Martin Holzenberger

Summary

Country: France

Publications

  1. ncbi request reprint Experimental IGF-I receptor deficiency generates a sexually dimorphic pattern of organ-specific growth deficits in mice, affecting fat tissue in particular
    M Holzenberger
    INSERM, U 515, Hopital Saint Antoine, 75571 Paris, France
    Endocrinology 142:4469-78. 2001
  2. pmc Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury
    Karmene Ahamed
    INSERM U719, Hospital Saint Antoine, 75012 Paris, France
    Respir Res 6:31. 2005
  3. ncbi request reprint Expression of insulin-like growth factor-I (IGF-I) and IGF-II in the avian brain: relationship of in situ hybridization patterns with IGF type 1 receptor expression
    M Holzenberger
    INSERM Unite 515, Hopital Saint Antoine, F 75571, Paris, France
    Int J Dev Neurosci 18:69-82. 2000
  4. ncbi request reprint A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit
    M Holzenberger
    U 515 INSERM, Hopital Saint Antoine, Paris, France
    Endocrinology 141:2557-66. 2000
  5. pmc Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene
    M Holzenberger
    INSERM U515, Hopital Saint Antoine, 184 rue du Fbg St Antoine, F 75571 Paris Cedex 12, France France
    Nucleic Acids Res 28:E92. 2000
  6. ncbi request reprint IGF-1 signaling and aging
    Martin Holzenberger
    INSERM U515, Hopital Saint Antoine, 75571 Paris 12, France
    Exp Gerontol 39:1761-4. 2004
  7. ncbi request reprint IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    Martin Holzenberger
    Institut National de la Santé et de la Recherche Médicale U515, Hopital Saint Antoine, 75571 Paris 12, France
    Nature 421:182-7. 2003
  8. ncbi request reprint The GH/IGF-I axis and longevity
    Martin Holzenberger
    INSERM U515, Hopital Saint Antoine, 184 rue Fbg St Antoine, 75571 Paris 12, France
    Eur J Endocrinol 151:S23-7. 2004
  9. pmc Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism
    Laurent Kappeler
    INSERM U893, Hopital Saint Antoine, Paris, France
    PLoS Biol 6:e254. 2008
  10. ncbi request reprint Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout
    Christele Desbois-Mouthon
    INSERM U680, Hopital St Antoine, Paris, France
    FASEB J 20:773-5. 2006

