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Species | Loic GuillevinSummaryCountry: France Publications
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Publications
Management of virus-induced systemic vasculitidesLoic Guillevin
Department of Internal Medicine, Hopital Avicenne, AP HP, Universite Paris Nord, 125 rue de Stalingrad, 93009 Bobigny Cedex, France
Curr Rheumatol Rep 4:60-6. 2002..Relapses are frequent...- Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: a prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty-five patientsLoic Guillevin
Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris Nord, Bobigny, France
Arthritis Rheum 49:93-100. 2003.... - [Systemic necrotizing vasculitides: classifications and therapeutic strategies]L Guillevin
Service de Medecine Interne, Hopital Avicenne, Universite Paris Nord, 125, rue de Stalingrad, 93000, Bobigny, France
Rev Med Interne 24:172-82. 2003.... - Indications of plasma exchanges for systemic vasculitidesLoic Guillevin
Department of Internal Medicine, Hopital Avicenne, Universite Paris Nord, Assistance Publique Hopitaux de Paris, Bobigny, France
Ther Apher Dial 7:155-60. 2003..We review herein these indications of plasma exchanges in the light of the results of major trials... 
Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patientsCamillo Ribi
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Rheum 58:586-94. 2008....- Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group DatabaseChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 62:616-26. 2010..This study was undertaken to describe the main characteristics of and long-term outcomes in patients with well-characterized PAN diagnoses... - Therapeutic strategies for systemic necrotizing vasculitidesLoic Guillevin
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, université Paris René Descartes, Paris, France
Allergol Int 56:105-11. 2007..Some of them have achieved promising positive effects, for example, anti-CD20 monoclonal antibodies, and are now being evaluated in prospective trials... - [Treatment of ANCA-associated vascularitides]Loic Guillevin
Service de Medecine Interne, Centre de référence national, Plan maladies rares, vascularites et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
Presse Med 36:922-7. 2007..These biologics must be prescribed extremely cautiously and only in trial settings, especially in view of the adverse effects, few but severe, recently been reported with them... - Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patientsCamillo Ribi
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 75679 Paris, France
Arthritis Rheum 62:1186-97. 2010.... - Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patientsPascal Cohen
Hopital Cochin, Assistance Publique Hopitaux de Paris, Université René Descartes Paris, Recherche Clinique et Thérapeutique, Paris, France
Arthritis Rheum 57:686-93. 2007..To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg-Strauss syndrome (CSS)... 
Association of gender with clinical expression, quality of life, disability, and depression and anxiety in patients with systemic sclerosisChristelle Nguyen
Universite Paris Descartes, Faculté de Médecine Paris Descartes, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
PLoS ONE 6:e17551. 2011..To assess the association of gender with clinical expression, health-related quality of life (HRQoL), disability, and self-reported symptoms of depression and anxiety in patients with systemic sclerosis (SSc)...- The three-year incidence of pulmonary arterial hypertension associated with systemic sclerosis in a multicenter nationwide longitudinal study in FranceEric Hachulla
Hopital Claude Huriez, Department of Internal Medicine, National Reference Center for Scleroderma, and University of Lille, Lille, France
Arthritis Rheum 60:1831-9. 2009..85%. The aim of this observational study was to investigate the incidence of PAH and pulmonary hypertension (PH) during a 3-year followup of patients from the same cohort (the ItinérAIR-Sclérodermie Study)... - Azathioprine or methotrexate maintenance for ANCA-associated vasculitisChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
N Engl J Med 359:2790-803. 2008..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy... - Risk factors for death and the 3-year survival of patients with systemic sclerosis: the French ItinérAIR-Sclérodermie studyEric Hachulla
Department of Internal Medicine, National Reference Center for Scleroderma, Claude Huriez Hospital, University of Lille, 59037 Lille Cedex, France
Rheumatology (Oxford) 48:304-8. 2009..This longitudinal study investigated survival, risk factors and causes of death in the multicentre ItinérAIR-Sclérodermie cohort of patients with SSc without severe pulmonary fibrosis or severe left heart disease at baseline... - Treatment of refractory and/or severe ANCA-associated systemic necrotizing vasculitidesLoic Guillevin
