Michel Hamon

Summary

Country: France

Publications

  1. ncbi request reprint [Neuropathic pain. Physiopathological mechanisms and therapeutic perspectives]
    Michel Hamon
    INSERM U677, CHU Pitie Salpetriere, 91, bld de l Hôpital, 75013 Paris
    Bull Acad Natl Med 192:921-6; discussion 926-8. 2008
  2. doi request reprint Monoamine neurocircuitry in depression and strategies for new treatments
    Michel Hamon
    INSERM U894, Centre of Psychiatry and Neurosciences, Paris, France
    Prog Neuropsychopharmacol Biol Psychiatry 45:54-63. 2013
  3. doi request reprint Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice
    Thibault Renoir
    INSERM, U677, Paris, F 75013, France
    Int J Neuropsychopharmacol 11:1149-62. 2008
  4. doi request reprint Inhibition of the bradycardic component of the von Bezold-Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors
    Florence Netzer
    UMR 677 INSERM UMPC, CHU Pitie Salpetriere, Paris, France
    Eur J Neurosci 29:2017-28. 2009
  5. doi request reprint Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice
    Sabah Kelai
    UPMC Univ Paris 06, UMR 5677, NeuroPsychoPharmacologie, Paris, France
    J Neurochem 107:1660-70. 2008
  6. ncbi request reprint Rapid up-regulation of the neuronal serotoninergic phenotype by brain-derived neurotrophic factor and cyclic adenosine monophosphate: relations with raphe astrocytes
    Prakasham Rumajogee
    Laboratoire de Neurobiologie des Signaux Intercellulaires, CNRS UMR 7101, Universite Pierre et Marie Curie, Paris, France
    J Neurosci Res 81:481-7. 2005
  7. ncbi request reprint Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice
    Valérie Kayser
    University Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
    Pain 130:235-48. 2007
  8. ncbi request reprint Critical role of B3 serotonergic cells in baroreflex inhibition during the defense reaction triggered by dorsal periaqueductal gray stimulation
    Jean Francois Bernard
    Universite Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
    J Comp Neurol 506:108-21. 2008
  9. doi request reprint GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain
    Florent Viguier
    INSERM U894, Neuropsychopharmacology, Centre de psychiatrie et Neurosciences, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Neuropharmacology 63:1093-106. 2012
  10. doi request reprint Inhibition of cardiac baroreflex by noxious thermal stimuli: a key role for lateral paragigantocellular serotonergic cells
    Rémi Gau
    Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, UMR 894, Paris, France
    Pain 146:315-24. 2009

Collaborators

Detail Information

Publications61

  1. ncbi request reprint [Neuropathic pain. Physiopathological mechanisms and therapeutic perspectives]
    Michel Hamon
    INSERM U677, CHU Pitie Salpetriere, 91, bld de l Hôpital, 75013 Paris
    Bull Acad Natl Med 192:921-6; discussion 926-8. 2008
    ..Such preclinical studies should contribute to the design of innovative strategies for more effective and well-tolerated treatments for neuropathic pain in cephalic and extra-cephalic territories...
  2. doi request reprint Monoamine neurocircuitry in depression and strategies for new treatments
    Michel Hamon
    INSERM U894, Centre of Psychiatry and Neurosciences, Paris, France
    Prog Neuropsychopharmacol Biol Psychiatry 45:54-63. 2013
    ....
  3. doi request reprint Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice
    Thibault Renoir
    INSERM, U677, Paris, F 75013, France
    Int J Neuropsychopharmacol 11:1149-62. 2008
    ..These 5-HTT-dependent effects, opposite to those of antidepressants, might contribute to MDMA-induced mood disorders...
  4. doi request reprint Inhibition of the bradycardic component of the von Bezold-Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors
    Florence Netzer
    UMR 677 INSERM UMPC, CHU Pitie Salpetriere, Paris, France
    Eur J Neurosci 29:2017-28. 2009
    ....
