J Honnorat

Summary

Affiliation: Hospices Civils de Lyon
Country: France

Publications

  1. pmc Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats
    Christiane S Hampe
    University of Washington, School of Medicine, SLU S 276, Seattle, WA 98109, USA
    Orphanet J Rare Dis 8:82. 2013
  2. doi request reprint Autoimmune limbic encephalopathy and anti-Hu antibodies in children without cancer
    Jerome Honnorat
    French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hopital Neurologique, Neurologie B, Bron, France
    Neurology 80:2226-32. 2013
  3. pmc Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia
    Mario U Manto
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, USA
    Orphanet J Rare Dis 6:3. 2011
  4. pmc In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
    Mario Manto
    FNRS Laboratoire de Neurologie Expérimentale, ULB, Belgium
    Orphanet J Rare Dis 5:31. 2010
  5. pmc An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients
    François Ducray
    INSERM, U842, Lyon, F 69372 France
    Mol Cancer 9:234. 2010
  6. ncbi request reprint Advances in paraneoplastic neurological syndromes
    Jerome Honnorat
    Hopital Neurologique, 50 Boulevard Pinel, 69677 Bron Cedex, France
    Curr Opin Oncol 16:614-20. 2004
  7. pmc Paraneoplastic neurological syndromes
    Jerome Honnorat
    Inserm U 842, Universite Claude Bernard Lyon 1, Lyon, France
    Orphanet J Rare Dis 2:22. 2007
  8. doi request reprint [Paraneoplastic neurological syndromes in 2008]
    J Honnorat
    UMR INSERM U842, Universite Claude Bernard Lyon 1, France
    Rev Neurol (Paris) 165:S59-65. 2009
  9. ncbi request reprint [Clinical presentation of immune mediated cerebellar ataxia]
    J Honnorat
    Neurologie B, Hopital Neurologique, Lyon
    Rev Neurol (Paris) 159:11-22. 2003
  10. pmc Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies
    J Honnorat
    Centre de Référence Maladies Rares Syndromes Neurologiques Paranéoplasiques, Hospices Civils de Lyon, Hopital Neurologique, Bron, France
    J Neurol Neurosurg Psychiatry 80:412-6. 2009

