P Gual

Summary

Country: France

Publications

  1. pmc Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients
    Adeline Bertola
    INSERM U895, Team 8 Hepatic complications of obesity, Nice, France
    PLoS ONE 5:e13577. 2010
  2. pmc The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease
    Stéphanie Patouraux
    INSERM, U1065, Equipe 8, Complications Hépatiques de l Obésité, Nice, France
    PLoS ONE 7:e35612. 2012
  3. pmc Serum markers of hepatocyte death and apoptosis are non invasive biomarkers of severe fibrosis in patients with alcoholic liver disease
    Vanessa Jeannette Lavallard
    Team 8, Hepatic complications of obesity, INSERM, U895, Nice, France
    PLoS ONE 6:e17599. 2011
  4. ncbi request reprint Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    Philippe Gual
    Inserm U 568 Molecular signaling and obesity IFR 50 Faculté de medecine, Avenue de Valombrose, 06107 Nice Cedex 2, France
    Biochimie 87:99-109. 2005
  5. ncbi request reprint Positive and negative regulation of glucose uptake by hyperosmotic stress
    P Gual
    INSERM U 568 and IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Diabetes Metab 29:566-75. 2003
  6. ncbi request reprint Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling
    J F Tanti
    INSERM Unité U 568, Faculty of Medicine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Ann Endocrinol (Paris) 65:43-8. 2004
  7. ncbi request reprint Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling
    Y Le Marchand-Brustel
    INSERM Unité U 568, Faculty of Medicine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Biochem Soc Trans 31:1152-6. 2003
  8. doi request reprint Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans
    V Kaddai
    INSERM U895, Mediterranean Center of Molecular Medicine C3M, Bâtiment Archimed, Nice Cedex 3, France
    Diabetologia 52:932-40. 2009
  9. ncbi request reprint MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632
    P Gual
    INSERM U568 and IFR50, Faculte de Medecine, Nice Cedex 02, France
    Diabetologia 46:1532-42. 2003
  10. ncbi request reprint Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes
    Philippe Gual
    INSERM U 568 and l Institut Fédératif de Recherches 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    J Biol Chem 278:26550-7. 2003

