Deborah Hirt

Summary

Country: France

Publications

  1. pmc Age-related effects on nelfinavir and M8 pharmacokinetics: a population study with 182 children
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hôpitaux Paris, France
    Antimicrob Agents Chemother 50:910-6. 2006
  2. pmc Plasma and intracellular tenofovir pharmacokinetics in the neonate (ANRS 12109 trial, step 2)
    Deborah Hirt
    Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Antimicrob Agents Chemother 55:2961-7. 2011
  3. pmc Very high concentrations of active intracellular phosphorylated emtricitabine in neonates (ANRS 12109 trial, step 2)
    Deborah Hirt
    Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Antimicrob Agents Chemother 55:2953-60. 2011
  4. doi Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Ther Drug Monit 31:557-65. 2009
  5. pmc Is the recommended dose of efavirenz optimal in young West African human immunodeficiency virus-infected children?
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:4407-13. 2009
  6. pmc Didanosine population pharmacokinetics in West African human immunodeficiency virus-infected children administered once-daily tablets in relation to efficacy after one year of treatment
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:4399-406. 2009
  7. pmc Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:1067-73. 2009
  8. doi Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109)
    D Hirt
    Universite Paris Descartes, EA3620, Paris, France
    Clin Pharmacol Ther 85:182-9. 2009
  9. pmc An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 65:629-36. 2008
  10. pmc Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients
    Deborah Hirt
    Service de Pharmacologie Clinique, AP HP, Hopital Cochin Saint Vincent de Paul, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 65:548-57. 2008

