Georges Herbein

Summary

Country: France

Publications

  1. pmc The macrophage in HIV-1 infection: from activation to deactivation?
    Georges Herbein
    Department of Virology, UPRES EA 4266 Pathogens and Inflammation, IFR 133 Inserm, Franche Comte University, CHU Besancon, Besancon, France
    Retrovirology 7:33. 2010
  2. pmc Cytomegalovirus and tumors: two players for one goal-immune escape
    Quentin Lepiller
    Department of Virology, University of Franche Comte, UPRES EA 4266, IFR 133, CHU Besancon, F 25030 Besanon, France
    Open Virol J 5:60-9. 2011
  3. pmc TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
    Amit Kumar
    Department of Virology, University of Franche Comte, CHRU Besançon, UPRES EA4266 Pathogens and Inflammation, SFR FED 4234, 25030 Besancon, France
    Mediators Inflamm 2013:484378. 2013
  4. pmc HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes
    Quentin Lepiller
    Department of Virology, University of Franche Comte, EA 4266 Pathogens and Inflammation, SFR FED4234, CHU Besancon, Besancon, France
    PLoS ONE 8:e59591. 2013
  5. pmc Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein
    W Abbas
    Department of Virology, University of Franche Comte, EA 4266, INSERM IFR 133, CHU Besancon, Besançon F 25030, France
    Cell Death Dis 3:e292. 2012
  6. pmc Molecular Understanding of HIV-1 Latency
    W Abbas
    Department of Virology, University of Franche Comte, 2 Place Saint Jacques, EA 4266, IFR 133, CHU Besancon, 25030 Besancon Cedex, France
    Adv Virol 2012:574967. 2012
  7. pmc Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein
    W Abbas
    Department of Virology, Pathogens and Inflammation Laboratory, University of Franche Comte, EA 4266, SFR FED 4234, CHRU Besançon, Besançon F 25030, France
    Cell Death Dis 5:e1080. 2014
  8. pmc Macrophage signaling in HIV-1 infection
    Georges Herbein
    Department of Virology, UPRES 4266 Pathogens and Inflammation, IFR 133 Inserm, University of Franche Comte, CHU Besancon, F 25030 Besancon, France
    Retrovirology 7:34. 2010
  9. ncbi request reprint Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages
    Audrey Varin
    Department of Virology, EA3186, IFR133, Franche Comte University, F 25030 Besancon, France
    J Biol Chem 280:42557-67. 2005
  10. ncbi request reprint Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages
    Georges Herbein
    Department of Virology, University of Franche Comte, Besancon, France
    Curr HIV Res 6:117-29. 2008

