Martine Heyman

Summary

Country: France

Publications

  1. ncbi Gut barrier dysfunction in food allergy
    Martine Heyman
    Faculte de Medecine Necker Enfants Malades, Paris, France
    Eur J Gastroenterol Hepatol 17:1279-85. 2005
  2. ncbi Evaluation of the impact of food technology on the allergenicity of cow's milk proteins
    M Heyman
    INSERM E9925, Faculte de Medecine Necker Enfants Malades, Paris, France
    Proc Nutr Soc 58:587-92. 1999
  3. ncbi Cytokine-induced alteration of the epithelial barrier to food antigens in disease
    M Heyman
    CJF 97 10 INSERM, Faculte Necker, 156 rue de Vaugirard, 75730 Paris, France
    Ann N Y Acad Sci 915:304-11. 2000
  4. ncbi Symposium on 'dietary influences on mucosal immunity'. How dietary antigens access the mucosal immune system
    M Heyman
    INSERM E9925, Faculte Necker, Paris, France
    Proc Nutr Soc 60:419-26. 2001
  5. ncbi Probiotic microorganisms: how they affect intestinal pathophysiology
    M Heyman
    INSERM EMI 0212, , Paris, France
    Cell Mol Life Sci 59:1151-65. 2002
  6. ncbi Stimulation of immunity without alteration of oral tolerance in mice fed with heat-treated fermented infant formula
    Sandrine Menard
    INSERM U793, Faculté Necker Enfants Malades, Paris, France
    J Pediatr Gastroenterol Nutr 43:451-8. 2006
  7. ncbi Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides
    Corinne Lebreton
    INSERM, UMR989, Paris, France
    Gastroenterology 143:698-707.e1-4. 2012
  8. ncbi Bifidobacterium breve and Streptococcus thermophilus secretion products enhance T helper 1 immune response and intestinal barrier in mice
    Sandrine Menard
    INSERM EMI 0212, Faculté Cochin Necker, 156 rue de Vaugirard, 75730 Paris, France
    Exp Biol Med (Maywood) 230:749-56. 2005
  9. ncbi Paracellular versus transcellular intestinal permeability to gliadin peptides in active celiac disease
    Sandrine Menard
    INSERM, Unit 989, Paris, France The University of Paris, Descartes, Paris, France
    Am J Pathol 180:608-15. 2012
  10. ncbi Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease
    Tamara Matysiak-Budnik
    INSERM EMI 0212, Faculté Necker Enfants Malades, Paris, France
    Gastroenterology 129:786-96. 2005

