William Hornebeck

Summary

Country: France

Publications

  1. ncbi request reprint Cumulative influence of elastin peptides and plasminogen on matrix metalloproteinase activation and type I collagen invasion by HT-1080 fibrosarcoma cells
    Eric Huet
    FRE 2260 CNRS, Université de Reims URCA, France
    Clin Exp Metastasis 19:107-17. 2002
  2. ncbi request reprint Matrix-directed regulation of pericellular proteolysis and tumor progression
    William Hornebeck
    Institut Fédératif de Recherche Biomolécules IFR 53, Centre National de la Recherche Scientifique CNRS, FRE 2534, Faculte de Medecine, Universite de Reims Champagne Ardenne, France
    Semin Cancer Biol 12:231-41. 2002
  3. ncbi request reprint The cell-elastin-elastase(s) interacting triade directs elastolysis
    William Hornebeck
    Universite de Reims Champagne Ardenne, UMR 6237 CNRS, Faculte de Medecine, 51 rue Cognacq Jay, 51095 Reims Cedex, France
    Front Biosci (Landmark Ed) 16:707-22. 2011
  4. ncbi request reprint Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival
    William Hornebeck
    Laboratoire de Biochimie, Faculte de Medecine, IFR53 Biomolecules, Centre National de la Recherche Scientifique CNRS FRE 2534, Universite de Reims Champagne Ardenne, 51, rue Cognacq Jay, 51095 Reims, France
    Pathol Biol (Paris) 51:569-73. 2003
  5. ncbi request reprint The elastin connection and melanoma progression
    William Hornebeck
    UMR 6198 CNRS, IFR 53 Biomolecules, Universite de Reims, Reims, France
    Anticancer Res 25:2617-25. 2005
  6. ncbi request reprint [Proteolysis directed by the extracellular matrix]
    William Hornebeck
    FRE 2534 CNRS IFR 53 Biomolécules, Faculte de Medecine, 51 rue Cognacq Jay, 51095 Reims, France
    J Soc Biol 197:25-30. 2003
  7. ncbi request reprint Beneficial and detrimental influences of tissue inhibitor of metalloproteinase-1 (TIMP-1) in tumor progression
    William Hornebeck
    Center National de la Recherche Scientifique CNRS UMR 6198, IFR53 Biomolecules, Faculties of Medicine and Sciences, Reims University, 51, rue Cognacq Jay, 51100 Reims, France
    Biochimie 87:377-83. 2005
  8. doi request reprint Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion
    Arnaud Robinet
    University of Reims Champagne Ardenne, Faculty of Medecine, UMR 6237 CNRS, Reims, France
    Life Sci 82:376-82. 2008
  9. ncbi request reprint The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunit
    Laurent Duca
    Laboratoire de Biochimie, UMR CNRS 6198, Faculte des Sciences, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France
    J Biol Chem 282:12484-91. 2007
  10. ncbi request reprint Elastin receptor (spliced galactosidase) occupancy by elastin peptides counteracts proinflammatory cytokine expression in lipopolysaccharide-stimulated human monocytes through NF-kappaB down-regulation
    Thomas Baranek
    Laboratoire d Immunologie et de Microbiologie, Immuno Pharmacologie Cellulaire et Moléculaire, EA3796 Unité de Formation et de Recherche de Pharmacie, Reims, France
    J Immunol 179:6184-92. 2007

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Cumulative influence of elastin peptides and plasminogen on matrix metalloproteinase activation and type I collagen invasion by HT-1080 fibrosarcoma cells
    Eric Huet
    FRE 2260 CNRS, Université de Reims URCA, France
    Clin Exp Metastasis 19:107-17. 2002
    ..As a consequence, elastin peptides and plasminogen-treated HT-1080 cells displayed a significant type I collagen matrix invasive capacity...