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Experimental IGF-I receptor deficiency generates a sexually dimorphic pattern of organ-specific growth deficits in mice, affecting fat tissue in particular
    M Holzenberger
    INSERM, U 515, Hopital Saint Antoine, 75571 Paris, France
    Endocrinology 142:4469-78. 2001
    ..Thus, IGF type I receptor deficiency produced mice with disproportionate postnatal organ growth, and these effects depended strongly on sex. A marked reduction in IGF-IR levels resulted in a major defect in adipose tissue...
  2. pmc Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury
    Karmene Ahamed
    INSERM U719, Hospital Saint Antoine, 75012 Paris, France
    Respir Res 6:31. 2005
    ..This led us to suspect that reduction of IGF-1R levels in lung tissue could prevent deleterious effects of oxygen exposure...
  3. ncbi request reprint Expression of insulin-like growth factor-I (IGF-I) and IGF-II in the avian brain: relationship of in situ hybridization patterns with IGF type 1 receptor expression
    M Holzenberger
    INSERM Unite 515, Hopital Saint Antoine, F 75571, Paris, France
    Int J Dev Neurosci 18:69-82. 2000
    ....
  4. ncbi request reprint A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit
    M Holzenberger
    U 515 INSERM, Hopital Saint Antoine, Paris, France
    Endocrinology 141:2557-66. 2000
    ..The phenotype of these mice developed exclusively postnatally, and body proportions were maintained. IGF-IRneo mice constitute a new model for human postnatal growth deficiency...
  5. pmc Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene
    M Holzenberger
    INSERM U515, Hopital Saint Antoine, 184 rue du Fbg St Antoine, F 75571 Paris Cedex 12, France France
    Nucleic Acids Res 28:E92. 2000
    ....
  6. ncbi request reprint IGF-1 signaling and aging
    Martin Holzenberger
    INSERM U515, Hopital Saint Antoine, 75571 Paris 12, France
    Exp Gerontol 39:1761-4. 2004
    ....
  7. ncbi request reprint IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    Martin Holzenberger
    Institut National de la Santé et de la Recherche Médicale U515, Hopital Saint Antoine, 75571 Paris 12, France
    Nature 421:182-7. 2003
    ..The Igf1r(+/-) mice display greater resistance to oxidative stress, a known determinant of ageing. These results indicate that the IGF-1 receptor may be a central regulator of mammalian lifespan...
  8. ncbi request reprint The GH/IGF-I axis and longevity
    Martin Holzenberger
    INSERM U515, Hopital Saint Antoine, 184 rue Fbg St Antoine, 75571 Paris 12, France
    Eur J Endocrinol 151:S23-7. 2004
    ..This hypothesis can be addressed, for example, by adequately combining existing transgenic mouse models...
  9. pmc Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism
    Laurent Kappeler
    INSERM U893, Hopital Saint Antoine, Paris, France
    PLoS Biol 6:e254. 2008
    ..Our results also suggest that tonic somatotropic signaling entails the risk of shortened lifespan...
  10. ncbi request reprint Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout
    Christele Desbois-Mouthon
    INSERM U680, Hopital St Antoine, Paris, France
    FASEB J 20:773-5. 2006
    ..Using the LIGFREKO model, we provide new evidence that IGF-1R/IRS-1/ERK signaling may be the intracellular pathway controlling the cell cycle via cyclin D1 and cyclin A in the regenerating liver...
  11. pmc Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles
    Patricia Leneuve
    INSERM U515, Hopital Saint Antoine, 184 r Fbg St Antoine, 75571 Paris 12, France
    Nucleic Acids Res 31:e21. 2003
    ..We rigorously tested the ability of MeuCre40 to solve tri-lox problems, by using it for the in vivo removal of neo(R)- and hprt-expression cassettes from three different tri-lox mutants...
  12. doi request reprint Early postnatal nutrition determines somatotropic function in mice
    Laurent Kappeler
    Institut National de la Sante et de la Recherche Medicale, Centre de Recherche Saint Antoine, Paris, France
    Endocrinology 150:314-23. 2009
    ..We suggest that, together with other hormones like leptin, IGF-I may play a role in modulating hypothalamic stimulation of the developing somatotropic function...
  13. doi request reprint [IGF-1 receptors in the brain control longevity in mice]
    Martin Holzenberger
    Centre de Recherche INSERM, Bâtiment Kourilsky, Hopital Saint Antoine, 75571 Paris Cedex 12, France
    Med Sci (Paris) 25:371-6. 2009
    ..This is important because growth hormone is sometimes proposed to elderly people as a substitutive treatment in order to compensate the negative effects of aging...
  14. ncbi request reprint c-myc-induced hepatocarcinogenesis in the absence of IGF-I receptor
    Axelle Cadoret
    INSERM U402, Faculte de Medecine, Hopital St Antoine, Paris, France
    Int J Cancer 114:668-72. 2005
    ....
  15. ncbi request reprint Genotyping of Cre-lox mice and detection of tissue-specific recombination by multiplex PCR
    P Leneuve
    , Paris, France
    Biotechniques 31:1156-60, 1162. 2001
    ..As many new conditional knockouts are spatiotemporally restricted, such assays will become increasingly useful. The proposed PCR strategy is flexible and may be adapted to the structural specificities of any target gene...
  16. doi request reprint Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples
    Jie Xu
    Inserm U938, Hopital Saint Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint Antoine, F 75012 Paris, France
    J Endocrinol 208:119-29. 2011
    ..Taken together, we showed that rank plot analysis is a useful method that allows straightforward studies of circadian endogenous GH levels in mice...
  17. ncbi request reprint IGF type 1 receptor: a cell cycle progression factor that regulates aging
    Joelle Dupont
    INRA, 37380 Nouzilly, Paris, France
    Cell Cycle 2:270-2. 2003
  18. doi request reprint Igf-I signaling and effects on longevity