  5. doi request reprint Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice
    Sabah Kelai
    UPMC Univ Paris 06, UMR 5677, NeuroPsychoPharmacologie, Paris, France
    J Neurochem 107:1660-70. 2008
    ....
  6. ncbi request reprint Rapid up-regulation of the neuronal serotoninergic phenotype by brain-derived neurotrophic factor and cyclic adenosine monophosphate: relations with raphe astrocytes
    Prakasham Rumajogee
    Laboratoire de Neurobiologie des Signaux Intercellulaires, CNRS UMR 7101, Universite Pierre et Marie Curie, Paris, France
    J Neurosci Res 81:481-7. 2005
    ..These data suggest that BDNF and cAMP, but not S100beta, rapidly induce both an up-regulation of the 5-HT neuronal phenotype and modifications of the neighboring astrocytes in a TrkB-dependent manner...
  7. ncbi request reprint Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice
    Valérie Kayser
    University Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
    Pain 130:235-48. 2007
    ..These results support the conclusion that the complex control of pain mechanisms by 5-HT, acting at multiple receptors, is physiologically relevant in mice...
  8. ncbi request reprint Critical role of B3 serotonergic cells in baroreflex inhibition during the defense reaction triggered by dorsal periaqueductal gray stimulation
    Jean Francois Bernard
    Universite Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
    J Comp Neurol 506:108-21. 2008
    ..These results show that activation of serotonergic cells in the mid-portion of B3 group is critical to trigger baroreflex inhibition occurring during the defense reaction evoked by dPAG stimulation...
  9. doi request reprint GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain
    Florent Viguier
    INSERM U894, Neuropsychopharmacology, Centre de psychiatrie et Neurosciences, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Neuropharmacology 63:1093-106. 2012
    ..In addition, 5-HT(7)R activation-induced c-Fos increase in the nucleus tractus solitarius and the parabrachial area suggests that supraspinal mechanisms might also be involved...
  10. doi request reprint Inhibition of cardiac baroreflex by noxious thermal stimuli: a key role for lateral paragigantocellular serotonergic cells
    Rémi Gau
    Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, UMR 894, Paris, France
    Pain 146:315-24. 2009
    ..These results show that activation of serotonergic cells in the LPGi is critical to trigger nucleus tractus solitarius-mediated cardiac baroreflex inhibition elicited by intense thermal noxious stimuli...
  11. ncbi request reprint Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons
    Alice Meunier
    Inserm U 713, Douleurs et Stress, Faculté de Médecine Pitié Salpêtrière, 91, Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Mol Ther 11:608-16. 2005
    ....
  12. ncbi request reprint Heterogeneous distribution of the serotonin 5-HT(1A) receptor mRNA in chemically identified neurons of the mouse rostral brainstem: Implications for the role of serotonin in the regulation of wakefulness and REM sleep
    Patricia Bonnavion
    Universite Pierre et Marie Curie Paris 6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, France
    J Comp Neurol 518:2744-70. 2010
    ..They also provide a neuroanatomical basis for understanding the influence of 5-HT(1A)R on REM sleep and wakefulness...
  13. ncbi request reprint GABA(B) receptors in 5-HT transporter- and 5-HT1A receptor-knock-out mice: further evidence of a transduction pathway shared with 5-HT1A receptors
    Clotilde Mannoury La Cour
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, Paris, France
    J Neurochem 89:886-96. 2004
    ....
  14. ncbi request reprint 5-HT-mediated inhibition of cardiovagal baroreceptor reflex response during defense reaction in the rat
    Marie Anne Comet
    Institut National de la Santé et de la Recherche Médicale U 288, CHU Pitie Salpetriere, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Am J Physiol Heart Circ Physiol 287:H1641-9. 2004
    ..Moreover, they support the idea that 5-HT(3) and GABA(A) receptors in the NTS contribute downstream to the inhibition of the baroreflex response caused by dPAG stimulation...