  2. ncbi request reprint Matrix-directed regulation of pericellular proteolysis and tumor progression
    William Hornebeck
    Institut Fédératif de Recherche Biomolécules IFR 53, Centre National de la Recherche Scientifique CNRS, FRE 2534, Faculte de Medecine, Universite de Reims Champagne Ardenne, France
    Semin Cancer Biol 12:231-41. 2002
    ..ECM undergoes conspicuous variations with aging linked to alterations of tissue organization and post-translational modifications of matrix constituents that modify cell-matrix interactions and MMP-2 activation pathway...
  3. ncbi request reprint The cell-elastin-elastase(s) interacting triade directs elastolysis
    William Hornebeck
    Universite de Reims Champagne Ardenne, UMR 6237 CNRS, Faculte de Medecine, 51 rue Cognacq Jay, 51095 Reims Cedex, France
    Front Biosci (Landmark Ed) 16:707-22. 2011
    ..Among properties, they are potent inducers of protease expression catalyzing collagenolysis or amplifying elastin degradation. The ability of unsaturated fatty acids and heparin(s) to control elastases action are delineated...
  4. ncbi request reprint Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival
    William Hornebeck
    Laboratoire de Biochimie, Faculte de Medecine, IFR53 Biomolecules, Centre National de la Recherche Scientifique CNRS FRE 2534, Universite de Reims Champagne Ardenne, 51, rue Cognacq Jay, 51095 Reims, France
    Pathol Biol (Paris) 51:569-73. 2003
    ..Besides, it exhibits keratinocyte and fibroblast growth factor-like activity and has been described as a cell survival factor...
  5. ncbi request reprint The elastin connection and melanoma progression
    William Hornebeck
    UMR 6198 CNRS, IFR 53 Biomolecules, Universite de Reims, Reims, France
    Anticancer Res 25:2617-25. 2005
    ..We propose that S-Gal might constitute a novel therapeutic target for controlling melanoma progression...
  6. ncbi request reprint [Proteolysis directed by the extracellular matrix]
    William Hornebeck
    FRE 2534 CNRS IFR 53 Biomolécules, Faculte de Medecine, 51 rue Cognacq Jay, 51095 Reims, France
    J Soc Biol 197:25-30. 2003
    ..Those data emphasize the potential interest of certain matrikins or pseudo-matrikins as therapeutic agents to control cell invasion...
  7. ncbi request reprint Beneficial and detrimental influences of tissue inhibitor of metalloproteinase-1 (TIMP-1) in tumor progression
    William Hornebeck
    Center National de la Recherche Scientifique CNRS UMR 6198, IFR53 Biomolecules, Faculties of Medicine and Sciences, Reims University, 51, rue Cognacq Jay, 51100 Reims, France
    Biochimie 87:377-83. 2005
    ..We consider that the proMMP-9/TIMP-1 balance is of critical importance in early events of tumor progression, and might show promise as diagnostic and prognostic marker of malignancy...
  8. doi request reprint Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion
    Arnaud Robinet
    University of Reims Champagne Ardenne, Faculty of Medecine, UMR 6237 CNRS, Reims, France
    Life Sci 82:376-82. 2008
    ..Our data document the importance of TSP-1 in promoting MMP-2-mediated cancer cell invasion through interaction between CBDs of the enzyme and TSRs motifs of TSP-1...
  9. ncbi request reprint The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunit
    Laurent Duca
    Laboratoire de Biochimie, UMR CNRS 6198, Faculte des Sciences, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France
    J Biol Chem 282:12484-91. 2007
    ..Altogether, our results indicate that the enzymatic activity of the Neu-1 subunit of the elastin receptor complex is responsible for its signal transduction, presumably through sialic acid generation from undetermined substrates...
