Annie Heitz

Summary

Country: France

Publications

  1. ncbi Knottin cyclization: impact on structure and dynamics
    Annie Heitz
    CNRS, UMR5048, Université Montpellier 1 et 2, Centre de Biochimie Structurale, 34090 Montpellier, France
    BMC Struct Biol 8:54. 2008
  2. ncbi KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007
    Jérôme Gracy
    Universite de Montpellier, CNRS, UMR5048, Centre de Biochimie Structurale, 34090 Montpellier, INSERM, U554, Montpellier, France
    Nucleic Acids Res 36:D314-9. 2008
  3. ncbi Squash inhibitors: from structural motifs to macrocyclic knottins
    Laurent Chiche
    Centre de Biochimie Structurale, CNRS UMR5048, INSERM UMR554, Universite Montpellier I, Faculte de Pharmacie, 34093 Montpellier, France
    Curr Protein Pept Sci 5:341-349. 2004
  4. ncbi Structure and folding of disulfide-rich miniproteins: insights from molecular dynamics simulations and MM-PBSA free energy calculations
    Cecil Combelles
    Universite de Montpellier, CNRS, UMR5048, Centre de Biochimie Structurale, 34090 Montpellier, France
    Proteins 73:87-103. 2008
  5. ncbi The KNOTTIN website and database: a new information system dedicated to the knottin scaffold
    Jean-Christophe Gelly
    Centre de Biochimie Structurale, , , 15 Avenue Charles Flahault, F-34093 Montpellier, France
    Nucleic Acids Res 32:D156-9. 2004
  6. ncbi Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations
    Aline Moulin
    Institut des Biomolecules Max Mousseron, UMR 5247, CNRS, Université Montpellier I et Université Montpellier II, BP 14491, Faculte de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    J Med Chem 50:5790-806. 2007

Collaborators

Detail Information

Publications6

  1. ncbi Knottin cyclization: impact on structure and dynamics
    Annie Heitz
    CNRS, UMR5048, Université Montpellier 1 et 2, Centre de Biochimie Structurale, 34090 Montpellier, France
    BMC Struct Biol 8:54. 2008
    ..Head-to-tail cyclization is intuitively expected to improve bioactivities by increasing stability and lowering flexibility as well as sensitivity to proteolytic attack...
  2. ncbi KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007
    Jérôme Gracy
    Universite de Montpellier, CNRS, UMR5048, Centre de Biochimie Structurale, 34090 Montpellier, INSERM, U554, Montpellier, France
    Nucleic Acids Res 36:D314-9. 2008
    ..The KNOTTIN database is available at http://knottin.cbs.cnrs.fr...
  3. ncbi Squash inhibitors: from structural motifs to macrocyclic knottins
    Laurent Chiche
    Centre de Biochimie Structurale, CNRS UMR5048, INSERM UMR554, Universite Montpellier I, Faculte de Pharmacie, 34093 Montpellier, France
    Curr Protein Pept Sci 5:341-349. 2004
    ..The solution structure of MCoTI-II will be compared with topologically similar cyclotides, homologous linear squash inhibitors and other knottins, and potential applications of such scaffolds will be discussed...
  4. ncbi Structure and folding of disulfide-rich miniproteins: insights from molecular dynamics simulations and MM-PBSA free energy calculations
    Cecil Combelles
    Universite de Montpellier, CNRS, UMR5048, Centre de Biochimie Structurale, 34090 Montpellier, France
    Proteins 73:87-103. 2008
    ..Overall, our work suggests that molecular dynamics simulations and the MM-PBSA approach to estimate free energies are useful tools to analyze and compare disulfide bridge connectivities in miniproteins...
  5. ncbi The KNOTTIN website and database: a new information system dedicated to the knottin scaffold
    Jean-Christophe Gelly
    Centre de Biochimie Structurale, , , 15 Avenue Charles Flahault, F-34093 Montpellier, France
    Nucleic Acids Res 32:D156-9. 2004
    ..The standardized numbering is used for automatic drawing of two-dimensional Colliers de Perles. The KNOTTIN website and database are available at http://knottin.cbs.cnrs.fr and http://knottin.com...
  6. ncbi Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations
    Aline Moulin
    Institut des Biomolecules Max Mousseron, UMR 5247, CNRS, Université Montpellier I et Université Montpellier II, BP 14491, Faculte de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    J Med Chem 50:5790-806. 2007
    ....