  15. doi request reprint 5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment
    Raymond Mongeau
    INSERM UMR S894, Paris, France
    J Neurochem 115:438-49. 2010
    ..The anxiolytic action of chronic paroxetine might be associated with an enhancement of 5-HT neurotransmission caused by a decreased 5-HT(2C) receptor-mediated inhibition of stress-induced increase in 5-HT release...
  16. doi request reprint The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances
    Vincent Fournet
    INSERM UMRS 952, CNRS UMR 7224, Universite Pierre et Marie Curie, Paris, France
    J Neurochem 121:99-114. 2012
    ..Altogether, these data indicate that the deletion of STOP protein in mice caused deep alterations in mood and cognitive performances and that STOP protein might have a crucial role in the 5-HT and norepinephrine networks development...
  17. doi request reprint Differential effects of calcitonin gene-related peptide receptor blockade by olcegepant on mechanical allodynia induced by ligation of the infraorbital nerve vs the sciatic nerve in the rat
    Benoît Michot
    INSERM, UMR_S894, CPN, NeuroPsychoPharmacologie, Paris, France
    Pain 153:1939-48. 2012
    ..These findings suggest that CGRP receptor blockade might be of potential interest to alleviate trigeminal neuropathic pain...
  18. doi request reprint Differential anti-neuropathic pain effects of tetrodotoxin in sciatic nerve- versus infraorbital nerve-ligated rats--behavioral, pharmacological and immunohistochemical investigations
    Valérie Kayser
    INSERM U894, Paris F 75013, France
    Neuropharmacology 58:474-87. 2010
    ..1 mg/kg i.p.). These results indicate that TTX alleviates pain-related behaviors in sciatic nerve-lesioned rats through mechanisms that involve complex interactions with opioidergic systems...
  19. doi request reprint Involvement of alpha1-adrenoceptors in conditioned place preference supported by nicotine in rats
    Benoit Forget
    INSERM, U677, Paris, F 75013, France
    Psychopharmacology (Berl) 205:503-15. 2009
    ..The noradrenergic system might be a critical mediator of psychostimulants and opiates hedonic value...
  20. ncbi request reprint Differential involvement of the endocannabinoid system in short- and long-term expression of incentive learning supported by nicotine in rats
    Benoit Forget
    INSERM, U677, Paris, F 75013, France
    Psychopharmacology (Berl) 189:59-69. 2006
    ..We previously reported that the CB1 cannabinoid receptor antagonist, rimonabant, impaired the acquisition and the short-term (24 h), but not long-term (3 weeks), expression of conditioned place preference (CPP) induced by nicotine in rats...
  21. ncbi request reprint Antihyperalgesic effects of cizolirtine in diabetic rats: behavioral and biochemical studies
    Bertrand Aubel
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, 91, Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Pain 110:22-32. 2004
    ..p.). These data suggest that the antihyperalgesic effect of cizolirtine in diabetic rats suffering from neuropathic pain implies an alpha(2)-adrenoceptor-dependent presynaptic inhibition of CGRP-containing primary afferent fibers...
  22. doi request reprint Neuronal phenotype dependency of agonist-induced internalization of the 5-HT(1A) serotonin receptor
    Elodie Bouaziz
    Centre de psychiatrie et Neurosciences, Inserm UMR 894, Paris F 75014, France, Universite Paris Descartes, Sorbonne Paris Cité, Paris 75270, France, Universite Pierre et Marie Curie, Paris F 75013, France, and Centre de recherche de l institut du cerveau et de la moelle épinière, CNRS UMR 7225, INSERM UMR 975, Paris F 75013, France
    J Neurosci 34:282-94. 2014
    ..Its differential occurrence in serotonergic neurons supports the idea that 5-HT(1A)R internalization might underlie 5-HT(1A) autoreceptor desensitization under SSRI antidepressant therapy...