  10. ncbi request reprint Elastin receptor (spliced galactosidase) occupancy by elastin peptides counteracts proinflammatory cytokine expression in lipopolysaccharide-stimulated human monocytes through NF-kappaB down-regulation
    Thomas Baranek
    Laboratoire d Immunologie et de Microbiologie, Immuno Pharmacologie Cellulaire et Moléculaire, EA3796 Unité de Formation et de Recherche de Pharmacie, Reims, France
    J Immunol 179:6184-92. 2007
    ....
  11. ncbi request reprint Elastin-derived peptides induce a T-helper type 1 polarization of human blood lymphocytes
    Romain Debret
    Laboratoire d Immunologie, Virologie et Bactériologie, Reims, France
    Arterioscler Thromb Vasc Biol 25:1353-8. 2005
    ....
  12. ncbi request reprint Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism
    Herve Emonard
    CNRS UMR 6198, IFR 53 Biomolecules, Faculty of Medicine, F 51100 Reims, France
    J Biol Chem 279:54944-51. 2004
    ..TIMP-2 complex is a TSP-independent two-step process, involving (i) initial binding to the cell membrane in a RAP-insensitive manner and (ii) subsequent LRP-dependent (RAP-sensitive) internalization and degradation...
  13. ncbi request reprint UVA-mediated down-regulation of MMP-2 and MT1-MMP coincides with impaired angiogenic phenotype of human dermal endothelial cells
    Jean Hubert Cauchard
    CNRS UMR 6198, IFR 53 Biomolecules, Faculty of Medicine, 51, rue Cognacq Jay, Reims 51100, France
    Biochem Biophys Res Commun 345:681-7. 2006
    ..The contribution of MT1-MMP, but not TIMP-1, to the regulation of HMECs' angiogenic phenotype following UVA irradiation was suggested using elastin-derived peptides and TIMP-1 blocking antibody, respectively...
  14. ncbi request reprint Binding of elastin peptides to S-Gal protects the heart against ischemia/reperfusion injury by triggering the RISK pathway
    Arnaud Robinet
    Laboratoire de Pharmacologie Medicale, Universite de Reims Champagne Ardenne, Faculte de Medecine, Reims, France
    FASEB J 21:1968-78. 2007
    ..Such protective effect might be lost with aging, since we found that hearts from 24-month-old rats did not respond to EPs...
  15. ncbi request reprint Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts
    Laurent Duca
    Laboratoire de Biochimie, UMR CNRS 6198, IFR53 Biomolecules, Faculty of Sciences, Universite de Reims Champagne Ardenne, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France
    Mol Pharmacol 67:1315-24. 2005
    ..Thus, p110gamma and B-Raf seem to be important modulators of dermal fibroblasts physiology and should now qualify as therapeutic targets in strategies aiming at limiting elastin degradation contribution to cancer progression...
  16. ncbi request reprint Regulation of matrix metalloproteinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an "old friend"
    Herve Emonard
    CNRS UMR 6198, IFR 53, Faculte de Medecine, 51, rue Cognacq Jay, 51095 Reims Cedex, France
    Biochimie 87:369-76. 2005
    ..This review attempts to summarize recent aspects on the cellular and molecular basis of LRP-mediated endocytic disposal of MMPs...
  17. ncbi request reprint Transforming growth factor-beta1 inhibits tumor growth in a mouse melanoma model by down-regulating the plasminogen activation system
    Laurent Ramont
    Laboratory of Medical Biochemistry and Molecular Biology, CNRS FRE 2534, IFR 53 Biomolecules, Faculty of Medicine, University of Reims Champagne Ardenne, 51 rue Cognacq Jay, F51095, Reims Cedex, France
    Exp Cell Res 291:1-10. 2003
    ..Collectively, these results suggest that TGF-beta1 may inhibit melanoma tumor growth by specifically decreasing plasmin activity of tumor cells and play a protective role during the earliest stages of tumor progression...
