Research Topics
Species | Olivier HanonSummaryCountry: France Publications
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Publications
Hypertension and dementiaOlivier Hanon
Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V, 54 56 Rue Pascal, 75013 Paris, France
Curr Cardiol Rep 5:435-40. 2003..Data from recent therapeutic trials open the way to the prevention of dementia (vascular or Alzheimer's type) by antihypertensive treatments and must be confirmed by other studies...
[Is there evidence that treatment of hypertension in the aged decreases the risk of cerebral ischaemic disease?]O Hanon
Service de Geriatrie, Hopital Broca, CHU Cochin Port Royal Université René Descartes, Paris V, 54 56, rue Pascal, 75013 Paris
Rev Neurol (Paris) 160:471-7. 2004
Prevention of dementia and cerebroprotection with antihypertensive drugsOlivier Hanon
Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V, 54 56 Rue Pascal, 75013 Paris, France
Curr Hypertens Rep 6:201-7. 2004..In this context, reduced incidence of dementia should be the primary outcome of future trials comparing different classes of antihypertensive drugs...
Prevention of dementia: lessons from SYST-EUR and PROGRESSOlivier Hanon
Department of Geriatrics, Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V, 54 56 Rue Pascal, 75013 Paris, France
J Neurol Sci 226:71-4. 2004..With the dihydropyridine calcium antagonists, a reduction in both Alzheimer's type and vascular dementia was demonstrated...
Diuretics for cardiovascular prevention in the elderlyO Hanon
Department of Geriatrics, Hopital Broca, rue Pascal, Paris, France
J Hum Hypertens 18:S15-22. 2004....
[Cognitive functions and hypertension]O Hanon
Service de Gerontologie, Hopital Broca, Paris
Arch Mal Coeur Vaiss 98:133-9. 2005..In this context, the effect of antihypertensive treatment on cognitive functions should represent one of the primary criteria of assessment in future morbidity and mortality studies in hypertensive patients...
Evolution of blood pressure in patients with Alzheimer's disease: a one year survey of a French Cohort (REAL.FR)O Hanon
Department of Geriatrics, Hopital Broca, 75013 Paris, France
J Nutr Health Aging 9:106-11. 2005..To determine the evolution of blood pressure in patients with moderate Alzheimer's disease among a one year longitudinal survey and to evaluate the relationship between blood pressure and cognitive functions...
Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory lossOlivier Hanon
Universite Paris Descartes, Department of Geriatrics, Hopital Broca, Paris, France
Stroke 36:2193-7. 2005..To evaluate the relationship between arterial stiffness and cognitive function in a population of elderly subjects reporting memory loss...
[Management of hypertension in the very elderly]Olivier Hanon
Service de Geriatrie, Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V, 54 56 Rue Pascal, 75013 Paris
Presse Med 35:1047-53. 2006..Most often, very elderly hypertensive patients will require two antihypertensive drugs for adequate blood pressure control. Generally their regimen should not include more than 3 antihypertensive drugs (including a thiazide diuretic)...
Relationship between antihypertensive drug therapy and cognitive function in elderly hypertensive patients with memory complaintsOlivier Hanon
Universite Paris Descartes, Department of Geriatrics, Hopital Broca, Paris, France
J Hypertens 24:2101-7. 2006..To evaluate the relationship between antihypertensive treatments and cognitive function in elderly hypertensive patients with memory complaints...
[Relationship between arterial pressure and cognitive functions. Data for the French Network on Alzheimer's disease (REAL.FR)]O Hanon
Service de Geriatrie, Hopital Broca, 54 56, rue Pascal, 75013 Paris, France
Rev Med Interne 24:292s-300s. 2003..The relationships between arterial hypertension and cognitive decline are complex and studies indicate controversial results...
Consensus of the French Society of Gerontology and Geriatrics and the French Society of Cardiology for the management of coronary artery disease in older adultsOlivier Hanon
Department of Geriatrics, Universite Paris Descartes, Hopital Broca, 54 56, rue Pascal, 75013 Paris, France
Arch Cardiovasc Dis 102:829-45. 2009....