Detail Information

Publications33

  1. pmc Age-related effects on nelfinavir and M8 pharmacokinetics: a population study with 182 children
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hôpitaux Paris, France
    Antimicrob Agents Chemother 50:910-6. 2006
    ..This assumption should be further evaluated...
  2. pmc Plasma and intracellular tenofovir pharmacokinetics in the neonate (ANRS 12109 trial, step 2)
    Deborah Hirt
    Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Antimicrob Agents Chemother 55:2961-7. 2011
    ..This dose should be given immediately after birth to reduce the delay before the active compound TFV-DP appears in cells...
  3. pmc Very high concentrations of active intracellular phosphorylated emtricitabine in neonates (ANRS 12109 trial, step 2)
    Deborah Hirt
    Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Antimicrob Agents Chemother 55:2953-60. 2011
    ..The exposure to the active form of FTC was high in neonates despite plasma drug concentrations equivalent to those in adults. Our results are similar to those obtained with zidovudine or lamivudine...
  4. doi Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Ther Drug Monit 31:557-65. 2009
    ..2 days. Serum Mn concentrations could be related to a decrease in PT; the effect was longer in patients with an early decrease in total bilirubin serum concentrations...
  5. pmc Is the recommended dose of efavirenz optimal in young West African human immunodeficiency virus-infected children?
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:4407-13. 2009
    ..These assumptions should be prospectively confirmed...
  6. pmc Didanosine population pharmacokinetics in West African human immunodeficiency virus-infected children administered once-daily tablets in relation to efficacy after one year of treatment
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:4399-406. 2009
    ..03) than that with a lower AUC. A didanosine dose of 360 mg/m2 administered as tablets should be a more appropriate dose than 240 mg/m2 to improve efficacy for these children. However, data on adverse events with this dosage are missing...
  7. pmc Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 53:1067-73. 2009
    ..FTC was shown to have good placental transfer (80%). Administering 1 mg FTC/kg as soon as possible after birth or 2 mg/kg 12 h after birth should produce neonatal concentrations comparable to the concentrations observed in adults...
  8. doi Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109)
    D Hirt
    Universite Paris Descartes, EA3620, Paris, France
    Clin Pharmacol Ther 85:182-9. 2009
    ..Tenofovir showed good placental transfer (60%). Administering 13 mg/kg of TDF as soon as possible after birth should produce neonatal concentrations comparable with those observed in adults...
  9. pmc An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study
    Deborah Hirt
    EA3620, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 65:629-36. 2008
    ..Few studies of ibuprofen pharmacokinetics have been performed and were limited to small groups of preterm infants, showing a large intersubject variability and an increase in clearance with either postnatal or gestational age...
  10. pmc Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients
    Deborah Hirt
    Service de Pharmacologie Clinique, AP HP, Hopital Cochin Saint Vincent de Paul, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 65:548-57. 2008
    ..However, for MDR1 and CYP2C19 polymorphism, there have been contradictory studies, showing either no impact on nelfinavir concentration or modified concentrations which could influence virological response...
  11. pmc Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté de Médecine René Descartes, Universite Paris 5, Paris, France
    Br J Clin Pharmacol 64:634-44. 2007
    ..A population pharmacokinetic model was developed to characterize the transfer of nelfinavir and its active metabolite M8 from maternal to cord plasma and amniotic fluid...
  12. pmc Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with 133 women
    Deborah Hirt
    Pharmacologie Clinique, Hopital Saint Vincent de Paul, Paris, France
    Antimicrob Agents Chemother 50:2079-86. 2006
    ..The Bayesian individual pharmacokinetic estimates suggested that the dosage should not be changed in pregnant women but may be doubled on the day of delivery...
  13. pmc Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women
    Sihem Benaboud
    Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 56:776-82. 2012
    ..9. Pregnant women had a 22% higher apparent clearance than nonpregnant and parturient women; however, this increase did not lead to subexposure and should not require a dosage adjustment...
  14. doi A novel pharmacokinetic approach to predict virologic failure in HIV-1-infected paediatric patients
    Naïm Bouazza
    Universite Paris Descartes, Sorbonne Paris, France
    AIDS 27:761-8. 2013
    ....
  15. pmc Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women
    Sihem Benaboud
    Université Paris Descartes Sorbonne Paris Cité, EA3620, Paris, France
    Antimicrob Agents Chemother 56:857-62. 2012
    ....
  16. pmc Is the recommended once-daily dose of lamivudine optimal in West African HIV-infected children?
    Naïm Bouazza
    EA 3620, Universite Paris Descartes, Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Antimicrob Agents Chemother 54:3280-6. 2010
    ..h was obtained with a 10-mg/kg once-daily lamivudine (3TC) dose for children below 17 kg; the recommended dose of 8 mg/kg seems to be sufficient in children weighing more than 17 kg. These assumptions should be prospectively confirmed...
  17. pmc Evaluation of nevirapine dosing recommendations in HIV-infected children
    Frantz Foissac
    EA 3620 Université Paris Descartes Sorbonne Paris Cité, Unité de RechercheClinique, Hôpital Tarnier, 89 rue d Assas, Paris, France
    Br J Clin Pharmacol 76:137-44. 2013
    ..The aims of this study were to investigate the population pharmacokinetics of NVP in children, establish factors that influence NVP pharmacokinetics and evaluate the current dosing recommendations...
  18. pmc Population pharmacokinetics of atazanavir/ritonavir in HIV-1-infected children and adolescents
    Frantz Foissac
    EA 3620 Université Paris Descartes, Paris, France
    Br J Clin Pharmacol 72:940-7. 2011
