Xavier Hanoulle

Summary

Country: France

Publications

  1. doi request reprint Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded
    Xavier Hanoulle
    UGSF, UMR CNRS, IFR, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Biochem Biophys Res Commun 381:634-8. 2009
  2. ncbi request reprint The domain 2 of the HCV NS5A protein is intrinsically unstructured
    Xavier Hanoulle
    Unite de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, IFR 147, Université Lille1 Sciences et Technologies, 59655 Villeneuve d Ascq, France
    Protein Pept Lett 17:1012-8. 2010
  3. pmc Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B
    Xavier Hanoulle
    Unite de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, IFR 147, Universite des Sciences et Technologies de Lille, F 59655 Villeneuve d Ascq, France
    J Biol Chem 284:13589-601. 2009
  4. doi request reprint Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation
    Caroline Smet-Nocca
    Unite de Glycobiologie Structurale et Fonctionnelle, CNRS UMR8576, IFR 147, Université de Lille1, 59655 Villeneuve d Ascq cedex, France
    Mol Biosyst 7:1420-9. 2011
  5. ncbi request reprint Structural and functional characterization of the interaction between cyclophilin B and a heparin-derived oligosaccharide
    Xavier Hanoulle
    Structural and Functional Glycobiology Unit, UMR 8576 CNRS, University of Sciences and Technologies of Lille, 59655 Villeneuve d Ascq, France
    J Biol Chem 282:34148-58. 2007
  6. pmc Tau aggregation in Alzheimer's disease: what role for phosphorylation?
    Guy Lippens
    CNRS UMR 8576, Unite de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, Villeneuve d Ascq, France
    Prion 1:21-5. 2007
  7. doi request reprint Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry
    Vanessa Dehennaut
    UMR CNRS 8576, UGSF, USTL, IFR 147, 59655 Villeneuve d Ascq, France
    Biochem Biophys Res Commun 369:539-46. 2008
  8. doi request reprint Graphical interpretation of Boolean operators for protein NMR assignments
    Dries Verdegem
    Unité de Glycobiologie Structurale et Fonctionelle, UMR 8576 CNRS, IFR 147, Universite des Sciences et Technologies de Lille, 59655, Villeneuve d Ascq, France
    J Biomol NMR 42:11-21. 2008
  9. pmc Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A
    Claire Rosnoblet
    Universite Lille Nord de France, F 59000 Lille, France
    J Biol Chem 287:44249-60. 2012
  10. ncbi request reprint ELISE NMR: experimental liquid sealing of NMR samples
    Jean Michel Wieruszeski
    CNRS Université de Lille 1 UMR 8576, USTL, Villeneuve d Ascq, France
    J Magn Reson 181:199-202. 2006

Collaborators

Detail Information

Publications10

  1. doi request reprint Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded
    Xavier Hanoulle
    UGSF, UMR CNRS, IFR, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Biochem Biophys Res Commun 381:634-8. 2009
    ..This lack of stable folding is thought to be essential for primary interactions of NS5A-D3 domain with other viral or host proteins, which could stabilize some specific conformations conferring new functional features...
  2. ncbi request reprint The domain 2 of the HCV NS5A protein is intrinsically unstructured
    Xavier Hanoulle
    Unite de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, IFR 147, Université Lille1 Sciences et Technologies, 59655 Villeneuve d Ascq, France
    Protein Pept Lett 17:1012-8. 2010
    ..We show that it forms an anchoring point for the host cell cyclophilin prolyl cis/trans isomerase, providing a molecular basis for the use of cyclophilin inhibitors in an antiviral strategy...
  3. pmc Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B
    Xavier Hanoulle
    Unite de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, IFR 147, Universite des Sciences et Technologies de Lille, F 59655 Villeneuve d Ascq, France
    J Biol Chem 284:13589-601. 2009
    ..NMR heteronuclear exchange spectroscopy yielded direct evidence that many proline residues in NS5A-D2 form a valid substrate for the enzymatic peptidyl-prolyl cis/trans isomerase (PPIase) activity of CypA and CypB...
  4. doi request reprint Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation
    Caroline Smet-Nocca
    Unite de Glycobiologie Structurale et Fonctionnelle, CNRS UMR8576, IFR 147, Université de Lille1, 59655 Villeneuve d Ascq cedex, France
    Mol Biosyst 7:1420-9. 2011
    ..Reciprocally, S400 O-GlcNAcylation reduces S404 phosphorylation by the CDK2/cyclinA3 kinase and interrupts the GSK3β-mediated sequential phosphorylation process...
  5. ncbi request reprint Structural and functional characterization of the interaction between cyclophilin B and a heparin-derived oligosaccharide
    Xavier Hanoulle
    Structural and Functional Glycobiology Unit, UMR 8576 CNRS, University of Sciences and Technologies of Lille, 59655 Villeneuve d Ascq, France
    J Biol Chem 282:34148-58. 2007
    ..We thus conclude that the glycanic moiety of HSPG serves as anchor for CypB at the cell surface, and that the signal could be transduced by CypB via its PPIase activity toward CD147...
  6. pmc Tau aggregation in Alzheimer's disease: what role for phosphorylation?
    Guy Lippens
    CNRS UMR 8576, Unite de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, Villeneuve d Ascq, France
    Prion 1:21-5. 2007
    ..We also discuss in this review the role of phosphorylation for the aggregation of the neuronal Tau protein, and compare it to the aggregation induced by external poly anions...
  7. doi request reprint Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry
    Vanessa Dehennaut
    UMR CNRS 8576, UGSF, USTL, IFR 147, 59655 Villeneuve d Ascq, France
    Biochem Biophys Res Commun 369:539-46. 2008
    ..Microinjection of anti-OGT antibodies leads to a delay of the GVBD kinetics. Our results hence demonstrate that OGT is a key molecule for the timely progression of the cell cycle...
  8. doi request reprint Graphical interpretation of Boolean operators for protein NMR assignments
    Dries Verdegem
    Unité de Glycobiologie Structurale et Fonctionelle, UMR 8576 CNRS, IFR 147, Universite des Sciences et Technologies de Lille, 59655, Villeneuve d Ascq, France
    J Biomol NMR 42:11-21. 2008
    ..We demonstrate here its general use for the case of a folded protein with a well-dispersed spectrum, but equally for a natively unfolded protein where spectral resolution is minimal...
  9. pmc Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A
    Claire Rosnoblet
    Universite Lille Nord de France, F 59000 Lille, France
    J Biol Chem 287:44249-60. 2012
    ..This work brings new insights into the comprehension of the molecular interplay between NS5B, NS5A, and CypA, three essentials proteins for HCV replication...
  10. ncbi request reprint ELISE NMR: experimental liquid sealing of NMR samples
    Jean Michel Wieruszeski
    CNRS Université de Lille 1 UMR 8576, USTL, Villeneuve d Ascq, France
    J Magn Reson 181:199-202. 2006
    ..For chloroform samples, a simple drop of water allows to efficiently seal the sample, avoiding solvent evaporation even over lengthy time periods...