[Ageing of the arterial wall]O Hanon
Service de géiatrie, hôital Broca, Paris
Arch Mal Coeur Vaiss 99:13-8. 2006..Therefore, atherosclerosis is a localised disease resulting in a decrease in arterial lumen, quite different from arteriosclerosis which is a diffuse, physiological condition which leads to an increase in the arterial lumen...
Cognitive decline and dementia in the elderly hypertensiveOlivier Hanon
Department of Geriatrics, , Paris, France
J Renin Angiotensin Aldosterone Syst 3:S32-8. 2002
[Difficulty in assessing renal function in elderly hypertensive patients. Results of a survey in the geriatric environment]Olivier Hanon
Service de Gerontologie, Hopital Broca, 54 56 Rue Pascal, 75013 Paris
Presse Med 31:1071-80. 2002....
Contemporary management of octogenarians hospitalized for heart failure in Europe: Euro Heart Failure Survey IIMichel Komajda
AP HP, Department of Cardiology, Pitie Salpetriere Hospital, University Pierre et Marie Curie Paris 6, Paris, France
Eur Heart J 30:478-86. 2009..International guidelines are frequently not implemented in the elderly population with heart failure (HF). This study determined the management of octogenarians with HF enrolled in Euro Heart Failure Survey II (EHFS II) (2004-05)...
Antihypertensive drugs and cognitive functionAnne Sophie Rigaud
Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V, 54 56 Rue Pascal, 75013 Paris, France
Curr Hypertens Rep 4:211-5. 2002..The fact that antihypertensive treatment has been demonstrated to decrease those risks offers a new opportunity to reduce the prevalence of such related disorders and to promote healthy aging...
Apolipoprotein E epsilon4 allele frequency in elderly depressed patients with and without cerebrovascular diseaseLatchezar Traykov
Hopital Broca, Paris, France
J Neurol Sci 257:280-3. 2007..In contrast, the results show no association between the presence of ApoE epsilon4 allele and vascular depression and provide further evidence in support of the concept that ApoE epsilon4 allele is not associated with clinical CVD...
Blood pressure and pulse wave velocity values in the institutionalized elderly aged 80 and over: baseline of the PARTAGE studyAthanase Benetos
Department of Geriatrics, University Hospital of Nancy, Nancy, France
J Hypertens 28:41-50. 2010..In the study herein, we present the baseline data values of this study...
Heart disease and changes in pulse wave velocity and pulse pressure amplification in the elderly over 80 years: the PARTAGE StudyPaolo Salvi
Department of Geriatrics, University Hospital of Nancy, Vandoeuvre les Nancy, France
J Hypertens 28:2127-33. 2010..The aim of the current research was to determine the influence of PPA and PWV, both manifestations of arterial stiffness, on heart disease in the elderly...
Renal function in older hospital patients is more accurately estimated using the Cockcroft-Gault formula than the modification diet in renal disease formulaRenaud Pequignot
Service de Geriatrie, Hôpital Charles Foix and Université Pierre et Marie Curie Paris 6, Ivry sur Seine, France, and Service de Médecine et de Réadaptation, Hopital National, Saint Maurice, France
J Am Geriatr Soc 57:1638-43. 2009..To compare the accuracy of the two most popular creatinine clearance (CrCl) estimation formulae (Cockcroft-Gault (CG) and Modification Diet in Renal Disease (MDRD)) in older hospitalized patients...
Effects of antihypertensive therapy on cognitive decline in Alzheimer's diseaseEmmanuelle Duron
Department of Geriatrics, University Descartes Paris 5, Broca Hospital, Paris, France
Am J Hypertens 22:1020-4. 2009..Our objective was to evaluate the impact of antihypertensive therapy on the cognitive function in subjects already diagnosed with Alzheimer's disease (AD)...
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Alzheimer's diseaseEmmanuelle Duron
Assistance Publique Hopitaux de Paris, Broca Hospital, Department of Geriatrics, 54 56 Rue Pascal, 75013 Paris, France
J Clin Endocrinol Metab 97:4673-81. 2012..Few large studies have been conducted to assess the relationship between circulating IGF and late-life cognition...