Collaborators

Detail Information

Publications32

  1. pmc The macrophage in HIV-1 infection: from activation to deactivation?
    Georges Herbein
    Department of Virology, UPRES EA 4266 Pathogens and Inflammation, IFR 133 Inserm, Franche Comte University, CHU Besancon, Besancon, France
    Retrovirology 7:33. 2010
    ..Finally IL-10 deactivation of macrophages will lead to immune failure observed at the very late stages of the HIV-1 disease...
  2. pmc Cytomegalovirus and tumors: two players for one goal-immune escape
    Quentin Lepiller
    Department of Virology, University of Franche Comte, UPRES EA 4266, IFR 133, CHU Besancon, F 25030 Besanon, France
    Open Virol J 5:60-9. 2011
    ..In return CMV, by acting directly on the cancer cell and/or on the tumor microenvironment, provides the tumor cell the ways to promote its immune escape and development of immune tolerance...
  3. pmc TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
    Amit Kumar
    Department of Virology, University of Franche Comte, CHRU Besançon, UPRES EA4266 Pathogens and Inflammation, SFR FED 4234, 25030 Besancon, France
    Mediators Inflamm 2013:484378. 2013
    ..Finally, we will discuss the emerging therapeutics options based on modulation of TNF activity that could ultimately lead to the cure of HIV-infected patients. ..
  4. pmc HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes
    Quentin Lepiller
    Department of Virology, University of Franche Comte, EA 4266 Pathogens and Inflammation, SFR FED4234, CHU Besancon, Besancon, France
    PLoS ONE 8:e59591. 2013
    ..The aim of this work was to investigate the pro-tumor influence of HCMV on primary human hepatocytes (PHH) and HepG2 cells...
  5. pmc Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein
    W Abbas
    Department of Virology, University of Franche Comte, EA 4266, INSERM IFR 133, CHU Besancon, Besançon F 25030, France
    Cell Death Dis 3:e292. 2012
    ..Our results indicate that HIV-1 Nef, through the nucleocytoplasmic relocalization of eEF1A and tRNAs, enhances resistance to stress-induced apoptosis in primary human macrophages...
  6. pmc Molecular Understanding of HIV-1 Latency
    W Abbas
    Department of Virology, University of Franche Comte, 2 Place Saint Jacques, EA 4266, IFR 133, CHU Besancon, 25030 Besancon Cedex, France
    Adv Virol 2012:574967. 2012
    ....
  7. pmc Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein
    W Abbas
    Department of Virology, Pathogens and Inflammation Laboratory, University of Franche Comte, EA 4266, SFR FED 4234, CHRU Besançon, Besançon F 25030, France
    Cell Death Dis 5:e1080. 2014
    ..Our results indicate that HIV-1 Nef, through the nucleocytoplasmic relocalization of eEF1A and tRNAs, enhances resistance to stress-induced apoptosis in primary human macrophages. ..
  8. pmc Macrophage signaling in HIV-1 infection
    Georges Herbein
    Department of Virology, UPRES 4266 Pathogens and Inflammation, IFR 133 Inserm, University of Franche Comte, CHU Besancon, F 25030 Besancon, France
    Retrovirology 7:34. 2010
    ..The role of HIV-1 proteins in the modulation of macrophage signaling will be discussed in regard to the formation of viral reservoirs and macrophage-mediated T cell apoptosis during HIV-1 infection...
  9. ncbi request reprint Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages
    Audrey Varin
    Department of Virology, EA3186, IFR133, Franche Comte University, F 25030 Besancon, France
    J Biol Chem 280:42557-67. 2005
    ..Therefore, our results suggest that extracellular Vpr could fuel the progression of AIDS via stimulation of HIV-1 provirus present in such cellular reservoirs as mononuclear phagocytes in HIV-infected patients...
  10. ncbi request reprint Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages
    Georges Herbein
    Department of Virology, University of Franche Comte, Besancon, France
    Curr HIV Res 6:117-29. 2008
    ....
  11. ncbi request reprint HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages
    Kashif A Khan
    Department of Virology, UPRES EA4266 Pathogens and Inflammation, SFR FED 4234, University of Franche Comte, CHU Besancon, Besancon, France
    J Innate Immun 5:639-56. 2013
    ....
  12. ncbi request reprint NF-kappaB-dependent control of HIV-1 transcription by the second coding exon of Tat in T cells