  23. doi request reprint N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain
    Valérie Kayser
    INSERM U894, Neuropsychopharmacology, Centre de psychiatrie et Neurosciences, 91 Boulevard de l Hopital, Paris F 75013, France
    Eur J Pain 15:451-8. 2011
    ..p.) reduced the anti-allodynic properties of zolmitriptan in CCI-ION rats. Combined administration of NMDA-receptor antagonist and 5-HT(1B/1D)-receptor agonist may be a promising approach for alleviating trigeminal neuropathic pain...
  24. pmc Hippocampal neurogenesis, depressive disorders, and antidepressant therapy
    Eleni Paizanis
    INSERM, U677, 75013 Paris, France
    Neural Plast 2007:73754. 2007
    ....
  25. ncbi request reprint Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice
    Bruno P Guiard
    Inserm UPMC, NeuroPsychoPharmacologie, CHU Pitie Salpetriere, Paris, France
    J Neurochem 95:1713-23. 2005
    ..These data supported the hypothesis that chronic NK1 receptor blockade induces a functional desensitization of 5-HT 1A autoreceptors similar to that observed with SSRIs...
  26. ncbi request reprint Glucocorticoid receptor-dependent desensitization of 5-HT1A autoreceptors by sleep deprivation: studies in GR-i transgenic mice
    Alexis Evrard
    UMR 677 INSERM UPMC, NeuroPsychoPharmacologie, CHUPitié Salpêtrière, Paris, France
    Sleep 29:31-6. 2006
    ..However, in stressful conditions, corticosterone can also induce a desensitization of these autoreceptors...
  27. ncbi request reprint Lentiviral-mediated targeted NF-kappaB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat
    Alice Meunier
    INSERM, UMR S 713, Paris, France
    Mol Ther 15:687-97. 2007
    ....
  28. doi request reprint Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1
    Veronique Fabre
    Universite Pierre et Marie Curie PARIS6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
    Eur Neuropsychopharmacol 21:33-44. 2011
    ..Thus, 5-HTT expression correlates with that of urocortin 1, suggesting that this peptide can be involved in the behavioral changes observed in 5-HTT mutant mice...
  29. pmc Freezing of enkephalinergic functions by multiple noxious foci: a source of pain sensitization?
    François Cesselin
    Team Pain, INSERM UMRS 975, CNRS UMR 7225, Paris, France
    PLoS ONE 4:e6874. 2009
    ..For example, a noxious mechanical stimulus does not alter the release of Met-enkephalin-like material (MELM) from segments of the spinal cord related to the stimulated area of the body, but does increase its release from other segments...
  30. ncbi request reprint [From inflammation to pain: experimental gene therapy]
    Alice Meunier
    Inserm E0331, INSERM U 288, Douleurs et Stress, Faculté de Médecine Pitié Salpêtrière, 91, Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Med Sci (Paris) 20:325-30. 2004
    ....
  31. pmc Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences
    Nicolas Narboux-Nême
    INSERM, UMR S 839, Institut du Fer a Moulin, Paris, France
    Neuropsychopharmacology 36:2538-50. 2011
    ..These findings are coherent with the notion that 5-HT has an important role in anxiety, and provide new insights into the role of endogenous 5-HT in defense behaviors...
  32. doi request reprint Biological rhythms and melatonin in mood disorders and their treatments
    Laurence Lanfumey
    INSERM, UMR 894, 75013 Paris, France
    Pharmacol Ther 138:176-84. 2013
    ....
  33. doi request reprint Multiple roles of serotonin in pain control mechanisms--implications of 5-HT₇ and other 5-HT receptor types
    Florent Viguier
    INSERM U894, CPN, Neuropsychopharmacology, Faculty of Medicine Pierre and Marie Curie, UPMC, Site Pitié Salpêtrière, 75013 Paris, France University Pierre et Marie Curie UPMC, Neuropsychopharmacology, Faculty of Medicine Pierre and Marie Curie, UPMC, Site Pitié Salpêtrière, 75013 Paris, France Electronic address
    Eur J Pharmacol 716:8-16. 2013
    ....