[Atrial fibrillation and cognitive function]Emmanuelle Duron
Hopital Broca, Paris
Psychol Neuropsychiatr Vieil 8:209-14. 2010..Thus, there is some evidence that FA could be associated with cognitive decline and dementia but this link should be supported by more powerful long term longitudinal studies...
Relationship between blood pressure and depression in the elderly. The Three-City StudyHermine Lenoir
INSERM U708, and Department of Geriatrics, Broca Hospital, 54 56 Rue Pascal, Paris, France
J Hypertens 26:1765-72. 2008..To examine the relationship between blood pressure and depression in a large sample of noninstitutionalized elderly people...
Vascular risk factors, cognitive decline, and dementiaE Duron
Broca Hospital, Paris, France
Vasc Health Risk Manag 4:363-81. 2008..Vascular risk factors and their treatments are a promising avenue of research for prevention of dementia, and further long-term, placebo-controlled, randomized studies, need to be performed...
Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: primary results of the Observational Study on Cognitive function And Systolic Blood Pressure Reduction open-label studyOlivier Hanon
University Paris Descartes, Department of Geriatrics, Broca Hospital, Paris, France
J Hypertens 26:1642-50. 2008..Recent studies have indicated a relationship between hypertension and cognitive function but therapeutic trials of antihypertensive therapy on the prevention of cognitive disorders have produced controversial findings...
[Hypertension in the elderly: particularities and precautions]Olivier Hanon
Université Paris Descartes 5, Departement de Geriatrie, Hopital Broca, F 75013 Paris, France
Presse Med 38:614-20. 2009..Cognitive function should be assessed in patients with hypertension older than 80 years, with the MMSE (Mini-Mental-State-Examination) to assess the risk of poor adherence, in view of the increased risk of dementia...
Relationship between orthostatic hypotension and cognitive impairment in the elderlyShima Mehrabian
Universite Paris Descartes, Department of Geriatrics, Hopital Broca, 54 56 Rue Pascal, 75013 Paris, France
J Neurol Sci 299:45-8. 2010..To determine the relationship between orthostatic hypotension (OH) and cognitive function in elderly subjects with memory complaints...
Antihypertensive treatments, cognitive decline, and dementiaEmmanuelle Duron
Department of Geriatrics, University Paris Descartes, Broca Hospital, AP HP, France
J Alzheimers Dis 20:903-14. 2010..A low blood pressure threshold that could be deleterious for cognitive function should also be determined...
Masked hypertension in the elderly: cross-sectional analysis of a population-based sampleCécilia Cacciolati
INSERM, U708, Paris, France
Am J Hypertens 24:674-80. 2011..However, MHT is poorly known in the elderly, although this age segment is at high risk of hypertension-related vascular events. Our objectives were to assess frequency and determinants of MHT in the elderly...
Feasibility of home blood pressure measurement in elderly individuals: cross-sectional analysis of a population-based sampleCécilia Cacciolati
1 INSERM, Neuroepidemiology U708, Bordeaux, France 2 UPMC Univ Paris 06, Paris, France
Am J Hypertens 25:1279-85. 2012..However, particular care must be given to very old, nonautonomous, and low educated individuals.American Journal of Hypertension, (2012); doi:10.1038/ajh.2012.121...
Improvement of impaired coronary vasodilator reserve in hypertensive patients by low-dose ACE inhibitor/diuretic therapy: a pilot PET studyJean-Jacques Mourad
St Michel Hospital, Paris, France
J Renin Angiotensin Aldosterone Syst 4:94-5. 2003
[Hypertension in the elderly and risk of dementia]Olivier Hanon
Universite Paris Descartes, Service de Geriatrie, Hopital Broca, AP HP, 75013, Paris
Rev Prat 60:649-53. 2010..e those who already have mild cognitive impairment or extensive cerebral white matter lesions, in order to optimize blood pressure control and monitor cognitive function (regular cognitive assessment, drugs adherence)...
[Cognitive decline and hypertension]A S Rigaud
Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V, 54 56, rue Pascal, 75013 Paris
Arch Mal Coeur Vaiss 96:47-51. 2003..In particular, the results of the Syst-Eur study, showing that a calcium inhibitor, nitrendipine, could reduce not only the incidence of stroke but also that of dementia, should be confirmed...