  18. doi request reprint Role of the elastin receptor complex (S-Gal/Cath-A/Neu-1) in skin repair and regeneration
    Frank Antonicelli
    Medicine Department CNRS UMR MeDYC 6237, University of Reims Champagne Ardenne, 51 rue Cognacq Jay, Reims Cedex, France
    Wound Repair Regen 17:631-8. 2009
    ....
  19. doi request reprint Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation
    Romain Debret
    Laboratoire de Biochimie, Universite de Reims Champagne Ardenne, CNRS UMR 6237, 51095 Reims Cedex, France
    Biochim Biophys Acta 1783:1718-27. 2008
    ....
  20. ncbi request reprint An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity. Implication in tumor invasion
    Francois Xavier Maquart
    CNRS FRE 2534, Laboratory of Biochemistry and Molecular Biology, IFR 53 Biomolecules, Faculty of Medicine, 51 rue Cognacq Jay, 51095 Reims Cedex, France
    Crit Rev Oncol Hematol 49:199-202. 2004
    ..In this introduction, we present the best characterized matrikines, derived from elastin, connective tissue glycoproteins, or collagens...
  21. ncbi request reprint Neutrophil elastase as a target in lung cancer
    Gautier Moroy
    Universite de Reims Champagne Ardenne, Faculte des Sciences, IFR53 Biomolecules, Laboratoire de Spectroscopies et Structures Biomoléculaires LSSBM, EA 4303 BP 1039, 51687 Reims Cedex2, France
    Anticancer Agents Med Chem 12:565-79. 2012
    ..et al., Biochem. Pharmacol., 2011, 81(5), 626-635) exhibiting such inhibitory bifunctionality. At last, we will propose an original synthetic scheme for designing a potent biheaded HNE/MMP-2 inhibitor...
  22. doi request reprint Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity
    Gwennaël Ledour
    Universite de Reims Champagne Ardenne, CNRS UMR 6229, Institut de Chimie Moleculaire de Reims, Faculte de Pharmacie, IFR53 Biomolecules, 51 rue de Cognacq Jay, 51096 Reims Cedex, France
    Bioorg Med Chem 16:8745-59. 2008
    ..Interaction with the S2 enzyme subsite is mainly responsible for the inhibitory properties of this derivative as confirmed by molecular docking computation...
  23. ncbi request reprint Control of melanoma invasiveness by anticollagenolytic agents: a reappraisal of an old concept
    Erika Bourguet
    Universite de Reims Champagne Ardenne, ICMR UMR 6229 CNRS, Faculte de Pharmacie, 51 rue Cognacq Jay, 51095 Reims, France
    Anticancer Agents Med Chem 9:576-9. 2009
    ..Such compounds could be of value by impeding collagenases to associate to plasma-membrane of invading cancer cells...
  24. ncbi request reprint Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies
    Gautier Moroy
    Laboratoire de Spectroscopies et Structures Biomoléculaires LSSBM, Faculte des Sciences, IFR53 Biomolecules, Universite de Reims Champagne Ardenne, BP 1039, 51687 Reims Cedex 2, France
    Bioorg Med Chem 15:4753-66. 2007
    ..Docking studies indicated that MMP-2, but not MMP-9, could accommodate such substitution; indeed 2a proved to inhibit MMP-2 (IC50=123 nM), while displaying no inhibitory capacity towards MMP-9...
  25. doi request reprint Mechanical forces-induced human osteoblasts differentiation involves MMP-2/MMP-13/MT1-MMP proteolytic cascade
    Stéphane Barthélémi
    Unité INSERM UMRS 926, Interface Biomatériaux Tissus Hôtes, Institut Biomolécules IFR53, Faculté d Odontologie, Universite de Reims Champagne Ardenne, 1 rue du Maréchal Juin, 51095 Reims Cedex, France
    J Cell Biochem 113:760-72. 2012
    ..So, these results suggest that the main proteolytic cascade, MMP-2/MMP-13/MT1-MMP, and more particularly, its initial regulator MT1-MMP is involved in osteoblast differentiation through mechanical forces...