Collaborators

Detail Information

Publications33

  1. ncbi Gut barrier dysfunction in food allergy
    Martine Heyman
    Faculte de Medecine Necker Enfants Malades, Paris, France
    Eur J Gastroenterol Hepatol 17:1279-85. 2005
    ....
  2. ncbi Evaluation of the impact of food technology on the allergenicity of cow's milk proteins
    M Heyman
    INSERM E9925, Faculte de Medecine Necker Enfants Malades, Paris, France
    Proc Nutr Soc 58:587-92. 1999
    ....
  3. ncbi Cytokine-induced alteration of the epithelial barrier to food antigens in disease
    M Heyman
    CJF 97 10 INSERM, Faculte Necker, 156 rue de Vaugirard, 75730 Paris, France
    Ann N Y Acad Sci 915:304-11. 2000
    ..In allergic diseases, such as cow's milk allergy, TNF alpha may be involved in the intestinal dysfunction and the associated enteropathy...
  4. ncbi Symposium on 'dietary influences on mucosal immunity'. How dietary antigens access the mucosal immune system
    M Heyman
    INSERM E9925, Faculte Necker, Paris, France
    Proc Nutr Soc 60:419-26. 2001
    ..Many other factors such as nutritional or environmental factors can also influence the properties of the epithelial barrier and the outcome of the immune response to lumen antigens...
  5. ncbi Probiotic microorganisms: how they affect intestinal pathophysiology
    M Heyman
    INSERM EMI 0212, , Paris, France
    Cell Mol Life Sci 59:1151-65. 2002
  6. ncbi Stimulation of immunity without alteration of oral tolerance in mice fed with heat-treated fermented infant formula
    Sandrine Menard
    INSERM U793, Faculté Necker Enfants Malades, Paris, France
    J Pediatr Gastroenterol Nutr 43:451-8. 2006
    ..This study analyzes the effect of long-term ingestion of a heat-treated, fermented milk formula on the development of oral tolerance or systemic immune response to soluble antigens in mice...
  7. ncbi Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides
    Corinne Lebreton
    INSERM, UMR989, Paris, France
    Gastroenterology 143:698-707.e1-4. 2012
    ..We studied intestinal epithelial cell lines that overexpress CD71 to determine how interactions between SIgA and CD71 promote transepithelial transport of gliadin peptides...
  8. ncbi Bifidobacterium breve and Streptococcus thermophilus secretion products enhance T helper 1 immune response and intestinal barrier in mice
    Sandrine Menard
    INSERM EMI 0212, Faculté Cochin Necker, 156 rue de Vaugirard, 75730 Paris, France
    Exp Biol Med (Maywood) 230:749-56. 2005
    ....
  9. ncbi Paracellular versus transcellular intestinal permeability to gliadin peptides in active celiac disease
    Sandrine Menard
    INSERM, Unit 989, Paris, France The University of Paris, Descartes, Paris, France
    Am J Pathol 180:608-15. 2012
    ..In active celiac disease, increases in transcellular permeability to intact gliadin peptides might be considered in treatment strategies aimed at controlling epithelial permeability to gluten...
  10. ncbi Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease
    Tamara Matysiak-Budnik
    INSERM EMI 0212, Faculté Necker Enfants Malades, Paris, France
    Gastroenterology 129:786-96. 2005
    ..To delineate the feasibility of this treatment, the effect of PEP on gliadin peptides was assessed in vitro, and ex vivo during their transport across intestinal biopsy specimens of active celiac disease patients...
  11. ncbi Differential role for CD23 splice forms in apical to basolateral transcytosis of IgE/allergen complexes
    Guillaume Montagnac
    Department of Infectious Diseases, Cochin Institute, INSERM U567 CNRS UMR 8104 Universitè Paris 5, Paris, France
    Traffic 6:230-42. 2005
    ....
  12. ncbi Food allergens are protected from degradation during CD23-mediated transepithelial transport
    Claudia Bevilacqua
    INSERM EMI0212, , Paris, France
    Int Arch Allergy Immunol 135:108-16. 2004
    ..CONCLUSIONS: These results confirm that CD23 is involved in the rapid transepithelial transport of intact allergens in sensitized animals, and indicate that CD23 opens a 'protected' transport pathway in IECs...
  13. ncbi Oral proteases: a new approach to managing coeliac disease
    Nadine Cerf-Bensussan
    INSERM U793, Faculté de Médecine René Descartes, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    Gut 56:157-60. 2007
    ..Development of new enzymes or enzymatic cocktails offers potentially more potent therapeutic tools that, however, need meticulous evaluation based on clinical, biological and histological criteria...
  14. ncbi A Bifidobacterium probiotic strain and its soluble factors alleviate chloride secretion by human intestinal epithelial cells
    Elise Heuvelin
    INSERM U793, 75730 Paris, France
    J Nutr 140:7-11. 2010
    ..Thus, Bb C50 and secreted soluble factors, by inhibiting phosphorylation processes, may promote intestinal homeostasis by controlling Cl(-) secretion...
  15. ncbi Mechanisms involved in alleviation of intestinal inflammation by bifidobacterium breve soluble factors
    Elise Heuvelin
    INSERM U793, Paris, France
    PLoS ONE 4:e5184. 2009
    ....
  16. ncbi In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain
    Jean Christophe Bambou
    INSERM, EMI 0212, 156 rue de Vaugirard, 75015 Paris, France
    J Biol Chem 279:42984-92. 2004
    ..These findings provide strong evidence that flagellin released by flagellated commensal bacteria in the intestinal lumen can induce a pro-inflammatory response in enterocytes in vivo...
  17. ncbi Gastric Helicobacter infection inhibits development of oral tolerance to food antigens in mice