[Medical management of libido disturbances in treated hypertensive patients: differences between men and women]X Girerd
Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, 83, Bd de l Hopital, 75013 Paris
Arch Mal Coeur Vaiss 96:758-62. 2003..Decrease in sexual desire is a disturbance affecting treated hypertensive subjects of both sexes. In contrast with erection problems, this abnormality has rarely been studied in hypertensives treated with antihypertensive drugs...
[Rational choice for second antihypertensive agent after failure of the first monotherapy: therapeutic strategy]X Girerd
Service de Medecine Interne, Hopital Broussais, 96, rue Didot, 75014 Paris
Arch Mal Coeur Vaiss 95:723-6. 2002..A strategy based on a single monotherapy followed, if necessary, by a rational choice for the second treatment in a fixed combination therapy is effective to achieve BP control in 84% of naive hypertensive patients...
Management of heart failure in the elderly: recommendations from the French Society of Cardiology (SFC) and the French Society of Gerontology and Geriatrics (SFGG)M Komajda
Department of Cardiology, Pitie Salpetriere Hospital, 47 83 boulevard de l Hopital, 75013 Paris, France
J Nutr Health Aging 10:434-44. 2006..The therapeutic programmes in which multidisciplinary teams are involved reduce the number and duration of hospitalisations and the costs generated by the disease...
[Study of the effect of season on the frequency of side effects or antihypertensive agents]X Girerd
Service de Medecine Interne, Hopital Broussais, 96, rue Didot, 75014 Paris
Arch Mal Coeur Vaiss 95:718-22. 2002..To evaluate the influence of season on side effects of antihypertensive treatments in hypertensive patients followed by cardiologists...
[Systolic blood pressures are not comparable when home blood pressure is measured with a wrist or an arm validated monitor]C Dourmap-Collas
Service d Endocrinologie Métabolisme, Hopital de la Pitie Salpetriere, Paris
Arch Mal Coeur Vaiss 98:774-8. 2005..To compare home blood pressure values obtained with two validated OMRON (wrist or arm) monitors used sequentially in the same subject...
Hypertension, cognitive decline and dementiaE Duron
Departement de Geriatrie, Hopital Broca, Université de Paris Descartes 5, 54 56 Rue Pascal, Paris
Arch Cardiovasc Dis 101:181-9. 2008..Further long-term randomised trials, designed especially to assess a link between antihypertensive therapy and cognitive decline or dementia are therefore needed...
Hypertension and dementiaA S Rigaud
Department of Geriatrics, Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V 54 56 Rue Pascal, 75013 Paris, France
Curr Hypertens Rep 3:454-7. 2001..The fact that antihypertensive treatment has been demonstrated to decrease that risk offers a new opportunity to reduce the prevalence of such related disorders and promote healthy aging...
[Cerebral complications of hypertension in the elderly]A S Rigaud
Service de Gerontologie, Hopital Broca, CHU Cochin Port Royal, 54 56, rue Pascal, 75013 Paris, France
Rev Med Interne 22:959-68. 2001..The benefit of calcium antagonists in the prevention of dementia in elderly hypertensive patients should be assessed in the Dementia Prevention in Hypertension trial (DEPHY)...
[Assessment of antihypertensive compliance using a self-administered questionnaire: development and use in a hypertension clinic]X Girerd
Service de Medecine Interne, Hopital Broussais, 96, rue Didot, F 75014 Paris
Presse Med 30:1044-8. 2001..The aim of this work was to select and validate interview questions to be used in a self-administered questionnaire for measurement of medication compliance in hypertensive patients...
Comparison between the three most popular formulae to estimate renal function, in subjects 75 years of age or olderSophie Chauvelier
Service de Geriatrie, Hôpital Charles Foix et Université UPMC Paris, Ivry sur Seine, France
Drugs Aging 29:885-90. 2012....
[Coronary artery disease in patient 80 years and older]Olivier Hanon
Departement de Geriatrie, Hopital Broca, Université de Paris Descartes 5, 75013 Paris, France
Rev Prat 58:1565-70. 2008....