Collaborators

Detail Information

Publications23

  1. pmc Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients
    Adeline Bertola
    INSERM U895, Team 8 Hepatic complications of obesity, Nice, France
    PLoS ONE 5:e13577. 2010
    ..We aimed at identifying expression patterns of inflammatory and immune response genes specifically associated with obesity and NASH in the liver of morbidly obese patients...
  2. pmc The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease
    Stéphanie Patouraux
    INSERM, U1065, Equipe 8, Complications Hépatiques de l Obésité, Nice, France
    PLoS ONE 7:e35612. 2012
    ..We aimed to quantify the liver, adipose tissue and serum levels of OPN in heavy alcohol drinkers and to compare them with the histological severity of hepatic inflammation and fibrosis...
  3. pmc Serum markers of hepatocyte death and apoptosis are non invasive biomarkers of severe fibrosis in patients with alcoholic liver disease
    Vanessa Jeannette Lavallard
    Team 8, Hepatic complications of obesity, INSERM, U895, Nice, France
    PLoS ONE 6:e17599. 2011
    ..Our aims were to quantify and correlate the circulating levels of Cytokeratin 18 (CK18) and its caspases-generated fragment to disease severity in heavy alcoholics...
  4. ncbi request reprint Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    Philippe Gual
    Inserm U 568 Molecular signaling and obesity IFR 50 Faculté de medecine, Avenue de Valombrose, 06107 Nice Cedex 2, France
    Biochimie 87:99-109. 2005
    ..Understanding how these agents inhibit IRS1 functions as well as identification of kinases involved in these inhibitory effects may provide novel targets for development of strategies to prevent insulin resistance...
  5. ncbi request reprint Positive and negative regulation of glucose uptake by hyperosmotic stress
    P Gual
    INSERM U 568 and IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Diabetes Metab 29:566-75. 2003
    ..Understanding how osmotic stress induces glucose transport or mediates insulin resistance may provide novel targets for strategies to enhance glucose transport or to prevent insulin resistance...
  6. ncbi request reprint Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling
    J F Tanti
    INSERM Unité U 568, Faculty of Medicine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Ann Endocrinol (Paris) 65:43-8. 2004
    ..Such studies may enable rational drug design to selectively inhibit the activity of the relevant enzymes and generate a novel class of therapeutic agents for type 2 diabetes...
  7. ncbi request reprint Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling
    Y Le Marchand-Brustel
    INSERM Unité U 568, Faculty of Medicine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Biochem Soc Trans 31:1152-6. 2003
    ..Identification of IRS-1 kinases could enable rational drug design in order to selectively inhibit the activity of the relevant enzymes and generate a novel class of therapeutic agents for type 2 diabetes...
  8. doi request reprint Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans
    V Kaddai
    INSERM U895, Mediterranean Center of Molecular Medicine C3M, Bâtiment Archimed, Nice Cedex 3, France
    Diabetologia 52:932-40. 2009
    ..Our goal was to determine whether proteins controlling GLUT4 trafficking are altered in insulin resistance linked to obesity...
  9. ncbi request reprint MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632
    P Gual
    INSERM U568 and IFR50, Faculte de Medecine, Nice Cedex 02, France
    Diabetologia 46:1532-42. 2003
    ..We aimed at identifying serine residues in IRS-1 phosphorylated in response to insulin stimulation and at determining the involved kinases...
  10. ncbi request reprint Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes
    Philippe Gual
    INSERM U 568 and l Institut Fédératif de Recherches 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    J Biol Chem 278:26550-7. 2003
    ..On the other hand, prolonged osmotic stress alters IRS-1 function by inducing its degradation, which could contribute to the down-regulation of insulin action...
  11. pmc Osteopontin deficiency aggravates hepatic injury induced by ischemia-reperfusion in mice
    S Patouraux
    1 INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire C3M, Equipe 8 Complications hépatiques de l obésité, Nice, France 2 Université de Nice Sophia Antipolis, Faculte de Medecine, Nice, France 3 Centre Hospitalier Universitaire de Nice, Pôle Biologique, Hopital Pasteur, Nice, France
    Cell Death Dis 5:e1208. 2014
    ..This could be due to its ability to partially prevent death of hepatocytes and to limit the production of toxic iNOS-derived NO by macrophages...
  12. ncbi request reprint [Metabolic fatty liver diseases: hepatic consequences of the metabolic syndrome]
    Rodolphe Anty
    INSERM, U568, Nice
    Gastroenterol Clin Biol 31:1127-34. 2007
    ..Drugs such as thiazolidinediones, known to reduce insulin resistance and inflammation, still need further evaluation...
  13. ncbi request reprint [Obesity, diabetes and insulin resistance. Alterations of insulin signalling]
    Yannick Le Marchand-Brustel
    INSERM, U568, Faculte de Medecine, Universite de Nice Sophia Antipolis, Avenue de Valombrose, 06107 Nice 02, France
    J Soc Biol 200:93-7. 2006
    ..The role of the ERK1 isoform in the development of adipose tissue and insulin sensitivity is also presented...
  14. ncbi request reprint Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway
    Adeline Bertola
    INSERM, U 568, F 06107 Nice, France, Universite de Nice Sophia Antipolis, Faculte de Medecine, F 06107, Nice, France
    J Biol Chem 282:10325-32. 2007
    ..These data provide the first evidence that in vitro HGF promotes glucose uptake through a Gab1/PI 3-kinase/PKB/AS160 pathway which was altered in tumor necrosis factor alpha-treated adipocytes...
  15. ncbi request reprint Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor
    P Gual
    Institut National de la Santé et de la Recherche Médicale U 145, Faculte de Medecine, Nice, France
    Endocrinology 139:884-93. 1998
    ....
  16. pmc Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation
    Romain Barres
    Institut National de la Sante et de la Recherche Medicale, Unité 568, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Mol Endocrinol 20:2864-75. 2006
    ....
  17. ncbi request reprint A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport
    Philippe Gual
    INSERM U 568 and IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice, Cedex 02, France
    J Biol Chem 277:43980-6. 2002
    ..These data provide the first evidence that activation of TC10 and remodeling of cortical actin, which could occur through the TC10 signaling, are required for osmotic shock-mediated Glut 4 translocation and glucose uptake...
  18. doi request reprint A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients
    R Anty
    Institut National de la Sante et de la Recherche Medicale, Nice, France
    Aliment Pharmacol Ther 32:1315-22. 2010
    ..Non-invasive approaches are useful to differentiate simple steatosis from non-alcoholic steatohepatitis (NASH) in obese and morbidly obese patients...
  19. ncbi request reprint Osmotic regulation of cellular glucose uptake
    Philippe Gual
    INSERM U 568, University of Nice Sophia Antipolis, Nice, France
    Methods Enzymol 428:343-54. 2007
    ....
  20. ncbi request reprint The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH
    Rodolphe Anty
    INSERM U 568, Nice, France
    Am J Gastroenterol 101:1824-33. 2006
    ..Its clinical usefulness in the diagnosis of NASH was evaluated in severely obese patients without or with MS, diabetes, and NASH and the potential roles of the liver and of the adipose tissue in CRP production were characterized...
  21. ncbi request reprint Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
    Karim Bouzakri
    INSERM U449 and CRNHL, IFR 62, R Laennec Medical Faculty, F 69370 Lyon Cedex 08, France
    Diabetes 52:1319-25. 2003
    ..Moreover, increased MAPK activity seems to play a role in the phosphorylation of IRS-1 on serine residue in human muscle cells...
  22. ncbi request reprint Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
    Soumeya Bekri
    Laboratoire d Hépato Gastroentérologie, EA1186, Faculté Médecine de Nice, Nice, France
    Gastroenterology 131:788-96. 2006
    ..We have investigated the possible involvement of hepcidin in massive obesity, a state of chronic low-grade inflammation. Three groups of severely obese patients with or without diabetes or nonalcoholic steatohepatitis were investigated...
  23. ncbi request reprint Glucose intolerance and hypoadiponectinemia are already present in lean patients with chronic hepatitis C infected with genotype non-3 viruses
    Rodolphe Anty
    Centre Hospitalier de Nice, pole digestif, Nice, France
    Eur J Gastroenterol Hepatol 19:671-7. 2007
    ....