    ..To investigate atazanavir (ATV) population pharmacokinetics in children and adolescents, establish factors that influence ATV pharmacokinetics and investigate the ATV exposure after recommended doses...
  19. doi Population pharmacokinetics of tenofovir in HIV-1-infected pediatric patients
    Naïm Bouazza
    EA 3620, Universite Paris Descartes, Sorbonne Paris Cité France, Paris, France
    J Acquir Immune Defic Syndr 58:283-8. 2011
    ..The main goal was then to suggest for the first time the dose of tenofovir disoproxil fumarate (TDF) to give in children...
  20. pmc Population pharmacokinetics of nevirapine in HIV-1-infected pregnant women and their neonates
    Sihem Benaboud
    EA3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 55:331-7. 2011
    ..The neonate must receive sdNVP immediately after birth when the infant is born less than 30 min after maternal drug intake to keep NVP concentrations above the IC(50)...
  21. doi High exposure to zidovudine during the first 2 weeks of life and concentration-toxicity relationships
    Deborah Hirt
    AP HP, Unite de recherche clinique, Hôpital Tarnier, Paris, France CIC 0901 Inserm, Cochin Necker, Paris, France AP HP, Service de Pharmacologie Clinique, Hopital Cochin, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France INSERM CESP U1018 Equipe VIH et IST, Le Kremlin Bicetre, France University of Paris Sud, Le Kremlin Bicetre, France AP HP, Service d Epidémiologie et Santé Publique, Hopital Bicetre, Le Kremlin Bicetre, France AP HP, Service de Neonatologie, hôpital Cochin Port Royal, Paris, France Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris, France Laboratoire d Ethique Médicale, Universite Paris Descartes, Paris, France Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France and AP HP, Unite d immunologie, Hématologie et Rhumatologie pédiatriques
    J Acquir Immune Defic Syndr 63:555-62. 2013
    ....
  22. pmc Concentrations of tenofovir and emtricitabine in breast milk of HIV-1-infected women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2
    Sihem Benaboud
    Unite de recherche clinique, Hôpital Tarnier, 89 rue d Assas, 75006 Paris, France
    Antimicrob Agents Chemother 55:1315-7. 2011
    ..The rare children who will acquire HIV despite TDF-FTC therapy will need to be monitored for viral resistance acquisition...
  23. pmc Pharmacokinetics and virological efficacy after switch to once-daily lopinavir-ritonavir in treatment-experienced HIV-1-infected children
    Frantz Foissac
    EA 3620 Université Paris Descartes, Paris, France
    Antimicrob Agents Chemother 55:4320-5. 2011
    ..The switch from the BID to the QD LPV/r regimen led to equivalent exposure and lower C(trough) values and resulted in lower levels of virological control in these antiretroviral-experienced children...
  24. doi Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA)
    Julien Fonsart
    Universite Paris Descartes, Faculte de Pharmacie, Paris F 75006, France
    Toxicol Appl Pharmacol 241:339-47. 2009
    ..Hence, males are exposed to significantly more toxic MDA, which could explain previously reported sexual dysmorphism in the acute effects and toxicity of MDMA in rats...
  25. pmc Population analysis of weight-, age-, and sex-related differences in the pharmacokinetics of lopinavir in children from birth to 18 years
    Vincent Jullien
    Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 50:3548-55. 2006
    ..The consequences of these pharmacokinetic discrepancies and the necessity to modify the currently recommended dosage regimen should be further investigated...
  26. pmc Population pharmacokinetics study of recommended zidovudine doses in HIV-1-infected children
    Floris Fauchet
    EA 3620 Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Antimicrob Agents Chemother 57:4801-8. 2013
    ..9 kg and from 300 to 250 mg BID for the WB from 30 to 39.9 kg. The highest dose, 300 mg BID, should be started from body weights of 40 kg. ..
  27. pmc Developmental pharmacokinetics of lamivudine in 580 pediatric patients ranging from neonates to adolescents
    Naïm Bouazza
    EA 3620, Universite Paris Descartes, Paris, France
    Antimicrob Agents Chemother 55:3498-504. 2011
    ....
  28. doi Determination of optimal cholecalciferol treatment in renal transplant recipients using a population pharmacokinetic approach
    Sihem Benaboud
    EA3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Eur J Clin Pharmacol 69:499-506. 2013
    ....
  29. pmc Lopinavir/ritonavir population pharmacokinetics in neonates and infants
    Saik Urien
    EA 3620, Universite Paris Descartes, Paris, France
    Br J Clin Pharmacol 71:956-60. 2011
    ..Lopinavir/ritonavir pharmacokinetics have been fully investigated in adults and children...
  30. doi Lopinavir/ritonavir monotherapy as a nucleoside analogue-sparing strategy to prevent HIV-1 mother-to-child transmission: the ANRS 135 PRIMEVA phase 2/3 randomized trial
    Roland Tubiana
    Service de Maladies Infectieuses, AP HP, Hopital Pitie Salpetriere, Paris, France
    Clin Infect Dis 57:891-902. 2013
    ..This multicenter trial evaluated whether lopinavir/ritonavir (LPV/r) monotherapy in HIV type 1-infected women not requiring antiretrovirals for themselves could control maternal viral load (VL)...
  31. doi Population pharmacokinetics of 3,4-methylenedioxymethamphetamine and main metabolites in rats
    Deborah Hirt
    Faculte de Pharmacie, Universite Paris Descartes, Paris F 75006, France
    Toxicol Sci 114:38-47. 2010
    ..Male rats were exposed to significantly more MDA and HMA than were females, which could explain why males are more sensitive to MDMA toxic effects than females...
  32. doi Blood concentrations are better predictors of chioroquine poisoning severity than plasma concentrations: a prospective study with modeling of the concentration/effect relationships
    Bruno Megarbane
    Medical and Toxicological Critical Care Department Paris Diderot University, Lariboisiere Hospital, Paris, France
    Clin Toxicol (Phila) 48:904-15. 2010
    ..We investigated the hypothesis that blood chloroquine concentrations better predicted chloroquine poisoning severity than plasma concentrations...
  33. doi Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen
    Innocent Safeukui
    Molecular Immunology of Parasites Unit, CNRS URA 2581, Institut Pasteur, Paris, France
    Blood 112:2520-8. 2008
    ..Cryptic ring retention uncovers a new role for the spleen in the control of parasite density, opening novel intervention opportunities...