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris, Paris, France
Isr Med Assoc J 10:89-91. 2008..Some of them (e.g., anti-tumor necrosis factor-alpha and anti-CD20 monoclonal antibodies) have achieved promising results and are now often used to treat severe cases... - [Microscopic polyangiitis]Christian Pagnoux
Service de Medecine Interne, Centre de référence national, Plan maladies rares, vascularites nécrosantes et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
Presse Med 36:895-901. 2007..Biological therapies are under evaluation. The remission rate is above 80% with these regimens, and the relapse rate is around 30% at 5 years, lower than for Wegener's granulomatosis... - Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndromeRégis Sablé-Fourtassou
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
Ann Intern Med 143:632-8. 2005..Since testing for antineutrophil cytoplasmic antibodies (ANCA) became available for routine evaluation, no large homogeneous cohort of patients with the Churg-Strauss syndrome has been studied... - Immunogenicity and safety of seasonal and 2009 pandemic A/H1N1 influenza vaccines for patients with autoimmune diseases: a prospective, monocentre trial on 199 patientsAlex Kostianovsky
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Sorbonne Paris Cité, INSERM U1060, Referral Center for Rare Autoimmune Systemic Diseases, Paris, France
Clin Exp Rheumatol 30:S83-9. 2012..This study was undertaken to evaluate immunogenicity and tolerance of seasonal (SFV) and A/H1N1 flu vaccines (HFV) in AID patients... - Extraocular manifestations of birdshot chorioretinopathy in 118 French patientsChristian Pagnoux
Department of Internal Medicine, National referral center for Systemic necrotizing vasculitides and systemic scleroderma, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
Presse Med 39:e97-e102. 2010..Published studies on birdshot chorioretinopathy (BCR) did not provide definitive information on possibly associated extraocular manifestations... - Sensitivity to change in systemic sclerosis of the McMaster-Toronto Arthritis Patient Preference Disability Questionnaire (MACTAR): shift in patient priorities over timeChristelle Nguyen
Paris Descartes University, UPRES EA 4058, Department of Internal Medicine, Referent Center for Necrotizing Vasculitis and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris, France
J Rheumatol 37:359-64. 2010..To assess the sensitivity to change of the McMaster-Toronto Arthritis Patient Preference Disability Questionnaire (MACTAR) in systemic sclerosis (SSc) and a shift in patient priorities over time... - Population-based prevalence study of Behçet's disease: differences by ethnic origin and low variation by age at immigrationAlfred Mahr
Department of Internal Medicine, Universite Paris 5 Rene Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 58:3951-9. 2008..To estimate the prevalence of Behçet's disease (BD) in a multiethnic population living in France, with particular focus on disease risk among immigrants... - Differences in patients with systemic sclerosis recruited from associations and tertiary care settingsCaroline Mestre-Stanislas
Universite Paris Descartes, Faculte de Medecine, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Presse Med 39:e205-9. 2010..To compare patients with systemic sclerosis (SSc) recruited from a patient association or a tertiary care setting... - Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohortsChristian Pagnoux
Hopital Cochin, AP HP, UNIVERSITE DE PARIS, Paris, France
Arthritis Rheum 58:2908-18. 2008..This study was undertaken to evaluate the applicability of those predictors in an independent cohort followed up by the French Vasculitis Study Group... - Diagnostic and prognostic relevance of neuromuscular biopsy in primary Sjögren's syndrome-related neuropathyBenjamin Terrier
Assistance Publique Hopitaux de Paris, Hopital de Bicetre, Le Kremlin Bicetre, France
Arthritis Rheum 57:1520-9. 2007..To evaluate the clinicobiologic presentation in patients with primary Sjögren's syndrome (SS)-related peripheral neuropathy, the histologic results of neuromuscular biopsy (NMB), and clinical outcome, and to identify prognostic factors... - Pulmonary arterial hypertension associated with systemic sclerosis in patients with functional class II dyspnoea: mild symptoms but severe outcomeEric Hachulla
Department of Internal Medicine, National Reference Center for Scleroderma, Claude Huriez Hospital, University of Lille, France
Rheumatology (Oxford) 49:940-4. 2010..To describe the history of SSc-associated pulmonary arterial hypertension (SSc-PAH) in patients with New York Heart Association (NYHA) functional class (FC) II dyspnoea at diagnosis... - Intravenous immunoglobulins for relapses of systemic vasculitides associated with antineutrophil cytoplasmic autoantibodies: results of a multicenter, prospective, open-label study of twenty-two patientsValerie Martinez