  34. ncbi request reprint Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress
    Nicolas Froger
    Institut National de la Santé et de la Recherche Médicale U288 Neuropsychopharmacologie Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, Centre Hospitalier Universitaire Pitie Salpetriere, 75013 Paris, France
    J Neurosci 24:2787-96. 2004
    ..These results demonstrate that impaired GR functioning affects normal adaptive responses of the HPA axis and 5-HT system to CMS and alters stress-related consequences on decision-making behaviors...
  35. doi request reprint Microtubule-associated STOP protein deletion triggers restricted changes in dopaminergic neurotransmission
    Caroline Bouvrais-Veret
    INSERM, U513, Creteil, France, and Univ Paris 12, Faculte de Medecine Henri Mondor, Creteil, France
    J Neurochem 104:745-56. 2008
    ..Altogether, these data showed that deletion of the ubiquitous STOP protein elicited restricted alterations in DAergic neurotransmission, preferentially in the meso-limbic pathway...
  36. ncbi request reprint Life-long hippocampal neurogenesis: environmental, pharmacological and neurochemical modulations
    Eleni Paizanis
    INSERM, U677, Paris, 75013, France
    Neurochem Res 32:1762-71. 2007
    ..We herein review the most significant data on hippocampal neurogenesis in brain under various pathological conditions, with a special attention to mood disorders including depression and addiction...
  37. ncbi request reprint Cannabinoid-serotonin interactions in alcohol-preferring vs. alcohol-avoiding mice
    Sabah Kelai
    UMR 677 INSERM UPMC, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, Paris, France
    J Neurochem 99:308-20. 2006
    ..However, the differences between C57BL/6 J and DBA/2 J mice indicate that such modulations of alcohol intake are under genetic control...
  38. doi request reprint Noxious stimulation excites serotonergic neurons: a comparison between the lateral paragigantocellular reticular and the raphe magnus nuclei
    Rémi Gau
    Universite Pierre et Marie Curie, Paris 6, Site Pitié Salpêtrière, Paris, France
    Pain 154:647-59. 2013
    ....
  39. doi request reprint The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network
    Vincent Fournet
    INSERM UMRS 952, CNRS UMR 7224, Universite Pierre et Marie Curie, Paris, France
    J Neurochem 115:1579-94. 2010
    ..Altogether, these data suggested that STOP deletion elicited peculiar 5-HT disconnectivity...
  40. ncbi request reprint Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain
    Clotilde Mannoury La Cour
    Unité Mixte de Recherche 677, Institut National de la Santé et de la Recherche Médicale INSERM Université Pierre et Marie Curie, Institut Fédératif 70 des Neurosciences, Facultéde Médecine Pierre et Marie Curie, Paris, France
    Mol Pharmacol 70:1013-21. 2006
    ..Such a disparity in G-protein coupling might explain regional differences in adaptive regulations of brain 5-HT1A receptors...
  41. ncbi request reprint 5-HT 1A/1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice
    Christelle Monaca
    INSERM U288, NeuroPsychoPharmacologie Moléculaire Cellulaire et Fonctionnelle, CHU Pitié Salpêtrière 91, Boulevard de l Hopital, 75013 Paris, France
    Neuropsychopharmacology 28:850-6. 2003
    ..Such a mechanism of action provides further support to the clinical strategy of antidepressant augmentation by 5-HT(1A) antagonists, because the latter would also counteract the direct sleep-inhibitory side-effects of SSRIs...
