Research Topics
Species | Deborah HirtSummaryCountry: France Publications
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Publications
Age-related effects on nelfinavir and M8 pharmacokinetics: a population study with 182 childrenDeborah Hirt
Pharmacologie Clinique, Assistance Publique Hôpitaux Paris, France
Antimicrob Agents Chemother 50:910-6. 2006..This assumption should be further evaluated...
Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitisDeborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Ther Drug Monit 31:557-65. 2009..2 days. Serum Mn concentrations could be related to a decrease in PT; the effect was longer in patients with an early decrease in total bilirubin serum concentrations...- Plasma and intracellular tenofovir pharmacokinetics in the neonate (ANRS 12109 trial, step 2)Deborah Hirt
Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
Antimicrob Agents Chemother 55:2961-7. 2011..This dose should be given immediately after birth to reduce the delay before the active compound TFV-DP appears in cells... - Is the recommended dose of efavirenz optimal in young West African human immunodeficiency virus-infected children?Deborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 53:4407-13. 2009..These assumptions should be prospectively confirmed... - Didanosine population pharmacokinetics in West African human immunodeficiency virus-infected children administered once-daily tablets in relation to efficacy after one year of treatmentDeborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 53:4399-406. 2009..03) than that with a lower AUC. A didanosine dose of 360 mg/m2 administered as tablets should be a more appropriate dose than 240 mg/m2 to improve efficacy for these children. However, data on adverse events with this dosage are missing... - Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonatesDeborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 53:1067-73. 2009..FTC was shown to have good placental transfer (80%). Administering 1 mg FTC/kg as soon as possible after birth or 2 mg/kg 12 h after birth should produce neonatal concentrations comparable to the concentrations observed in adults... - Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109)D Hirt
Universite Paris Descartes, EA3620, Paris, France
Clin Pharmacol Ther 85:182-9. 2009..Tenofovir showed good placental transfer (60%). Administering 13 mg/kg of TDF as soon as possible after birth should produce neonatal concentrations comparable with those observed in adults... - An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic studyDeborah Hirt
EA3620, Universite Paris Descartes, Paris, France
Br J Clin Pharmacol 65:629-36. 2008..Few studies of ibuprofen pharmacokinetics have been performed and were limited to small groups of preterm infants, showing a large intersubject variability and an increase in clearance with either postnatal or gestational age... - Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patientsDeborah Hirt
Service de Pharmacologie Clinique, AP HP, Hopital Cochin Saint Vincent de Paul, Universite Paris Descartes, Paris, France
Br J Clin Pharmacol 65:548-57. 2008..However, for MDR1 and CYP2C19 polymorphism, there have been contradictory studies, showing either no impact on nelfinavir concentration or modified concentrations which could influence virological response... - Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samplesDeborah Hirt
Pharmacologie Clinique, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté de Médecine René Descartes, Universite Paris 5, Paris, France
Br J Clin Pharmacol 64:634-44. 2007..A population pharmacokinetic model was developed to characterize the transfer of nelfinavir and its active metabolite M8 from maternal to cord plasma and amniotic fluid... - Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with 133 womenDeborah Hirt
Pharmacologie Clinique, Hopital Saint Vincent de Paul, Paris, France
Antimicrob Agents Chemother 50:2079-86. 2006..The Bayesian individual pharmacokinetic estimates suggested that the dosage should not be changed in pregnant women but may be doubled on the day of delivery... - Very high concentrations of active intracellular phosphorylated emtricitabine in neonates (ANRS 12109 trial, step 2)Deborah Hirt
Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
Antimicrob Agents Chemother 55:2953-60. 2011..The exposure to the active form of FTC was high in neonates despite plasma drug concentrations equivalent to those in adults. Our results are similar to those obtained with zidovudine or lamivudine... - Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 womenSihem Benaboud
Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 56:776-82. 2012..9. Pregnant women had a 22% higher apparent clearance than nonpregnant and parturient women; however, this increase did not lead to subexposure and should not require a dosage adjustment... - Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 womenSihem Benaboud
Université Paris Descartes Sorbonne Paris Cité, EA3620, Paris, France