    Ulrich Mahlknecht
    Franche Comte School of Medicine, Hopital Saint Jacques, 2 Place Saint Jacques, F 25030 Besancon Cedex, France
    J Leukoc Biol 83:718-27. 2008
    ....
  13. doi request reprint Bcl-3-regulated transcription from major immediate-early promoter of human cytomegalovirus in monocyte-derived macrophages
    Kashif Aziz Khan
    Department of Virology, Institut Fédératif de Recherche 133, Equipe d Accueil 3186, Franche Comte University, Centre Hospitalier Universitaire de Besancon, Besancon, France
    J Immunol 182:7784-94. 2009
    ..Thus, activation of p52/Bcl-3 complexes in MDMs and p50/p65 heterodimers in fibroblasts in response to HCMV infection might explain the low-level growth of the virus in MDMs vs efficient growth in fibroblasts...
  14. ncbi request reprint Increased nuclear factor-kappaB activation in peripheral blood monocytes of patients with rheumatoid arthritis is mediated primarily by tumor necrosis factor-alpha
    Isabelle Dichamp
    Department of Virology, CHU Besancon, Franche Comte University, Besancon, France
    J Rheumatol 34:1976-83. 2007
    ..We assessed NF-kappaB activation in peripheral blood mononuclear cells (PBMC), peripheral blood lymphocytes (PBL), and monocytes from patients with RA, patients with ankylosing spondylitis (AS), and healthy subjects...
  15. pmc A subset of functional effector-memory CD8+ T lymphocytes in human immunodeficiency virus-infected patients
    Anne Zelie Decrion
    Department of Virology, Franche Comte School of Medicine, Besancon, France
    Immunology 121:405-15. 2007
    ..These findings indicate that a subset of functional effector-memory CD8(+) T cells specific for HIV, CMV and EBV antigens may contribute to an efficient immune response in HIV-infected subjects...
  16. ncbi request reprint HIV and inflammation
    Anne Zelie Decrion
    Department of Virology, EA3186, IFR133, Franche Comte University, Besancon, France
    Curr HIV Res 3:243-59. 2005
    ..Understanding the role of inflammation in HIV infection could lead to new therapeutic strategies that could ultimately enhance immune restoration and limit the formation of viral reservoirs in HIV-infected patients...
  17. pmc Increased HCMV seroprevalence in patients with hepatocellular carcinoma
    Quentin Lepiller
    Department of Virology, University of Franche Comte, EA 4266, IFR 133 Inserm, CHU Besancon, F 25030 Besancon, France
    Virol J 8:485. 2011
    ..The goal of the present study was to determine a potential correlation between HCMV infection and the appearance of HCC...
  18. pmc The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA
    Wasim Abbas
    Department of Virology, University of Franche Comte, UPRES EA 4266, IFR 133 Inserm, CHU Besancon, F 25030, Besancon, France
    Virol J 9:103. 2012
    ..Human immunodeficiency virus type 1 (HIV-1) Nef-encoded protein plays key functions at almost all stages of the viral life cycle, but its role in translation is largely unknown...
  19. doi request reprint Spondyloarthropathy and chronic B hepatitis. Effect of anti-TNF therapy
    Daniel Wendling
    Service de Rhumatologie, CHU Minjoz, 25030 Besancon, France
    Joint Bone Spine 76:308-11. 2009
    ..Here, we describe 4 cases in patients with spondyloarthropathies. Long-term monitoring of the hepatitis B virus (HBV) load is in order in HBV-positive patients treated with TNF antagonists...
  20. doi request reprint Is HIV infection a TNF receptor signalling-driven disease?
    Georges Herbein
    Department of Virology, EA3186, IFR133, Franche Comte University, Hopital Saint Jacques, Besancon Cedex, France
    Trends Immunol 29:61-7. 2008
    ..This article proposes a model that highlights the role of HIV proteins in the modulation of TNF receptor signalling and could explain both immune suppression and the formation of viral reservoirs during HIV infection...
  21. pmc Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production
    Eric Toussirot
    Clinical Investigation Center Biotherapy CBT 506, University Hospital of Besancon, Besancon, France
    PLoS ONE 8:e70939. 2013
    ....
  22. pmc Cellular Activation and Intracellular HCV Load in Peripheral Blood Monocytes Isolated from HCV Monoinfected and HIV-HCV Coinfected Patients
    Isabelle Dichamp