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Rheum 58:308-17. 2008.... - Churg-strauss syndrome: clinical symptoms, complementary investigations, prognosis and outcome, and treatmentBertrand Dunogué
Department of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases including Vasculitis, Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, France
Semin Respir Crit Care Med 32:298-309. 2011..Future therapies might reflect these differences more strongly... - Long-term outcome of 37 patients with Wegener's granulomatosis with renal involvementJacques Eric Gottenberg
Department of Internal Medicine, Nationale referral center for Vasculitides and Scleroderma, Hopital Cochin, AP HP, Universite Paris 5, Paris
Presse Med 36:771-8. 2007..This prospective study sought to assess the long-term outcome and identify prognostic factors of patients with kidney disease related to Wegener's granulomatosis (WG)... - Therapeutic options for systemic sclerosis related interstitial lung diseasesLuc Mouthon
Universite Paris Descartes, UPRES EA 4058, Pôle de Médecine Interne et Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Respir Med 104:S59-69. 2010..A subgroup of patients with rapidly progressive ILD might benefit from pulsed intravenous cyclophosphamide combined with prednisone 15 mg daily but this remains to be confirmed... - Microscopic polyangiitis and polyarteritis nodosa: how and when do they start?Christian Agard
Hopital Avicenne, Assistance Publique Hopitaux de Paris, France
Arthritis Rheum 49:709-15. 2003..To describe initial clinical symptoms attributable to microscopic polyangiitis (MPA) or polyarteritis nodosa (PAN)... - Scleroderma renal crisis: a retrospective multicentre study on 91 patients and 427 controlsLoic Guillevin
Department of Internal Medicine, Hopital Cochin, Paris Cedex 14, France
Rheumatology (Oxford) 51:460-7. 2012..This study was undertaken to describe SRC characteristics, prognosis and outcome, and evaluate the responsibility of CSs in its occurrence... - Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trialRaphaele Seror
Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Ann Rheum Dis 69:2125-30. 2010.... - Is pulmonary arterial hypertension really a late complication of systemic sclerosis?Eric Hachulla
Department of Internal Medicine, National Reference Center for Scleroderma, Claude Huriez Hospital, University of Lille, 59037 Lille Cedex, France
Chest 136:1211-9. 2009..PAH is generally considered to be a late complication of limited cutaneous SSc. This study identified and investigated a subset of SSc patients with early-onset PAH... - [Interstitial lung disease in systemic sclerosis]Luc Mouthon
Service de Medecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites et la Sclérodermie Systémique, AP HP, Paris
Presse Med 35:1943-51. 2006..A subgroup of patients with rapidly progressive ILD might benefit from intravenous cyclophosphamide pulses in association with 15 mg/d prednisone... - Wegener's granulomatosis strictly and persistently localized to one organ is rare: assessment of 16 patients from the French Vasculitis Study Group databaseChristian Pagnoux
Department of Internal Medicine, Hopital Cochin, 75879 Paris cedex 14, France
J Rheumatol 38:475-8. 2011..To study the frequency and characteristics of patients with Wegener's granulomatosis (WG) strictly and persistently localized to one organ... - The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohortLoic Guillevin
Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases Vasculitides and Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, UPRES 4058, Universite Paris Descartes, INSERM 1016, Paris, France loic guillevin cch aphp fr
Medicine (Baltimore) 90:19-27. 2011..The better WG prognosis for patients with ENT manifestations, even for patients with other visceral involvement, compared with the prognosis for those without ENT manifestations, probably reflects WG phenotype heterogeneity... - [Therapeutic management of systemic sclerosis]Luc Mouthon
Service de Medecine Interne, Hopital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Faculte de Medecine
Presse Med 35:1975-82. 2006..Physical therapy and rehabilitation may help to treat disability and loss of function in SSc patients... - Infliximab or rituximab for refractory Wegener's granulomatosis: long-term follow up. A prospective randomised multicentre study on 17 patientsMathilde de Menthon
Department of Internal Medicine, Hopital Cochin, University Paris Descartes, Paris, France