  42. pmc Sleep-stabilizing effects of E-6199, compared to zopiclone, zolpidem and THIP in mice
    Chloé Alexandre
    Universite Pierre et Marie Curie PARIS6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, France
    Sleep 31:259-70. 2008
    ..These compounds have the capacity to initiate and maintain sleep, but decrease REM sleep and delta activity within NREM sleep. In order to avoid such sleep adverse effects, the development of novel compounds remains of interest...
  43. ncbi request reprint Up-regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B-dependent mechanisms
    Prakasham Rumajogee
    Laboratoire de Neurobiologie des Signaux Intercellulaires, CNRS UMR 7101, Universite Pierre et Marie Curie, Paris, France
    J Neurochem 83:1525-8. 2002
    ..These findings suggest that an auto-amplifying mechanism underlies the promoting effect of BDNF on the differentiation of serotoninergic neurones through TrkB activation, which is also triggered by cAMP...
  44. ncbi request reprint Antinociceptive effect of cardiopulmonary chemoreceptor and baroreceptor reflex activation in the rat
    Caroline Sévoz-Couche
    NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle INSERM U288, CHU Pitie Salpetriere, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Pain 99:71-81. 2002
    ....
  45. ncbi request reprint Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats
    Christine Duarte
    INSERM U 288, Faculty of Medicine Pitié Salpêtrière, Paris, France
    Neuropsychopharmacology 28:1903-15. 2003
    ..This suggests that the appetitive effects of cocaine are subserved by mechanisms different, at least in part, from those of morphine and food, and that D(3)R play a role only in the former...
  46. pmc Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy
    Margot Fournier
    Universite Pierre et Marie Curie Paris 6, CRICM Centre de Recherche de l Institut du Cerveau et de la Moelle épinière, UMR S975, Paris, France
    PLoS ONE 4:e6629. 2009
    ..These findings raise the possibility that effective compensatory mechanisms modulate the phenotypic expression of disease in parkin-related parkinsonism...
  47. pmc Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
    Francine Cote
    Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, CNRS, Unité Mixte de Recherche 7091 et Institut Fédératif de Recherche 70, Hopital de la Pitie Salpetriere, Paris, France
    Proc Natl Acad Sci U S A 100:13525-30. 2003
    ..This report links loss of tph1 gene expression, and thus of peripheral 5-HT, to a cardiac dysfunction phenotype. The tph1-/- mutant may be valuable for investigating cardiovascular dysfunction observed in heart failure in humans...
  48. ncbi request reprint Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors
    Daniela Popa
    Unité Mixte de Recherche 677, Institut National de la Santé et de la Recherche Médicale Université Pierre et Marie Curie, 75013 Paris, France
    J Neurosci 25:11231-8. 2005
    ..Moreover, 5-HT(2A) gene knock-out leads to functional compensations yielding adaptive changes opposite to those caused by pharmacological blockade of 5-HT(2A) receptors in 5-HT(2A)+/+ mice...
  49. ncbi request reprint 5-HT1 receptors
    Laurence Lanfumey
    INSERM U 288, Faculté de Médecine Pitié Salpêtrière, 91, Boulevard de l Hopital, 75013 Paris, France
    Curr Drug Targets CNS Neurol Disord 3:1-10. 2004
    ....
  50. doi request reprint Differential effects of free versus imposed motor activity on alcohol consumption in C57BL/6J versus DBA/2J mice
    Capucine Pichard
    CNRS UMR 7593 and University Paris VI Pierre et Marie Curie, Paris, France
    Alcohol 43:593-601. 2009
    ..They also tend to demonstrate that, at least for vulnerable subjects, forced and intensive activities may not have the same benefits regarding alcohol consumption...
  51. doi request reprint A new vesicular scaffolding complex mediates the G-protein-coupled 5-HT1A receptor targeting to neuronal dendrites
    Sana Al Awabdh
    INSERM U894, Centre de psychiatrie et Neurosciences, Paris F 75014, France
    J Neurosci 32:14227-41. 2012
    ..This targeting pathway opens new insights for G-protein-coupled receptors trafficking in neurons...