  26. doi request reprint Inhibition of stromelysin-1 by caffeic acid derivatives from a propolis sample from Algeria
    Narimane Segueni
    Unité MEDyC, Université de Reims Champagne Ardennes, UFR de Medecine, Reims, France
    Planta Med 77:999-1004. 2011
    ..3 × 10 (-7) M). In addition, both caffeic acid and (+)-chicoric acid methyl ester present in fraction B (3) significantly inhibited UVA-mediated MMP-3 upregulation by fibroblasts...
  27. ncbi request reprint The elastin peptides-mediated induction of pro-collagenase-1 production by human fibroblasts involves activation of MEK/ERK pathway via PKA- and PI(3)K-dependent signaling
    Laurent Duca
    Universite de Reims Champagne Ardenne, FRE CNRS 2534, IFR53 Biomolecules, UFR Sciences Exactes et Naturelles et UFR Médecine, Laboratoire de Biochimie, Moulin de la Housse, Reims, France
    FEBS Lett 524:193-8. 2002
    ....
  28. pmc Tissue inhibitor of metalloproteinases-1 signalling pathway leading to erythroid cell survival
    Elise Lambert
    Laboratoire de Biochimie, CNRS FRE 2534, IFR53 Biomolecules, UFR Sciences Exactes et Naturelles et UFR Médecine, BP 1039, Universite de Reims Champagne Ardenne, France
    Biochem J 372:767-74. 2003
    ..We conclude that TIMP-1 induces haematopoietic cell survival via the JAK2/PI 3-kinase/Akt/Bad pathway...
  29. ncbi request reprint Proteolyzed matrix as a template for the regulation of tumor progression
    William Hornebeck
    Faculte de Medecine, Centre National de la Recherche Scientifique CNRS, FRE 2534, IFR 53 Biomolecules, Universite de Reims, Champagne Ardenne, 51, rue Cognacq Jay, 51095 Reims Cedex, France
    Biomed Pharmacother 57:223-30. 2003
    ..A matrix-directed pharmacological approach in cancer is now emerging...
  30. ncbi request reprint Influence of cultured dermal fibroblasts on human melanoma cell proliferation, matrix metalloproteinase-2 (MMP-2) expression and invasion in vitro
    Carole Ntayi
    Department of Dermatology CNRS FRE 2534, Faculty of Medicine, University of Reims, 51, rue Cognacq Jay, 51095 Reims, France
    Arch Dermatol Res 295:236-41. 2003
    ....
  31. ncbi request reprint Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP
    Arnaud Robinet
    Laboratoire de Biochimie et Biologie Moleculaire, CNRS UMR 6198, IFR 53 Biomolecules, Faculte de Medecine, Universite de Reims Champagne Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France
    J Cell Sci 118:343-56. 2005
    ..Finally, the effect of elastin peptides on pseudotube formation in MT1-MMP-siRNA transfected cells was totally abolished. These data emphasise the crucial role of MT1-MMP in the elastin-induced angiogenic phenotype of endothelial cells...
  32. ncbi request reprint MMPs inhibitors: new succinylhydroxamates with selective inhibition of MMP-2 over MMP-3
    Valérie Marcq
    IFR 53, UMR CNRS 6013, Faculte de Pharmacie, 51 rue Cognacq Jay, 51096 Reims Cedex, France
    Bioorg Med Chem Lett 13:2843-6. 2003
    ..Potent MMP-2 inhibition and good selectivity for that enzyme have been observed for compounds 1a, 2 and 22...
  33. ncbi request reprint Activation of latent transforming growth factor beta 1 and inhibition of matrix metalloprotease activity by a thrombospondin-like tripeptide linked to elaidic acid
    Jean Hubert Cauchard
    Laboratory of Biochemistry and Molecular Biology, UMR 6198 CNRS, IFR 53 Biomolecules, Faculty of Medicine, University of Reims Champagne Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France
    Biochem Pharmacol 67:2013-22. 2004
    ..At a 1 microM concentration, the lipopeptide decreased by up to 80% enzyme activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be considered as a promising model compound to prevent age-associated dermal alterations...