Clin Exp Rheumatol 29:S63-71. 2011..To compare efficacy and tolerance of infliximab versus rituximab to treat refractory Wegener's granulomatosis (WG), and clarify their respective indications... - Hepatitis B virus-associated polyarteritis nodosa: clinical characteristics, outcome, and impact of treatment in 115 patientsLoic Guillevin
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Medicine (Baltimore) 84:313-22. 2005..The major cause of death is gastrointestinal tract involvement. Importantly, the frequency of HBV-PAN has decreased in relation to improved blood safety and vaccination campaigns... - Indications for biotherapy in systemic vasculitidesLoic Guillevin
Department of Internal Medicine, French Vasculitis Study Group, Centre de Référence Vascularites et Sclérodermie, Hopital Cochin, Universite Paris Descartes, Paris, France
Clin Rev Allergy Immunol 32:85-96. 2007..Results of international ongoing trials will determine whether the agents may also have a place as first-line treatment... - Indication for plasma exchange for systemic necrotizing vasculiditiesLoic Guillevin
Department of Internal Medicine, Referral Center for Rare Diseases, Vasculitis and Scleroderma, Hopital Cochin, AP HP, Université de Paris René Descartes, 27, rue du Faubourg Saint Jacques, Paris, France
Transfus Apher Sci 36:179-85. 2007..Although PE does not improve survival, their adjunction to corticosteroids and immunosuppressants for patients with alveolar hemorrhage could also limit the severity of this severe manifestation... - Advances in the treatments of systemic vasculitidesLoic Guillevin
Service de Medecine Interne, Hopital Cochin, Assistance Publique Hopitaux de Paris, université Paris René Descartes, 27 rue du Faubourg Saint Jacques, Paris, France
Clin Rev Allergy Immunol 35:72-8. 2008..The strategies that improve patient's outcome are discussed in the light of the prospective trials organized by international research groups... - [Classification of systemic vasculatides]Loic Guillevin
Centre de référence national, Plan maladies rares, vascularites et sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris 5 Rene Descartes, Paris, France
Presse Med 36:845-53. 2007.... - Lymphoma complicating common variable immunodeficiency with granulomatous disease: report of two casesVéronique Le Guern
Department of Internal Medicine, Hopital Avicenne, Assistance Publique Hôpitaux de Paris and Université Paris Nord, Bobigny, France
Eur J Haematol 71:459-63. 2003..We describe two CVID patients with systemic granulomatosis who developed B-cell lymphomas, one related to Epstein Barr virus infection, 5 and 12 yr after CVID had been diagnosed... - Central nervous system involvement in Wegener granulomatosisRaphaele Seror
Department of Internal Medicine, Hopital Cochin, Universite Rene Descartes Paris 5, Assistance Publique Hopitaux de Paris, Paris, France
Medicine (Baltimore) 85:54-65. 2006.... - When should immunosuppressants be prescribed to treat systemic vasculitides?Loic Guillevin
Service de Medecine Interne, Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris Nord, Bobigny, France
Intern Med 42:313-7. 2003..The new therapeutic strategies comprise also new immunosuppressants and new immunomodulating agents which could replace or be associated to the "older drugs"... - Thiabendazole-induced acute liver failure requiring transplantation and subsequent diagnosis of polyarteritis nodosaMatthieu Groh
Department of Internal Medicine, Hopital Cochin, Referral Center for Rare Autoimmune and Systemic Diseases, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Clin Exp Rheumatol 30:S107-9. 2012..His outcome was favourable after second OLT, under steroids, cyclophosphamide pulses and tacrolimus. In retrospect, his initial symptoms and hypereosinophilia were probably attributable to PAN... - Patients with systemic inflammatory and autoimmune diseases are at risk of vaccine-preventable illnessesCecile Marchand-Janssen
Universite Paris Descartes, Faculte de Medecine, INSERM, CIC BT505, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Pôle de médecine, CIC de vaccinologie Cochin Pasteur, Paris, France
Rheumatology (Oxford) 50:1099-105. 2011..To evaluate vaccine coverage and humoral immunity to tetanus, diphtheria and poliomyelitis in adults followed for systemic inflammatory and/or autoimmune diseases (SIADs)... - Mood and anxiety disorders in systemic sclerosis patientsThierry Baubet
Université de Paris 13, Assistance Publique Hopitaux de Paris AP HP, Hopital Avicenne, Service de Psychopathologie, EA 3413, 93009 Bobigny Cedex, France
Presse Med 40:e111-9. 2011..To assess the prevalence of mood and anxiety disorders in systemic sclerosis (SSc) patients and the association of these disorders with clinical features... - Anti-PL7 antisynthetase syndrome under interferon therapyAchille Aouba
Department of Adult Haematology, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 149, rue de Sevres, 75015 Paris, France