Antimicrob Agents Chemother 56:857-62. 2012.... - Is the recommended once-daily dose of lamivudine optimal in West African HIV-infected children?Naïm Bouazza
EA 3620, Universite Paris Descartes, Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
Antimicrob Agents Chemother 54:3280-6. 2010..h was obtained with a 10-mg/kg once-daily lamivudine (3TC) dose for children below 17 kg; the recommended dose of 8 mg/kg seems to be sufficient in children weighing more than 17 kg. These assumptions should be prospectively confirmed... - Population pharmacokinetics of atazanavir/ritonavir in HIV-1-infected children and adolescentsFrantz Foissac
EA 3620 Université Paris Descartes, Paris, France
Br J Clin Pharmacol 72:940-7. 2011..To investigate atazanavir (ATV) population pharmacokinetics in children and adolescents, establish factors that influence ATV pharmacokinetics and investigate the ATV exposure after recommended doses... - Population pharmacokinetics of tenofovir in HIV-1-infected pediatric patientsNaïm Bouazza
EA 3620, Universite Paris Descartes, Sorbonne Paris Cité France, Paris, France
J Acquir Immune Defic Syndr 58:283-8. 2011..The main goal was then to suggest for the first time the dose of tenofovir disoproxil fumarate (TDF) to give in children... - Population pharmacokinetics of nevirapine in HIV-1-infected pregnant women and their neonatesSihem Benaboud
EA3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 55:331-7. 2011..The neonate must receive sdNVP immediately after birth when the infant is born less than 30 min after maternal drug intake to keep NVP concentrations above the IC(50)... - Concentrations of tenofovir and emtricitabine in breast milk of HIV-1-infected women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2Sihem Benaboud
Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
Antimicrob Agents Chemother 55:1315-7. 2011..The rare children who will acquire HIV despite TDF-FTC therapy will need to be monitored for viral resistance acquisition... - Population analysis of weight-, age-, and sex-related differences in the pharmacokinetics of lopinavir in children from birth to 18 yearsVincent Jullien
Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
Antimicrob Agents Chemother 50:3548-55. 2006..The consequences of these pharmacokinetic discrepancies and the necessity to modify the currently recommended dosage regimen should be further investigated... - Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA)Julien Fonsart
Universite Paris Descartes, Faculte de Pharmacie, Paris F 75006, France
Toxicol Appl Pharmacol 241:339-47. 2009..Hence, males are exposed to significantly more toxic MDA, which could explain previously reported sexual dysmorphism in the acute effects and toxicity of MDMA in rats... - Pharmacokinetics and virological efficacy after switch to once-daily lopinavir-ritonavir in treatment-experienced HIV-1-infected childrenFrantz Foissac
EA 3620 Université Paris Descartes, Paris, France
Antimicrob Agents Chemother 55:4320-5. 2011..The switch from the BID to the QD LPV/r regimen led to equivalent exposure and lower C(trough) values and resulted in lower levels of virological control in these antiretroviral-experienced children... - Developmental pharmacokinetics of lamivudine in 580 pediatric patients ranging from neonates to adolescentsNaïm Bouazza
EA 3620, Universite Paris Descartes, Paris, France
Antimicrob Agents Chemother 55:3498-504. 2011.... - Lopinavir/ritonavir population pharmacokinetics in neonates and infantsSaik Urien
EA 3620, Universite Paris Descartes, Paris, France
Br J Clin Pharmacol 71:956-60. 2011..Lopinavir/ritonavir pharmacokinetics have been fully investigated in adults and children... - Determination of optimal cholecalciferol treatment in renal transplant recipients using a population pharmacokinetic approachSihem Benaboud
EA3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
Eur J Clin Pharmacol 69:499-506. 2013.... - Population pharmacokinetics of 3,4-methylenedioxymethamphetamine and main metabolites in ratsDeborah Hirt
Faculte de Pharmacie, Universite Paris Descartes, Paris F 75006, France
Toxicol Sci 114:38-47. 2010..Male rats were exposed to significantly more MDA and HMA than were females, which could explain why males are more sensitive to MDMA toxic effects than females... - Blood concentrations are better predictors of chioroquine poisoning severity than plasma concentrations: a prospective study with modeling of the concentration/effect relationshipsBruno Megarbane
Medical and Toxicological Critical Care Department Paris Diderot University, Lariboisiere Hospital, Paris, France
Clin Toxicol (Phila) 48:904-15. 2010..We investigated the hypothesis that blood chloroquine concentrations better predicted chloroquine poisoning severity than plasma concentrations... - Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleenInnocent Safeukui
Molecular Immunology of Parasites Unit, CNRS URA 2581, Institut Pasteur, Paris, France
Blood 112:2520-8. 2008..Cryptic ring retention uncovers a new role for the spleen in the control of parasite density, opening novel intervention opportunities...