  34. doi request reprint TIMP-1 binding to proMMP-9/CD44 complex localized at the cell surface promotes erythroid cell survival
    Elise Lambert
    URCA, CNRS UMR 6237 MEDyC, Laboratoire Signalisation et Récepteurs Matriciels, Moulin de Housse, 51687 Reims Cedex 2, France
    Int J Biochem Cell Biol 41:1102-15. 2009
    ..Therefore, our results indicate that the anti-apoptotic signalling of TIMP-1 depends on the formation of a ternary complex between TIMP-1, proMMP-9 and CD44 at the UT-7 erythroid cell surface...
  35. ncbi request reprint The metalloprotease-directed shedding of BP 180 (collagen XVII) from human keratinocytes in culture is unaffected by ceramide and cell-matrix interaction
    Anne Laure Labrousse
    Department of Dermatology, CNRS FRE 2260, IFR 53 Biomolecules, Faculty of Medicine, 51, rue Cognacq Jay, 51095 Reims Cedex, France
    Eur J Dermatol 12:240-6. 2002
    ..Overall our data indicated that the metalloprotease-mediated shedding of BP180 from keratinocytes in culture is insensitive either to agents which activate MAP kinase pathway (ceramide) or to cell-matrix interactions...
  36. ncbi request reprint Carbamylation differentially alters type I collagen sensitivity to various collagenases
    Stéphane Jaisson
    Laboratory of Biochemistry and Molecular Biology, CNRS UMR 6198, IFR53 Biomolecules, Faculty of Medicine, University of Reims Champagne Ardenne, 51 rue Cognacq Jay, 51095 Reims Cedex, France
    Matrix Biol 26:190-6. 2007
    ....
  37. doi request reprint Regeneration of human dermis by a multi-headed Peptide
    Joan Attia-Vigneau
    Regentis International, University of Reims Champagne Ardenne URCA, Faculty of Medicine, SFR CAP Santé, Reims, France
    J Invest Dermatol 134:58-67. 2014
    ..It also induced a proper fiber network organization, reflecting the potency of TFP in skin remodeling and regeneration. ..
  38. doi request reprint Elastin fragmentation and atherosclerosis progression: the elastokine concept
    Pascal Maurice
    Laboratoire Signalisation et Récepteurs Matriciels SiRMa, FRE CNRS 3481 MEDyC, Universite de Reims Champagne Ardenne, Faculté des sciences exactes et naturelles, Reims, France
    Trends Cardiovasc Med 23:211-21. 2013
    ..Finally, we discuss the ERC and its derived signaling pathways as promising therapeutic targets. ..
  39. ncbi request reprint Improved gelatinase a selectivity by novel zinc binding groups containing galardin derivatives
    Franck Augé
    UMR 6013 Isolement, Structure, Transformation et Synthèse de Produits Naturelles, Faculte de Pharmacie, IFR53 Biomolecules, Universite de Reims Champagne Ardenne, 51 rue Cognacq Jay, France
    Bioorg Med Chem Lett 13:1783-6. 2003
    ..On the contrary, those that are based on a hydrazide scaffold present potent selectivity for MMP-2 versus MMP-1...
  40. ncbi request reprint Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes
    Alexia Grandjean-Laquerriere
    Laboratoire d Immunologie EA2070, IFR 53 Biomolecules, INSERM, CNRS, 1 Avenue du Maréchal Juin, 51100, Reims, France
    Cytokine 18:168-77. 2002
    ..Simultaneous AP-1 activation by agents like PDTC might, partially or totally, depending on cytokine-type, counterbalanced the inhibitory effect exerted on UVB-induced NF-kappaB activation in keratinocytes...