Joint Bone Spine 78:94-7. 2011.... - Remittent non-destructive polysynovitis in P-ANCA-positive vasculitis patients with anti-CCP antibodiesChristian Pagnoux
Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75879 Paris cedex 14, France
Joint Bone Spine 77:604-7. 2010.... - Analysis of Wegener's granulomatosis responses to rituximab: current evidence and therapeutic prospectsAchille Aouba
Department of Internal Medicine and the French Vasculitis Study Group, Assistance Publique Hopitaux de Paris, Universite Paris, 5 René Descartes, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France
Clin Rev Allergy Immunol 34:65-73. 2008..This promising biotherapy opens the way for other therapeutic agents targeting B lymphocytes and to improve our understanding of the pathophysiology of ANCA-associated vasculitis... - Low influenza vaccination rate among patients with systemic sclerosisLuc Mouthon
Department of Internal Medicine, Cochin Hospital, Paris Cedex 14, France
Rheumatology (Oxford) 49:600-6. 2010..To evaluate the influenza vaccination rate and factors influencing it in patients with SSc... - Interstitial lung disease associated with systemic sclerosis: what is the evidence for efficacy of cyclophosphamide?Alice Berezne
Paris Descartes University, Faculty of Medicine, UPRES EA 4058, Department of Internal Medicine and Reference Center for Necrotizing Vasculitides and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France
Ann N Y Acad Sci 1110:271-84. 2007..Since only a minority of SSc patients develops severe ILD, we propose that further studies evaluating CYC should focus on the subgroup of SSc patients with worsening ILD... - Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohortCloé Comarmond
Hopital Cochin, AP HP, and Universite Paris Descartes, Paris 5, Paris, France
Arthritis Rheum 65:270-81. 2013..This study was undertaken to describe the main characteristics of a larger patient cohort and their long-term outcomes... - Alveolar haemorrhage in ANCA-associated vasculitides: 80 patients' features and prognostic factorsAlex Kostianovsky
Department of Internal Medicine, Hopital Cochin, Assistance Publique, Hopitaux de Paris, Universite Paris Descartes, Paris, France
Clin Exp Rheumatol 30:S77-82. 2012..Our objective was to determine the prognostic value of AH in this context... - Reporting of corticosteroid use in systemic disease trials: evidence from a systematic review of the potential impact on treatment effectChristian Pagnoux
INSERM U738, Universite Paris Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Care Res (Hoboken) 62:1002-8. 2010..To study how corticosteroid therapy is planned and described in reports of systemic disease trials and estimate the impact of the between-arm difference in corticosteroid dose on treatment effect... - Incidence and predictors of urotoxic adverse events in cyclophosphamide-treated patients with systemic necrotizing vasculitidesGuillaume Le Guenno
Hopital Cochin, Assistance Publique Hopitaux de Paris, and Université Paris 5, Paris, France
Arthritis Rheum 63:1435-45. 2011..To assess hemorrhagic cystitis and urinary tract cancer incidence and predictors in cyclophosphamide (CYC)-treated patients with systemic necrotizing vasculitis (SNV)... - Prevalence and characteristics of moderate to severe pulmonary hypertension in systemic sclerosis with and without interstitial lung diseaseDavid Launay
Department of Internal Medicine, National Center for Vascular Manifestations of Scleroderma, Regional University Hospital Claude Huriez Hospital, Lille, France
J Rheumatol 34:1005-11. 2007..To determine the prevalence and characteristics of moderate to severe pulmonary hypertension (PH) in patients with systemic sclerosis (SSc) with and without interstitial lung disease (ILD)... - [New insights into the pathogenesis of ANCA-positive vasculitides]Philippe Guilpain
Service de Medecine Interne, Centre national de références pour les vascularites systémiques et la sclérodermie systémique, Hopital Cochin, AP HP, Universite Paris V, Paris, France
Presse Med 36:854-9. 2007..A pathogenic role for antiproteinase 3 antibodies has not yet been clearly established in vivo although it is well documented in vitro... - Virus-induced systemic vasculitides: new therapeutic approachesLoic Guillevin
Department of Internal Medicine, Hopital Cochin, AP HP, Universite Rene Descartes Paris V, 27, rue du Faubourg Saint Jacques, Paris, France
Clin Dev Immunol 11:227-31. 2004..In vasculitis related to HCV-associated cryoglobulinemia, plasma exchanges improve the outcome but the poor effectiveness of antiviral drugs is not able to favor, usually, a definite recovery of the patients and relapses are frequent... - [Periostitis in systemic necrotizing vasculitides: Study of the 4 cases identified among the 1762 patients of the FVSG database and review of the literature]Sophie Périchon