    Tamara Matysiak-Budnik
    INSERM EMI-0212, , Paris, France
    Infect Immun 71:5219-24. 2003
    ..We conclude that H. felis can inhibit the development of oral tolerance to OVA in mice and that this inhibition is prevented by rebamipide...
  18. ncbi CARD15/NOD2 is required for Peyer's patches homeostasis in mice
    Frederick Barreau
    U843, INSERM, Paris, France UMR S843, Universite Paris Diderot, Paris, France
    PLoS ONE 2:e523. 2007
    ..Using a new mouse model invalidated for Card15/Nod2 (KO), we thus analysed the impact of the gene in these lymphoid formations together with the development of experimental colitis...
  19. ncbi Intestinal permeability in coeliac disease: insight into mechanisms and relevance to pathogenesis
    Martine Heyman
    INSERM U989, Universite Paris Descartes, Paris, France
    Gut 61:1355-64. 2012
    ..These recent findings might be useful for the design of new treatments...
  20. ncbi T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells
    Julia Mallegol
    INSERM U793, Paris, France
    Gastroenterology 132:1866-76. 2007
    ..To characterize further the role of human epithelial exosomes in antigen presentation, their capacity to load antigenic peptides, bind immune target cells, and induce T-cell activation was analyzed in vitro...
  21. ncbi In vitro transfer of clarithromycin and amoxicillin across the epithelial barrier: effect of Helicobacter pylori
    Tamara Matysiak-Budnik
    INSERM EMI 0212, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75730 Paris
    J Antimicrob Chemother 50:865-72. 2002
    ..pylori. In 24 h studies, clarithromycin, but not amoxicillin, showed rapid intracellular accumulation. No difference was found between the transepithelial passage of amoxicillin across the HT29-19A and Caco2 monolayers...
  22. ncbi Effects of specific lactic acid bacteria on the intestinal permeability to macromolecules and the inflammatory condition
    Martine Heyman
    INSERM EMI 0212, , Paris, France
    Acta Paediatr Suppl 94:34-6. 2005
    ..Thus, specific lactic acid bacteria and their metabolites seem to affect positively the intestinal function...
  23. ncbi Helicobacter pylori increases the epithelial permeability to a food antigen in human gastric biopsies
    Tamara Matysiak-Budnik
    INSERM EMI-0212, , Necker-Enfants Malades, Paris, France
    Am J Gastroenterol 99:225-32. 2004
    ..This phenomenon may contribute to the maintenance of gastric inflammation and could play a role in the development of allergic sensitization to dietary antigens in susceptible individuals...
  24. ncbi Pathways of gliadin transport in celiac disease
    Martine Heyman
    INSERM U793, Paris, France
    Ann N Y Acad Sci 1165:274-8. 2009
    ..Our results indicate a CD71-mediated transcytosis of gliadin peptides that may participate in the pathogenesis of CD in genetically predisposed individuals...
  25. ncbi Alterations of the intestinal transport and processing of gliadin peptides in celiac disease
    Tamara Matysiak-Budnik
    INSERM EMI 0212, , Paris
    Gastroenterology 125:696-707. 2003
    ..In patients with ACD, incomplete degradation of the 33-mer and protected transport of the peptide 31-49 might favor their respective immunostimulatory and toxic effects...
  26. ncbi Coeliac disease: an update on facts and questions based on the 10th International Symposium on Coeliac Disease
    Nadine Cerf-Bensussan
    INSERM EMI-0212, , Paris, France
    J Pediatr Gastroenterol Nutr 37:412-21. 2003
  27. ncbi [Gastric permeability and Helicobacter pylori]
    Tamara Matysiak-Budnik
    INSERM EMI-0212, , 156, rue de Vaugirard, 75015, Paris
    Gastroenterol Clin Biol 28:444-54. 2004
  28. ncbi The epithelial cell cytoskeleton and intracellular trafficking. II. Intestinal epithelial cell exosomes: perspectives on their structure and function
    Guillaume van Niel
    INSERM EMI0212, , 75730 Paris, France
    Am J Physiol Gastrointest Liver Physiol 283:G251-5. 2002
    ..IEC exosomes therefore, constitute a link by which IEC may influence antigen presentation in the mucosal or systemic immune system independent of direct cellular contact with effector cells...
  29. ncbi In-vitro transfer of nitazoxanide across the intestinal epithelial barrier
    Tamara Matysiak-Budnik
    INSERM EMI 0212, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75730 Paris, France
    J Pharm Pharmacol 54:1413-7. 2002
    ..No difference between the apical to basal and basal to apical fluxes of the drug was observed, suggesting that both topical and systemic modes of action of this antibiotic are successful...
  30. ncbi Food allergy and Helicobacter pylori
    Tamara Matysiak-Budnik
    INSERM E 9925, , Paris, France
    J Pediatr Gastroenterol Nutr 34:5-12. 2002
  31. ncbi Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease
    Tamara Matysiak-Budnik
    Institut National de la Sante et de la Recherche Medicale INSERM, U793, Paris 75730, Cedex 15, France
    J Exp Med 205:143-54. 2008
    ..Our findings strongly implicate CD71 in the pathogenesis of CD...
  32. ncbi [Celiac disease: one step toward therapeutic evolution?]
    Nadine Cerf-Bensussan
    Gastroenterol Clin Biol 27:352-3. 2003
  33. ncbi Effect of rebamipide on the colonic barrier in interleukin-10-deficient mice
    David Laharie
    INSERM ERI 10, Universite Victor Segalen, Bordeaux, France
    Dig Dis Sci 52:84-92. 2007
    ..These properties could be helpful in the management of some inflammatory bowel diseases...