    Martin Holzenberger
    INSERM UMR 938, Saint Antoine Hospital, and University Pierre and Marie Curie, Paris, France
    Nestle Nutr Workshop Ser Pediatr Program 68:237-45; discussion 246-9. 2011
    ..Finally, several functional mutations of the human IGF-IR have been discovered in centenarians...
  19. ncbi request reprint [Ageing, genetics and the somatotropic axis]
    Laurent Kappeler
    Inserm U 515, Hopital Saint Antoine, 184, rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    Med Sci (Paris) 22:259-65. 2006
    ..We further report recent evidence showing that human lifespan might be controlled in similar ways. Finally, we shed some light on clinical GH treatment in humans, from an endocrinologist's point of view...
  20. ncbi request reprint Inactivation of the IGF-I receptor gene in primary Sertoli cells highlights the autocrine effects of IGF-I
    P Froment
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Lyon F 69003, France
    J Endocrinol 194:557-68. 2007
    ..The described in vitro system for loss-of-function analysis of the IGF-IR can be readily transposed to study the role of other intratesticular growth factors involved in spermatogenesis...
  21. ncbi request reprint The role of insulin-like signalling in the regulation of ageing
    M Holzenberger
    INSERM, Hopital Saint Antoine, Paris, France
    Horm Res 62:89-92. 2004
    ..If it was, it could have implications for growth hormone therapy, which increases serum IGF-I levels...
  22. doi request reprint Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation
    Jie Xu
    INSERM, Hopital Saint Antoine, Paris, 75012, France Université Pierre et Marie Curie, UPMC, Paris, 75005, France
    Aging Cell 13:19-28. 2014
    ..Together, these results provide a possible explanation why IGF-1R(+/-) was less efficient in extending lifespan in C57BL/6J compared with 129/SvPas. ..
  23. pmc Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis
    Ralph Epaud
    Inserm UMRS 938, Hopital Saint Antoine, Paris, France
    PLoS ONE 7:e48071. 2012
    ..Lethal respiratory failure in neonatal IGF-1R knockout mice suggested a particular role for this receptor in pulmonary development, and we therefore investigated the consequences of IGF-1R inactivation in lung tissue...
  24. ncbi request reprint IGF type 1 receptor ligand binding characteristics are altered in a subgroup of children with intrauterine growth retardation
    B Ducos
    Laboratoire d'Explorations Fonctionnelles Endocriniennes, , , and INSERM, U-515, , 75571 Paris, France
    J Clin Endocrinol Metab 86:5516-24. 2001
    ..Our results suggest heterogeneous alterations in IGF-IR binding function in IUGR patients...
  25. ncbi request reprint Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
    Kohjiro Ueki
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Genet 38:583-8. 2006
    ..We propose that therapeutic improvement of insulin and IGF-I signaling in beta cells might protect against type 2 diabetes...
  26. pmc Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
    Tatsuya Kondo
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 111:1835-42. 2003
    ..These data indicate that both insulin and IGF-1 signaling in endothelium play a role in retinal neovascularization through the expression of vascular mediators, with the effect of insulin being most important in this process...
  27. ncbi request reprint Biology of insulin-like growth factors in development
    Joelle Dupont
    Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, UMR 6073, Nouzilly, France
    Birth Defects Res C Embryo Today 69:257-71. 2003
    ....
  28. pmc Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation
    Marianna Sadagurski
    Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Biol 26:2675-87. 2006
    ..In conclusion, these results reveal that IGF-1R plays an inhibitory role in the regulation of skin development and differentiation...
  29. doi request reprint Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium
    Brent W Sutherland
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 68:3495-504. 2008
    ..Collectively, these data support a critical role for IGF-IR signaling in prostate tumorigenesis and identify an important IGF-IR-dependent growth control mechanism...
  30. ncbi request reprint [Physiology of somatotropic axis: interest of gene inactivation experiments]
    Yves Le Bouc
    Hôpital d Enfants Armand Trousseau 75571 Paris, 26 avenue du Docteur Arnold Netter
    Bull Acad Natl Med 187:1225-43; discussion 1244-7. 2003
    ..Invalidations combining different properties--specificities according to tissue, development stage or inducibility by an exogenous product--will facilitate fine dissection of the roles of the various ubiquitous actors in the IGF system...
  31. pmc Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function
    Palle G Laustsen
    Joslin Diabetes Center, Boston, MA 02215, USA
    Mol Cell Biol 27:1649-64. 2007
    ....
  32. ncbi request reprint Major components of the insulin-like growth factor axis are expressed early in chicken embryogenesis, with IGF binding protein ( IGFBP) -5 expression subject to regulation by Sonic Hedgehog
    Gordon J Allan
    Hannah Research Institute, Ayr, Scotland, KA6 5HL, UK
    Anat Embryol (Berl) 207:73-84. 2003
    ....
  33. pmc Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
    Terumasa Okada
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:8977-82. 2007
    ..Together these data provide direct genetic evidence that insulin/FoxO1/Pdx-1 signaling is one pathway that is crucial for islet compensatory growth response to insulin resistance...
  34. ncbi request reprint Cre-mediated recombination in the skin melanocyte lineage
    Veronique Delmas
    Genesis 36:73-80. 2003
    ..In conclusion, Tyr::Cre transgenic mice provide a valuable tool to follow the cell lineage and to examine gene function in melanocyte development and transformation...