Pôle de Médecine Interne, centre de référence vascularites systémiques nécrosantes et sclérodermie systémique, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
Presse Med 39:e165-73. 2010..Periostitis (periosteal new bone formation) is a rare manifestation of systemic necrotizing vasculitis... - Natural and disease associated anti-myeloperoxidase (MPO) autoantibodiesPhilippe Guilpain
Paris Descartes University, Faculty of Medicine, UPRES EA 4058, Department of Internal Medicine, Paris, France
Autoimmun Rev 7:421-5. 2008..Thus, anti-MPO Abs could play a pathogenic role in vivo by triggering an oxidative burst leading to severe endothelial damages... - Predictors at diagnosis of a first Wegener's granulomatosis relapse after obtaining complete remissionCarole Pierrot-Deseilligny Despujol
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 27, Paris, France
Rheumatology (Oxford) 49:2181-90. 2010..Although in most patients with WG, induction therapy leads to complete remission (CR), the high relapse rate remains a major problem. This study was undertaken to identify potential predictors of these relapses... - [Treatment of systemic autoimmune and inflammatory diseases with rituximab]Guillaume Bussone
Universite Paris Descartes, Pôle de Médecine Interne, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hopital Cochin, Assistance Publique Hopitaux de Paris, F 75679 Paris cedex 14, France
Presse Med 38:808-23. 2009..Relapses of the disease are common around six months after rituximab infusion. The response to retreatment with rituximab is usually the same that was obtained after the first course of treatment... - Churg-Strauss syndrome: evidence for disease subtypes?Christian Pagnoux
Department of Internal Medicine, French Vasculitis Study Group, National Referral Center for Necrotizing Vasculitides and Systemic Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Curr Opin Rheumatol 22:21-8. 2010..Conversely, physiopathogenetic mechanisms are not completely elucidated and clearly multiple, thereby suggesting the existence of different disease subtypes... - Efficacy and tolerance of infliximab in refractory Takayasu arteritis: French multicentre studyArsene Mekinian
Service de Medecine Interne, Universite Paris 13, AP HP, Hopital Jean Verdier, Bondy 93140, France
Rheumatology (Oxford) 51:882-6. 2012..To analyse the efficacy and tolerance of infliximab in refractory Takayasu arteritis (TA)... - [Neuropsychiatric manifestations in systemic sclerosis]David Launay
Universite Lille 2, Service de Medecine Interne, Centre de référence de la sclérodermie systémique, Hopital Claude Huriez, CHRU Lille, F 59037 Lille Cedex, France
Presse Med 39:539-47. 2010..If morphological CNS abnormalities could be linked to neuropsychiatric manifestations, it would be possible to identify neuropsychiatric scleroderma as we can now identify neuropsychiatric systemic lupus erythematosus... - Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated Christian Pagnoux
Hopital Cochin, Service de Medecine Interne, 27, rue du Faubourg Saint Jacques, Paris Cedex 14, France
Medicine (Baltimore) 84:115-28. 2005.... - Esophageal involvement as an initial manifestation of Churg-Strauss syndromeOlivier Mir
Service de Medecine Interne, centre de référence maladies rares, Hopital Cochin, AP HP, Universite Paris Descartes, Paris
Presse Med 36:57-60. 2007..Churg-Strauss syndrome (CSS) is a systemic disease characterized by asthma, blood and tissue eosinophilia, and necrotizing vasculitis with extravascular eosinophilic granulomas... - [Antileukotrienes and Churg-Strauss syndrome]Philippe Guilpain
Service de Medecine Interne, AP HP, Hopital Cochin, Universite Paris V, Paris, France
Presse Med 36:890-4. 2007..The onset of Churg-Strauss syndrome in patients treated with LTRA usually requires that they stop this treatment. Prescription of LTRA In patients with Churg-Strauss syndrome should be discussed with specialists... - [Pneumococcal infections and vaccination in patients with systemic autoimmune and/or inflammatory diseases]Paula Duchet-Niedziolka
Centre d Investigation Clinique de Vaccinologie Cochin Pasteur, Pôle de médecine, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Paris Cedex 14, France
Presse Med 38:243-50. 2009..More immunogenic vaccine strategy should be evaluated in patients with systemic autoimmune and/or inflammatory diseases to provide better vaccine coverage... - Pathogenic effects of antimyeloperoxidase antibodies in patients with microscopic polyangiitisPhilippe Guilpain
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 56:2455-63. 2007..The aim of this study was to investigate whether anti-MPO antibodies can activate MPO to generate an oxidative stress that is potentially deleterious to the endothelium...