet 55:163-6. 2012
    ..However, it appears that MLPA strategy, that moderates the identification of large MYBPC3 rearrangements, might confirm a clinical diagnosis only in a small number of patients (<1%)...
  11. doi request reprint [Fabry disease among hypertrophic cardiomyopathy of genetic origin]
    P Bouvagnet
    Laboratoire Cardiogénétique, Groupe Hospitalier Est, Hospices Civils de Lyon, Lyon, France
    Rev Med Interne 31:S233-7. 2010
    ..It is important to think about a putative Fabry disease in cases with hypertrophic cardiomyopathy not associated with any obvious cause...
  12. ncbi request reprint Identification of iduronate sulfatase gene alterations in 70 unrelated Hunter patients
    R Froissart
    Biochimie Pédiatrique, Hopital Debrousse, Lyon, France
    Clin Genet 53:362-8. 1998
    ..The mother was not found to be a carrier in five cases among the 44 sporadic cases. Haplotype analysis demonstrated a higher frequency of mutations in male meiosis...
  13. ncbi request reprint [Long QT syndrome in children: analysis of the Lyon series]
    M Iraqi
    Service de Cardiologie Pediatrique, Hopital Louis Pradel, Lyon
    Arch Mal Coeur Vaiss 99:134-40. 2006
    ..This confirms the limits of genetic diagnosis, which could be envisaged in all cases. All of the clinical and ECG data should be combined with the genetic analysis in order to confirm the diagnosis...