    Pathogens and Inflammation Department, UPRES EA4266, SFR FED 4234, University of Franche Comte, Besancon, France Department of Virology, CHRU Besançon, Besancon, France
    PLoS ONE 9:e96907. 2014
    ..We hypothesized that a modified activation of peripheral blood monocytes in HIV-HCV coinfected compared to HCV monoinfected patients may contribute to different monocytes reservoirs of HCV replication...
  23. ncbi request reprint CXCR4-mediated T cell apoptosis in human immunodeficiency virus infection
    Anne Zelie Decrion
    Department of Virology and Institut d Etude et de Transfert de Gènes, University of Franche Comte School of Medicine, Hopital Saint Jacques, 2 Place Saint Jacques, F 25030 Besancon Cedex, France
    J Gen Virol 85:1471-8. 2004
    ..Several immune and viral factors thus play a role in CXCR4-mediated T cell apoptosis in HIV infection: CD4/CD8 phenotype, viral envelope phenotype, T cell activation and T cell-macrophage intercellular contacts...
  24. pmc LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing
    Valentin Le Douce
    University of Strasbourg, EA4438, Institute of Parasitology, Strasbourg, France
    Nucleic Acids Res 40:1904-15. 2012
    ..Finally, our data suggest that LSD1-induced H3K4 trimethylation is linked to hSET1 recruitment at the integrated provirus...
  25. doi request reprint In vitro and in vivo effects of zinc on cytokine signalling in human T cells
    Audrey Varin
    Department of Virology, EA 3186 IFR 133, Franche Comte University, Hopital Saint Jacques, Besancon Cedex, France
    Exp Gerontol 43:472-82. 2008
    ..Our results suggest that zinc can have a potent immunomodulatory effect via the modulation of cytokine signalling and AICD, however this effect depends on the function and the activation status of the T cells...
  26. ncbi request reprint Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis
    Audrey Varin
    Department of Virology and Institut d Etude et de Transfert de Gènes, Franche Comte University, F 25030 Besancon, France
    J Biol Chem 278:2219-27. 2003
    ..Therefore, our results suggest that exogenous Nef could fuel the progression of the disease via stimulation of HIV-1 provirus present in such cellular reservoirs as mononuclear phagocytes in HIV-infected patients...
  27. ncbi request reprint NF-kappaB, AP-1, Zinc-deficiency and aging
    Georges Herbein
    Department of Virology, IFR 133, EA 3186, Franche Comte University, F 25030, Besancon, France
    Biogerontology 7:409-19. 2006
    ..In this review we summarize our present knowledge on NF-kappaB and AP-1 activation and underline the role of Zn in this process, especially in the context of Zn deficiency observed in aged persons leading to immunosenescence...
  28. doi request reprint Plasma membrane signaling in HIV-1 infection
    Wasim Abbas
    Department of Virology, EA 4266 Pathogens and Inflammation, SFR FED4234, University of Franche Comte, CHRU Besançon, F 25030 Besancon, France Electronic address
    Biochim Biophys Acta 1838:1132-42. 2014
    ..This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking. ..
  29. ncbi request reprint Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients
    Alain Coaquette
    Department of Virology, Franche Comte University School of Medicine, Besancon, France
    Clin Infect Dis 39:155-61. 2004
    ..The presence of multiple gB genotypes, rather than the presence of a single gB genotype, could be a critical factor associated with severe clinical manifestations in immunocompromised patients...
  30. pmc HIV-1 latency in monocytes/macrophages
    Amit Kumar
    UPRES EA4266, SFR FED 4234, Pathogens and Inflammation Laboratory, Department of Virology, CHRU Besançon, University of Franche Comte, F 25030 Besancon, France
    Viruses 6:1837-60. 2014
    ..In this review we will describe our current understanding of the mechanism of latency in monocyte/macrophage lineage and how such cells can be specifically eliminated from the infected host. ..
  31. doi request reprint Epigenetic regulation of HIV-1 transcription
    Manoj Kumar Tripathy
    Department of Virology, University of Franche Comte, EA4266, IFR133 INSERM, CHU Besancon, Besancon, France
    Epigenomics 3:487-502. 2011
    ..Understanding the molecular mechanisms underlying HIV-1 transcriptional silencing and activation is thus a major challenge in the fight against AIDS and will certainly lead to new therapeutic tools...