[Heart failure, a disease of the elderly]Olivier Hanon
Service de cardiologie, Hopital Broca, Paris
Presse Med 33:1079-82. 2004..This work-up must assess the cognitive function, autonomy, somatic status, living conditions and the medico-social management of these patients...
Management of octogenarians hospitalized for heart failure in Euro Heart Failure Survey IMichel Komajda
Department of Cardiology, Pitie Salpetriere Hospital, University Pierre et Marie Curie, 47 83 boulevard de l Hopital, 75013 Paris, France
Eur Heart J 28:1310-8. 2007..Here, the aim is to study the management of octogenarians hospitalized for heart failure in Euro Heart Failure Survey I. Heart Failure (HF) is common in older people and associated with poor outcome...
Endothelin gene variants and aortic and cardiac structure in never-treated hypertensivesM Lajemi
, Institut des Cordeliers, Paris, France
Am J Hypertens 14:755-60. 2001..CONCLUSIONS: These results indicate that the influence of endothelin system genes can be detected first on arterial parameters...
Relevance of 10-min delayed recall in dementia screeningJ De Rotrou
Department of Geriatrics, Broca Hospital, Paris, France
Eur J Neurol 14:144-9. 2007..In demented patients with MMSE score > or =26, MIS-D properties still remained satisfying (sensitivity: 75%, specificity: 92%). MIS-D is a more relevant screening test than MIS alone at very early stages of dementia...
[What is the most relevant definition of orthostatic hypotension: systolic blood pressure drop, diastolic blood pressure drop, or both?]E Duron
Service de Geriatrie, Hopital Broca, 54 56 Rue Pascal, 75013 Paris
Arch Mal Coeur Vaiss 100:689-94. 2007..For elderly people, a question can be raised about diastolic BP relevance in OH's definition...
[Relationship of white matter lesions on brain computed tomography and cognitive function in elderly subjects with mild cognitive impairment]E Duron
Service de Geriatrie, Hopital Broca, Paris
Arch Mal Coeur Vaiss 100:654-9. 2007..White matter lesions (WML) are frequently disclosed on elderly people computed tomography (CT) brain scan...
[Association between blood pressure level and the follow up of the guidelines concerning the use of self blood pressure measurement]O Hanon
, , Paris
Arch Mal Coeur Vaiss 97:762-6. 2004..CONCLUSION: Among hypertensives referred to hypertension specialists most of subjects use SMBP device without a specific design of supervision. Subjects with the most severe hypertension are those who have the best formation for SMBP...
Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humansO Hanon
Department of Internal Medicine and INSERM U337, Hopital Broussais, Hopital Europeen Georges Pompidou, Paris, France
Hypertension 38:1185-9. 2001....
Lack of association between renin-angiotensin system, gene polymorphisms, and wall thickness of the radial and carotid arteriesX Girerd
From the Department of Internal Medicine and INSERM U337, the Department of Pharmacology and INSERM U337 and the Laboratory of Molecular Biology, Broussais Hospital, Paris, France
Hypertension 32:579-83. 1998..These results suggest that these gene polymorphisms have an undetectable role in the geometry of the radial and carotid arteries compared with usual determinants such as blood pressure and age...
How to limit screening of patients for atheromatous renal artery stenosis in two-drug resistant hypertension?Michel Ducher
E Herriot Hospital, Claude Bernard University, Lyon, France
J Nephrol 18:161-5. 2005....
Executive functions deficit in mild cognitive impairmentLatchezar Traykov
Hopital Henri Mondor, Department of Neurology, University Paris XII, Creteil, France
Cogn Behav Neurol 20:219-24. 2007....
Rationale, design and methods of the OSCAR study: observational study on cognitive function and systolic blood pressure reduction in hypertensive patientsAtul Pathak
Department of Clinical Pharmacology, Faculty of Medicine and University Hospital of Toulouse, Universite Paul Sabatier, Toulouse, France
Fundam Clin Pharmacol 21:199-205. 2007..The OSCAR trial is the first international observational study focusing on MMSE in a wide international cohort of hypertensive patients. The results are expected in 2007...