  41. ncbi request reprint Triterpenes and phytosterols as human leucocyte elastase inhibitors
    Anne Claire Mitaine-Offer
    Laboratoire de Pharmacognosie, Faculte de Pharmacie, Universite de Reims Champagne Ardenne, Reims, France
    Planta Med 68:930-2. 2002
    ....
  42. ncbi request reprint Inhibition of plasmin-mediated prostromelysin-1 activation by interaction of long chain unsaturated fatty acids with kringle 5
    Eric Huet
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, London W6 8LH, UK
    Biochem Pharmacol 67:643-54. 2004
    ....
  43. ncbi request reprint Elastin-derived peptides upregulate matrix metalloproteinase-2-mediated melanoma cell invasion through elastin-binding protein
    Carole Ntayi
    Department of Dermatology, CNRS FRE 2534, Faculty of Medicine, University of Reims, Champagne Ardenne, France
    J Invest Dermatol 122:256-65. 2004
    ..We hypothesize that ED following interactions with S-Gal elastin receptor can favor melanoma cells invasion through a three-dimensional type I collagen matrix by upregulating MMP-2 activation...
  44. ncbi request reprint Introduction: stroma reaction and cancer progression
    William Hornebeck
    Crit Rev Oncol Hematol 49:177-8. 2004
  45. ncbi request reprint Elastin-elastases and inflamm-aging
    Frank Antonicelli
    Faculty of Medicine Extracellular Matrix and Cell Signaling Reims University, UMR 6198 CNRS 51095 Reims Cedex, France
    Curr Top Dev Biol 79:99-155. 2007
    ....
  46. ncbi request reprint Stromal reaction in cutaneous melanoma
    Anne Laure Labrousse
    Service de Dermatologie, Hopital Robert Debre, 51092 Reims, France
    Crit Rev Oncol Hematol 49:269-75. 2004
    ....
  47. ncbi request reprint A novel strategy for designing specific gelatinase A inhibitors: potential use to control tumor progression
    Franck Augé
    UMR CNRS 6013 Isolement, Structures, Transformation et Synthèse de Produits Naturels, Reims Cedex, France
    Crit Rev Oncol Hematol 49:277-82. 2004
    ..We propose second generation selective MMPs, directed toward gelatinase A (MMP-2), based on a non-hydroxamate Zn-ligand grafted on the galardin (ilomastat) skeleton...
  48. ncbi request reprint Low UVA doses activate the transcription factor NFAT in human fibroblasts by a calcium-calcineurin pathway
    Cécile Mazière
    Laboratoire de Biochimie EA 2087 and INSERM ERI 12, CHU Amiens, Hopital Nord, Place Victor Pauchet, 80054 Amiens Cedex 1, France
    Free Radic Biol Med 39:1629-37. 2005
    ..Because NFAT regulates several genes implicated in the inflammatory response, the enhancement of NFAT activity by low UVA doses might be interpreted in view of the proinflammatory action of solar radiation...
  49. ncbi request reprint Molecular mobility of elastin: effect of molecular architecture
    Valerie Samouillan
    Laboratoire de Physique des Polymères, Universite Paul Sabatier, 31062 Toulouse Cedex 4, France
    Biomacromolecules 3:531-7. 2002
    ..Major differences between the relaxation behavior of elastin and its soluble derivatives have been discussed and correlated with the molecular architecture of the proteins...
  50. ncbi request reprint Beneficial influence of microsatellite instability on gelatinase-tissue inhibitors of metalloproteinase balance in colorectal cancer
    Gerard Thiefin
    CHU Reims, Hopital Robert Debre, Service d Hepato Gastroenterologie, Reims F 51092, France
    Anticancer Res 27:583-8. 2007
    ..It was hypothesized that the difference in cancer progression might be related to distinct gelatinase-tissue inhibitors of metalloproteinase (TIMPs) balance in MSI-H and MSS sporadic CRC...