Collaborators

Detail Information

Publications42

  1. pmc Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats
    Christiane S Hampe
    University of Washington, School of Medicine, SLU S 276, Seattle, WA 98109, USA
    Orphanet J Rare Dis 8:82. 2013
    ..To assess the effect of epitope-specific GAD65Ab on cognitive and motor functions, we conducted behavioral experiments in rats that received cerebellar injections with two distinct monoclonal GAD65Ab (b96.11 and b78)...
  2. doi request reprint Autoimmune limbic encephalopathy and anti-Hu antibodies in children without cancer
    Jerome Honnorat
    French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hopital Neurologique, Neurologie B, Bron, France
    Neurology 80:2226-32. 2013
    ..The aim of this study was to describe the clinical presentation of children and adolescents with anti-Hu antibodies (Hu-Abs)...
  3. pmc Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia
    Mario U Manto
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, USA
    Orphanet J Rare Dis 6:3. 2011
    ..To investigate whether Stiff-person syndrome (SPS) and cerebellar ataxia (CA) are associated with distinct GAD65-Ab epitope specificities and neuronal effects...
  4. pmc In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
    Mario Manto
    FNRS Laboratoire de Neurologie Expérimentale, ULB, Belgium
    Orphanet J Rare Dis 5:31. 2010
    ..Patients' antibodies cause a decrease of the density of NMDA-R and synaptic mediated currents, but the in vivo effects on the extracellular glutamate and glutamatergic transmission are unknown...
  5. pmc An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients
    François Ducray
    INSERM, U842, Lyon, F 69372 France
    Mol Cancer 9:234. 2010
    ..The gene expression (n = 56) and genomic profiles (n = 67) of responders and non-responders to first-line chemotherapy or radiation therapy alone were compared on Affymetrix Plus 2 gene expression arrays and BAC CGH arrays...
  6. ncbi request reprint Advances in paraneoplastic neurological syndromes
    Jerome Honnorat
    Hopital Neurologique, 50 Boulevard Pinel, 69677 Bron Cedex, France
    Curr Opin Oncol 16:614-20. 2004
    ..To describe specificities and new advances in paraneoplastic neurologic syndromes (PNSs)...
  7. pmc Paraneoplastic neurological syndromes
    Jerome Honnorat
    Inserm U 842, Universite Claude Bernard Lyon 1, Lyon, France
    Orphanet J Rare Dis 2:22. 2007
    ..As PNS are believed to be immune-mediated, suppression of the immune response represents another treatment approach...
  8. doi request reprint [Paraneoplastic neurological syndromes in 2008]
    J Honnorat
    UMR INSERM U842, Universite Claude Bernard Lyon 1, France
    Rev Neurol (Paris) 165:S59-65. 2009
    ..Interestingly, the likelihood of improvement is significantly higher in patients with these antibodies against neuronal surface antigens than in those with classical anti-onconeural antibodies or without antibodies...
  9. ncbi request reprint [Clinical presentation of immune mediated cerebellar ataxia]
    J Honnorat
    Neurologie B, Hopital Neurologique, Lyon
    Rev Neurol (Paris) 159:11-22. 2003
    ....
  10. pmc Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies
    J Honnorat
    Centre de Référence Maladies Rares Syndromes Neurologiques Paranéoplasiques, Hospices Civils de Lyon, Hopital Neurologique, Bron, France
    J Neurol Neurosurg Psychiatry 80:412-6. 2009
    ..However, it is not clear whether these antibodies are associated with specific neurological symptoms or are only markers of anti-cancer immune reaction...
  11. ncbi request reprint Onconeural antibodies are essential to diagnose paraneoplastic neurological syndromes
    J Honnorat
    Hôpital Pierre Wertheimer, Hospices Civils de Lyon and INSERM U433 and Institut Fédératif des Neurosciences, Lyon, France
    Acta Neurol Scand Suppl 183:64-8. 2006
    ..Unfortunately, about one-third of the patients do not have detectable antibodies and 5-10% have an atypical antibody that is not well characterized...
  12. doi request reprint New concepts in paraneoplastic neurological syndromes
    J Honnorat
    Centre de Référence Maladies Rares Syndromes Neurologiques Paranéoplasiques, Hospices Civils de Lyon, Hopital Neurologique, 59 Boulevard Pinel, Lyon Cedex 03, France
    Rev Neurol (Paris) 167:729-36. 2011
    ....
  13. pmc Clinical and imaging predictors of intracerebral haemorrhage in stroke patients treated with intravenous tissue plasminogen activator
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    J Neurol Neurosurg Psychiatry 76:70-5. 2005
    ..To evaluate clinical, biological, and pretreatment imaging variables for predictors of tissue plasminogen activator (tPA) related intracerebral haemorrhage (ICH) in stroke patients...
  14. ncbi request reprint Pulmonary embolism: an unusual complication of cerebral venous thrombosis
    S Cakmak
    Neurology and Neurosurgery Hospital, INSERM U 630, Lyon, France
    Neurology 65:1136-7. 2005
  15. ncbi request reprint Baseline magnetic resonance imaging parameters and stroke outcome in patients treated by intravenous tissue plasminogen activator
    N Nighoghossian
    Cerebrovascular Disease Center, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    Stroke 34:458-63. 2003
    ....
  16. ncbi request reprint Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes
    D Ricard
    Institut National de la Santé et de la Recherche Médicale U 433, Institut Federatif des Neurosciences de Lyon, Hopital Neurologique, 69003 Lyon, France
    J Neurosci 21:7203-14. 2001
    ....
  17. ncbi request reprint Early diagnosis of hemorrhagic transformation: diffusion/perfusion-weighted MRI versus CT scan
    N Nighoghossian
    Cerebrovascular Disease and Ataxia Research Center, Lyon, France
    Cerebrovasc Dis 11:151-6. 2001
    ..Day 7 CT confirmed HT in all patients who had early suspicion of bleeding according to DWI criteria. CONCLUSION: This study suggests that new MRI techniques may allow an early detection of HT, thus improving the management of stroke...
  18. ncbi request reprint Intravenous tPA in acute ischemic stroke related to internal carotid artery dissection
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    Neurology 54:2159-61. 2000
    ..Four patients of 11 (36.4%) made an excellent recovery (day 90 m-RS score: 0 to 1). This study demonstrates the feasibility of IV thrombolysis with tPA (0.8 mg/kg) in ischemic stroke related to ICA dissection within the first 7 hours...
  19. ncbi request reprint Transient neurologic symptoms related to cerebral amyloid angiopathy: usefulness of T2*-weighted imaging
    J A Roch
    Cerebrovascular Unit, Prof P Trouillas, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Bron, France
    Cerebrovasc Dis 20:412-4. 2005
  20. ncbi request reprint Hemiplegia in posterior cerebral artery occlusion: acute MRI assessment
    A Montavont
    Cerebrovascular Disease Center, Lyon, France
    Cerebrovasc Dis 16:452-3. 2003
  21. ncbi request reprint Hyperthyroidism and cerebral venous thrombosis
    S Mouton
    Cerebrovascular Disease Center, Lyon, France
    Eur Neurol 54:78-80. 2005
    ..Hyperthyroidism may have an impact on FVIII level. Accordingly in patients with hyperthyroidism and neurological symptoms, the diagnosis of CVT should be considered and an exhaustive coagulation screening may be appropriate...
  22. ncbi request reprint [Long-term outcome in patients with symptomatic low-grade oligodendrogliomatous tumors treated by cytotoxic agents]
    H Catenoix
    Service de Neurologie B, Hopital Neurologique, Lyon
    Rev Neurol (Paris) 162:1069-75. 2006
    ..However, symptomatic low-grade gliomas require prompt therapeutic intervention because of neurological impairment, uncontrolled seizures, and deterioration of life quality...
  23. ncbi request reprint [Necrosis of a hypophyseal adenoma and ischemic cerebral vascular accident ]
    H Catenoix
    Service de Neurologie B, Hopital Neurologique, Pierre Wertheimer, Lyon
    Rev Neurol (Paris) 158:734-6. 2002
    ..Neuroophthalmologic examination and hormonal screening were normal. Though pituitary apoplexy and stroke might represent a fortuitous association, several mechanisms underlying such clinical picture are advanced...
  24. ncbi request reprint Thrombolytic therapy in acute ischemic stroke patients with cardiac thrombus
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    Neurology 57:2122-5. 2001
    ..One patient had late recurrent cerebral embolism and died. These data suggest that the presence of a cardiac thrombus is not associated with a high risk of recurrent embolism in patients with stroke who are given IV tPA...
  25. ncbi request reprint [Delayed post-anoxic leukoencephalopathy]
    L Peter
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon
    Rev Neurol (Paris) 160:1085-8. 2004
    ..The onset of post-anoxic encephalopathies can be delayed after the acute hypoxic injury...
  26. ncbi request reprint Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes
    J Honnorat
    INSERM U 433, Hopital Neurologique, Lyon, France
    Eur J Neurosci 11:4226-32. 1999
    ..The identification of the Ulip/CRMP proteins as recognized by anti-CV2 sera should provide new insights into the role of Ulip/CRMPs in oligodendrocytes and into pathophysiology of PND...
  27. ncbi request reprint [Knowledge about stroke in patients admitted in a French Stroke Unit]
    L Derex
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon, France
    Rev Neurol (Paris) 160:331-7. 2004
    ..Educational campaigns must stress the risk factors and symptoms of stroke and the appropriate response in the hopes of reducing admission delay and improving stroke prevention...
  28. ncbi request reprint Seronegative paraneoplastic cerebellar degeneration: the PNS Euronetwork experience
    F Ducray
    French Reference Center on Paraneoplastic Neurological Syndrome, Department of Neuro Oncology, Hospices Civils de Lyon, Hopital Neurologique, Bron, France Lyon Neuroscience Research Center INSERM U1028 CNRS UMR 5292, Lyon, France Université de Lyon Université Claude Bernard Lyon 1, Lyon, France
    Eur J Neurol 21:731-5. 2014
    ..To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies (seronegative PCD)...
  29. ncbi request reprint [Cerebral venous thrombosis presenting as subarachnoid hemorrhage]
    E Tidahy
    Service d Urgences Neurovasculaires, Hopital Neurologique, Lyon
    Rev Neurol (Paris) 160:459-61. 2004
    ..Unfractionated intravenous heparin treatment resulted in resolution of subarachnoid hemorrhage on control brain CT scan and quick clinical recovery...
  30. ncbi request reprint Redifferentiation therapy in brain tumors: long-lasting complete regression of glioblastomas and an anaplastic astrocytoma under long term 1-alpha-hydroxycholecalciferol