  52. ncbi request reprint Controversies on the role of 5-HT(2C) receptors in the mechanisms of action of antidepressant drugs
    Cédric B P Martin
    INSERM UMR S894, Centre de psychiatrie et Neurosciences, Paris, France UPMC, Univ Paris 06, Paris, France Paris Descartes, Univ Paris 05, Paris, France
    Neurosci Biobehav Rev 42:208-23. 2014
    ..Setting the record straight about drug-induced changes in 5-HT2C receptor function in specific brain regions should help to determine which pharmacotherapeutic strategy is best for affective and anxiety disorders. ..
  53. ncbi request reprint Effects of the novel analgesic, cizolirtine, in a rat model of neuropathic pain
    Valérie Kayser
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, 91, Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Pain 104:169-77. 2003
    ..These results suggest that cizolirtine may be useful for alleviating some neuropathic somatosensory disorders, in particular cold allodynia, with a reduced risk of undesirable side effects...
  54. ncbi request reprint Immunolabelling of the 5-HT 3B receptor subunit in the central and peripheral nervous systems in rodents
    Edith Doucet
    INSERM U677, F 75013 Paris, France
    Eur J Neurosci 26:355-66. 2007
    ..homomeric 5-HT(3A) receptors in the peripheral and central nervous systems in rodents...
  55. ncbi request reprint [Neurobiology of depression: new data]
    Laurence Lanfumey
    UMR 677 INSERM UPMC, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Therapie 60:431-40. 2005
    ..The possibility that structural remodelling may contribute to the physiopathology of mood disorders provides new avenues of research toward understanding the cellular basis of mood disorders...
  56. ncbi request reprint The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord
    Sébastien Ballet
    NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, INSERM U288, Faculté de Médecine Pitié Salpêtrière, Paris, France
    J Neurochem 81:659-62. 2002
    ..Because dynorphin has pronociceptive properties, such a decrease in spinal dynorphin A (1-8)-like material release might underlie the long-lasting antinociceptive effects of intrathecally administered neuropeptide FF and analogues...
  57. ncbi request reprint Glutamate and NO mediation of the pressor response to 5-HT3 receptor stimulation in the nucleus tractus solitarii
    Caroline Sévoz-Couche
    INSERM U 288, CHU Pitie Salpetriere, 91 blvd de l Hôpital, 75634 Paris Cedex 13, France
    Neuroreport 13:837-41. 2002
    ..These data suggest that ionotropic glutamate receptors and the associated NO/cGMP transduction mechanism contribute downstream to the pressor effect elicited by 5-HT3 receptor stimulation in the NTS...
  58. ncbi request reprint Respective roles of dopamine D2 and D3 receptors in food-seeking behaviour in rats
    Christine Duarte
    INSERM U 288, Faculty of Medicine Pitié Salpêtrière, 91, Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Psychopharmacology (Berl) 166:19-32. 2003
    ..Dopaminergic mechanisms are thought to be critically involved in reward-related processes and seeking behaviour...
  59. ncbi request reprint Toxic cardiac effects of catecholamines: role of beta-adrenoceptor downregulation
    Fazia Brouri
    Service de Pharmacologie, Hopital de la Pitie Salpetriere, Paris, France
    Eur J Pharmacol 456:69-75. 2002
    ....
  60. ncbi request reprint A haplotype of the norepinephrine transporter (Net) gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD)
    Nicolas Ramoz
    INSERM U675, IFR02, Faculty Xavier Bichat, University of Paris, Paris, France
    Neuropsychopharmacology 34:2135-42. 2009
    ....
  61. ncbi request reprint Gene therapy of chronic pain
    Michel Pohl
    INSERM E 0331, Faculté de Médecine Pitié Salpêtrière, 91 Bld de l Hôpital, 75013 Paris, France
    Curr Gene Ther 3:223-38. 2003
    ....