    P Trouillas
    Neurology Service, H pital Neurologique, Lyon, France
    J Neurooncol 51:57-66. 2001
    ..Agents able to redifferentiate neoplastic cells in vitro are known. We proposed alfacalcidol, a vitamin D analog able to bind to nuclear receptors regulating mitotic activity, in the treatment of malignant gliomas...
  31. ncbi request reprint Collapsin response mediator protein-3/unc-33-like protein-4 gene: organization, chromosomal mapping and expression in the developing mouse brain
    T T Quach
    Faculte de Medecine Laennec, INSERM U433, Lyon, France
    Gene 242:175-82. 2000
    ....
  32. ncbi request reprint [CSF levels and diagnostic utility of cerebrospinal fluid beta2-microglobulin]
    C Caudie
    Fédération de biologie, Service d Immunologie et Neuro Immunologie, Lyon
    Ann Biol Clin (Paris) 63:631-7. 2005
    ..Elevation of CSF beta2-microglobulin ratio is a sensitive marker of central nervous system disease activity by infiltrating lymphocytes in intracranial lymphomas (10/10) and paraneoplastic neurological syndromes (2/3)...
  33. ncbi request reprint FDG-PET improves tumour detection in patients with paraneoplastic neurological syndromes
    S Younes-Mhenni
    Neurology B, Hôpital Pierre Wertheimer, Universite Claude Bernard, Lyon, France
    Brain 127:2331-8. 2004
    ....
  34. doi request reprint Clinical presentation of immune-mediated cerebellar ataxia
    G Demarquay
    Centre de référence, de diagnostic et de traitement des syndromes neurologiques paranéoplasiques, Hopital Neurologique Pierre Wertheimer, 69677 Bron Cedex, France
    Rev Neurol (Paris) 167:408-17. 2011
    ..The most striking example is paraneoplastic cerebellar ataxia (PCA), which is characterized by autoimmune cross-reaction between tumoral and nervous system antigens...
  35. doi request reprint [Paraneoplastic chorea and behavioral disorders in a patient with anti-CV2/CRMP5 antibodies and two different tumors]
    T Ritzenthaler
    Service de Neurologie B, Hopital Neurologique Pierre Wertheimer, 59, boulevard Pinel, 69677 Bron, France
    Rev Neurol (Paris) 166:90-5. 2010
    ..Paraneoplastic movement disorders are rare. Reported cases frequently describe association with anti-CV2/CRMP5 antibodies...
  36. ncbi request reprint Patterns of care and survival of glioblastoma patients: a comparative study between 2004 and 2008 in Lyon, France
    N Badaoui
    Service de Neuro Oncologie, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 59, boulevard Pinel 69394 Lyon cedex, France
    Rev Neurol (Paris) 170:222-7. 2014
    ..The treatment of glioblastomas (GBMs) has changed significantly since 2005. However, the extent to which this change has improved overall survival (OS) of patients treated outside clinical trials remains to be determined...
  37. doi request reprint [Paraneoplastic neurological syndromes]
    A Didelot
    Centre de référence de diagnostic et de traitement des syndromes neurologiques paranéoplasiques, Hospices Civils de Lyon, Hopital Neurologique, 59, boulevard Pinel, 69677 Bron, France
    Rev Med Interne 32:605-11. 2011
    ..Conversely, PNS associated with ONA targeting intracellular antigens are of poor outcome despite mild improvement under immunosuppressive therapies in some patients...
  38. ncbi request reprint Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study
    N Nighoghossian
    Cerebrovascular Disease Center, and CREATIS UMR CNRS 5515, Lyon, France
    Stroke 33:735-42. 2002
    ..MBs might be a potential risk factor for early cerebral bleeding (CB) after ischemic stroke. Therefore, we assessed the impact of MBs on the occurrence of CB after cerebral infarction...
  39. ncbi request reprint [Management of malignant gliomas diagnosed during pregnancy]
    F Ducray
    Service de Neurologie B, Hopital Neurologique Pierre Wertheimer, Lyon
    Rev Neurol (Paris) 162:322-9. 2006
    ..Glioma is seldom diagnosed during pregnancy. In this situation management presents difficult problems for both neuro-oncologists and obstetricians. We report four cases and discuss the management of this unusual situation...
  40. ncbi request reprint High and low grade oligodendrogliomas (ODG): correlation of amino-acid and glucose uptakes using PET and histological classifications
    F Giammarile
    Service de Medecine Nucleaire, Centre Leon Berard, Lyon, France
    J Neurooncol 68:263-74. 2004
    ..The preferential protein metabolism, already noticeable for low-grade tumor, correlated with glucose metabolism and helped to separate, in vivo, high and low grade tumors...
  41. ncbi request reprint [DNA microarray technology: principles and applications to the study of neurological disorders]
    F Ducray
    Service de Neurologie B, Hopital Neurologique Pierre Wertheimer, Lyon
    Rev Neurol (Paris) 163:409-20. 2007
    ..In this review we discuss the basic principles behind gene expression microarrays, CGH arrays and DNA microarray genotyping, and their potential applications to neurological diseases...
  42. pmc Peri-ictal pseudoprogression in patients with brain tumor
    Sylvain Rheims
    Service de Neuro Oncologie, Hospices Civils de Lyon, 59 Boulevard Pinel, 69003 Lyon, France
    Neuro Oncol 13:775-82. 2011
    ..This phenomenon is important to recognize in order to avoid futile therapeutic escalation...